RGD Reference Report - Immunomodulation by roquinimex decreases the expression of IL-23 (p19) mRNA in the brains of herpes simplex virus type 1 infected BALB/c mice. - Rat Genome Database

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Immunomodulation by roquinimex decreases the expression of IL-23 (p19) mRNA in the brains of herpes simplex virus type 1 infected BALB/c mice.

Authors: Peltoniemi, J  Broberg, E K  Halenius, A  Setala, N  Eralinna, J-P  Salmi, A A  Roytta, M  Hukkanen, V 
Citation: Peltoniemi J, etal., Clin Exp Immunol. 2004 Aug;137(2):305-12. doi: 10.1111/j.1365-2249.2004.02528.x.
RGD ID: 39457939
Pubmed: PMID:15270847   (View Abstract at PubMed)
PMCID: PMC1809122   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1365-2249.2004.02528.x   (Journal Full-text)

Herpes simplex virus (HSV) is a common neurotropic virus which infects epithelial cells and subsequently the trigeminal ganglia (TG) and brain tissue. We studied how immunomodulation with roquinimex (Linomide) affects the course of corneal HSV infection in BALB/c mice. BALB/c mice have also been used in a model for HSV-based vectors in treating an autoimmune disease of the central nervous system (CNS). We addressed the questions of how immunomodulation affects the local as well as the systemic immune response and whether roquinimex could facilitate the spread of HSV to the CNS. The cytokine response in the brain and TG was studied using a quantitative rapid real-time RT-PCR method. We were interested in whether immunomodulation affects the expression of the recently described Th1-cytokine IL-23p19 in the brain and TG. The expression of IL-23 mRNA was decreased in brains of roquinimex-treated BALB/c mice. Also the expression of IL-12p35 and IFN-gamma mRNAs decreased. No significant changes were seen in IL-4 and IL-10 mRNA expression. The cytokine response was also studied using supernatants of stimulated splenocytes by EIA. Roquinimex treatment suppressed the production of IFN-gamma and also the production of IL-10 in HSV-infected BALB/c mice.

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide decreases expression ISOIl23a (Mus musculus)39457939; 394579394-hydroxy-N and 1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide decreases expression of Il23a mRNA in brainRGD 
4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide decreases expression EXP 394579394-hydroxy-N and 1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide decreases expression of Il23a mRNA in brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il23a  (interleukin 23 subunit alpha)

Genes (Mus musculus)
Il23a  (interleukin 23, alpha subunit p19)

Genes (Homo sapiens)
IL23A  (interleukin 23 subunit alpha)


Additional Information