IL23A (interleukin 23 subunit alpha) - Rat Genome Database

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Gene: IL23A (interleukin 23 subunit alpha) Chlorocebus sabaeus
Analyze
Symbol: IL23A
Name: interleukin 23 subunit alpha
RGD ID: 18776259
Description: ENCODES a protein that exhibits interleukin-23 receptor binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); T cell proliferation (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); interleukin-23 complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin-23 subunit alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,289,486 - 52,296,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,295,106 - 52,297,244 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,689,882 - 193,696,291 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface receptor signaling pathway via JAK-STAT  (IEA)
cell surface receptor signaling pathway via STAT  (IEA)
defense response to Gram-negative bacterium  (IEA)
defense response to virus  (IEA)
immune response  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
negative regulation of interleukin-10 production  (IEA)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of defense response to virus by host  (IEA)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IEA)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-17 production  (IEA)
positive regulation of memory T cell differentiation  (IEA)
positive regulation of natural killer cell proliferation  (IEA)
positive regulation of neutrophil chemotaxis  (IEA)
positive regulation of NK T cell activation  (IEA)
positive regulation of NK T cell proliferation  (IEA)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of T cell mediated cytotoxicity  (IEA)
positive regulation of T cell proliferation  (IEA)
positive regulation of T-helper 1 type immune response  (IEA)
positive regulation of T-helper 17 cell lineage commitment  (IEA)
positive regulation of T-helper 17 type immune response  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type II interferon production  (IEA)
T cell proliferation  (IEA,ISO)
tissue remodeling  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IL23A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,289,486 - 52,296,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,295,106 - 52,297,244 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,689,882 - 193,696,291 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
IL23A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,338,884 - 56,340,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,334,174 - 56,340,410 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,732,668 - 56,734,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,018,930 - 55,020,461 (+)NCBINCBI36Build 36hg18NCBI36
Build 341255,018,929 - 55,020,460NCBI
Celera1256,386,015 - 56,387,546 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,771,325 - 53,772,856 (+)NCBIHuRef
CHM1_11256,700,047 - 56,701,578 (+)NCBICHM1_1
T2T-CHM13v2.01256,306,530 - 56,308,056 (+)NCBIT2T-CHM13v2.0
Il23a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,132,009 - 128,133,953 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,132,008 - 128,134,621 (-)EnsemblGRCm39 Ensembl
GRCm3810128,296,140 - 128,298,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,296,139 - 128,298,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,733,196 - 127,735,140 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,699,089 - 127,701,033 (-)NCBIMGSCv36mm8
Celera10130,684,464 - 130,686,407 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.51NCBI
Il23a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,306,320 - 1,308,434 (-)NCBIGRCr8
mRatBN7.27721,809 - 723,923 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7721,809 - 723,923 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,478,053 - 3,480,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,354,036 - 5,356,151 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,656,694 - 5,658,809 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,710,609 - 2,712,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,710,609 - 2,712,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,689,128 - 2,691,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,584,112 - 1,586,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,584,111 - 1,586,226 (-)NCBI
Celera7597,260 - 599,374 (-)NCBICelera
Cytogenetic Map7q11NCBI
Il23a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,947,803 - 3,949,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,946,964 - 3,949,180 (+)NCBIChiLan1.0ChiLan1.0
IL23A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,992,032 - 37,993,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,987,711 - 37,990,161 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,575,321 - 32,576,856 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,828,902 - 32,830,621 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,828,902 - 32,830,617 (-)Ensemblpanpan1.1panPan2
IL23A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110635,384 - 640,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10638,719 - 640,359 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10700,688 - 704,049 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010646,091 - 649,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10647,540 - 649,181 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110623,343 - 626,704 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010866,496 - 869,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010990,220 - 993,580 (+)NCBIUU_Cfam_GSD_1.0
Il23a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,124,372 - 58,126,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646743,688 - 745,836 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646743,630 - 745,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL23A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,732,165 - 21,734,267 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,732,416 - 21,733,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Il23a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,662,753 - 11,665,418 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,662,851 - 11,664,444 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000003198   ⟹   ENSCSAP00000001486
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1152,295,106 - 52,297,244 (+)Ensembl
RefSeq Acc Id: XM_008003652   ⟹   XP_008001843
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11152,293,769 - 52,296,735 (+)NCBI
Vero_WHO_p1.0NW_023666037193,689,882 - 193,692,243 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005239953
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037193,689,884 - 193,696,291 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008001843 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001486
  ENSCSAP00000001486.1
RefSeq Acc Id: XP_008001843   ⟸   XM_008003652
- UniProtKB: A0A0D9QYP7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000001486   ⟸   ENSCSAT00000003198


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005166 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003198.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  IL-23_alpha UniProtKB/TrEMBL
KEGG Report csab:103238523 UniProtKB/TrEMBL
NCBI Gene IL23A ENTREZGENE
PANTHER INTERLEUKIN-23 SUBUNIT ALPHA UniProtKB/TrEMBL
  PTHR15947 UniProtKB/TrEMBL
Pfam IL23 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A0D9QYP7 ENTREZGENE, UniProtKB/TrEMBL