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Gene: HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4) Homo sapiens
Symbol: HCN4
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
RGD ID: 737126
Description: Exhibits cation channel activity and identical protein binding activity. Involved in several processes, including inorganic cation import across plasma membrane; regulation of heart contraction; and response to purine-containing compound. Localizes to HCN channel complex and perinuclear region of cytoplasm. Implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; and sick sinus syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; hyperpolarization-activated, cyclic nucleotide-gated k+ 4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; SSS2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1573,319,859 - 73,368,958 (-)EnsemblGRCh38hg38GRCh38
GRCh381573,319,859 - 73,368,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371573,612,200 - 73,661,605 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361571,400,988 - 71,448,230 (-)NCBINCBI36hg18NCBI36
Build 341571,400,987 - 71,448,230NCBI
Celera1550,490,801 - 50,540,207 (-)NCBI
Cytogenetic Map15q24.1NCBI
HuRef1550,443,643 - 50,492,812 (-)NCBIHuRef
CHM1_11573,730,167 - 73,779,572 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HCN4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737126
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.