Il23a (interleukin 23, alpha subunit p19) - Rat Genome Database

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Gene: Il23a (interleukin 23, alpha subunit p19) Mus musculus
Analyze
Symbol: Il23a
Name: interleukin 23, alpha subunit p19
RGD ID: 1552166
MGI Page MGI
Description: Contributes to interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of defense response to virus by host; positive regulation of immune response; and positive regulation of neutrophil chemotaxis. Acts upstream of or within T cell proliferation and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Part of interleukin-23 complex. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL23A (interleukin 23 subunit alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-; IL-23; IL-23 subunit alpha; IL-23-A; IL-23p19; interleukin-23 subunit alpha; interleukin-23 subunit p19; p1; p19
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,132,009 - 128,133,953 (-)NCBIGRCm39mm39
GRCm39 Ensembl10128,132,008 - 128,134,621 (-)Ensembl
GRCm3810128,296,140 - 128,298,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,296,139 - 128,298,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,733,196 - 127,735,140 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610127,699,089 - 127,701,033 (-)NCBImm8
Celera10130,684,464 - 130,686,407 (-)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide  (EXP)
4-nitroquinoline N-oxide  (EXP)
5-methoxypsoralen  (EXP)
6alpha-methylprednisolone  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
azathioprine  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
berberine  (EXP)
beta-D-glucan  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bucladesine  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
celastrol  (EXP)
cisplatin  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (ISO)
cyanidin cation  (EXP,ISO)
cyclophosphamide  (EXP)
D-penicillamine  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
estriol  (EXP)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
ferulic acid  (EXP)
flutamide  (ISO)
folic acid  (EXP)
fragrance  (ISO)
furan  (ISO)
gentamycin  (ISO)
hydroquinone  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxychloroquine  (EXP)
imiquimod  (EXP)
levamisole  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
melphalan  (EXP)
methotrexate  (EXP,ISO)
misoprostol  (ISO)
muramyl dipeptide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
peptidoglycan  (ISO)
phenytoin  (EXP)
phorbol 12,13-dibutanoate  (ISO)
phytoestrogen  (EXP)
pioglitazone  (EXP)
piroxicam  (ISO)
poly(methyl methacrylate) macromolecule  (ISO)
potassium dichromate  (EXP)
prednisolone  (ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (EXP,ISO)
rac-lactic acid  (ISO)
resiquimod  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium sulfate  (EXP)
streptozocin  (EXP)
tacrolimus hydrate  (EXP)
tadalafil  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tofacitinib  (EXP)
trichloroethene  (ISO)
triptonide  (EXP)
tunicamycin  (ISO)
vincristine  (ISO)
wortmannin  (ISO)
zinc protoporphyrin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
defense response to Gram-negative bacterium  (ISO)
defense response to virus  (IEA)
immune response  (IC)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
negative regulation of interleukin-10 production  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of activation of Janus kinase activity  (IBA,ISO)
positive regulation of defense response to virus by host  (IDA,ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-17 production  (IC,ISO)
positive regulation of memory T cell differentiation  (IDA)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of neutrophil chemotaxis  (IDA)
positive regulation of NK T cell activation  (ISO)
positive regulation of NK T cell proliferation  (IC,ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of T cell mediated cytotoxicity  (IDA)
positive regulation of T cell proliferation  (IBA,IDA,ISO)
positive regulation of T-helper 1 type immune response  (IDA,ISO)
positive regulation of T-helper 17 cell lineage commitment  (IBA,IDA)
positive regulation of T-helper 17 type immune response  (IC,IDA,ISO)
positive regulation of transcription by RNA polymerase II  (IGI)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of tyrosine phosphorylation of STAT protein  (ISO)
T cell proliferation  (IDA)
tissue remodeling  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Interleukin-18 Mediates Immune Responses to Campylobacter jejuni Infection in Gnotobiotic Mice. Bereswill S, etal., PLoS One. 2016 Jun 20;11(6):e0158020. doi: 10.1371/journal.pone.0158020. eCollection 2016.
2. Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice. Broberg EK, etal., J Interferon Cytokine Res. 2002 Jun;22(6):641-51. doi: 10.1089/10799900260100123.
3. Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection. Chackerian AA, etal., Infect Immun. 2006 Nov;74(11):6092-9. doi: 10.1128/IAI.00621-06. Epub 2006 Aug 21.
4. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. Conti HR, etal., J Exp Med. 2009 Feb 16;206(2):299-311. doi: 10.1084/jem.20081463. Epub 2009 Feb 9.
5. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. Cooper AM, etal., J Immunol. 2002 Feb 1;168(3):1322-7. doi: 10.4049/jimmunol.168.3.1322.
6. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. Cruz A, etal., J Exp Med. 2010 Aug 2;207(8):1609-16. doi: 10.1084/jem.20100265. Epub 2010 Jul 12.
7. Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis. Dietze-Schwonberg K, etal., Exp Dermatol. 2018 Jan;27(1):101-103. doi: 10.1111/exd.13455. Epub 2017 Dec 6.
8. Th1-mediated immunity against Helicobacter pylori can compensate for lack of Th17 cells and can protect mice in the absence of immunization. Ding H, etal., PLoS One. 2013 Jul 11;8(7):e69384. doi: 10.1371/journal.pone.0069384. Print 2013.
9. IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment. Erdmann H, etal., Immunobiology. 2013 Jun;218(6):910-23. doi: 10.1016/j.imbio.2012.10.005. Epub 2012 Oct 26.
10. Acute alcohol intoxication suppresses the interleukin 23 response to Klebsiella pneumoniae infection. Happel KI, etal., Alcohol Clin Exp Res. 2006 Jul;30(7):1200-7. doi: 10.1111/j.1530-0277.2006.00144.x.
11. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. Happel KI, etal., J Exp Med. 2005 Sep 19;202(6):761-9. doi: 10.1084/jem.20050193. Epub 2005 Sep 12.
12. The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection. Heimesaat MM, etal., Gut Pathog. 2016 Jul 6;8:21. doi: 10.1186/s13099-016-0106-4. eCollection 2016.
13. Inflammatory monocyte recruitment is regulated by interleukin-23 during systemic bacterial infection. Indramohan M, etal., Infect Immun. 2012 Dec;80(12):4099-105. doi: 10.1128/IAI.00589-12. Epub 2012 Sep 10.
14. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. Khader SA, etal., J Immunol. 2005 Jul 15;175(2):788-95. doi: 10.4049/jimmunol.175.2.788.
15. BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. Kitada S, etal., J Exp Med. 2017 May 1;214(5):1313-1331. doi: 10.1084/jem.20161076. Epub 2017 Mar 29.
16. IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. Kleinschek MA, etal., J Immunol. 2006 Jan 15;176(2):1098-106. doi: 10.4049/jimmunol.176.2.1098.
17. IL-23 p19 knockout mice exhibit minimal defects in responses to primary and secondary infection with Francisella tularensis LVS. Kurtz SL, etal., PLoS One. 2014 Oct 8;9(10):e109898. doi: 10.1371/journal.pone.0109898. eCollection 2014.
18. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. Lieberman LA, etal., J Immunol. 2004 Aug 1;173(3):1887-93. doi: 10.4049/jimmunol.173.3.1887.
19. Interleukin-23 (IL-23), independent of IL-17 and IL-22, drives neutrophil recruitment and innate inflammation during Clostridium difficile colitis in mice. McDermott AJ, etal., Immunology. 2016 Jan;147(1):114-24. doi: 10.1111/imm.12545. Epub 2015 Dec 2.
20. IL-23 is required for protection against systemic infection with Listeria monocytogenes. Meeks KD, etal., J Immunol. 2009 Dec 15;183(12):8026-34. doi: 10.4049/jimmunol.0901588.
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. MGD IEA MGD IEA
23. IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage. Noll J, etal., J Hepatol. 2016 May;64(5):1147-1157. doi: 10.1016/j.jhep.2016.01.013. Epub 2016 Jan 22.
24. Distinct effects of endogenous interleukin-23 on eosinophilic airway inflammation in response to different antigens. Ogawa R, etal., Allergol Int. 2015 Sep;64 Suppl:S24-9. doi: 10.1016/j.alit.2015.04.005. Epub 2015 May 16.
25. Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. Okada Y, etal., Clin Exp Immunol. 2013 Dec;174(3):459-71. doi: 10.1111/cei.12200.
26. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
27. Immunomodulation by roquinimex decreases the expression of IL-23 (p19) mRNA in the brains of herpes simplex virus type 1 infected BALB/c mice. Peltoniemi J, etal., Clin Exp Immunol. 2004 Aug;137(2):305-12. doi: 10.1111/j.1365-2249.2004.02528.x.
28. IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Peng J, etal., Cell Res. 2010 Jan;20(1):62-71. Epub 2009 Nov 24.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. Mouse MP Annotation Import Pipeline RGD automated import pipeline
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. Rudner XL, etal., Infect Immun. 2007 Jun;75(6):3055-61. doi: 10.1128/IAI.01329-06. Epub 2007 Apr 2.
34. IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and -dependent mechanisms. Szymczak WA, etal., Am J Pathol. 2012 Apr;180(4):1547-59. doi: 10.1016/j.ajpath.2011.12.038. Epub 2012 Feb 16.
35. TLR2 deficiency by compromising p19 (IL-23) expression limits Th 17 cell responses to Mycobacterium tuberculosis. Teixeira-Coelho M, etal., Int Immunol. 2011 Feb;23(2):89-96. doi: 10.1093/intimm/dxq459. Epub 2010 Dec 14.
36. Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2. Yao Z, etal., Aging (Albany NY). 2020 May 2;12(9):7639-7651. doi: 10.18632/aging.103101. Epub 2020 May 2.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11114383   PMID:11217851   PMID:11390512   PMID:12023369   PMID:12417590   PMID:12477932   PMID:12610626   PMID:12646495   PMID:12847224  
PMID:14566340   PMID:14568135   PMID:14610273   PMID:14662908   PMID:14688363   PMID:14978083   PMID:15489334   PMID:15657292   PMID:16141072   PMID:16141073   PMID:16339539   PMID:16482511  
PMID:16648837   PMID:16670770   PMID:16670771   PMID:16688182   PMID:16698929   PMID:16751361   PMID:16818672   PMID:16849446   PMID:16919486   PMID:16920909   PMID:16982811   PMID:17030948  
PMID:17030949   PMID:17052755   PMID:17071720   PMID:17088434   PMID:17142310   PMID:17142769   PMID:17200411   PMID:17277169   PMID:17294405   PMID:17351619   PMID:17548652   PMID:17804196  
PMID:17897860   PMID:17899546   PMID:17919942   PMID:17982049   PMID:18250458   PMID:18264109   PMID:18311793   PMID:18336386   PMID:18375954   PMID:18391061   PMID:18400195   PMID:18490716  
PMID:18566439   PMID:18570589   PMID:18579699   PMID:18600259   PMID:18606706   PMID:18698497   PMID:18762568   PMID:18787221   PMID:18799693   PMID:18802055   PMID:18818389   PMID:18831919  
PMID:18832731   PMID:18955477   PMID:18958885   PMID:18978771   PMID:19017979   PMID:19039774   PMID:19059877   PMID:19060952   PMID:19088061   PMID:19185846   PMID:19200759   PMID:19201478  
PMID:19273625   PMID:19289819   PMID:19299021   PMID:19339380   PMID:19342674   PMID:19357249   PMID:19357708   PMID:19380813   PMID:19409487   PMID:19414740   PMID:19469707   PMID:19501566  
PMID:19542449   PMID:19570828   PMID:19592489   PMID:19624579   PMID:19625643   PMID:19635858   PMID:19648929   PMID:19657089   PMID:19666510   PMID:19727119   PMID:19853481   PMID:19890042  
PMID:19995958   PMID:20017902   PMID:20083652   PMID:20130220   PMID:20131264   PMID:20228197   PMID:20360853   PMID:20364087   PMID:20382845   PMID:20393462   PMID:20404142   PMID:20404153  
PMID:20408896   PMID:20421647   PMID:20434372   PMID:20458705   PMID:20600778   PMID:20624950   PMID:20732640   PMID:20832339   PMID:20921529   PMID:21036146   PMID:21093318   PMID:21097874  
PMID:21135172   PMID:21148126   PMID:21169541   PMID:21172868   PMID:21194981   PMID:21278737   PMID:21282337   PMID:21289639   PMID:21304519   PMID:21321105   PMID:21336274   PMID:21372631  
PMID:21402701   PMID:21516111   PMID:21670317   PMID:21741931   PMID:21746859   PMID:21807912   PMID:21858022   PMID:21873635   PMID:21931625   PMID:21953641   PMID:22003199   PMID:22005301  
PMID:22025517   PMID:22089030   PMID:22101830   PMID:22202675   PMID:22287718   PMID:22297634   PMID:22306017   PMID:22355103   PMID:22387269   PMID:22519587   PMID:22591694   PMID:22624013  
PMID:22753938   PMID:22772566   PMID:22792286   PMID:22799166   PMID:22972933   PMID:22977257   PMID:23034650   PMID:23050010   PMID:23064362   PMID:23086919   PMID:23178247   PMID:23180821  
PMID:23200826   PMID:23200827   PMID:23233727   PMID:23241743   PMID:23319736   PMID:23334414   PMID:23341605   PMID:23460846   PMID:23469022   PMID:23475182   PMID:23528817   PMID:23554941  
PMID:23623497   PMID:23677049   PMID:23752068   PMID:23754427   PMID:23781104   PMID:23843079   PMID:23913046   PMID:23940256   PMID:24019552   PMID:24040208   PMID:24238108   PMID:24283842  
PMID:24292977   PMID:24293139   PMID:24300243   PMID:24343647   PMID:24379290   PMID:24387596   PMID:24434636   PMID:24442441   PMID:24453427   PMID:24569709   PMID:24664521   PMID:24829419  
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PMID:25348165   PMID:25371211   PMID:25452564   PMID:25600958   PMID:25637493   PMID:25639230   PMID:25761673   PMID:25838550   PMID:25902485   PMID:25908663   PMID:25959063   PMID:25965582  
PMID:26006013   PMID:26160380   PMID:26189370   PMID:26216045   PMID:26223651   PMID:26239416   PMID:26242598   PMID:26358260   PMID:26377898   PMID:26431947   PMID:26511769   PMID:26647405  
PMID:26660726   PMID:26912904   PMID:26993035   PMID:27019190   PMID:27043160   PMID:27111864   PMID:27189410   PMID:27193261   PMID:27297018   PMID:27341090   PMID:27351934   PMID:27365293  
PMID:27369778   PMID:27384869   PMID:27540765   PMID:27551155   PMID:27634762   PMID:27729335   PMID:27795421   PMID:27820809   PMID:27864285   PMID:27956175   PMID:27956525   PMID:27984001  
PMID:27995603   PMID:28087239   PMID:28282579   PMID:28290522   PMID:28299442   PMID:28377495   PMID:28555647   PMID:28646040   PMID:28690333   PMID:28855306   PMID:29187586   PMID:29364878  
PMID:29386115   PMID:29398651   PMID:29524223   PMID:29602153   PMID:29615652   PMID:29650963   PMID:29760082   PMID:29870687   PMID:29909020   PMID:29925696   PMID:29950727   PMID:30018073  
PMID:30292634   PMID:30307739   PMID:30355616   PMID:30389414   PMID:30427069   PMID:31020341   PMID:31132747   PMID:31154574   PMID:31158699   PMID:31166866   PMID:31230747   PMID:31350179  
PMID:31707227   PMID:31776355   PMID:32003148   PMID:32203518   PMID:32410846   PMID:32427877   PMID:32471485   PMID:32554431   PMID:32632165   PMID:33259477   PMID:33664371   PMID:33724710  
PMID:33983951   PMID:33989521   PMID:34093846   PMID:34227806   PMID:34433045   PMID:34473953   PMID:34484224   PMID:35468842  


Genomics

Comparative Map Data
Il23a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,132,009 - 128,133,953 (-)NCBIGRCm39mm39
GRCm39 Ensembl10128,132,008 - 128,134,621 (-)Ensembl
GRCm3810128,296,140 - 128,298,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,296,139 - 128,298,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,733,196 - 127,735,140 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610127,699,089 - 127,701,033 (-)NCBImm8
Celera10130,684,464 - 130,686,407 (-)NCBICelera
Cytogenetic Map10D3NCBI
IL23A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,338,884 - 56,340,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1256,334,174 - 56,340,410 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,732,668 - 56,734,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,018,930 - 55,020,461 (+)NCBINCBI36hg18NCBI36
Build 341255,018,929 - 55,020,460NCBI
Celera1256,386,015 - 56,387,546 (+)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1253,771,325 - 53,772,856 (+)NCBIHuRef
CHM1_11256,700,047 - 56,701,578 (+)NCBICHM1_1
T2T-CHM13v2.01256,306,530 - 56,308,056 (+)NCBI
Il23a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27721,809 - 723,923 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7721,809 - 723,923 (-)Ensembl
Rnor_6.072,710,609 - 2,712,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,710,609 - 2,712,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,689,128 - 2,691,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,584,112 - 1,586,226 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.171,584,111 - 1,586,226 (-)NCBI
Celera7597,260 - 599,374 (-)NCBICelera
Cytogenetic Map7q11NCBI
Il23a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,947,803 - 3,949,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,946,964 - 3,949,180 (+)NCBIChiLan1.0ChiLan1.0
IL23A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11232,828,902 - 32,830,621 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,828,902 - 32,830,617 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,575,321 - 32,576,856 (-)NCBIMhudiblu_PPA_v0panPan3
IL23A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110635,384 - 640,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10638,719 - 640,359 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10700,688 - 704,049 (+)NCBI
ROS_Cfam_1.010646,091 - 649,452 (+)NCBI
ROS_Cfam_1.0 Ensembl10647,540 - 649,181 (+)Ensembl
UMICH_Zoey_3.110623,343 - 626,704 (+)NCBI
UNSW_CanFamBas_1.010866,496 - 869,858 (+)NCBI
UU_Cfam_GSD_1.010990,220 - 993,580 (+)NCBI
Il23a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,124,372 - 58,126,957 (-)NCBI
SpeTri2.0NW_004936646743,630 - 745,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL23A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,732,165 - 21,734,267 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,732,416 - 21,733,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IL23A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,289,486 - 52,296,735 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,295,106 - 52,297,244 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037193,689,882 - 193,696,291 (-)NCBIVero_WHO_p1.0
Il23a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,662,753 - 11,665,418 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462480211,662,851 - 11,664,444 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
PMC182190P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,297,078 - 128,297,971UniSTSGRCm38
MGSCv3710127,734,134 - 127,735,027UniSTSGRCm37
Celera10130,685,401 - 130,686,294UniSTS
Cytogenetic Map10D3UniSTS
Il23a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,297,078 - 128,297,555UniSTSGRCm38
Celera10130,685,401 - 130,685,878UniSTS
Cytogenetic Map10D3UniSTS
cM Map1076.51UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122785970129466996Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122785970129466996Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122785970129466996Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125633671129466375Mouse
12911219Frct3b_mfear conditioning traits 3b (mouse)10127675574129466996Mouse
12911221Frct3d_mfear conditioning traits 3d (mouse)10127675574129466996Mouse
12904000Opfaq7_mopen field activity QTL 7 (mouse)10127746318129466375Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:174
Interacting mature miRNAs:189
Transcripts:ENSMUST00000026449
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000026449   ⟹   ENSMUSP00000026449
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,132,008 - 128,133,953 (-)Ensembl
GRCm38.p6 Ensembl10128,296,139 - 128,298,084 (-)Ensembl
RefSeq Acc Id: ENSMUST00000218109
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,132,531 - 128,134,621 (-)Ensembl
GRCm38.p6 Ensembl10128,296,662 - 128,298,752 (-)Ensembl
RefSeq Acc Id: NM_031252   ⟹   NP_112542
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,132,009 - 128,133,953 (-)NCBI
GRCm3810128,296,140 - 128,298,084 (-)ENTREZGENE
MGSCv3710127,733,196 - 127,735,140 (-)RGD
Celera10130,684,464 - 130,686,407 (-)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112542   ⟸   NM_031252
- Peptide Label: precursor
- UniProtKB: Q9EQ14 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026449   ⟸   ENSMUST00000026449

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQ14-F1-model_v2 AlphaFold Q9EQ14 1-196 view protein structure

Promoters
RGD ID:6819463
Promoter ID:MM_KWN:5982
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell
Transcripts:NM_031252
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,734,911 - 127,735,912 (-)MPROMDB
RGD ID:8673596
Promoter ID:EPDNEW_M14829
Type:single initiation site
Name:Il23a_1
Description:Mus musculus interleukin 23, alpha subunit p19 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810128,298,096 - 128,298,156EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1932410 AgrOrtholog
Ensembl Genes ENSMUSG00000025383 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000026449 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026449 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-23_alpha UniProtKB/Swiss-Prot
KEGG Report mmu:83430 UniProtKB/Swiss-Prot
MGD MGI:1932410 ENTREZGENE
NCBI Gene 83430 ENTREZGENE
PANTHER PTHR15947 UniProtKB/Swiss-Prot
Pfam IL23 UniProtKB/Swiss-Prot
PhenoGen Il23a PhenoGen
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt IL23A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE