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Gene: Hcn1 (hyperpolarization-activated cyclic nucleotide-gated potassium channel 1) Rattus norvegicus
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Symbol: Hcn1
Name: hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
Description: Exhibits identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to interferon-beta; maternal behavior; and response to L-glutamate. Localizes to several cellular components, including basolateral plasma membrane; dendrite; and dendrite membrane. Used to study anxiety disorder and mood disorder. Biomarker of complex cortical dysplasia with other brain malformations; epilepsy (multiple); and meningitis. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Orthologous to human HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1); INTERACTS WITH (+)-pilocarpine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: hyperpolarization-activated, cyclic nucleotide-gated potassium channel 1 (HCN1); potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Orthologs:
Allele / Splice: Hcn1A354V  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0250,099,576 - 50,499,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl250,099,576 - 50,499,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0268,473,431 - 68,874,494 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4249,525,949 - 49,939,066 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1249,454,181 - 49,867,299 (+)NCBI
Celera245,196,523 - 45,593,603 (+)NCBICelera
Cytogenetic Map2q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hcn1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620688
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-04-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.