Clcn5 (chloride voltage-gated channel 5) - Rat Genome Database

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Gene: Clcn5 (chloride voltage-gated channel 5) Rattus norvegicus
Analyze
Symbol: Clcn5
Name: chloride voltage-gated channel 5
RGD ID: 2362
Description: Enables voltage-gated chloride channel activity. Involved in chloride transport. Located in endosome and membrane. Used to study renal tubular transport disease. Human ortholog(s) of this gene implicated in Dent disease 1; X-linked nephrolithiasis type I; X-linked recessive hypophosphatemic rickets; and low molecular weight proteinuria with hypercalciuric nephrocalcinosis. Orthologous to human CLCN5 (chloride voltage-gated channel 5); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chloride channel 5; chloride channel protein 5; chloride channel, voltage-sensitive 5; chloride transporter ClC-5; clC-5; CLC5; h(+)/Cl(-) exchange transporter 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,857,260 - 18,011,844 (+)NCBIGRCr8
mRatBN7.2X15,185,380 - 15,339,977 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX15,185,451 - 15,334,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX20,124,321 - 20,150,472 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X19,932,829 - 19,958,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,197,788 - 16,223,939 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X16,170,585 - 16,196,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX16,050,780 - 16,196,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,955,709 - 16,981,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X27,383,769 - 27,409,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X27,437,237 - 27,463,346 (+)NCBI
CeleraX15,387,005 - 15,413,019 (+)NCBICelera
RH 3.4 MapX169.21RGD
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical part of cell  (ISO,ISS)
cytosol  (IEA,ISO)
early endosome  (IBA)
endosome  (IDA,ISO)
endosome membrane  (IEA)
Golgi apparatus  (IBA,ISO)
Golgi membrane  (IEA)
membrane  (IDA,ISO)
plasma membrane  (IBA,IEA,ISO)
synaptic vesicle  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM. Isnard-Bagnis C, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C220-32.
4. Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5. Jouret F, etal., Kidney Int. 2004 Jan;65(1):198-208.
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Intrarenal and subcellular localization of rat CLC5. Luyckx VA, etal., Am J Physiol. 1998 Nov;275(5 Pt 2):F761-9.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Identification of a new outwardly rectifying Cl- channel that belongs to a subfamily of the ClC Cl- channels. Sakamoto H, etal., J Biol Chem 1996 Apr 26;271(17):10210-6.
15. Expression and canalicular localization of two isoforms of the ClC-3 chloride channel from rat hepatocytes. Shimada K, etal., Am J Physiol Gastrointest Liver Physiol 2000 Aug;279(2):G268-76.
16. Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease. Steinmeyer K, etal., J Biol Chem 1995 Dec 29;270(52):31172-7.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12815097   PMID:17195847   PMID:17897319   PMID:19946888   PMID:21063094   PMID:25008349   PMID:25587118   PMID:26173747  


Genomics

Comparative Map Data
Clcn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,857,260 - 18,011,844 (+)NCBIGRCr8
mRatBN7.2X15,185,380 - 15,339,977 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX15,185,451 - 15,334,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX20,124,321 - 20,150,472 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X19,932,829 - 19,958,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,197,788 - 16,223,939 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X16,170,585 - 16,196,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX16,050,780 - 16,196,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,955,709 - 16,981,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X27,383,769 - 27,409,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X27,437,237 - 27,463,346 (+)NCBI
CeleraX15,387,005 - 15,413,019 (+)NCBICelera
RH 3.4 MapX169.21RGD
Cytogenetic MapXq12NCBI
CLCN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X49,922,596 - 50,099,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX49,922,596 - 50,099,235 (+)EnsemblGRCh38hg38GRCh38
GRCh37X49,687,206 - 49,863,887 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X49,718,955 - 49,750,632 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X49,537,191 - 49,560,557NCBI
CeleraX53,756,528 - 53,932,992 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX47,156,646 - 47,337,277 (+)NCBIHuRef
CHM1_1X49,766,989 - 49,943,526 (+)NCBICHM1_1
T2T-CHM13v2.0X49,238,534 - 49,416,892 (+)NCBIT2T-CHM13v2.0
Clcn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,020,049 - 7,185,597 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,020,049 - 7,185,597 (-)EnsemblGRCm39 Ensembl
GRCm38X7,153,810 - 7,319,358 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,153,810 - 7,319,358 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X6,735,945 - 6,765,840 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,316,432 - 6,345,645 (-)NCBIMGSCv36mm8
CeleraX4,285,826 - 4,305,500 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.21NCBI
Clcn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555431,077,007 - 1,250,352 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555431,076,988 - 1,256,352 (+)NCBIChiLan1.0ChiLan1.0
CLCN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X51,350,269 - 51,512,532 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X51,353,651 - 51,515,909 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X42,137,523 - 42,299,716 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X49,851,472 - 50,013,375 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX49,854,165 - 50,006,363 (+)Ensemblpanpan1.1panPan2
CLCN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,705,789 - 42,860,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,704,627 - 42,853,812 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX17,082,898 - 17,238,055 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,846,347 - 42,999,814 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,846,266 - 42,993,780 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,830,221 - 42,985,707 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,817,844 - 42,972,995 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,912,678 - 43,067,849 (+)NCBIUU_Cfam_GSD_1.0
Clcn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X35,203,152 - 35,361,974 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367211,445,779 - 1,596,814 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367211,552,312 - 1,602,360 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,613,628 - 43,811,526 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,779,016 - 43,809,472 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X48,706,075 - 48,736,547 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,772,176 - 46,934,886 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX46,772,305 - 46,927,861 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666086358,698 - 521,112 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clcn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248931,390,344 - 1,577,110 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248931,390,417 - 1,581,457 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Clcn5
584 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:35
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000003895
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
RH94389  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X15,334,120 - 15,334,204 (+)MAPPERmRatBN7.2
Rnor_6.0X16,196,595 - 16,196,678NCBIRnor6.0
Rnor_5.0X16,981,719 - 16,981,802UniSTSRnor5.0
RGSC_v3.4X27,409,781 - 27,409,864UniSTSRGSC3.4
CeleraX15,412,923 - 15,413,006UniSTS
RH 3.4 MapX169.21UniSTS
Cytogenetic MapXq13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000003895   ⟹   ENSRNOP00000003895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX15,308,113 - 15,334,264 (+)Ensembl
Rnor_6.0 EnsemblX16,170,576 - 16,196,691 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079054   ⟹   ENSRNOP00000074459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX15,185,451 - 15,334,264 (+)Ensembl
Rnor_6.0 EnsemblX16,050,780 - 16,196,789 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099230   ⟹   ENSRNOP00000083323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX15,280,959 - 15,334,264 (+)Ensembl
RefSeq Acc Id: NM_001414393   ⟹   NP_001401322
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,857,260 - 18,011,844 (+)NCBI
mRatBN7.2X15,185,380 - 15,339,977 (+)NCBI
RefSeq Acc Id: NM_017106   ⟹   NP_058802
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,979,980 - 18,006,131 (+)NCBI
mRatBN7.2X15,308,113 - 15,334,264 (+)NCBI
Rnor_6.0X16,170,585 - 16,196,691 (+)NCBI
Rnor_5.0X16,955,709 - 16,981,815 (+)NCBI
RGSC_v3.4X27,383,769 - 27,409,877 (+)RGD
CeleraX15,387,005 - 15,413,019 (+)RGD
Sequence:
RefSeq Acc Id: XM_039099512   ⟹   XP_038955440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,901,035 - 18,011,844 (+)NCBI
mRatBN7.2X15,229,221 - 15,339,977 (+)NCBI
RefSeq Acc Id: NP_058802   ⟸   NM_017106
- Peptide Label: isoform 2
- UniProtKB: A6KPB2 (UniProtKB/TrEMBL),   A0A8I5ZVV0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074459   ⟸   ENSRNOT00000079054
Ensembl Acc Id: ENSRNOP00000003895   ⟸   ENSRNOT00000003895
RefSeq Acc Id: XP_038955440   ⟸   XM_039099512
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVV0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083323   ⟸   ENSRNOT00000099230
RefSeq Acc Id: NP_001401322   ⟸   NM_001414393
- Peptide Label: isoform 1
- UniProtKB: P51796 (UniProtKB/Swiss-Prot),   A0A0G2K839 (UniProtKB/Swiss-Prot),   P70642 (UniProtKB/Swiss-Prot),   A0A8I5ZVV0 (UniProtKB/TrEMBL)
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51796-F1-model_v2 AlphaFold P51796 1-816 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701751
Promoter ID:EPDNEW_R12275
Type:initiation region
Name:Clcn5_1
Description:chloride voltage-gated channel 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X16,170,536 - 16,170,596EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2362 AgrOrtholog
BioCyc Gene G2FUF-2897 BioCyc
Ensembl Genes ENSRNOG00000002862 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055028199 UniProtKB/Swiss-Prot
  ENSRNOG00060025939 UniProtKB/Swiss-Prot
  ENSRNOG00065011568 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003895.7 UniProtKB/Swiss-Prot
  ENSRNOT00000079054.2 UniProtKB/Swiss-Prot
  ENSRNOT00000099230.1 UniProtKB/TrEMBL
  ENSRNOT00055048884 UniProtKB/Swiss-Prot
  ENSRNOT00060045151 UniProtKB/Swiss-Prot
  ENSRNOT00065018853 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.580.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1280.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clc chloride channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CBS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl_channel-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25749 UniProtKB/Swiss-Prot
NCBI Gene 25749 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  H(+)/CL(-) EXCHANGE TRANSPORTER 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage_CLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clcn5 PhenoGen
PRINTS CLCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLCHANNEL5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002862 RatGTEx
  ENSRNOG00055028199 RatGTEx
  ENSRNOG00060025939 RatGTEx
  ENSRNOG00065011568 RatGTEx
SMART CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54631 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC211125
UniProt A0A0G2K839 ENTREZGENE
  A0A8I5ZVV0 ENTREZGENE, UniProtKB/TrEMBL
  A6KPB2 ENTREZGENE, UniProtKB/TrEMBL
  CLCN5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70642 ENTREZGENE
UniProt Secondary A0A0G2K839 UniProtKB/Swiss-Prot
  P70642 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Clcn5  chloride voltage-gated channel 5  Clcn5  chloride channel, voltage-sensitive 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Clcn5  chloride channel, voltage-sensitive 5  Clcn5  chloride channel 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Clcn5  Chloride channel 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog is associated with Dent's disease 727659
gene_disease mutation leads to hereditary nephrocalcinosis (Dents disease)characterized by low-molecular weight proteinuria and other renal disorders 628537
gene_disease mutation leads to hereditary nephrocalcinosis (Dents disease)characterized by low-molecular weight proteinuria and other renal disorders 628538
gene_expression expressed in the epididymis and the vas deferens 628537
gene_expression expressed in the epididymis and the vas deferens 628538
gene_expression exclusively present in the proton-ATPase-rich narrow and clear cells 628537
gene_expression exclusively present in the proton-ATPase-rich narrow and clear cells 628538
gene_function voltage-gated ion channel 628537
gene_function voltage-gated ion channel 628538
gene_process responsible for chloride transport 628537
gene_process responsible for chloride transport 628538
gene_product member of the chloride channel family