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HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals.

Authors: Muller, F  Scholten, A  Ivanova, E  Haverkamp, S  Kremmer, E  Kaupp, UB 
Citation: Muller F, etal., Eur J Neurosci 2003 May;17(10):2084-96.
Pubmed: (View Article at PubMed) PMID:12786975

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels codetermine the integrative behaviour of neurons and shape their response to synaptic stimulation. We used immunohistochemistry and patch-clamp recording to study the composition and distribution of HCN channels in the rat retina. All four HCN channel isoforms (HCN1-4) are expressed differentially in the retina. In particular, different classes of bipolar cells have a different inventory of HCN channels. We found no evidence for the formation of heterooligomeric HCN channels. HCN channels are densely clustered at synaptic terminals of bipolar cells and photoreceptors. This suggests that HCN channels are involved in the control of transmitter release.


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RGD Object Information
RGD ID: 1299239
Created: 2004-06-01
Species: All species
Last Modified: 2006-04-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.