HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4)

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Gene: HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4) Canis lupus familiaris

Analyze

Symbol:

HCN4

Name:

hyperpolarization activated cyclic nucleotide gated potassium channel 4

RGD ID:

12375578

Description:

ENCODES a protein that exhibits identical protein binding (inferred); intracellular cAMP-activated cation channel activity (inferred); monoatomic ion channel activity (inferred); INVOLVED IN cellular response to aldosterone (ortholog); in utero embryonic development (ortholog); monoatomic cation transport (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial fibrillation (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN axon (ortholog); basolateral plasma membrane (ortholog); HCN channel complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cardiac hyperpolarization-activated current subunit 4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	36,637,492 - 36,656,194 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	36,639,908 - 36,656,406 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	36,573,522 - 36,617,524 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	36,844,740 - 36,888,776 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	36,844,723 - 36,889,181 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	36,796,738 - 36,840,679 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	36,822,594 - 36,866,568 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	37,078,286 - 37,122,259 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arrhythmogenic right ventricular cardiomyopathy (ISO)

atrial fibrillation (ISO)

Bardet-Biedl syndrome (ISO)

Bloom syndrome (ISO)

Brugada syndrome (ISO)

Brugada syndrome 8 (ISO)

cardiac arrest (ISO)

Cardiac Arrhythmias (ISO)

cardiomyopathy (ISO)

colorectal cancer (ISO)

congestive heart failure (ISO)

dilated cardiomyopathy (ISO)

Dilated Cardiomyopathy with Left Ventricular Noncompaction (ISO)

genetic disease (ISO)

Gilles de la Tourette syndrome (ISO)

hypertrophic cardiomyopathy (ISO)

Idiopathic Generalized Epilepsy 18 (ISO)

Left Ventricular Hypertrophy (ISO)

left ventricular noncompaction (ISO)

long QT syndrome (ISO)

schizophrenia (ISO)

Sick Sinus Syndrome 2, Autosomal Dominant (ISO)

Sudden Cardiac Death (ISO)

Sudden Unexpected Nocturnal Death Syndrome (ISO)

Tay-Sachs disease (ISO)

Ventricular Tachycardia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to aldosterone (ISO)

cellular response to cAMP (IEA)

cellular response to cGMP (IEA)

in utero embryonic development (ISO)

membrane depolarization during SA node cell action potential (IEA)

monoatomic cation transport (IEA,ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

potassium ion import across plasma membrane (IEA)

potassium ion transmembrane transport (IEA)

potassium ion transport (IEA)

regulation of cardiac muscle cell action potential involved in regulation of contraction (IEA)

regulation of cardiac muscle contraction (IEA)

regulation of heart contraction (ISO)

regulation of heart rate (IEA)

regulation of heart rate by cardiac conduction (IEA)

regulation of membrane depolarization (IEA)

regulation of membrane potential (IEA)

response to cisplatin (ISO)

SA node cell action potential (IEA)

sodium ion import across plasma membrane (IEA)

sodium ion transmembrane transport (IEA)

sodium ion transport (IEA)

transmembrane transport (IEA)

Cellular Component

axon (ISO)

basolateral plasma membrane (ISO)

cellular anatomical entity (IEA)

HCN channel complex (IEA,ISO)

membrane (IEA)

neuron projection (ISO)

neuronal cell body (ISO)

obsolete intrinsic component of plasma membrane (ISO)

perinuclear region of cytoplasm (IEA)

plasma membrane (IEA)

plasma membrane (ISO)

terminal bouton (ISO)

Molecular Function

identical protein binding (IEA)

intracellular cAMP-activated cation channel activity (IEA)

monoatomic ion channel activity (IEA)

protein binding (ISO)

sodium channel activity (IEA)

voltage-gated potassium channel activity (IEA)

voltage-gated potassium channel activity involved in SA node cell action potential depolarization (IEA)

voltage-gated sodium channel activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acebutolol pharmacodynamics pathway (ISO)

adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway (ISO)

amiodarone pharmacodynamics pathway (ISO)

amlodipine pharmacodynamics pathway (ISO)

atenolol pharmacodynamics pathway (ISO)

betaxolol pharmacodynamics pathway (ISO)

bisoprolol pharmacodynamics pathway (ISO)

bupranolol drug pathway (ISO)

bupranolol pharmacodynamics pathway (ISO)

carvedilol pharmacodynamics pathway (ISO)

diltiazem pharmacodynamics pathway (ISO)

disopyramide pharmacodynamics pathway (ISO)

dobutamine pharmacodynamics pathway (ISO)

esmolol pharmacodynamics pathway (ISO)

flecainde pharmacodynamics pathway (ISO)

fosphenytoin pharmacodynamics pathway (ISO)

ibutilide pharmacodynamics pathway (ISO)

isoprenaline pharmacodynamics pathway (ISO)

isradipine pharmacodynamics pathway (ISO)

levobunolol pharmacodynamics pathway (ISO)

lidocaine pharmacodynamics pathway (ISO)

metoprolol pharmacodynamics pathway (ISO)

mexiletine pharmacodynamics pathway (ISO)

nadolol pharmacodynamics pathway (ISO)

nebivolol pharmacodynamics pathway (ISO)

nifedipine pharmacodynamics pathway (ISO)

nimodipine pharmacodynamics pathway (ISO)

nisoldipine pharmacodynamics pathway (ISO)

nitrendipine pharmacodynamics pathway (ISO)

penbutolol pharmacodynamics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

pindolol pharmacodynamics pathway (ISO)

procainamide pharmacodynamics pathway (ISO)

propranolol pharmacodynamics pathway (ISO)

quinidine pharmacodynamics pathway (ISO)

sotalol pharmacodynamics pathway (ISO)

timolol pharmacodynamics pathway (ISO)

verapamil pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:15914112	PMID:25404650

Genomics

Comparative Map Data

HCN4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	36,637,492 - 36,656,194 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	36,639,908 - 36,656,406 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	36,573,522 - 36,617,524 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	36,844,740 - 36,888,776 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	36,844,723 - 36,889,181 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	36,796,738 - 36,840,679 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	36,822,594 - 36,866,568 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	37,078,286 - 37,122,259 (-)	NCBI		UU_Cfam_GSD_1.0

HCN4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	73,319,859 - 73,368,958 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	15	73,319,859 - 73,368,958 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	73,612,200 - 73,661,299 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	71,400,988 - 71,448,230 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	71,400,987 - 71,448,230	NCBI
Celera	15	50,490,801 - 50,540,207 (-)	NCBI		Celera
Cytogenetic Map	15	q24.1	NCBI
HuRef	15	50,443,643 - 50,492,812 (-)	NCBI		HuRef
CHM1_1	15	73,730,167 - 73,779,572 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	71,136,994 - 71,186,091 (-)	NCBI		T2T-CHM13v2.0

Hcn4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	58,730,232 - 58,770,458 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	58,730,695 - 58,770,458 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	58,822,949 - 58,863,175 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	58,823,412 - 58,863,175 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	58,671,319 - 58,708,762 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	58,621,649 - 58,659,092 (+)	NCBI		MGSCv36	mm8
Celera	9	56,052,112 - 56,089,597 (+)	NCBI		Celera
Cytogenetic Map	9	B	NCBI

Hcn4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	59,222,206 - 59,259,626 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	59,221,653 - 59,259,639 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	64,753,125 - 64,790,548 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	8	63,030,680 - 63,068,103 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	8	60,895,392 - 60,932,815 (+)	NCBI	Rnor_WKY
Rnor_6.0	8	63,599,907 - 63,637,327 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	63,600,663 - 63,639,654 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	63,367,893 - 63,405,313 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	62,629,828 - 62,667,248 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	62,648,881 - 62,686,299 (+)	NCBI
Celera	8	58,680,131 - 58,717,545 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Hcn4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	4,139,852 - 4,181,377 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	4,139,852 - 4,181,377 (+)	NCBI	ChiLan1.0	ChiLan1.0

HCN4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	15	70,994,405 - 71,043,256 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	70,997,020 - 71,042,285 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	15	52,231,906 - 52,285,220 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

Hcn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	114,675,949 - 114,722,220 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	32,529,847 - 32,570,284 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936471	32,527,551 - 32,570,548 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HCN4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	60,010,283 - 60,050,689 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	60,010,396 - 60,052,258 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	64,633,705 - 64,677,047 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HCN4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	10,107,342 - 10,158,885 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	10,110,579 - 10,156,292 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	131,447,372 - 131,496,994 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hcn4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	968,748 - 1,008,200 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	968,608 - 1,007,969 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in HCN4
386 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium			1								1
Low	5	2	14		4		6		12		9	6
Below cutoff		3	7	6	2	6		6		8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022412726	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038441755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038461068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038517529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038579892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038644105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY686750	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000365	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCAFT00000047649 ⟹ ENSCAFP00000042974

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	30	36,639,908 - 36,656,406 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845048090 ⟹ ENSCAFP00845037733

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	30	36,844,723 - 36,889,181 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845048158 ⟹ ENSCAFP00845037774

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	30	36,844,723 - 36,889,009 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845048216 ⟹ ENSCAFP00845037819

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	30	36,844,723 - 36,888,776 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845048265 ⟹ ENSCAFP00845037858

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	30	36,844,723 - 36,888,328 (-)	Ensembl

RefSeq Acc Id:

XM_038441755 ⟹ XP_038297683

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	30	36,844,740 - 36,888,776 (-)	NCBI

RefSeq Acc Id:

XM_038461068 ⟹ XP_038316996

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	30	36,573,522 - 36,617,524 (-)	NCBI

RefSeq Acc Id:

XM_038517529 ⟹ XP_038373457

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	30	36,796,738 - 36,840,679 (-)	NCBI

RefSeq Acc Id:

XM_038579892 ⟹ XP_038435820

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	30	37,078,286 - 37,122,259 (-)	NCBI

RefSeq Acc Id:

XM_038644105 ⟹ XP_038500033

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	30	36,822,594 - 36,866,568 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038297683	(Get FASTA)	NCBI Sequence Viewer
	XP_038316996	(Get FASTA)	NCBI Sequence Viewer
	XP_038373457	(Get FASTA)	NCBI Sequence Viewer
	XP_038435820	(Get FASTA)	NCBI Sequence Viewer
	XP_038500033	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAT99306	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSCAFP00000042974 ⟸ ENSCAFT00000047649

RefSeq Acc Id:	XP_038373457 ⟸ XM_038517529
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038500033 ⟸ XM_038644105
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038297683 ⟸ XM_038441755
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038316996 ⟸ XM_038461068
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038435820 ⟸ XM_038579892
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSCAFP00845037774 ⟸ ENSCAFT00845048158

RefSeq Acc Id:

ENSCAFP00845037819 ⟸ ENSCAFT00845048216

RefSeq Acc Id:

ENSCAFP00845037858 ⟸ ENSCAFT00845048265

RefSeq Acc Id:

ENSCAFP00845037733 ⟸ ENSCAFT00845048090

Protein Domains

Cyclic nucleotide-binding

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000031809	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00845027098	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSCAFP00000042974.3	UniProtKB/TrEMBL
	ENSCAFP00000067578.1	UniProtKB/TrEMBL
	ENSCAFP00000071457.1	UniProtKB/TrEMBL
	ENSCAFP00000072357.1	UniProtKB/TrEMBL
	ENSCAFP00000072441.1	UniProtKB/TrEMBL
	ENSCAFP00000072577.1	UniProtKB/TrEMBL
	ENSCAFP00000074010.1	UniProtKB/TrEMBL
	ENSCAFP00000075105.1	UniProtKB/TrEMBL
	ENSCAFP00845037733.1	UniProtKB/TrEMBL
	ENSCAFP00845037774.1	UniProtKB/TrEMBL
	ENSCAFP00845037819	ENTREZGENE
	ENSCAFP00845037819.1	UniProtKB/TrEMBL
	ENSCAFP00845037858.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000047649.3	UniProtKB/TrEMBL
	ENSCAFT00000095027.1	UniProtKB/TrEMBL
	ENSCAFT00000101658.1	UniProtKB/TrEMBL
	ENSCAFT00000103937.1	UniProtKB/TrEMBL
	ENSCAFT00000104120.1	UniProtKB/TrEMBL
	ENSCAFT00000105800.1	UniProtKB/TrEMBL
	ENSCAFT00000108772.1	UniProtKB/TrEMBL
	ENSCAFT00000109811.1	UniProtKB/TrEMBL
	ENSCAFT00845048090.1	UniProtKB/TrEMBL
	ENSCAFT00845048158.1	UniProtKB/TrEMBL
	ENSCAFT00845048216	ENTREZGENE
	ENSCAFT00845048216.1	UniProtKB/TrEMBL
	ENSCAFT00845048265.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.70	UniProtKB/TrEMBL
	2.60.120.10	UniProtKB/TrEMBL
	Helix hairpin bin	UniProtKB/TrEMBL
InterPro	cNMP-bd-like	UniProtKB/TrEMBL
	cNMP-bd_CS	UniProtKB/TrEMBL
	cNMP-bd_dom	UniProtKB/TrEMBL
	Ion_trans_dom	UniProtKB/TrEMBL
	Ion_trans_N	UniProtKB/TrEMBL
	K_chnl_volt-dep_EAG/ELK/ERG	UniProtKB/TrEMBL
	RmlC-like_jellyroll	UniProtKB/TrEMBL
NCBI Gene	HCN4	ENTREZGENE
PANTHER	I[[H]] CHANNEL, ISOFORM E	UniProtKB/TrEMBL
	POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4	UniProtKB/TrEMBL
Pfam	cNMP_binding	UniProtKB/TrEMBL
	Ion_trans	UniProtKB/TrEMBL
	Ion_trans_N	UniProtKB/TrEMBL
PRINTS	EAGCHANLFMLY	UniProtKB/TrEMBL
	PRICHEXTENSN	UniProtKB/TrEMBL
PROSITE	CNMP_BINDING_1	UniProtKB/TrEMBL
	CNMP_BINDING_3	UniProtKB/TrEMBL
SMART	cNMP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51206	UniProtKB/TrEMBL
	Voltage-gated potassium channels	UniProtKB/TrEMBL
UniProt	A0A8I3PSU5_CANLF	UniProtKB/TrEMBL
	A0A8I3PXZ5_CANLF	UniProtKB/TrEMBL
	A0A8I3QDK2_CANLF	UniProtKB/TrEMBL
	A0A8I3S694_CANLF	UniProtKB/TrEMBL
	A0A8P0NTF9_CANLF	UniProtKB/TrEMBL
	A0A8P0PM77_CANLF	UniProtKB/TrEMBL
	A0A8P0PNQ6_CANLF	UniProtKB/TrEMBL
	A0A8P0PQW5_CANLF	UniProtKB/TrEMBL
	A0A8P0TJG9_CANLF	UniProtKB/TrEMBL
	A0A8P0TQR1_CANLF	UniProtKB/TrEMBL
	A0A8P0TR15_CANLF	UniProtKB/TrEMBL
	A0A8P0TUV6_CANLF	UniProtKB/TrEMBL
	Q68J49_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:58306	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB