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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620873
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il23a
Name: interleukin 23 subunit alpha
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il23aincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of IL23A mRNAPMID:21742974
Il23amultiple interactionsEXP 6480464CTDMIRLET7I mRNA affects the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]PMID:21742974
Il23aaffects expressionISOIL23A (Homo sapiens)6480464CTDLipopolysaccharides affects the expression of IL23A proteinPMID:24749687
Il23aincreases expressionISOIl23a (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of IL23A mRNAPMID:17464197 PMID:21989142 PMID:23999131 PMID:33049506
Il23aincreases expressionISOIL23A (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of IL23A mRNAPMID:15516327 PMID:15860229 PMID:35811015
Il23aincreases secretionISOIl23a (Mus musculus)6480464CTDLipopolysaccharides results in increased secretion of IL23A proteinPMID:33049506
Il23aincreases secretionISOIL23A (Homo sapiens)6480464CTDLipopolysaccharides results in increased secretion of IL23A proteinPMID:22127699
Il23amultiple interactionsISOIl23a (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]; cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]]PMID:17464197 PMID:21989142 PMID:23999131 PMID:33049506
Il23amultiple interactionsISOIL23A (Homo sapiens)6480464CTD2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester affects the reaction [Lipopolysaccharides affects the expression of IL23A protein]; 6-formylindolo(3,2-b)carbazole affects the reaction [Lipopolysaccharides affects the expression of IL23A protein]; [Lipopolysaccharides co-treated with resiquimod] results in increased expression of [IL12B protein binds to IL23A protein]; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of IL23A mRNA; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL23A protein binds to IL12B protein]]; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]PMID:17053051 PMID:18490488 PMID:24749687 PMID:35811015
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