Hcn4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4) - Rat Genome Database

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Gene: Hcn4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4) Rattus norvegicus
Analyze
Symbol: Hcn4
Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 4
RGD ID: 71065
Description: Predicted to enable identical protein binding activity and monoatomic cation channel activity. Involved in cellular response to aldosterone and response to cisplatin. Located in basolateral plasma membrane; neuronal cell body; and terminal bouton. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4); hyperpolarization-activated, cyclic nucleotide-gated K+ 4; hyperpolarization-activated, cyclic nucleotide-gated potassium channel 4 (HCN4); potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2859,222,206 - 59,259,626 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl859,221,653 - 59,259,639 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx864,753,125 - 64,790,548 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0863,030,680 - 63,068,103 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0860,895,392 - 60,932,815 (+)NCBIRnor_WKY
Rnor_6.0863,599,907 - 63,637,327 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl863,600,663 - 63,639,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0863,367,893 - 63,405,313 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4862,629,828 - 62,667,248 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1862,648,881 - 62,686,299 (+)NCBI
Celera858,680,131 - 58,717,545 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Transcriptional control of pacemaker channel genes HCN2 and HCN4 by Sp1 and implications in re-expression of these genes in hypertrophied myocytes. Lin H, etal., Cell Physiol Biochem. 2009;23(4-6):317-26. doi: 10.1159/000218178. Epub 2009 May 6.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Monteggia LM, etal., Brain Res Mol Brain Res 2000 Sep 30;81(1-2):129-39.
7. HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals. Muller F, etal., Eur J Neurosci 2003 May;17(10):2084-96.
8. Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes. Muto T, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2710-8. Epub 2007 Jul 20.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. Notomi T and Shigemoto R, J Comp Neurol. 2004 Apr 5;471(3):241-76.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Shi W, etal., Circ Res 1999 Jul 9;85(1):e1-6.
17. Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Stevens DR, etal., Nature. 2001 Oct 11;413(6856):631-5.
18. Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells. Stradleigh TW, etal., J Comp Neurol. 2011 Sep 1;519(13):2546-73. doi: 10.1002/cne.22638.
19. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. Whitaker GM, etal., J Biol Chem. 2007 Aug 3;282(31):22900-9. Epub 2007 Jun 6.
20. Hyperpolarisation-activated cyclic nucleotide channel 4 (HCN4) involvement in Tourette's syndrome autoimmunity. Yeh CB, etal., J Neuroimmunol. 2012 Sep 15;250(1-2):18-26. doi: 10.1016/j.jneuroim.2012.05.009. Epub 2012 Jun 7.
21. Declines in levels of hyperpolarization-activated cation (HCN) channels in the rat ovary after cisplatin exposure. Yeh J, etal., Reprod Sci. 2009 Oct;16(10):986-94. Epub 2009 Jul 7.
Additional References at PubMed
PMID:10228147   PMID:12750403   PMID:14657344   PMID:15056713   PMID:16407510   PMID:16648453   PMID:17065201   PMID:17173866   PMID:17311321   PMID:18255311   PMID:18282314   PMID:18326556  
PMID:19236845   PMID:19477969   PMID:19820968   PMID:20220080   PMID:21753027   PMID:21798320   PMID:22006928   PMID:22281825   PMID:22403875   PMID:22694806   PMID:22748890   PMID:23172916  
PMID:23357121   PMID:24776929   PMID:26065643   PMID:26695361   PMID:27496876   PMID:27569278   PMID:31409881   PMID:36214984  


Genomics

Comparative Map Data
Hcn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2859,222,206 - 59,259,626 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl859,221,653 - 59,259,639 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx864,753,125 - 64,790,548 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0863,030,680 - 63,068,103 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0860,895,392 - 60,932,815 (+)NCBIRnor_WKY
Rnor_6.0863,599,907 - 63,637,327 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl863,600,663 - 63,639,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0863,367,893 - 63,405,313 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4862,629,828 - 62,667,248 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1862,648,881 - 62,686,299 (+)NCBI
Celera858,680,131 - 58,717,545 (+)NCBICelera
Cytogenetic Map8q24NCBI
HCN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381573,319,859 - 73,368,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1573,319,859 - 73,368,958 (-)EnsemblGRCh38hg38GRCh38
GRCh371573,612,200 - 73,661,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361571,400,988 - 71,448,230 (-)NCBINCBI36Build 36hg18NCBI36
Build 341571,400,987 - 71,448,230NCBI
Celera1550,490,801 - 50,540,207 (-)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1550,443,643 - 50,492,812 (-)NCBIHuRef
CHM1_11573,730,167 - 73,779,572 (-)NCBICHM1_1
T2T-CHM13v2.01571,136,994 - 71,186,091 (-)NCBIT2T-CHM13v2.0
Hcn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39958,730,232 - 58,770,458 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl958,730,695 - 58,770,458 (+)EnsemblGRCm39 Ensembl
GRCm38958,822,949 - 58,863,175 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl958,823,412 - 58,863,175 (+)EnsemblGRCm38mm10GRCm38
MGSCv37958,671,319 - 58,708,762 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36958,621,649 - 58,659,092 (+)NCBIMGSCv36mm8
Celera956,052,112 - 56,089,597 (+)NCBICelera
Cytogenetic Map9BNCBI
Hcn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554504,139,852 - 4,181,377 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554504,139,852 - 4,181,377 (+)NCBIChiLan1.0ChiLan1.0
HCN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11570,994,405 - 71,043,256 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1570,997,020 - 71,042,285 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01552,231,906 - 52,285,220 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HCN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13036,637,492 - 36,656,194 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3036,639,908 - 36,656,406 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3036,573,522 - 36,617,524 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03036,844,740 - 36,888,776 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3036,844,723 - 36,889,181 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13036,796,738 - 36,840,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03036,822,594 - 36,866,568 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03037,078,286 - 37,122,259 (-)NCBIUU_Cfam_GSD_1.0
Hcn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640114,675,949 - 114,722,220 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647132,529,847 - 32,570,284 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647132,527,551 - 32,570,548 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl760,010,283 - 60,050,689 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1760,010,396 - 60,052,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2764,633,705 - 64,677,047 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HCN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12610,107,342 - 10,158,885 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2610,110,579 - 10,156,292 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048131,447,372 - 131,496,994 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624781968,748 - 1,008,200 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624781968,608 - 1,007,969 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hcn4
68 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoReporter assay//real-timeRT-PCR//Western blotFunctional MTI17516552

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:20
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000012644
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 2 2 2 43
Low 19 4 4 4 3 5 31 16 28 10 3
Below cutoff 3 19 4 7 4 5 6 18 12 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012644   ⟹   ENSRNOP00000012644
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl859,222,206 - 59,259,639 (+)Ensembl
Rnor_6.0 Ensembl863,600,663 - 63,639,654 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103911   ⟹   ENSRNOP00000080600
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl859,221,653 - 59,259,639 (+)Ensembl
RefSeq Acc Id: NM_021658   ⟹   NP_067690
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2859,222,206 - 59,259,626 (+)NCBI
Rnor_6.0863,599,907 - 63,637,327 (+)NCBI
Rnor_5.0863,367,893 - 63,405,313 (+)NCBI
RGSC_v3.4862,629,828 - 62,667,248 (+)RGD
Celera858,680,131 - 58,717,545 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067690 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF01493 (Get FASTA)   NCBI Sequence Viewer  
  AAF62176 (Get FASTA)   NCBI Sequence Viewer  
  EDL95687 (Get FASTA)   NCBI Sequence Viewer  
  Q9JKA7 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_067690   ⟸   NM_021658
- UniProtKB: Q9QZW4 (UniProtKB/Swiss-Prot),   Q9JKA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012644   ⟸   ENSRNOT00000012644
RefSeq Acc Id: ENSRNOP00000080600   ⟸   ENSRNOT00000103911
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKA7-F1-model_v2 AlphaFold Q9JKA7 1-1198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71065 AgrOrtholog
BioCyc Gene G2FUF-30253 BioCyc
Ensembl Genes ENSRNOG00000009450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012644 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000080600.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012644 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000103911.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59266 UniProtKB/Swiss-Prot
NCBI Gene 59266 ENTREZGENE
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HCN4 RGD
PhenoGen Hcn4 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHH6_RAT UniProtKB/TrEMBL
  A0A8I5ZPZ1_RAT UniProtKB/TrEMBL
  HCN4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QZW4 ENTREZGENE
UniProt Secondary Q9QZW4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-03 Hcn4  hyperpolarization activated cyclic nucleotide-gated potassium channel 4  Hcn4  hyperpolarization-activated, cyclic nucleotide-gated K+ 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Hcn4  hyperpolarization-activated, cyclic nucleotide-gated K+ 4      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of a family of hyperpolarization -activated, cyclic nucleotide-gated channels 70760