Ltc4s (leukotriene C4 synthase) - Rat Genome Database

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Gene: Ltc4s (leukotriene C4 synthase) Rattus norvegicus
Analyze
Symbol: Ltc4s
Name: leukotriene C4 synthase
RGD ID: 620677
Description: Enables glutathione binding activity and leukotriene-C4 synthase activity. Involved in several processes, including cellular response to lipid; leukotriene biosynthetic process; and response to axon injury. Predicted to be located in endoplasmic reticulum membrane and nuclear outer membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Biomarker of glomerulonephritis and peripheral nervous system disease. Orthologous to human LTC4S (leukotriene C4 synthase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase LTC4; leukotriene-C(4) synthase; LTC4 synthase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bmd4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,060,002 - 35,066,466 (-)NCBIGRCr8
mRatBN7.21034,560,476 - 34,562,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,560,360 - 34,562,651 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,235,902 - 39,237,857 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,775,154 - 7,777,109 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,229,574 - 34,231,529 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,736,486 - 35,743,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,737,664 - 35,739,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,498,195 - 35,506,088 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,786,877 - 35,788,838 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,787,925 - 35,789,881 (-)NCBI
Celera1033,909,805 - 33,911,766 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone. Abe M, etal., J Cell Physiol 2003 Jul;196(1):154-64.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Jame AJ, etal., Clin Exp Allergy. 2007 Jun;37(6):880-92.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. Ma KF, etal., World J Gastroenterol. 2008 May 7;14(17):2748-56.
6. The membrane organization of leukotriene synthesis. Mandal AK, etal., Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6587-92. Epub 2004 Apr 14.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain. Okubo M, etal., Glia. 2010 Apr;58(5):599-610.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. Petric R, etal., Biochim Biophys Acta. 1995 Jan 20;1254(2):207-15.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs. Schroder O, etal., Biochem Biophys Res Commun. 2003 Dec 12;312(2):271-6.
17. Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis. Schroder O, etal., Cell Mol Life Sci. 2005 Jan;62(1):87-94.
18. Expression and regulation of leukotriene-synthesis enzymes in rat liver cells. Shimada K, etal., Hepatology. 1998 Nov;28(5):1275-81.
19. High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris. Wetterholm A, etal., Protein Expr Purif. 2008 Jul;60(1):1-6. Epub 2008 Mar 23.
20. Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats. Yang SL and Lou YJ, Biochem Pharmacol. 2007 Mar 1;73(5):724-35. Epub 2006 Nov 18.
21. Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. Yang SL, etal., Pharmacology. 2007;80(1):11-20. Epub 2007 May 10.
Additional References at PubMed
PMID:7599836   PMID:8706658   PMID:9153254   PMID:11319240   PMID:12023288   PMID:12445492   PMID:15530365   PMID:16552728   PMID:17397868   PMID:17632546   PMID:17632548   PMID:18053799  
PMID:19233132   PMID:23505109   PMID:25540197   PMID:27791009  


Genomics

Comparative Map Data
Ltc4s
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,060,002 - 35,066,466 (-)NCBIGRCr8
mRatBN7.21034,560,476 - 34,562,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,560,360 - 34,562,651 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,235,902 - 39,237,857 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,775,154 - 7,777,109 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,229,574 - 34,231,529 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,736,486 - 35,743,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,737,664 - 35,739,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,498,195 - 35,506,088 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,786,877 - 35,788,838 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,787,925 - 35,789,881 (-)NCBI
Celera1033,909,805 - 33,911,766 (-)NCBICelera
Cytogenetic Map10q22NCBI
LTC4S
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,793,986 - 179,796,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,793,980 - 179,796,647 (+)EnsemblGRCh38hg38GRCh38
GRCh375179,220,987 - 179,223,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,153,592 - 179,156,119 (+)NCBINCBI36Build 36hg18NCBI36
Build 345179,153,591 - 179,156,119NCBI
Celera5174,846,142 - 174,848,669 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,947,161 - 173,949,688 (+)NCBIHuRef
CHM1_15178,653,394 - 178,655,921 (+)NCBICHM1_1
T2T-CHM13v2.05180,349,182 - 180,351,843 (+)NCBIT2T-CHM13v2.0
Ltc4s
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,127,288 - 50,129,378 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,127,288 - 50,129,443 (-)EnsemblGRCm39 Ensembl
GRCm381150,236,461 - 50,238,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,236,461 - 50,238,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,049,974 - 50,051,973 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,079,895 - 50,081,894 (-)NCBIMGSCv36mm8
Celera1154,797,050 - 54,799,049 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.4NCBI
Ltc4s
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955408788,856 - 791,505 (-)NCBIChiLan1.0ChiLan1.0
LTC4S
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,735,060 - 174,739,519 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,874,599 - 172,879,058 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,946,346 - 174,950,805 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15182,256,113 - 182,261,003 (+)NCBIpanpan1.1PanPan1.1panPan2
LTC4S
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,893,927 - 1,897,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,894,380 - 1,897,752 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,012,534 - 2,020,224 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,863,608 - 1,871,298 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,867,307 - 1,871,411 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,835,205 - 1,842,895 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,914,372 - 1,922,062 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,154,596 - 2,162,286 (-)NCBIUU_Cfam_GSD_1.0
Ltc4s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,765,712 - 119,768,688 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739975,493 - 978,482 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936739975,494 - 978,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTC4S
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,799,449 - 78,802,285 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,799,446 - 78,802,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,365,497 - 80,368,339 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LTC4S
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,523,784 - 81,526,297 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2381,523,775 - 81,526,179 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,900,551 - 12,903,368 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ltc4s
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,670,632 - 42,672,846 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,668,963 - 42,673,385 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ltc4s
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:73
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000004359
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 15 15 15 2 1 1
Low 3 39 37 21 19 21 8 11 62 21 35 10 8
Below cutoff 4 5 5 5 10 14 5

Sequence


RefSeq Acc Id: ENSRNOT00000004359   ⟹   ENSRNOP00000004359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,560,555 - 34,561,801 (-)Ensembl
Rnor_6.0 Ensembl1035,737,664 - 35,739,625 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110795   ⟹   ENSRNOP00000087343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,560,360 - 34,562,651 (-)Ensembl
RefSeq Acc Id: NM_053639   ⟹   NP_446091
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,061,633 - 35,063,594 (-)NCBI
mRatBN7.21034,560,555 - 34,562,516 (-)NCBI
Rnor_6.01035,737,664 - 35,739,625 (-)NCBI
Rnor_5.01035,498,195 - 35,506,088 (-)NCBI
RGSC_v3.41035,786,877 - 35,788,838 (-)RGD
Celera1033,909,805 - 33,911,766 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246219   ⟹   XP_006246281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,061,562 - 35,063,505 (-)NCBI
mRatBN7.21034,560,484 - 34,562,427 (-)NCBI
Rnor_6.01035,736,486 - 35,739,535 (-)NCBI
Rnor_5.01035,498,195 - 35,506,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085020   ⟹   XP_038940948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,061,562 - 35,063,684 (-)NCBI
mRatBN7.21034,560,484 - 34,562,624 (-)NCBI
RefSeq Acc Id: XM_063268266   ⟹   XP_063124336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,060,002 - 35,066,466 (-)NCBI
RefSeq Acc Id: NP_446091   ⟸   NM_053639
- UniProtKB: Q925U2 (UniProtKB/Swiss-Prot),   G3V6E6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006246281   ⟸   XM_006246219
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q1E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004359   ⟸   ENSRNOT00000004359
RefSeq Acc Id: XP_038940948   ⟸   XM_039085020
- Peptide Label: isoform X3
- UniProtKB: A6HE07 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087343   ⟸   ENSRNOT00000110795
RefSeq Acc Id: XP_063124336   ⟸   XM_063268266
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q925U2-F1-model_v2 AlphaFold Q925U2 1-150 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697151
Promoter ID:EPDNEW_R7676
Type:single initiation site
Name:Ltc4s_1
Description:leukotriene C4 synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,739,627 - 35,739,687EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620677 AgrOrtholog
BioCyc Gene G2FUF-25248 BioCyc
BioCyc Pathway PWY66-375 [leukotriene biosynthesis] BioCyc
BioCyc Pathway Image PWY66-375 BioCyc
Ensembl Genes ENSRNOG00000003244 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004359 ENTREZGENE
  ENSRNOT00000004359.3 UniProtKB/TrEMBL
  ENSRNOT00000110795.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 5_LipOase_AP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FLAP/GST2/LTC4S_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPEG-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114097 UniProtKB/Swiss-Prot
NCBI Gene 114097 ENTREZGENE
PANTHER LEUKOTRIENE C4 SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MICROSOMAL GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LTC4S RGD
PhenoGen Ltc4s PhenoGen
PRINTS 5LPOXGNASEAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FLAP_GST2_LTC4S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003244 RatGTEx
Superfamily-SCOP SSF161084 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A7K1_RAT UniProtKB/TrEMBL
  A0A8L2Q1E0 ENTREZGENE, UniProtKB/TrEMBL
  A6HE06_RAT UniProtKB/TrEMBL
  A6HE07 ENTREZGENE, UniProtKB/TrEMBL
  G3V6E6 ENTREZGENE
  LTC4S_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V6E6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ltc4s  leukotriene C4 synthase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ltc4s  leukotriene C4 synthase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation inhibited by steroids at the transcriptional level 724432