Bhlhe41 (basic helix-loop-helix family, member e41) - Rat Genome Database

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Gene: Bhlhe41 (basic helix-loop-helix family, member e41) Rattus norvegicus
Analyze
Symbol: Bhlhe41
Name: basic helix-loop-helix family, member e41
RGD ID: 70900
Description: Predicted to enable several functions, including DNA-binding transcription factor binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein dimerization activity. Involved in circadian rhythm and regulation of neuronal synaptic plasticity. Predicted to be active in nucleus. Orthologous to human BHLHE41 (basic helix-loop-helix family member e41); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: basic helix-loop-helix domain containing class B 3; basic helix-loop-helix domain containing, class B3; Bhlhb3; class B basic helix-loop-helix protein 3; class E basic helix-loop-helix protein 41; Dec2; enhancer-of-split and hairy-related protein 1; SHARP-1; Sharp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84180,565,003 - 180,569,415 (-)NCBIGRCr8
mRatBN7.24178,834,264 - 178,838,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4178,834,271 - 178,838,468 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4185,117,084 - 185,121,450 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04180,901,598 - 180,905,964 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04179,522,031 - 179,526,399 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04180,230,742 - 180,235,138 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4180,232,382 - 180,234,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04244,394,139 - 244,398,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4167,334,944 - 167,338,512 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiolic acid  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
crocidolite asbestos  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ketamine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
troglitazone  (EXP)
undecane  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. BHLHB3: a candidate tumor suppressor in lung cancer. Falvella FS, etal., Oncogene. 2008 Jun 12;27(26):3761-4. doi: 10.1038/sj.onc.1211038. Epub 2008 Jan 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Dec1 and Dec2 are regulators of the mammalian molecular clock. Honma S, etal., Nature 2002 Oct 24;419(6909):841-4.
5. MicroRNA-873 acts as a tumor suppressor in esophageal cancer by inhibiting differentiated embryonic chondrocyte expressed gene 2. Liang Y, etal., Biomed Pharmacother. 2018 Sep;105:582-589. doi: 10.1016/j.biopha.2018.05.152. Epub 2018 Jun 8.
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Rossner MJ, etal., Mol Cell Neurosci 1997;10(3-4):460-75.
13. SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Rossner MJ, etal., Mol Cell Neurosci 1997;10(3-4):460-75.
14. The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells. Zhao Q, etal., Oncotarget. 2016 Oct 25;7(43):70290-70302. doi: 10.18632/oncotarget.11844.
Additional References at PubMed
PMID:12657651   PMID:14672706   PMID:15038852   PMID:15147242   PMID:15193144   PMID:15560782   PMID:17487425   PMID:18411297   PMID:19786558   PMID:21430201   PMID:24446161   PMID:24736997  


Genomics

Comparative Map Data
Bhlhe41
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84180,565,003 - 180,569,415 (-)NCBIGRCr8
mRatBN7.24178,834,264 - 178,838,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4178,834,271 - 178,838,468 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4185,117,084 - 185,121,450 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04180,901,598 - 180,905,964 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04179,522,031 - 179,526,399 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04180,230,742 - 180,235,138 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4180,232,382 - 180,234,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04244,394,139 - 244,398,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4167,334,944 - 167,338,512 (-)NCBICelera
Cytogenetic Map4q44NCBI
BHLHE41
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,120,030 - 26,125,037 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1226,120,030 - 26,125,037 (-)EnsemblGRCh38hg38GRCh38
GRCh371226,272,963 - 26,277,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,164,226 - 26,169,113 (-)NCBINCBI36Build 36hg18NCBI36
Build 341226,164,227 - 26,169,113NCBI
Celera1231,419,506 - 31,424,550 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1226,043,295 - 26,047,960 (-)NCBIHuRef
CHM1_11226,237,976 - 26,243,020 (-)NCBICHM1_1
T2T-CHM13v2.01225,992,585 - 25,998,690 (-)NCBIT2T-CHM13v2.0
Bhlhe41
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396145,803,969 - 145,811,146 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6145,803,969 - 145,811,284 (-)EnsemblGRCm39 Ensembl
GRCm386145,858,243 - 145,865,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6145,858,243 - 145,865,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv376145,811,257 - 145,813,860 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366145,819,896 - 145,822,499 (-)NCBIMGSCv36mm8
Celera6148,934,952 - 148,937,555 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.7NCBI
Bhlhe41
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541321,100,021 - 21,103,358 (-)NCBIChiLan1.0ChiLan1.0
BHLHE41
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21070,697,481 - 70,702,552 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11270,693,542 - 70,698,949 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01260,194,758 - 60,199,344 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11262,806,113 - 62,810,773 (+)NCBIpanpan1.1PanPan1.1panPan2
BHLHE41
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12721,464,302 - 21,469,119 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2724,913,768 - 24,918,529 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02721,659,233 - 21,663,998 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2721,659,186 - 21,663,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12721,469,068 - 21,473,810 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02721,491,838 - 21,496,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02725,081,155 - 25,085,938 (-)NCBIUU_Cfam_GSD_1.0
Bhlhe41
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494583,384,039 - 83,391,789 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365481,306,939 - 1,314,678 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BHLHE41
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl547,686,404 - 47,692,762 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1547,687,662 - 47,692,761 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2551,429,074 - 51,433,848 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BHLHE41
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11125,872,139 - 25,879,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1125,874,108 - 25,876,826 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660699,196,174 - 9,200,076 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bhlhe41
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475213,000,525 - 13,003,079 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475213,000,238 - 13,004,777 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bhlhe41
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:80
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000070957
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
RH143816  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24178,835,730 - 178,835,842 (+)MAPPERmRatBN7.2
Rnor_6.04180,232,209 - 180,232,320NCBIRnor6.0
Rnor_5.04244,395,606 - 244,395,717UniSTSRnor5.0
RH 3.4 Map41070.3UniSTS
Cytogenetic Map4q43UniSTS
AI170756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24178,834,487 - 178,834,688 (+)MAPPERmRatBN7.2
Rnor_6.04180,230,966 - 180,231,166NCBIRnor6.0
Rnor_5.04244,394,363 - 244,394,563UniSTSRnor5.0
Celera4167,334,878 - 167,335,078UniSTS
RH 3.4 Map41067.7UniSTS
Cytogenetic Map4q43UniSTS
Bhlhe41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24178,835,532 - 178,835,812 (+)MAPPERmRatBN7.2
Rnor_6.04180,232,011 - 180,232,290NCBIRnor6.0
Rnor_5.04244,395,408 - 244,395,687UniSTSRnor5.0
Cytogenetic Map4q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 88 87 56 25 56 6 215 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000070957   ⟹   ENSRNOP00000064008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4178,836,870 - 178,838,468 (-)Ensembl
Rnor_6.0 Ensembl4180,232,382 - 180,234,804 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094651   ⟹   ENSRNOP00000095943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4178,834,271 - 178,838,468 (-)Ensembl
RefSeq Acc Id: NM_133303   ⟹   NP_579837
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84180,565,003 - 180,569,355 (-)NCBI
mRatBN7.24178,834,264 - 178,838,618 (-)NCBI
RefSeq Acc Id: XM_063285422   ⟹   XP_063141492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84180,565,005 - 180,569,415 (-)NCBI
Protein Sequences
Protein RefSeqs NP_579837 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141492 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB63586 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064008.2
  ENSRNOP00000095943
  ENSRNOP00000095943.1
  ENSRNOP00000105933
GenBank Protein O35779 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000064008   ⟸   ENSRNOT00000070957
Ensembl Acc Id: ENSRNOP00000095943   ⟸   ENSRNOT00000094651
RefSeq Acc Id: NP_579837   ⟸   NM_133303
- UniProtKB: O35779 (UniProtKB/Swiss-Prot),   A0A8I6GLD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141492   ⟸   XM_063285422
- Peptide Label: isoform X1
- UniProtKB: O35779 (UniProtKB/Swiss-Prot)
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35779-F1-model_v2 AlphaFold O35779 1-410 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70900 AgrOrtholog
BioCyc Gene G2FUF-42448 BioCyc
Ensembl Genes ENSRNOG00000048961 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070957.2 UniProtKB/TrEMBL
  ENSRNOT00000094651 ENTREZGENE
  ENSRNOT00000094651.1 UniProtKB/TrEMBL
  ENSRNOT00000160326 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HES_HEY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orange_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117095 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bhlhe41 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048961 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Orange domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GLD9 ENTREZGENE, UniProtKB/TrEMBL
  BHE41_RAT UniProtKB/Swiss-Prot
  M0R3T6_RAT UniProtKB/TrEMBL
  O35779 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-19 Bhlhe41  basic helix-loop-helix family, member e41  Bhlhb3  basic helix-loop-helix domain containing, class B3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Bhlhb3  basic helix-loop-helix domain containing, class B3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the suprachiasmic nucleus of the hypothalamus (SCN) in a circadian fashion 625726
gene_expression expressed in the caudate putamen, pineal gland, granular cell layer of the cerebellum, olfactory bulb, piriform cortex, hippocampus and hypothalamic nuclei 625726
gene_process expression may be associated with neuronal stimulation 728119
gene_product member of a family of neuronal bHLH proteins 728119