Hcn2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2) - Rat Genome Database

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Gene: Hcn2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2) Rattus norvegicus
Analyze
Symbol: Hcn2
Name: hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
RGD ID: 620689
Description: Enables PDZ domain binding activity and molecular adaptor activity. Involved in several processes, including aging; cellular response to aldosterone; and response to cisplatin. Located in several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of dermatitis; meningitis; and visual epilepsy. Human ortholog(s) of this gene implicated in familial febrile seizures 2. Orthologous to human HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hyperpolarization activated cyclic nucleotide-gated potassium channel 2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,969,801 - 9,988,839 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,970,368 - 9,988,841 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,850,727 - 12,869,795 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0714,728,808 - 14,747,876 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0712,588,170 - 12,607,205 (-)NCBIRnor_WKY
Rnor_6.0712,851,730 - 12,870,087 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,851,739 - 12,874,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,021,934 - 13,051,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,485,257 - 11,503,614 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,485,256 - 11,503,614 (-)NCBI
Celera78,143,888 - 8,161,946 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. HCN1 and HCN2 in Rat DRG neurons: levels in nociceptors and non-nociceptors, NT3-dependence and influence of CFA-induced skin inflammation on HCN2 and NT3 expression. Acosta C, etal., PLoS One. 2012;7(12):e50442. doi: 10.1371/journal.pone.0050442. Epub 2012 Dec 7.
2. Functional presynaptic HCN channels in the rat globus pallidus. Boyes J, etal., Eur J Neurosci. 2007 Apr;25(7):2081-92.
3. Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Brewster AL, etal., Neurobiol Dis. 2005 Jun-Jul;19(1-2):200-7.
4. Reciprocal modulation of I (h) and I (TASK) in thalamocortical relay neurons by halothane. Budde T, etal., Pflugers Arch. 2008 Sep;456(6):1061-73. Epub 2008 May 14.
5. Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body. Buniel M, etal., J Comp Neurol. 2008 Oct 1;510(4):367-77.
6. Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine. Cho HJ, etal., Neuroscience. 2009 Aug 18;162(2):453-61. Epub 2009 May 3.
7. Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. Dougherty KA, etal., J Neurophysiol. 2013 Apr;109(7):1940-53. doi: 10.1152/jn.00010.2013. Epub 2013 Jan 16.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Age-related down-regulation of HCN channels in rat sinoatrial node. Huang X, etal., Basic Res Cardiol. 2007 Sep;102(5):429-35. Epub 2007 Jun 18.
11. Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. Kanyshkova T, etal., J Neurosci. 2009 Jul 8;29(27):8847-57.
12. Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction. Kimura K, etal., Genes Cells. 2004 Jul;9(7):631-40.
13. Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion. Li CJ, etal., Mol Neurobiol. 2014 Oct;50(2):704-20. doi: 10.1007/s12035-014-8736-3. Epub 2014 May 18.
14. Transcriptional control of pacemaker channel genes HCN2 and HCN4 by Sp1 and implications in re-expression of these genes in hypertrophied myocytes. Lin H, etal., Cell Physiol Biochem. 2009;23(4-6):317-26. doi: 10.1159/000218178. Epub 2009 May 6.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Monteggia LM, etal., Brain Res Mol Brain Res 2000 Sep 30;81(1-2):129-39.
17. HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals. Muller F, etal., Eur J Neurosci 2003 May;17(10):2084-96.
18. Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes. Muto T, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2710-8. Epub 2007 Jul 20.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heart. Pachucki J, etal., Circ Res. 1999 Sep 17;85(6):498-503.
21. HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2. Ramakrishnan NA, etal., J Biol Chem. 2012 Nov 2;287(45):37628-46. doi: 10.1074/jbc.M112.375832. Epub 2012 Sep 4.
22. GOA pipeline RGD automated data pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Shi W, etal., Circ Res 1999 Jul 9;85(1):e1-6.
25. Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells. Tu H, etal., Neuroscience. 2010 Jan 13;165(1):39-52. doi: 10.1016/j.neuroscience.2009.10.002. Epub 2009 Oct 6.
26. Hyperpolarization-activated channels in trigeminal ganglia innervating healthy and pulp-exposed teeth. Wells JE, etal., Int Endod J. 2007 Sep;40(9):715-21. Epub 2007 Jul 23.
27. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. Whitaker GM, etal., J Biol Chem. 2007 Aug 3;282(31):22900-9. Epub 2007 Jun 6.
28. Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes HCN2 and HCN4. Xiao J, etal., J Cell Physiol. 2007 Aug;212(2):285-92.
29. Declines in levels of hyperpolarization-activated cation (HCN) channels in the rat ovary after cisplatin exposure. Yeh J, etal., Reprod Sci. 2009 Oct;16(10):986-94. Epub 2009 Jul 7.
30. Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. Zha Q, etal., J Neurochem. 2008 Apr;105(1):68-77. Epub 2007 Nov 5.
Additional References at PubMed
PMID:10228147   PMID:14991560   PMID:15016091   PMID:15056713   PMID:15245481   PMID:15292247   PMID:15525777   PMID:15564593   PMID:15958747   PMID:16175581   PMID:16395601   PMID:16648453  
PMID:16760342   PMID:16979600   PMID:17065201   PMID:17311321   PMID:18255311   PMID:18326556   PMID:18397293   PMID:18450385   PMID:18524809   PMID:18614814   PMID:18768480   PMID:19236845  
PMID:19500574   PMID:20220080   PMID:20726890   PMID:21753027   PMID:21796099   PMID:21798320   PMID:22006928   PMID:22377439   PMID:22748890   PMID:22871113   PMID:23620341   PMID:24460767  
PMID:24592881   PMID:25290015   PMID:25659346   PMID:25813712   PMID:25998542   PMID:26021557   PMID:26065643   PMID:26341471   PMID:27496876   PMID:27542339   PMID:27569278   PMID:29806529  
PMID:31432175   PMID:32165274   PMID:32454040   PMID:33653265   PMID:34875252   PMID:35008085  


Genomics

Comparative Map Data
Hcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,969,801 - 9,988,839 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,970,368 - 9,988,841 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,850,727 - 12,869,795 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0714,728,808 - 14,747,876 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0712,588,170 - 12,607,205 (-)NCBIRnor_WKY
Rnor_6.0712,851,730 - 12,870,087 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,851,739 - 12,874,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,021,934 - 13,051,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,485,257 - 11,503,614 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,485,256 - 11,503,614 (-)NCBI
Celera78,143,888 - 8,161,946 (-)NCBICelera
Cytogenetic Map7q11NCBI
HCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819589,881 - 617,159 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl19589,881 - 617,159 (+)EnsemblGRCh38hg38GRCh38
GRCh3719589,881 - 617,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619540,893 - 568,159 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419540,892 - 568,157NCBI
Celera19200,463 - 228,092 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19373,968 - 384,301 (+)NCBIHuRef
CHM1_119589,749 - 616,575 (+)NCBICHM1_1
T2T-CHM13v2.019543,772 - 571,465 (+)NCBIT2T-CHM13v2.0
Hcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,552,468 - 79,571,942 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,552,468 - 79,571,942 (+)EnsemblGRCm39 Ensembl
GRCm381079,716,634 - 79,736,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,179,379 - 79,198,853 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,119,763 - 79,139,237 (+)NCBIMGSCv36mm8
Celera1080,731,157 - 80,750,702 (+)NCBICelera
Cytogenetic Map10C1NCBI
Hcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,124,640 - 7,194,223 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,124,060 - 7,143,730 (-)NCBIChiLan1.0ChiLan1.0
HCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.119559,108 - 584,128 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v019521,348 - 528,203 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,920,089 - 57,941,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,920,740 - 57,938,374 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,722,746 - 57,741,278 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,663,358 - 58,681,919 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,663,358 - 58,681,919 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,717,402 - 57,735,597 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,196,864 - 58,215,545 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,400,096 - 58,421,283 (-)NCBIUU_Cfam_GSD_1.0
Hcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,625,528 - 217,639,390 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588142,786 - 208,606 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936588202,101 - 209,255 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,708,162 - 77,730,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,708,159 - 77,730,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16326,437 - 358,119 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6324,517 - 358,119 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,626,637 - 8,752,781 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,889,025 - 7,908,639 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,889,616 - 7,908,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hcn2
48 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI18458081
Mir133a1rno-miR-133a-3pMirtarbaseexternal_infoReporter assay//real-timeRT-PCR//Western blotFunctional MTI17516552

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:69
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000011837
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 2 48 3
Low 3 25 26 14 12 14 8 9 26 32 37 11 8
Below cutoff 30 26 7 26 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011837   ⟹   ENSRNOP00000011837
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,970,368 - 9,988,841 (-)Ensembl
Rnor_6.0 Ensembl712,851,739 - 12,874,215 (-)Ensembl
RefSeq Acc Id: NM_053684   ⟹   NP_446136
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,970,368 - 9,988,839 (-)NCBI
Rnor_6.0712,851,730 - 12,870,087 (-)NCBI
Rnor_5.0713,021,934 - 13,051,802 (-)NCBI
RGSC_v3.4711,485,257 - 11,503,614 (-)RGD
Celera78,143,888 - 8,161,946 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078239   ⟹   XP_038934167
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,969,801 - 9,978,022 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446136   ⟸   NM_053684
- UniProtKB: Q9JKA9 (UniProtKB/Swiss-Prot),   F1LRY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011837   ⟸   ENSRNOT00000011837
RefSeq Acc Id: XP_038934167   ⟸   XM_039078239
- Peptide Label: isoform X1
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKA9-F1-model_v2 AlphaFold Q9JKA9 1-863 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620689 AgrOrtholog
BioCyc Gene G2FUF-34884 BioCyc
Ensembl Genes ENSRNOG00000008831 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011837 ENTREZGENE
  ENSRNOP00000011837.7 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011837 ENTREZGENE
  ENSRNOT00000011837.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114244 UniProtKB/Swiss-Prot
NCBI Gene 114244 ENTREZGENE
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HCN2 RGD
PhenoGen Hcn2 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LRY7 ENTREZGENE, UniProtKB/TrEMBL
  HCN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6BCT5 UniProtKB/Swiss-Prot
  Q9QZW6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-12 Hcn2  hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2  Hcn2  hyperpolarization activated cyclic nucleotide-gated potassium channel 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Hcn2  hyperpolarization activated cyclic nucleotide-gated potassium channel 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hcn2  hyperpolarization activated cyclic nucleotide-gated potassium channel 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neonatal and adult cardiac ventricle  
gene_product member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides 70760