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Gene: Hcn4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4) Rattus norvegicus
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Symbol: Hcn4
Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Description: Predicted to have cation channel activity and identical protein binding activity. Involved in cellular response to aldosterone and response to cisplatin. Localizes to the basolateral plasma membrane; neuronal cell body; and terminal bouton. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 6-propyl-2-thiouracil; amiodarone; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4); hyperpolarization-activated, cyclic nucleotide-gated K+ 4; hyperpolarization-activated, cyclic nucleotide-gated potassium channel 4 (HCN4); potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0863,599,907 - 63,637,327 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0863,367,893 - 63,405,313 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4862,629,828 - 62,667,248 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1862,648,881 - 62,686,299 (+)NCBI
Celera858,680,131 - 58,717,545 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hcn4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 71065
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.