 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations |
Welcome {{ username}}
Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{gene.symbol}}: {{ gene.description }}
Save List to My RGD
| Create Name: | |
| Description: |
|
| Save what matters to you |
| {{ loginError }} |
| Sign in with your RGD account |
| Create New Account | Recover Password |
{{ watchLinkText }}
Select categories you would like to watch. Updates to this gene will be send to {{ username }}
Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
 |
Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
|
MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Gene Ontology AnnotationsDisease Annotations
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology AnnotationsBiological Process
|
|
Cellular Component
|
|
Molecular Function
|
|
References - curated| 1. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 2. | Lefebvre DL and Rosen CF, Biochim Biophys Acta. 2005 Jun 20;1724(1-2):71-85. Epub 2005 Apr 8. |
| 3. | Lefebvre DL, etal., Biochem J 2001 Apr 15;355(Pt 2):297-305. |
| 4. | Legembre P, etal., J Biol Chem 2004 Nov 5;279(45):46742-7. Epub 2004 Sep 3. |
| 5. | RGD automated data pipeline |
| 6. | RGD automated import pipeline for gene-chemical interactions |
| 7. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
References - uncuratedGenomics
Comparative Map Data| Nuak2 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NUAK2 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nuak2 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nuak2 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NUAK2 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NUAK2 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nuak2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NUAK2 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NUAK2 (Chlorocebus sabaeus - African green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nuak2 (Heterocephalus glaber - naked mole-rat) |
No map positions available. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Position Markers| D13Hmgc64 |
|
||||||||||||||||||||||||||||||
| RH127904 |
|
QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
||||||||
Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 3 | 8 | 6 | 3 | 6 | 31 | 29 | 21 | 5 | ||||
| Low | 43 | 49 | 35 | 16 | 35 | 8 | 10 | 43 | 6 | 20 | 6 | 8 | |
| Below cutoff | 1 |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_001007617 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_008769444 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR07020967 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AAHX01075103 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC081899 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473958 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| U12530 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000000039 ⟹ ENSRNOP00000000039 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
|
| RefSeq Acc Id: | NM_001007617 ⟹ NP_001007618 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
|
||||||||||||||||||||
| Sequence: |
GACCTCTGAGCCTGCGGCTCTCCGCGCGCTGCTGCTGCTGCCCGACCCCCTCCGCCTCGCCGTChide sequence |
| RefSeq Acc Id: | XM_008769444 ⟹ XP_008767666 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
|
||||||||
| Sequence: |
GTCCCTCGCGGCTCCCGGCTCGCCGGAGCTCATAGCGCGTCCCTTGTGGTGTCCTCGGCAGAGThide sequence |
Protein Sequences| Protein RefSeqs | NP_001007618 | (Get FASTA) | NCBI Sequence Viewer |
| XP_008767666 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAH81899 | (Get FASTA) | NCBI Sequence Viewer |
| EDM09799 | (Get FASTA) | NCBI Sequence Viewer | |
| Q66HE5 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_001007618 ⟸ NM_001007617 |
| - UniProtKB: | Q66HE5 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MESVALHRRGNLAPSASALATESARPLADRLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGhide sequence |
| RefSeq Acc Id: | XP_008767666 ⟸ XM_008769444 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
MSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERPRLNERDARHFFRQIVSALHYCHhide sequence |
| RefSeq Acc Id: | ENSRNOP00000000039 ⟸ ENSRNOT00000000039 |
Protein Domains
Protein kinase
TranscriptomePromoters| RGD ID: | 13698812 | ||||||||
| Promoter ID: | EPDNEW_R9335 | ||||||||
| Type: | multiple initiation site | ||||||||
| Name: | Nuak2_1 | ||||||||
| Description: | NUAK family kinase 2 | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
|
Strain Variation
Strain Sequence Variants (Rnor 6.0)
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
Damaging VariantsAssembly: Rnor_5.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 13 | 54176662 | 54176663 | G | A | snv | SDLEF7/Barth (UDEL), SS/JrHsdMcwi (MCW), M520/N (KNAW), LEW/NCrl (KNAW), F344/NCrl (KNAW), LEW/Crl (KNAW), F344/NHsd (KNAW), F344/NRrrc (SOLiD) (KNAW), SS/JrHsdMcwi (KNAW), LN/MavRrrc (KNAW), LE/OrlBarth (UDEL), SS/Jr (KNAW), F344/NRrrc (Illumina) (KNAW) |
| 13 | 54176752 | 54176753 | T | C | snv | F344/NHsd (KNAW), FHH/EurMcwi (KNAW), FHL/EurMcwi (KNAW), GK/Ox (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), M520/N (KNAW), SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), Crl:SD (UDEL), IS/Kyo (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), F344/Stm (KyushuU), F344/Jcl (KyushuU), F344/NCrl (KNAW), F344/NRrrc (SOLiD) (KNAW), WKY/NHsd (KNAW), WKY/NCrl (KNAW), WKY/N (KNAW), F344/NRrrc (Illumina) (KNAW), SS/JrHsdMcwi (KNAW), SS/Jr (KNAW), LN/MavRrrc (KNAW), SS/JrHsdMcwi (MCW), FHL/EurMcwi (MCW), DOB/Oda (KyushuU), GH/OmrMcwi (MCW), FHH/EurMcwi (MCW) |
Assembly: Rnor_6.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 13 | 49107973 | 49107974 | G | A | snv | F344/NCrl (RGD), SS/JrHsdMcwi (MCW), SS/JrHsdMcwi (RGD), SS/Jr (RGD), M520/N (MCW), F344/NRrrc (MCW), LN/MavRrrc (RGD), LEW/NCrlBR (RGD) |
| 13 | 49108063 | 49108064 | T | C | snv | FHL/EurMcwi (RGD), F344/NCrl (RGD), FHH/EurMcwi (RGD), GK/Ox (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), LN/MavRrrc (RGD), SS/Jr (RGD), SS/JrHsdMcwi (RGD), WKY/NCrl (RGD), WKY/N (MCW), M520/N (MCW), F344/NRrrc (MCW), CDR, SS/JrHsdMcwi (MCW), FHL/EurMcwi (MCW), WKY/NHsd (RGD), GH/OmrMcwi (MCW), FHH/EurMcwi (MCW) |
Assembly: RGSC_v3.4
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 13 | 45221240 | 45221241 | G | A | snv | LN/MavRrrc (ICL), LCR/2Mco (UMich), LEW/NCrl (ICL), HCR/2Mco (UMich), F344/NCrl (ICL), LEW/Crl (ICL), F344/NHsd (ICAHN), F344/NRrrc (KNAW), M520/N (KNAW), SS/JrHsdMcwi (MCW), SS/JrHsdMcwi (ICL), SS/Jr (ICL), SS/JrHsdMcwi (MDC), HCR/1Mco (UMich) |
| 13 | 45221330 | 45221331 | T | C | snv | LN/MavRrrc (ICL), SS/Jr (ICL), SS/JrHsdMcwi (ICL), WKY/NHsd (ICL), WKY/NCrl (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), LCR/2Mco (UMich), F344/NHsd (ICAHN), LEW/NCrl (ICL), LEW/Crl (ICL), GK/Ox (ICL), FHL/EurMcwi (ICL), FHH/EurMcwi (ICL), F344/NCrl (ICL), GH/OmrMcwi (MCW), SS/JrHsdMcwi (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (MCW), WKY/N (KNAW), M520/N (KNAW), F344/NRrrc (KNAW), FHH/EurMcwi (MDC), SS/JrHsdMcwi (MDC) |
Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1359167 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000000034 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000000039 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000000039 | ENTREZGENE, UniProtKB/Swiss-Prot |
| IMAGE_CLONE | IMAGE:7110518 | IMAGE-MGC_LOAD |
| InterPro | Kinase-like_dom_sf | UniProtKB/Swiss-Prot |
| Prot_kinase_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_AS | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:289419 | UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93817 | IMAGE-MGC_LOAD |
| NCBI Gene | 289419 | ENTREZGENE |
| Pfam | Pkinase | UniProtKB/Swiss-Prot |
| PhenoGen | Nuak2 | PhenoGen |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| SMART | S_TKc | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | SSF56112 | UniProtKB/Swiss-Prot |
| UniGene | Rn.16922 | ENTREZGENE |
| UniProt | NUAK2_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2016-03-17 | Nuak2 | NUAK family kinase 2 | Nuak2 | NUAK family, SNF1-like kinase, 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2006-03-30 | Nuak2 | NUAK family, SNF1-like kinase, 2 | 1200013b22rik | SNF1/AMP-activated protein kinase | Symbol and Name updated | 1299863 | APPROVED |
 |
| More on Nuak2 | |
|
Alliance Gene |
|
NCBI Gene |
|
Ensembl Gene |
|
|
JBrowse: rn5 rn6 |
|
NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 1359167 |
| Created: | 2005-07-29 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-06-09 |
| Status: | ACTIVE |
