Ilvbl (ilvB acetolactate synthase like) - Rat Genome Database

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Gene: Ilvbl (ilvB acetolactate synthase like) Rattus norvegicus
Analyze
Symbol: Ilvbl
Name: ilvB acetolactate synthase like
RGD ID: 1307988
Description: Predicted to enable acetolactate synthase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid alpha-oxidation; isoleucine biosynthetic process; and valine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of acetolactate synthase complex. Orthologous to human ILVBL (ilvB acetolactate synthase like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-hydroxyacyl-CoA lyase 2; acetolactate synthase-like protein; ilvB (bacterial acetolactate synthase)-like; LOC362843
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,690,445 - 11,700,498 (-)NCBIGRCr8
mRatBN7.2711,039,870 - 11,049,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,039,871 - 11,049,924 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,858,794 - 13,868,869 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,736,181 - 15,746,256 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,614,088 - 13,624,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,044,586 - 14,054,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,044,586 - 14,054,639 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,201,069 - 14,211,122 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,593,095 - 12,603,148 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,593,102 - 12,602,948 (-)NCBI
Celera79,161,349 - 9,171,402 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19946888   PMID:28289220  


Genomics

Comparative Map Data
Ilvbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,690,445 - 11,700,498 (-)NCBIGRCr8
mRatBN7.2711,039,870 - 11,049,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,039,871 - 11,049,924 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,858,794 - 13,868,869 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,736,181 - 15,746,256 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,614,088 - 13,624,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,044,586 - 14,054,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,044,586 - 14,054,639 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,201,069 - 14,211,122 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,593,095 - 12,603,148 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,593,102 - 12,602,948 (-)NCBI
Celera79,161,349 - 9,171,402 (-)NCBICelera
Cytogenetic Map7q11NCBI
ILVBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,114,987 - 15,125,786 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1915,114,984 - 15,125,786 (-)EnsemblGRCh38hg38GRCh38
GRCh371915,225,798 - 15,236,597 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,086,785 - 15,097,577 (-)NCBINCBI36Build 36hg18NCBI36
Build 341915,086,786 - 15,096,968NCBI
Celera1915,121,522 - 15,132,314 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,793,615 - 14,804,441 (-)NCBIHuRef
CHM1_11915,225,270 - 15,236,095 (-)NCBICHM1_1
T2T-CHM13v2.01915,239,931 - 15,250,730 (-)NCBIT2T-CHM13v2.0
Ilvbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,410,178 - 78,420,336 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1078,410,180 - 78,420,336 (+)EnsemblGRCm39 Ensembl
GRCm381078,574,344 - 78,584,502 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,574,346 - 78,584,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv371078,037,245 - 78,047,247 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361077,977,671 - 77,987,622 (+)NCBIMGSCv36mm8
Celera1079,596,716 - 79,606,718 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Ilvbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554958,130,875 - 8,140,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554958,130,875 - 8,140,152 (+)NCBIChiLan1.0ChiLan1.0
ILVBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22020,028,859 - 20,039,748 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11919,031,470 - 19,042,359 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,648,081 - 14,658,879 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11915,632,614 - 15,643,554 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1915,632,614 - 15,643,414 (-)Ensemblpanpan1.1panPan2
ILVBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12047,013,033 - 47,021,511 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2047,012,557 - 47,021,778 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,863,113 - 46,872,559 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02047,504,784 - 47,514,232 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2047,504,776 - 47,514,232 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12046,736,880 - 46,746,330 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02047,155,949 - 47,165,396 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02047,427,211 - 47,436,661 (+)NCBIUU_Cfam_GSD_1.0
Ilvbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118205,794,992 - 205,803,665 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365965,343,761 - 5,354,264 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365965,343,895 - 5,352,804 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ILVBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl262,435,155 - 62,451,371 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1262,435,368 - 62,447,030 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,996,400 - 62,008,051 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ILVBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,717,252 - 13,728,880 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,715,767 - 13,728,855 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660745,805,040 - 5,816,682 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ilvbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249012,198,272 - 2,206,545 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249012,198,000 - 2,207,849 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ilvbl
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:128
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000039852
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
RH129156  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,039,651 - 11,039,834 (+)MAPPERmRatBN7.2
Rnor_6.0714,044,367 - 14,044,549NCBIRnor6.0
Rnor_5.0714,200,850 - 14,201,032UniSTSRnor5.0
RGSC_v3.4712,592,876 - 12,593,058UniSTSRGSC3.4
Celera79,161,130 - 9,161,312UniSTS
RH 3.4 Map766.4UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21 27 182 121 35 121 176 105 105 57
Low 114 45 26 34 26 24 43 74 10 40 24
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000039852   ⟹   ENSRNOP00000036958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,039,871 - 11,049,924 (-)Ensembl
Rnor_6.0 Ensembl714,044,586 - 14,054,639 (-)Ensembl
RefSeq Acc Id: NM_001108738   ⟹   NP_001102208
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,690,445 - 11,700,498 (-)NCBI
mRatBN7.2711,039,871 - 11,049,924 (-)NCBI
Rnor_6.0714,044,586 - 14,054,639 (-)NCBI
Rnor_5.0714,201,069 - 14,211,122 (-)NCBI
RGSC_v3.4712,593,095 - 12,603,148 (-)RGD
Celera79,161,349 - 9,171,402 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241070   ⟹   XP_006241132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,690,447 - 11,700,413 (-)NCBI
mRatBN7.2711,039,870 - 11,049,835 (-)NCBI
Rnor_6.0714,044,588 - 14,054,500 (-)NCBI
Rnor_5.0714,201,069 - 14,211,122 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241071   ⟹   XP_006241133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,690,447 - 11,700,429 (-)NCBI
mRatBN7.2711,039,870 - 11,049,832 (-)NCBI
Rnor_6.0714,044,588 - 14,054,500 (-)NCBI
Rnor_5.0714,201,069 - 14,211,122 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079414   ⟹   XP_038935342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,690,447 - 11,697,793 (-)NCBI
mRatBN7.2711,039,873 - 11,047,236 (-)NCBI
RefSeq Acc Id: XM_063263750   ⟹   XP_063119820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,690,447 - 11,700,382 (-)NCBI
RefSeq Acc Id: NP_001102208   ⟸   NM_001108738
- UniProtKB: D4ACG2 (UniProtKB/TrEMBL),   A6K931 (UniProtKB/TrEMBL),   A6K936 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241133   ⟸   XM_006241071
- Peptide Label: isoform X1
- UniProtKB: A6K934 (UniProtKB/TrEMBL),   A6K936 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241132   ⟸   XM_006241070
- Peptide Label: isoform X1
- UniProtKB: A6K934 (UniProtKB/TrEMBL),   A6K936 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036958   ⟸   ENSRNOT00000039852
RefSeq Acc Id: XP_038935342   ⟸   XM_039079414
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119820   ⟸   XM_063263750
- Peptide Label: isoform X1
- UniProtKB: A6K936 (UniProtKB/TrEMBL),   A6K934 (UniProtKB/TrEMBL)
Protein Domains
Thiamine pyrophosphate enzyme central   Thiamine pyrophosphate enzyme N-terminal TPP-   Thiamine pyrophosphate enzyme TPP-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACG2-F1-model_v2 AlphaFold D4ACG2 1-672 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307988 AgrOrtholog
BioCyc Gene G2FUF-34837 BioCyc
BioCyc Pathway PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
BioCyc Pathway Image PWY66-387 BioCyc
  PWY66-388 BioCyc
Ensembl Genes ENSRNOG00000028512 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039852.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.970 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  THDP-binding UniProtKB/TrEMBL
  Thiamin_PyroP_enz_cen_dom UniProtKB/TrEMBL
  Thiamin_PyroP_enz_TPP-bd_dom UniProtKB/TrEMBL
  TPP-bd_CS UniProtKB/TrEMBL
  TPP_enz UniProtKB/TrEMBL
  TPP_enzyme-bd_C UniProtKB/TrEMBL
KEGG Report rno:362843 UniProtKB/TrEMBL
NCBI Gene 362843 ENTREZGENE
PANTHER 2-HYDROXYACYL-COA LYASE 2 UniProtKB/TrEMBL
  PTHR18968 UniProtKB/TrEMBL
Pfam TPP_enzyme_C UniProtKB/TrEMBL
  TPP_enzyme_M UniProtKB/TrEMBL
  TPP_enzyme_N UniProtKB/TrEMBL
PhenoGen Ilvbl PhenoGen
PROSITE TPP_ENZYMES UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028512 RatGTEx
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
  SSF52518 UniProtKB/TrEMBL
UniProt A6K931 ENTREZGENE, UniProtKB/TrEMBL
  A6K934 ENTREZGENE, UniProtKB/TrEMBL
  A6K936 ENTREZGENE, UniProtKB/TrEMBL
  D4ACG2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Ilvbl  ilvB acetolactate synthase like  Ilvbl  ilvB (bacterial acetolactate synthase)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ilvbl  ilvB (bacterial acetolactate synthase)-like   Ilvbl_predicted  ilvB (bacterial acetolactate synthase)-like (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ilvbl_predicted  ilvB (bacterial acetolactate synthase)-like (predicted)      Symbol and Name status set to approved 70820 APPROVED