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Gene: Smad6 (SMAD family member 6) Rattus norvegicus
Symbol: Smad6
Name: SMAD family member 6
Description: Predicted to have several functions, including DNA-binding transcription factor inhibitor activity; SMAD binding activity; and signaling receptor binding activity. Involved in response to estrogen. Predicted to localize to several cellular components, including Golgi apparatus; cytosol; and nuclear body. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; endocytosis pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH acrylamide; bisphenol A; C60 fullerene.
Type: protein-coding
Also known as: LOC367100; MAD homolog 6; MAD homolog 6 (Drosophila); mothers against decapentaplegic homolog 6
Homo sapiens (human) : SMAD6 (SMAD family member 6)  HGNC  Alliance
Mus musculus (house mouse) : Smad6 (SMAD family member 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad6 (SMAD family member 6)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD6 (SMAD family member 6)
Canis lupus familiaris (dog) : SMAD6 (SMAD family member 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad6 (SMAD family member 6)
Sus scrofa (pig) : SMAD6 (SMAD family member 6)
Chlorocebus sabaeus (African green monkey) : SMAD6 (SMAD family member 6)
Heterocephalus glaber (naked mole-rat) : Smad6 (SMAD family member 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0868,897,746 - 68,967,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,898,296 - 68,966,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,608,372 - 68,677,705 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,144,395 - 68,214,652 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1868,163,448 - 68,232,779 (-)NCBI
Celera863,858,003 - 63,926,291 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Smad6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305069
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.