Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4) Homo sapiens
Symbol: HCN4
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
Description: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; hyperpolarization-activated, cyclic nucleotide-gated k+ 4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; SSS2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381573,319,859 - 73,368,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371573,612,200 - 73,661,605 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361571,400,988 - 71,448,230 (-)NCBINCBI36hg18NCBI36
Build 341571,400,987 - 71,448,230NCBI
Celera1550,490,801 - 50,540,207 (-)NCBI
Cytogenetic Map15q24.1NCBI
HuRef1550,443,643 - 50,492,812 (-)NCBIHuRef
CHM1_11573,730,167 - 73,779,572 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HCN4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737126
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.