Hcn1 (hyperpolarization-activated cyclic nucleotide-gated potassium channel 1) - Rat Genome Database

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Gene: Hcn1 (hyperpolarization-activated cyclic nucleotide-gated potassium channel 1) Rattus norvegicus
Analyze
Symbol: Hcn1
Name: hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
RGD ID: 620688
Description: Exhibits identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to interferon-beta; maternal behavior; and response to L-glutamate. Localizes to several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study anxiety disorder and mood disorder. Biomarker of complex cortical dysplasia with other brain malformations; epilepsy (multiple); and meningitis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Orthologous to human HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hyperpolarization-activated, cyclic nucleotide-gated potassium channel 1 (HCN1); potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Hcn1A354V  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2249,495,771 - 49,899,702 (+)NCBI
Rnor_6.0 Ensembl250,099,576 - 50,499,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0250,099,576 - 50,499,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0268,473,431 - 68,874,494 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4249,525,949 - 49,939,066 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1249,454,181 - 49,867,299 (+)NCBI
Celera245,196,523 - 45,593,603 (+)NCBICelera
Cytogenetic Map2q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Atkinson SE and Williams SR, J Neurophysiol. 2009 Aug;102(2):735-51. doi: 10.1152/jn.00083.2009. Epub 2009 May 20.
2. Battefeld A, etal., J Neurosci Res. 2010 Nov 1;88(14):3067-78. doi: 10.1002/jnr.22475.
3. Bender RA, etal., J Neurosci. 2003 Jul 30;23(17):6826-36.
4. Bender RA, etal., J Neurosci. 2007 Apr 25;27(17):4697-706.
5. Boyes J, etal., Eur J Neurosci. 2007 Apr;25(7):2081-92.
6. Brauer AU, etal., FASEB J. 2001 Dec;15(14):2689-701.
7. Brewster AL, etal., Neurobiol Dis. 2005 Jun-Jul;19(1-2):200-7.
8. Cho HJ, etal., Neuroscience. 2009 Aug 18;162(2):453-61. Epub 2009 May 3.
9. Dougherty KA, etal., J Neurophysiol. 2013 Apr;109(7):1940-53. doi: 10.1152/jn.00010.2013. Epub 2013 Jan 16.
10. GOA data from the GO Consortium
11. Hablitz JJ and Yang J, Epilepsia. 2010 Jul;51 Suppl 3:52-5. doi: 10.1111/j.1528-1167.2010.02610.x.
12. Jung S, etal., J Neurosci. 2011 Oct 5;31(40):14291-5. doi: 10.1523/JNEUROSCI.1148-11.2011.
13. Kim CS, etal., Neuron. 2012 Aug 9;75(3):503-16. doi: 10.1016/j.neuron.2012.05.027.
14. Li B, etal., J Neurosci. 2012 Feb 29;32(9):3164-75. doi: 10.1523/JNEUROSCI.5143-11.2012.
15. Li CJ, etal., Mol Neurobiol. 2014 Oct;50(2):704-20. doi: 10.1007/s12035-014-8736-3. Epub 2014 May 18.
16. Li S, etal., Neuroscience. 2010 Feb 3;165(3):654-61. doi: 10.1016/j.neuroscience.2009.10.053. Epub 2009 Nov 3.
17. Lorincz A, etal., Nat Neurosci 2002 Nov;5(11):1185-93.
18. McClelland S, etal., Ann Neurol. 2011 Sep;70(3):454-64. doi: 10.1002/ana.22479.
19. MGD data from the GO Consortium
20. Monteggia LM, etal., Brain Res Mol Brain Res 2000 Sep 30;81(1-2):129-39.
21. Muller F, etal., Eur J Neurosci 2003 May;17(10):2084-96.
22. NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Noam Y, etal., J Biol Chem. 2010 May 7;285(19):14724-36. doi: 10.1074/jbc.M109.070391. Epub 2010 Mar 9.
24. Oertel D, etal., Neuroscience. 2008 Jun 12;154(1):77-86. doi: 10.1016/j.neuroscience.2008.01.085. Epub 2008 Feb 29.
25. Ohno Y, etal., PLoS One. 2015 May 13;10(5):e0123529. doi: 10.1371/journal.pone.0123529. eCollection 2015.
26. Ramakrishnan NA, etal., J Biol Chem. 2009 Jan 30;284(5):3227-38. doi: 10.1074/jbc.M806177200. Epub 2008 Nov 13.
27. Ramakrishnan NA, etal., J Biol Chem. 2012 Nov 2;287(45):37628-46. doi: 10.1074/jbc.M112.375832. Epub 2012 Sep 4.
28. RGD automated data pipeline
29. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. RGD automated import pipeline for gene-chemical interactions
31. Schridde U, etal., Eur J Neurosci. 2006 Jun;23(12):3346-58.
32. Shi W, etal., Circ Res 1999 Jul 9;85(1):e1-6.
33. Stadler K, etal., Cereb Cortex. 2014 Jan;24(1):199-210. doi: 10.1093/cercor/bhs305. Epub 2012 Oct 4.
34. Stevens DR, etal., Nature. 2001 Oct 11;413(6856):631-5.
35. Stradleigh TW, etal., J Comp Neurol. 2011 Sep 1;519(13):2546-73. doi: 10.1002/cne.22638.
36. Strauss U, etal., Eur J Neurosci. 2004 Jun;19(11):3048-58.
37. Tu H, etal., Neuroscience. 2010 Jan 13;165(1):39-52. doi: 10.1016/j.neuroscience.2009.10.002. Epub 2009 Oct 6.
38. Wells JE, etal., Int Endod J. 2007 Sep;40(9):715-21. Epub 2007 Jul 23.
39. Wilkars W, etal., FASEB J. 2014 May;28(5):2177-90. doi: 10.1096/fj.13-242032. Epub 2014 Jan 22.
40. Yeh J, etal., Reprod Sci. 2009 Oct;16(10):986-94. Epub 2009 Jul 7.
41. Zha Q, etal., J Neurochem. 2008 Apr;105(1):68-77. Epub 2007 Nov 5.
Additional References at PubMed
PMID:14991560   PMID:15056713   PMID:15245481   PMID:15479642   PMID:15525777   PMID:15564593   PMID:15869503   PMID:15958747   PMID:16503331   PMID:16648453   PMID:16870744   PMID:17095562  
PMID:17196750   PMID:17311321   PMID:17687042   PMID:17848552   PMID:18397293   PMID:18450385   PMID:18524809   PMID:18657617   PMID:20220080   PMID:21052544   PMID:21185265   PMID:21326231  
PMID:21504900   PMID:21753027   PMID:21795621   PMID:21798320   PMID:22006928   PMID:22363812   PMID:22722099   PMID:22748890   PMID:22871113   PMID:23187002   PMID:23821600   PMID:24403084  
PMID:25659346   PMID:26021557   PMID:26341471   PMID:27184742   PMID:27496876   PMID:27542339   PMID:27568501   PMID:27569278   PMID:27685769   PMID:27965425   PMID:28086084   PMID:30053369  
PMID:30351409   PMID:30408474   PMID:31292305   PMID:32248813  


Genomics

Comparative Map Data
Hcn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2249,495,771 - 49,899,702 (+)NCBI
Rnor_6.0 Ensembl250,099,576 - 50,499,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0250,099,576 - 50,499,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0268,473,431 - 68,874,494 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4249,525,949 - 49,939,066 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1249,454,181 - 49,867,299 (+)NCBI
Celera245,196,523 - 45,593,603 (+)NCBICelera
Cytogenetic Map2q15NCBI
HCN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl545,254,948 - 45,696,498 (-)EnsemblGRCh38hg38GRCh38
GRCh38545,254,948 - 45,696,380 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37545,255,050 - 45,696,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36545,295,109 - 45,731,977 (-)NCBINCBI36hg18NCBI36
Build 34545,297,729 - 45,731,977NCBI
Celera545,153,108 - 45,590,074 (-)NCBI
Cytogenetic Map5p12NCBI
HuRef545,207,222 - 45,649,517 (-)NCBIHuRef
CHM1_1545,254,898 - 45,696,071 (-)NCBICHM1_1
Hcn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913117,738,856 - 118,117,564 (+)NCBIGRCm39mm39
GRCm39 Ensembl13117,738,856 - 118,123,954 (+)Ensembl
GRCm3813117,602,320 - 117,981,028 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13117,602,320 - 117,987,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713118,391,127 - 118,769,835 (+)NCBIGRCm37mm9NCBIm37
MGSCv3613118,721,981 - 119,096,083 (+)NCBImm8
Celera13122,021,998 - 122,417,756 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1366.34NCBI
Hcn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544617,151,311 - 17,457,888 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544617,146,915 - 17,457,843 (+)NCBIChiLan1.0ChiLan1.0
HCN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1569,724,749 - 70,161,427 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl569,724,767 - 70,158,761 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0564,673,392 - 65,116,259 (+)NCBIMhudiblu_PPA_v0panPan3
HCN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1464,777,069 - 65,162,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl464,775,577 - 65,160,444 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha464,536,272 - 64,921,927 (+)NCBI
ROS_Cfam_1.0465,274,982 - 65,661,386 (+)NCBI
UMICH_Zoey_3.1465,037,683 - 65,423,922 (+)NCBI
UNSW_CanFamBas_1.0465,160,205 - 65,546,474 (+)NCBI
UU_Cfam_GSD_1.0465,696,155 - 66,082,848 (+)NCBI
Hcn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213208,115,409 - 208,479,849 (+)NCBI
SpeTri2.0NW_00493648017,051,902 - 17,416,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1629,439,263 - 29,809,748 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11629,439,294 - 29,808,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21630,946,691 - 31,323,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HCN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1444,029,173 - 44,443,669 (-)NCBI
Vero_WHO_p1.0NW_02366607134,696,131 - 35,142,081 (-)NCBI
Hcn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247599,636,380 - 10,044,832 (+)NCBI

Position Markers
D2Rat201  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2249,657,069 - 49,657,252 (+)MAPPER
Rnor_6.0250,260,210 - 50,260,392NCBIRnor6.0
Rnor_5.0268,633,684 - 68,633,866UniSTSRnor5.0
RGSC_v3.4249,691,463 - 49,691,646RGDRGSC3.4
RGSC_v3.4249,691,464 - 49,691,646UniSTSRGSC3.4
RGSC_v3.1249,619,697 - 49,619,879RGD
Celera245,357,036 - 45,357,216UniSTS
RH 3.4 Map2335.0RGD
RH 3.4 Map2335.0UniSTS
RH 2.0 Map2303.0RGD
SHRSP x BN Map219.5698RGD
Cytogenetic Map2q15UniSTS
RH127885  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2249,899,619 - 49,899,836 (+)MAPPER
Rnor_6.0250,499,717 - 50,499,933NCBIRnor6.0
Rnor_5.0268,874,412 - 68,874,628UniSTSRnor5.0
RGSC_v3.4249,938,984 - 49,939,200UniSTSRGSC3.4
Celera245,593,521 - 45,593,737UniSTS
RH 3.4 Map1883.8UniSTS
Cytogenetic Map2q15UniSTS
BE107645  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2249,801,276 - 49,801,495 (+)MAPPER
Rnor_6.0250,402,380 - 50,402,598NCBIRnor6.0
Rnor_5.0268,776,557 - 68,776,775UniSTSRnor5.0
RGSC_v3.4249,840,417 - 49,840,635UniSTSRGSC3.4
Celera245,496,583 - 45,496,801UniSTS
RH 3.4 Map2333.4UniSTS
Cytogenetic Map2q15UniSTS
HCN1__6701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2249,898,874 - 49,899,735 (+)MAPPER
Rnor_6.0250,498,972 - 50,499,832NCBIRnor6.0
Rnor_5.0268,873,667 - 68,874,527UniSTSRnor5.0
RGSC_v3.4249,938,239 - 49,939,099UniSTSRGSC3.4
Celera245,592,776 - 45,593,636UniSTS
Cytogenetic Map2q15UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)23127638105149020Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2789360052893600Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)2944467968866454Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21055527555555275Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21423783059237830Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)216679272245624402Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21901646564016465Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22027698165276981Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22064137165641371Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22261295267612952Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22328064775687607Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)223837491149614623Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491169852800Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491169852800Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)223837719169852670Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)223837719169852670Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22618609783819822Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22618609783819822Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22618609783819822Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226186097135654963Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226186097142053534Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)227161361148295267Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)227161361148295267Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)227161361148295267Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227161361148295267Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22776030172760301Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22872786752507805Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23127237976272379Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23408817591101903Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23513320280133202Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)236245223112175725Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240171834105089682Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24106343956736627Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24277691662238534Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242776916169852800Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242776916195645082Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243133606217498545Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243133606217498545Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243141290114164944Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243141290114164944Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243141290154583160Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight as a percentage of body weight (CMO:0000654)24314978885642672Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243149788198704485Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246537589217498710Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:15
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000016142
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31
Low 8 6 33 19
Below cutoff 2 29 20 12 7 12 7 7 10 21 22 9 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000089218   ⟹   ENSRNOP00000073952
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl250,099,576 - 50,499,799 (+)Ensembl
RefSeq Acc Id: NM_053375   ⟹   NP_445827
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2249,495,771 - 49,899,702 (+)NCBI
Rnor_6.0250,099,576 - 50,499,799 (+)NCBI
Rnor_5.0268,473,431 - 68,874,494 (+)NCBI
RGSC_v3.4249,525,949 - 49,939,066 (+)RGD
Celera245,196,523 - 45,593,603 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445827 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF01490 (Get FASTA)   NCBI Sequence Viewer  
  AAF62173 (Get FASTA)   NCBI Sequence Viewer  
  Q9JKB0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_445827   ⟸   NM_053375
- Sequence:
RefSeq Acc Id: ENSRNOP00000073952   ⟸   ENSRNOT00000089218
Protein Domains
Cyclic nucleotide-binding

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620688 AgrOrtholog
Ensembl Genes ENSRNOG00000055382 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073952 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089218 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K/Na_HCN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84390 UniProtKB/Swiss-Prot
NCBI Gene 84390 ENTREZGENE
PANTHER PTHR45689:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hcn1 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LSH6_RAT UniProtKB/TrEMBL
  HCN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QZW7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Hcn1  hyperpolarization-activated, cyclic nucleotide-gated potassium channel 1    hyperpolarization-activated, cyclic nucleotide-gated potassium channel 1 (HCN1)  Name updated 1299863 APPROVED
2002-08-07 Hcn1  hyperpolarization-activated, cyclic nucleotide-gated potassium channel 1 (HCN1)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression localized to cerebral cortex, hippocampus, cerebellum, and facial motor neurons  
gene_product member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides 70760