Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Smad6 (SMAD family member 6) Rattus norvegicus
Analyze
Symbol: Smad6
Name: SMAD family member 6
Description: Predicted to have several functions, including DNA-binding transcription factor inhibitor activity; SMAD binding activity; and signaling receptor binding activity. Involved in response to estrogen. Predicted to localize to several cellular components, including Golgi apparatus; cytosol; and nuclear body. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; endocytosis pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH acrylamide; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC367100; MAD homolog 6; MAD homolog 6 (Drosophila); mothers against decapentaplegic homolog 6
Orthologs:
Homo sapiens (human) : SMAD6 (SMAD family member 6)  HGNC  Alliance
Mus musculus (house mouse) : Smad6 (SMAD family member 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad6 (SMAD family member 6)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD6 (SMAD family member 6)
Canis lupus familiaris (dog) : SMAD6 (SMAD family member 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad6 (SMAD family member 6)
Sus scrofa (pig) : SMAD6 (SMAD family member 6)
Chlorocebus sabaeus (African green monkey) : SMAD6 (SMAD family member 6)
Heterocephalus glaber (naked mole-rat) : Smad6 (SMAD family member 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0868,897,746 - 68,967,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,898,296 - 68,966,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,608,372 - 68,677,705 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,144,395 - 68,214,652 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1868,163,448 - 68,232,779 (-)NCBI
Celera863,858,003 - 63,926,291 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Smad6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305069
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.