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Gene: Meox2 (mesenchyme homeobox 2) Rattus norvegicus

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Symbol:

Meox2

Name:

mesenchyme homeobox 2

RGD ID:

3079

Description:

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in fibroblast proliferation and myofibroblast differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Biomarker of myocardial infarction. Orthologous to human MEOX2 (mesenchyme homeobox 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

growth arrest-specific homeobox; homeobox protein MOX-2; mesenchyme homeo box 2; mesenchyme homeo box 2 (growth arrest-specific homeo box)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MEOX2 (mesenchyme homeobox 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Meox2 (mesenchyme homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Meox2 (mesenchyme homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MEOX2 (mesenchyme homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MEOX2 (mesenchyme homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Meox2 (mesenchyme homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MEOX2 (mesenchyme homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MEOX2 (mesenchyme homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Meox2 (mesenchyme homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PPP1R15A (protein phosphatase 1 regulatory subunit 15A)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MEOX2 (mesenchyme homeobox 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Meox2 (mesenchyme homeobox 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	meox2a (mesenchyme homeobox 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	meox2b (mesenchyme homeobox 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	btn	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	meox2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	59,584,025 - 59,644,722 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	59,583,785 - 59,644,700 (+)	Ensembl				GRCr8
mRatBN7.2	6	53,856,760 - 53,917,467 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	53,856,758 - 53,917,467 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	54,156,909 - 54,224,375 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	54,471,799 - 54,539,259 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	53,944,436 - 54,011,867 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	56,625,768 - 56,689,195 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	56,625,650 - 56,689,238 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	66,231,865 - 66,293,008 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	55,895,760 - 55,957,066 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	52,995,636 - 53,056,305 (+)	NCBI		Celera
RGSC_v3.1	6	55,898,885 - 55,960,192 (+)	NCBI
Cytogenetic Map	6	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

myocardial infarction (IEP)

Myocardial Ischemia (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,7-dihydropurine-6-thione (EXP)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-hexachlorocyclohexane (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (EXP)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

Cuprizon (EXP)

dibutyl phthalate (ISO)

dichlorine (EXP)

diethylstilbestrol (EXP,ISO)

dioxygen (ISO)

fentin chloride (EXP)

furan (EXP)

gamma-hexachlorocyclohexane (EXP)

glycidol (EXP)

hydrogen cyanide (ISO)

lipopolysaccharide (ISO)

melphalan (ISO)

mercaptopurine (EXP)

mercury atom (ISO)

mercury(0) (ISO)

mirex (EXP)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nevirapine (EXP)

nickel atom (ISO)

ozone (EXP)

paracetamol (ISO)

PCB138 (ISO)

phenobarbital (EXP)

phorbol 13-acetate 12-myristate (ISO)

Pirarubicin (EXP)

pirinixic acid (EXP,ISO)

potassium cyanide (ISO)

purine-6-thiol (EXP)

rofecoxib (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

troglitazone (ISO)

valdecoxib (EXP)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (IEA,ISO)

fibroblast proliferation (IMP)

limb development (IEA,ISO)

myofibroblast differentiation (IEP)

negative regulation of cell migration involved in sprouting angiogenesis (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

roof of mouth development (IEA,ISO)

skeletal muscle tissue development (IEA,ISO)

somite development (IBA)

somite specification (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO)

nuclear speck (IEA)

nucleus (IBA,IEA,ISO)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor activity (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype.	Cunnington RH, etal., J Cell Sci. 2014 Jan 1;127(Pt 1):40-9. doi: 10.1242/jcs.126722. Epub 2013 Oct 23.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells.	Gorski DH, etal., Mol Cell Biol 1993 Jun;13(6):3722-33.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:9073066	PMID:10403250	PMID:12925591	PMID:15680482	PMID:16116430	PMID:16284941	PMID:16335786	PMID:17074759	PMID:20160044	PMID:20421348	PMID:20516212	PMID:22166940
PMID:22206000	PMID:25280940	PMID:36713029

Genomics

Comparative Map Data

Meox2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	59,584,025 - 59,644,722 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	59,583,785 - 59,644,700 (+)	Ensembl				GRCr8
mRatBN7.2	6	53,856,760 - 53,917,467 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	53,856,758 - 53,917,467 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	54,156,909 - 54,224,375 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	54,471,799 - 54,539,259 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	53,944,436 - 54,011,867 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	56,625,768 - 56,689,195 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	56,625,650 - 56,689,238 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	66,231,865 - 66,293,008 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	55,895,760 - 55,957,066 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	52,995,636 - 53,056,305 (+)	NCBI		Celera
RGSC_v3.1	6	55,898,885 - 55,960,192 (+)	NCBI
Cytogenetic Map	6	q21	NCBI

MEOX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	15,611,212 - 15,686,683 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	15,611,212 - 15,686,683 (-)	Ensembl			hg38	GRCh38
GRCh37	7	15,650,837 - 15,726,308 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	15,617,362 - 15,692,833 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	15,424,076 - 15,499,534	NCBI
Celera	7	15,630,544 - 15,706,034 (-)	NCBI		Celera
Cytogenetic Map	7	p21.2	NCBI
HuRef	7	15,535,672 - 15,611,245 (-)	NCBI		HuRef
CHM1_1	7	15,650,236 - 15,725,903 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	15,744,456 - 15,819,945 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	15,703,946 - 15,779,448 (-)	NCBI

Meox2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	37,158,539 - 37,229,533 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	37,158,539 - 37,229,533 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	37,108,540 - 37,179,534 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	37,108,540 - 37,179,534 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	37,835,133 - 37,906,115 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	37,618,812 - 37,689,794 (+)	NCBI		MGSCv36	mm8
Celera	12	38,548,347 - 38,608,374 (+)	NCBI		Celera
Cytogenetic Map	12	A3	NCBI
cM Map	12	16.84	NCBI

Meox2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	18,924,605 - 18,988,478 (-)	Ensembl
ChiLan1.0	NW_004955410	18,924,669 - 18,988,478 (-)	NCBI	ChiLan1.0	ChiLan1.0

MEOX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	20,447,134 - 20,522,883 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	68,769,680 - 68,847,538 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	16,268,225 - 16,343,914 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	15,598,460 - 15,673,935 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	15,598,466 - 15,673,935 (-)	Ensembl			panPan2	panpan1.1

MEOX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	30,258,737 - 30,324,438 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	29,864,318 - 30,324,006 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	29,780,887 - 29,846,794 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	30,174,433 - 30,240,144 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	30,174,125 - 30,239,967 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	30,276,649 - 30,342,528 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	29,996,478 - 30,062,402 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	30,307,318 - 30,373,202 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Meox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	74,564,415 - 74,629,128 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936546	2,239,442 - 2,304,099 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936546	2,239,442 - 2,304,099 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MEOX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	84,943,199 - 85,010,157 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	84,945,178 - 85,009,939 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	93,770,697 - 93,771,213 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MEOX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	42,403,474 - 42,476,469 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	42,403,741 - 42,476,453 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666042	62,025,173 - 62,098,121 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Meox2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	14,483,789 - 14,547,374 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624739	14,483,750 - 14,547,491 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Meox2
251 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	380
Count of miRNA genes:	207
Interacting mature miRNAs:	244
Transcripts:	ENSRNOT00000008803
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	44510974	89510974	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	39028659	63457441	Rat
4889933	Bss88	Bone structure and strength QTL 88	3.8		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	6	53684921	98684921	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	40957564	85957564	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	45153786	90153786	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
5684992	Bmd83	Bone mineral density QTL 82	4.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	6	53684921	98684921	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	31185002	76185002	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	46050607	116278722	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	46047353	91047353	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	44510974	89510974	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	44510974	89510974	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	33328841	78328841	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	30937632	75937632	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	33328841	78328841	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	39028659	86867923	Rat
5684963	Bss99	Bone structure and strength QTL 99	3.1		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	6	53684921	98684921	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	40163183	85163183	Rat

Markers in Region

D6Rat205

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	53,913,918 - 53,914,055 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	56,685,647 - 56,685,783	NCBI	Rnor6.0
Rnor_5.0	6	66,289,460 - 66,289,596	UniSTS	Rnor5.0
RGSC_v3.4	6	55,953,517 - 55,953,654	RGD	RGSC3.4
RGSC_v3.4	6	55,953,518 - 55,953,654	UniSTS	RGSC3.4
Celera	6	53,052,757 - 53,052,893	UniSTS
RGSC_v3.1	6	55,956,643 - 55,956,780	RGD
SHRSP x BN Map	6	40.9199	RGD
SHRSP x BN Map	6	40.9199	UniSTS
Cytogenetic Map	6	q21	UniSTS

AI598524

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	53,917,008 - 53,917,177 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	56,688,737 - 56,688,905	NCBI	Rnor6.0
Rnor_5.0	6	66,292,550 - 66,292,718	UniSTS	Rnor5.0
RGSC_v3.4	6	55,956,608 - 55,956,776	UniSTS	RGSC3.4
Celera	6	53,055,847 - 53,056,015	UniSTS
RH 3.4 Map	6	383.4	UniSTS
Cytogenetic Map	6	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
12	12	63	125	90	90	59	26	59	6	252	122	11	103	51	89	31	4	4

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017149	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z17223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008803 ⟹ ENSRNOP00000008803

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	59,583,785 - 59,644,700 (+)	Ensembl
mRatBN7.2 Ensembl	6	53,856,758 - 53,917,467 (+)	Ensembl
Rnor_6.0 Ensembl	6	56,625,650 - 56,689,238 (+)	Ensembl

RefSeq Acc Id:

NM_017149 ⟹ NP_058845

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	59,584,025 - 59,644,722 (+)	NCBI
mRatBN7.2	6	53,856,760 - 53,917,467 (+)	NCBI
Rnor_6.0	6	56,625,768 - 56,689,195 (+)	NCBI
Rnor_5.0	6	66,231,865 - 66,293,008 (+)	NCBI
RGSC_v3.4	6	55,895,760 - 55,957,066 (+)	RGD
Celera	6	52,995,636 - 53,056,305 (+)	RGD

Sequence:

show sequence

GTCAAGTGTTTATACGTGCAGGAGACTGGCCGCTCGGCTCAGGACTGGGATTAGCGGGCTCTGC
TCAAACCCGCGCGGCTTTTACATTAGGAGTGAGTGGGGGAGAGTCCTAGGATTTCTAGTGAAAA
GTGACAGCGCTTGGTGGACTTTGGGACCTTCGTGAAGTCTTCTGCTTGGAAGCTGAGACTTGCA
TGCCATGGAACACCCCCTCTTTGGCTGCCTGCGCAGCCCCCACGCCACAGCGCAAGGCTTGCAC
CCCTTCTCGCAGTCTTCTCTGGCCCTCCATGGAAGATCTGACCACATGTCCTACCCCGAACTCT
CCACATCTTCCTCGTCTTGCATAATCGCGGGATACCCCAATGAGGAGGGCATGTTTGCCAGCCA
GCATCACAGGGGGCACCACCACCACCACCACCACCACCATCACCACCACCAGCAGCAGCAGCAC
CAGGCTCTGCAAAGCAACTGGCACCTCCCGCAGATGTCCTCCCCGCCAAGCGCGGCCCGGCACA
GCCTTTGCCTGCAGCCTGATTCCGGAGGGCCCCCGGAGCTGGGGAGCAGCCCTCCGGTCCTGTG
CTCCAACTCTTCTAGCCTGGGCTCCAGCACCCCGACCGGAGCCGCGTGCGCACCAAGGGATTAT
GGCCGTCAAGCGCTGTCACCCGCAGAAGTGGAGAAGAGAAGTGGCAGCAAAAGAAAAAGCGACA
GTTCAGATTCCCAGGAAGGAAATTACAAGTCAGAAGTGAACAGCAAACCTAGGAAGGAAAGAAC
AGCTTTCACCAAAGAGCAAATCAGAGAACTTGAGGCAGAGTTCGCCCATCATAACTATCTGACC
AGACTGAGAAGATATGAGATAGCGGTGAACCTAGACCTCACTGAAAGACAGGTGAAAGTGTGGT
TCCAGAACAGGAGAATGAAGTGGAAGCGGGTCAAGGGGGGACAACAAGGAGCTGCAGCCCGAGA
AAAGGAACTGGTGAATGTGAAAAAGGGAACACTTCTTCCATCAGAGCTGTCAGGAATTGGTGCA
GCCACCCTCCAGCAGACAGGGGACTCACTAGCAAATGACGACAGTCGCGATAGTGACCACAGCT
CTGAGCACGCACACTTATGATACATACAGAGACCAGCTCCGTTCTCAGGAAAGCACCATTGTGA
TGGCAAATCTCACCCAAACATCGTTTACATGGCAGATGACTGTGGCAGTGTTGCTTAATATAAT
TAAACGCAGGCATCTCAAGTCTGTTTCTCATGATTGATAGAAGGTTTACACTAAGTGCCTCTTA
TTGAAGATGCTTCCACAGTGAAATTGGAGAAAGTGAACATATCTAAATATACTTGTTCCTTATA
TGACAGAGAGGGAGATGAATGTTTGCTTTGGCTTGCACTGAAAATTAAATTGCTACCAAGAGCA
AACTCGGTAAGACATTTTGACTCAAGTTGTCTCCAGAGTGAAGATGTTATAGAAATGCTTTGAA
CATTCCAGTTGTACCAGGTCATGTGTGTGACACTGGGCAGGTATTTGCTTTTGCTTGCACTGAA
ACTTAAACTGCTATCAAGTTAACCCATGAAATAGTTTATCTTGAACAGCCACAGTGCCTGAAAT
CACCAAGTGGATATAAAATGAACTGAAATTCTGTATATATTACTCCTAAGTCATTTTCCTGTCT
TCACTAATTTTAGCAAATGCATTCATATTAGCTGATGAAAATAGGCTTTCCCGTGGACAAATGC
AGCCAGCTTCTTGTATTTTTATACATTTTTTTGTCAGTCAGAGACATCAGTATGTGCTTACTTG
TGTTCAAGTAGAGGAAATGCAGTAGAGTCTGATAGGACATATTCTTGGTACCACAGACAAAACA
AATCTTCTGTTGCATTGACTATCAACTGCTGCAGATACATTAGAGAACACACCTAGCCCCCCTC
CAGCCTCCCTCTGTTATCGCTCGAAGACATTAGCGTCATAGGCAAGTAGTTACCTTGCCAAATG
AGTCTTGTGTGGCAGATGTCTGATTTTGTATCTTTAAACTGTTAATGGTATGTGTCTGCTTCAG
TTAACAGGGAAAAAGATTTCTTCCTCATTGTTTATGATACAAAACCCAAGTGCCAAACAAAGCT
AGTTCTTCAAGGGATAGATGAGAAACTGAATGTCTGACAAGTAGACTCAGCGAAAATACATTAT
TTTTCAGAGGCTGTGTATTCATGCAGTACAAGTCCTTGTATTTTGTAAAAAAAAAAGTTAAATA
AATG

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Protein Sequences


Protein RefSeqs	NP_058845	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA78931	(Get FASTA)	NCBI Sequence Viewer
	EDM03320	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008803
GenBank Protein	P39020	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_058845 ⟸ NM_017149

- UniProtKB:

P39020 (UniProtKB/Swiss-Prot), G3V6T9 (UniProtKB/TrEMBL), A6HBB5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQH
HRGHHHHHHHHHHHHQQQQHQALQSNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCS
NSSSLGSSTPTGAACAPRDYGRQALSPAEVEKRSGSKRKSDSSDSQEGNYKSEVNSKPRKERTA
FTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREK
ELVNVKKGTLLPSELSGIGAATLQQTGDSLANDDSRDSDHSSEHAHL

hide sequence

Ensembl Acc Id:

ENSRNOP00000008803 ⟸ ENSRNOT00000008803

Protein Domains

Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P39020-F1-model_v2	AlphaFold	P39020	1-303	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694564

Promoter ID:

EPDNEW_R5089

Type:

initiation region

Name:

Meox2_1

Description:

mesenchyme homeobox 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	56,625,725 - 56,625,785	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3079	AgrOrtholog
BioCyc Gene	G2FUF-37782	BioCyc
Ensembl Genes	ENSRNOG00000006588	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000008803	ENTREZGENE
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot
	Homeobox_CS	UniProtKB/Swiss-Prot
	Homeobox_dom	UniProtKB/Swiss-Prot
	Homeobox_metazoa	UniProtKB/Swiss-Prot
	MOX-1/MOX-2	UniProtKB/Swiss-Prot
KEGG Report	rno:29279	UniProtKB/Swiss-Prot
NCBI Gene	29279	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN MOX-2	UniProtKB/Swiss-Prot
	PTHR24328	UniProtKB/Swiss-Prot
Pfam	Homeodomain	UniProtKB/Swiss-Prot
PhenoGen	Meox2	PhenoGen
PRINTS	HOMEOBOX	UniProtKB/Swiss-Prot
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot
	HOMEOBOX_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000006588	RatGTEx
SMART	HOX	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot
TIGR	TC209311
UniProt	A6HBB5	ENTREZGENE, UniProtKB/TrEMBL
	G3V6T9	ENTREZGENE, UniProtKB/TrEMBL
	MEOX2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Meox2	mesenchyme homeobox 2		mesenchyme homeo box 2	Name updated	1299863	APPROVED
2002-06-10	Meox2	mesenchyme homeo box 2			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	expression is downregulated by platelet-derived growth factor (PDGF) or serum growth factors in vascular smooth muscle cells	69891

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD