Bhlhe41 (basic helix-loop-helix family, member e41)

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Gene: Bhlhe41 (basic helix-loop-helix family, member e41) Rattus norvegicus

Analyze

Symbol:

Bhlhe41

Name:

basic helix-loop-helix family, member e41

RGD ID:

70900

Description:

Predicted to enable several functions, including DNA-binding transcription factor binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein dimerization activity. Involved in circadian rhythm and regulation of neuronal synaptic plasticity. Predicted to be active in nucleus. Orthologous to human BHLHE41 (basic helix-loop-helix family member e41); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

basic helix-loop-helix domain containing class B 3; basic helix-loop-helix domain containing, class B3; Bhlhb3; class B basic helix-loop-helix protein 3; class E basic helix-loop-helix protein 41; Dec2; enhancer-of-split and hairy-related protein 1; SHARP-1; Sharp1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	178,834,264 - 178,838,618 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	178,834,271 - 178,838,468 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	185,117,084 - 185,121,450 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	180,901,598 - 180,905,964 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	179,522,031 - 179,526,399 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	180,230,742 - 180,235,138 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	180,232,382 - 180,234,804 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	244,394,139 - 244,398,535 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	4	167,334,944 - 167,338,512 (-)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

esophageal cancer (ISO)

Familial Natural Short Sleep 1 (ISO)

genetic disease (ISO)

lung adenocarcinoma (ISO)

Lung Neoplasms (ISO)

oral squamous cell carcinoma (ISO)

sleep disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,3-dinitrobenzene (EXP)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bexarotene (EXP)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cannabidiolic acid (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chloroprene (EXP)

choline (ISO)

cisplatin (EXP,ISO)

clofibric acid (EXP)

crocidolite asbestos (ISO)

dexamethasone (EXP)

dichloroacetic acid (ISO)

diethyl maleate (EXP)

dimethylarsinic acid (ISO)

dimethylarsinous acid (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

fenamidone (ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

ketamine (EXP)

L-methionine (ISO)

lipopolysaccharide (ISO)

methylarsonic acid (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nickel dichloride (EXP)

O-methyleugenol (ISO)

oxaliplatin (EXP)

panobinostat (ISO)

paracetamol (ISO)

pentanal (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

progesterone (EXP,ISO)

propanal (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

sevoflurane (EXP)

silicon dioxide (EXP,ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

Tesaglitazar (EXP)

testosterone (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (EXP,ISO)

topotecan (EXP)

tributylstannane (ISO)

trichloroethene (EXP,ISO)

troglitazone (EXP)

undecane (EXP)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (IBA)

circadian regulation of gene expression (IBA,IEA,ISO)

circadian rhythm (IEP,ISO)

negative regulation of DNA-templated transcription (ISO,ISS)

negative regulation of myotube differentiation (IEA,ISO)

negative regulation of transcription by competitive promoter binding (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

nervous system development (NAS)

regulation of neurogenesis (IBA)

regulation of neuronal synaptic plasticity (IEP,NAS)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

nucleus (IBA)

Molecular Function

bHLH transcription factor binding (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA,ISO,ISS)

E-box binding (IEA,ISO)

histone deacetylase binding (IEA,ISO)

MRF binding (IEA,ISO)

protein binding (ISO)

protein dimerization activity (IEA)

protein heterodimerization activity (IEA,ISO)

protein homodimerization activity (IEA,ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA,ISO)

sequence-specific double-stranded DNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	BHLHB3: a candidate tumor suppressor in lung cancer.	Falvella FS, etal., Oncogene. 2008 Jun 12;27(26):3761-4. doi: 10.1038/sj.onc.1211038. Epub 2008 Jan 28.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Dec1 and Dec2 are regulators of the mammalian molecular clock.	Honma S, etal., Nature 2002 Oct 24;419(6909):841-4.
5.	MicroRNA-873 acts as a tumor suppressor in esophageal cancer by inhibiting differentiated embryonic chondrocyte expressed gene 2.	Liang Y, etal., Biomed Pharmacother. 2018 Sep;105:582-589. doi: 10.1016/j.biopha.2018.05.152. Epub 2018 Jun 8.
6.	Gene Data Set	MGD Curation, June 12, 2002
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation.	Rossner MJ, etal., Mol Cell Neurosci 1997;10(3-4):460-75.
13.	SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation.	Rossner MJ, etal., Mol Cell Neurosci 1997;10(3-4):460-75.
14.	The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells.	Zhao Q, etal., Oncotarget. 2016 Oct 25;7(43):70290-70302. doi: 10.18632/oncotarget.11844.

Additional References at PubMed

PMID:12657651	PMID:14672706	PMID:15038852	PMID:15147242	PMID:15193144	PMID:15560782	PMID:17487425	PMID:18411297	PMID:19786558	PMID:21430201	PMID:24446161	PMID:24736997

Genomics

Comparative Map Data

Bhlhe41
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	178,834,264 - 178,838,618 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	178,834,271 - 178,838,468 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	185,117,084 - 185,121,450 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	180,901,598 - 180,905,964 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	179,522,031 - 179,526,399 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	180,230,742 - 180,235,138 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	180,232,382 - 180,234,804 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	244,394,139 - 244,398,535 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	4	167,334,944 - 167,338,512 (-)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

BHLHE41
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	26,120,030 - 26,125,037 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	26,120,030 - 26,125,037 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	26,272,963 - 26,277,970 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	26,164,226 - 26,169,113 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	26,164,227 - 26,169,113	NCBI
Celera	12	31,419,506 - 31,424,550 (-)	NCBI		Celera
Cytogenetic Map	12	p12.1	NCBI
HuRef	12	26,043,295 - 26,047,960 (-)	NCBI		HuRef
CHM1_1	12	26,237,976 - 26,243,020 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	25,992,585 - 25,998,690 (-)	NCBI		T2T-CHM13v2.0

Bhlhe41
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	145,803,969 - 145,811,146 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	145,803,969 - 145,811,284 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	145,858,243 - 145,865,420 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	145,858,243 - 145,865,558 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	145,811,257 - 145,813,860 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	145,819,896 - 145,822,499 (-)	NCBI		MGSCv36	mm8
Celera	6	148,934,952 - 148,937,555 (-)	NCBI		Celera
Cytogenetic Map	6	G3	NCBI
cM Map	6	77.7	NCBI

Bhlhe41
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955413	21,100,021 - 21,103,358 (-)	NCBI	ChiLan1.0	ChiLan1.0

BHLHE41
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	70,693,542 - 70,698,949 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	60,194,758 - 60,199,344 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	62,806,113 - 62,810,773 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

BHLHE41
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	21,464,302 - 21,469,119 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	24,913,768 - 24,918,529 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	21,659,233 - 21,663,998 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	21,659,186 - 21,663,998 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	21,469,068 - 21,473,810 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	21,491,838 - 21,496,575 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	25,081,155 - 25,085,938 (-)	NCBI		UU_Cfam_GSD_1.0

Bhlhe41
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	83,384,039 - 83,391,789 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936548	1,306,939 - 1,314,678 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BHLHE41
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	47,686,404 - 47,692,762 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	47,687,662 - 47,692,761 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	51,429,074 - 51,433,848 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BHLHE41
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	25,872,139 - 25,879,985 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	25,874,108 - 25,876,826 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	9,196,174 - 9,200,076 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bhlhe41
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	13,000,525 - 13,003,079 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	13,000,238 - 13,004,777 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bhlhe41
9 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	93
Count of miRNA genes:	80
Interacting mature miRNAs:	85
Transcripts:	ENSRNOT00000070957
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
2303623	Vencon2	Ventilatory control QTL 2	3.8		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	4	135204660	180204660	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	135699135	180699135	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	137755016	181392681	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	138503169	179293946	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	144639524	182687754	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	144639524	182687754	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	145568712	182687754	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	155561574	182687754	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	157710145	182687754	Rat

Markers in Region

RH143816

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	178,835,730 - 178,835,842 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	180,232,209 - 180,232,320	NCBI	Rnor6.0
Rnor_5.0	4	244,395,606 - 244,395,717	UniSTS	Rnor5.0
RH 3.4 Map	4	1070.3	UniSTS
Cytogenetic Map	4	q43	UniSTS

AI170756

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	178,834,487 - 178,834,688 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	180,230,966 - 180,231,166	NCBI	Rnor6.0
Rnor_5.0	4	244,394,363 - 244,394,563	UniSTS	Rnor5.0
Celera	4	167,334,878 - 167,335,078	UniSTS
RH 3.4 Map	4	1067.7	UniSTS
Cytogenetic Map	4	q43	UniSTS

Bhlhe41

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	178,835,532 - 178,835,812 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	180,232,011 - 180,232,290	NCBI	Rnor6.0
Rnor_5.0	4	244,395,408 - 244,395,687	UniSTS	Rnor5.0
Cytogenetic Map	4	q43	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		4	1		4		6	9	25		1	4	6
Low	3	39	24	9	15	9	2	2	47	29	39	7	2
Below cutoff			30	30		30			2	6	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002729454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF009329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000070957 ⟹ ENSRNOP00000064008

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	178,836,870 - 178,838,468 (-)	Ensembl
Rnor_6.0 Ensembl	4	180,232,382 - 180,234,804 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094651 ⟹ ENSRNOP00000095943

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	178,834,271 - 178,838,468 (-)	Ensembl

RefSeq Acc Id:

NM_133303 ⟹ NP_579837

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	178,834,264 - 178,838,618 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_579837	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB63586	(Get FASTA)	NCBI Sequence Viewer
	O35779	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000064008 ⟸ ENSRNOT00000070957

RefSeq Acc Id:

ENSRNOP00000095943 ⟸ ENSRNOT00000094651

RefSeq Acc Id:	NP_579837 ⟸ NM_133303
- UniProtKB:	O35779 (UniProtKB/Swiss-Prot), A0A8I6GLD9 (UniProtKB/TrEMBL)

Protein Domains

bHLH Orange

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35779-F1-model_v2	AlphaFold	O35779	1-410	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70900	AgrOrtholog
BioCyc Gene	G2FUF-42448	BioCyc
Ensembl Genes	ENSRNOG00000048961	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000064008.2	UniProtKB/TrEMBL
	ENSRNOP00000095943	ENTREZGENE
	ENSRNOP00000095943.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000070957.2	UniProtKB/TrEMBL
	ENSRNOT00000094651	ENTREZGENE
	ENSRNOT00000094651.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	6.10.250.980	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Orange_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	117095	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 41	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Hairy_orange	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Bhlhe41	PhenoGen
PROSITE	BHLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ORANGE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	HLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ORANGE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Orange domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF47459	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6GLD9	ENTREZGENE, UniProtKB/TrEMBL
	BHE41_RAT	UniProtKB/Swiss-Prot
	M0R3T6_RAT	UniProtKB/TrEMBL
	O35779	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-02-19	Bhlhe41	basic helix-loop-helix family, member e41	Bhlhb3	basic helix-loop-helix domain containing, class B3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Bhlhb3	basic helix-loop-helix domain containing, class B3			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the suprachiasmic nucleus of the hypothalamus (SCN) in a circadian fashion	625726
gene_expression	expressed in the caudate putamen, pineal gland, granular cell layer of the cerebellum, olfactory bulb, piriform cortex, hippocampus and hypothalamic nuclei	625726
gene_process	expression may be associated with neuronal stimulation	728119
gene_product	member of a family of neuronal bHLH proteins	728119

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

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Imported Annotations - PID (archival)