Gene: Hcn4 (hyperpolarization-activated, cyclic nucleotide-gated K+ 4) Mus musculus
Symbol: Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Description: ENCODES a protein that exhibits intracellular cAMP-activated cation channel activity; identical protein binding (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN cation transport; in utero embryonic development; regulation of heart contraction; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH abnormal heart rate; abnormal impulse conducting system conduction; abnormal nervous system electrophysiology; ASSOCIATED WITH 2-Aminoadipic 2-Oxoadipic Aciduria (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial fibrillation (ortholog); FOUND IN axon; basolateral plasma membrane (ortholog); HCN channel complex (ortholog); INTERACTS WITH choline; folic acid; L-methionine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BCNG-3; Bcng3; brain cyclic nucleotide-gated channel 3; Hcn3; hyperpolarization-activated, cyclic nucleotide-gated K+ 3; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38958,823,512 - 58,860,955 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37958,671,319 - 58,708,762 (+)NCBIGRCm37mm9NCBIm37
MGSCv36958,621,649 - 58,659,092 (+)NCBImm8
Celera956,052,112 - 56,089,597 (+)NCBICelera
Cytogenetic Map9 BNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hcn4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737127
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-02-05
Status: ACTIVE