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Gene: Hcn4 (hyperpolarization-activated, cyclic nucleotide-gated K+ 4) Mus musculus
Symbol: Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
RGD ID: 737127
Description: Exhibits intracellular cAMP-activated cation channel activity. Involved in cation transport; in utero embryonic development; and regulation of heart contraction. Localizes to axon. Is expressed in eye; future brain; heart; septum transversum; and venous system. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 1,2-dimethylhydrazine; choline; dextran sulfate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BCNG-3; Bcng3; brain cyclic nucleotide-gated channel 3; Hcn3; hyperpolarization-activated, cyclic nucleotide-gated K+ 3; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39958,730,232 - 58,770,458 (+)NCBI
GRCm38958,822,949 - 58,863,175 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl958,823,412 - 58,863,175 (+)EnsemblGRCm38mm10GRCm38
MGSCv37958,671,319 - 58,708,762 (+)NCBIGRCm37mm9NCBIm37
MGSCv36958,621,649 - 58,659,092 (+)NCBImm8
Celera956,052,112 - 56,089,597 (+)NCBICelera
Cytogenetic Map9BNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hcn4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737127
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.