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Gene: Hcn4 (hyperpolarization-activated, cyclic nucleotide-gated K+ 4) Mus musculus
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Symbol: Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
RGD ID: 737127
Description: Exhibits intracellular cAMP-activated cation channel activity. Involved in cation transport; in utero embryonic development; and regulation of heart contraction. Localizes to axon. Is expressed in eye; future brain; heart; septum transversum; and venous system. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 1,2-dimethylhydrazine; choline; dextran sulfate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BCNG-3; Bcng3; brain cyclic nucleotide-gated channel 3; Hcn3; hyperpolarization-activated, cyclic nucleotide-gated K+ 3; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39958,730,232 - 58,770,458 (+)NCBI
GRCm38958,822,949 - 58,863,175 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl958,823,412 - 58,863,175 (+)EnsemblGRCm38mm10GRCm38
MGSCv37958,671,319 - 58,708,762 (+)NCBIGRCm37mm9NCBIm37
MGSCv36958,621,649 - 58,659,092 (+)NCBImm8
Celera956,052,112 - 56,089,597 (+)NCBICelera
Cytogenetic Map9BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hcn4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737127
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.