Nuak2 (NUAK family kinase 2) - Rat Genome Database

Name: Nuak2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Nuak2 (NUAK family kinase 2) Rattus norvegicus

Analyze

Symbol:

Nuak2

Name:

NUAK family kinase 2

RGD ID:

1359167

Description:

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in cellular response to glucose starvation and protein phosphorylation. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

1200013b22rik; MGC93817; NUAK family SNF1-like kinase 2; NUAK family, SNF1-like kinase, 2; Snark; SNF1/AMP kinase-related kinase; SNF1/AMP-activated protein kinase; UV126

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NUAK2 (NUAK family kinase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Nuak2 (NUAK family, SNF1-like kinase, 2)	HGNC	EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Nuak2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NUAK2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NUAK2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nuak2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NUAK2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NUAK2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nuak2 (NUAK family kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Nuak2 (NUAK family, SNF1-like kinase, 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NUAK2 (NUAK family kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nuak2 (NUAK family, SNF1-like kinase, 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG43143	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Caenorhabditis elegans (roundworm):	unc-82	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	KIN4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Saccharomyces cerevisiae (baker's yeast):	FRK1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	43,753,454 - 43,770,604 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	13	43,753,832 - 43,770,604 (+)	Ensembl
Rnor_6.0	13	49,092,306 - 49,109,055 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	49,092,306 - 49,109,050 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	54,159,277 - 54,177,744 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	45,205,573 - 45,222,322 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	13	45,219,615 - 45,236,360 (+)	NCBI
Celera	13	44,088,713 - 44,105,461 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Anencephaly 2 (ISO)

autistic disorder (ISO)

gastrointestinal stromal tumor (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

aristolochic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

dibenz[a,h]anthracene (ISO)

dichloroacetic acid (ISO)

fenamidone (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

graphite (EXP)

indole-3-methanol (EXP)

lead diacetate (ISO)

leflunomide (ISO)

methotrexate (ISO)

N,N-diethyl-m-toluamide (EXP)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

oxaliplatin (EXP)

panobinostat (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

pirinixic acid (ISO)

poly(vinylpyrrolidone) (EXP)

potassium chromate (ISO)

propiconazole (ISO)

quercitrin (ISO)

Salinomycin (ISO)

silicon dioxide (ISO)

silver atom (EXP,ISO)

silver(0) (EXP,ISO)

sodium arsenite (ISO)

Soman (EXP)

succimer (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (ISO)

trichostatin A (ISO)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (ISO,ISS)

apoptotic process (IEA)

cellular response to glucose starvation (IBA,IDA,ISO)

intracellular signal transduction (IBA)

negative regulation of apoptotic process (ISO,ISS)

protein localization to nucleus (ISO,ISS)

protein phosphorylation (IBA,IDA,IEA,ISO)

regulation of hippo signaling (ISO,ISS)

Cellular Component

cytoplasm (IBA)

nuclear speck (ISO)

Molecular Function

ATP binding (IDA,IEA,ISO)

magnesium ion binding (IDA,ISO)

protein binding (ISO)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IDA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Regulation of SNARK activity in response to cellular stresses.	Lefebvre DL and Rosen CF, Biochim Biophys Acta. 2005 Jun 20;1724(1-2):71-85. Epub 2005 Apr 8.
3.	Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK.	Lefebvre DL, etal., Biochem J 2001 Apr 15;355(Pt 2):297-305.
4.	Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness.	Legembre P, etal., J Biol Chem 2004 Nov 5;279(45):46742-7. Epub 2004 Sep 3.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:14575707	PMID:14976552	PMID:15489334	PMID:19927127

Genomics

Comparative Map Data

Nuak2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	43,753,454 - 43,770,604 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	13	43,753,832 - 43,770,604 (+)	Ensembl
Rnor_6.0	13	49,092,306 - 49,109,055 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	49,092,306 - 49,109,050 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	54,159,277 - 54,177,744 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	45,205,573 - 45,222,322 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	13	45,219,615 - 45,236,360 (+)	NCBI
Celera	13	44,088,713 - 44,105,461 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

NUAK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	205,302,063 - 205,321,745 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	205,302,063 - 205,321,745 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	205,271,191 - 205,290,873 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	203,537,814 - 203,557,506 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	1	178,406,280 - 178,425,974 (-)	NCBI
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	176,436,830 - 176,456,534 (-)	NCBI		HuRef
CHM1_1	1	206,694,514 - 206,714,205 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	204,566,371 - 204,586,053 (-)	NCBI

Nuak2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	132,243,816 - 132,261,226 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	1	132,243,864 - 132,261,226 (+)	Ensembl
GRCm38	1	132,316,125 - 132,333,488 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	132,316,126 - 132,333,488 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	134,212,715 - 134,230,065 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	1	134,143,684 - 134,161,034 (+)	NCBI			mm8
Celera	1	134,923,119 - 134,940,418 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI

Nuak2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	41,051,419 - 41,069,066 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	41,050,396 - 41,069,066 (-)	NCBI	ChiLan1.0	ChiLan1.0

NUAK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	185,197,675 - 185,217,264 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	185,197,678 - 185,217,264 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	180,910,956 - 180,931,147 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

NUAK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	1,797,899 - 1,816,087 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	1,798,802 - 1,816,185 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	1,891,562 - 1,909,750 (-)	NCBI
ROS_Cfam_1.0	38	1,794,369 - 1,812,549 (-)	NCBI
ROS_Cfam_1.0 Ensembl	38	1,795,278 - 1,812,621 (-)	Ensembl
UMICH_Zoey_3.1	38	1,790,360 - 1,808,543 (-)	NCBI
UNSW_CanFamBas_1.0	38	2,181,580 - 2,199,756 (-)	NCBI
UU_Cfam_GSD_1.0	38	2,381,515 - 2,399,704 (-)	NCBI

Nuak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	69,839,564 - 69,864,148 (+)	NCBI
SpeTri2.0	NW_004936557	7,085,777 - 7,104,430 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NUAK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	65,980,041 - 66,001,764 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	65,980,035 - 66,001,665 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	72,201,232 - 72,222,949 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NUAK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	24,016,909 - 24,036,640 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	25	24,016,930 - 24,036,641 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666055	24,716,229 - 24,735,961 (+)	NCBI	Vero_WHO_p1.0

Nuak2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	5,850,600 - 5,869,547 (+)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624807	5,850,857 - 5,869,284 (+)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

D13Hmgc64

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	43,763,752 - 43,763,948 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	49,102,205 - 49,102,400	NCBI	Rnor6.0
Rnor_5.0	13	54,170,894 - 54,171,089	UniSTS	Rnor5.0
RGSC_v3.4	13	45,215,472 - 45,215,667	UniSTS	RGSC3.4
Celera	13	44,098,614 - 44,098,806	UniSTS
Cytogenetic Map	13	q13	UniSTS

RH127904

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	43,770,170 - 43,770,390 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	49,108,622 - 49,108,841	NCBI	Rnor6.0
Rnor_5.0	13	54,177,311 - 54,177,530	UniSTS	Rnor5.0
RGSC_v3.4	13	45,221,889 - 45,222,108	UniSTS	RGSC3.4
Celera	13	44,105,028 - 44,105,247	UniSTS
Cytogenetic Map	13	q13	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	5994668	44807491	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	11929449	45417941	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	32284471	77284471	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
2303032	Bp328	Blood pressure QTL 328			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	41184022	45417941	Rat
4145117	Mcs27	Mammary carcinoma susceptibility QTL 27		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	13	43437904	47841255	Rat
6893344	Cm79	Cardiac mass QTL 79	1.5	0.04	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	43720770	62022792	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	138
Count of miRNA genes:	87
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000000039
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3		8	6	3	6			31	29	21	5
Low		43	49	35	16	35	8	10	43	6	20	6	8
Below cutoff								1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U12530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000000039 ⟹ ENSRNOP00000000039

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	43,753,832 - 43,770,604 (+)	Ensembl
Rnor_6.0 Ensembl	13	49,092,306 - 49,109,050 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109571 ⟹ ENSRNOP00000096256

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	43,753,832 - 43,770,604 (+)	Ensembl

RefSeq Acc Id:

NM_001007617 ⟹ NP_001007618

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	43,753,854 - 43,770,604 (+)	NCBI
Rnor_6.0	13	49,092,306 - 49,109,055 (+)	NCBI
Rnor_5.0	13	54,159,277 - 54,177,744 (+)	NCBI
RGSC_v3.4	13	45,205,573 - 45,222,322 (+)	RGD
Celera	13	44,088,713 - 44,105,461 (+)	RGD

Sequence:

show sequence

GACCTCTGAGCCTGCGGCTCTCCGCGCGCTGCTGCTGCTGCCCGACCCCCTCCGCCTCGCCGTC
CCCGCACCATGGAGTCGGTGGCCTTACACCGGCGCGGGAACCTGGCTCCCTCGGCCTCCGCCCT
GGCCACGGAGAGCGCCCGGCCGCTGGCGGACCGGCTCATCAAGTCGCCCAAACCTCTGATGAAG
AAGCAGGCGGTGAAGCGGCACCATCACAAACACAACCTGAGGCACCGCTACGAGTTCCTGGAGA
CCCTGGGCAAGGGCACCTACGGGAAGGTGAAGAAAGCACGAGAGAGCTCGGGACGCCTGGTGGC
CATCAAGTCTATCAGGAAGGACAAAATCAAAGATGAGCAGGATCTGTTGCACATAAGGAGGGAG
ATCGAGATCATGTCTTCACTCAACCACCCCCACATCATTGCCATCCATGAAGTGTTTGAGAACA
GCAGCAAGATTGTGATTGTCATGGAGTACGCCAGCCGAGGCGATCTGTACGATTACATCAGTGA
GCGGCCACGGCTGAATGAGCGGGACGCCAGGCATTTCTTCCGACAGATCGTGTCCGCCCTGCAC
TACTGCCACCAGAACGGGATTGTTCACCGGGACCTCAAGCTGGAGAACATCCTTCTAGATGCCA
GTGGCAACATCAAGATTGCTGATTTTGGCCTCTCCAACCTGTATCACAAAGGCAAGTTCCTCCA
GACGTTCTGTGGGAGCCCTCTCTATGCCTCACCTGAGATCGTCAACGGGAAGCCCTATGTGGGC
CCAGAGGTGGACAGCTGGTCTCTGGGCGTTCTTCTGTACATCCTGGTGCATGGCACCATGCCCT
TTGACGGGCAGGATCATAAAACCCTGGTGAAACAAATCAGTAGCGGGGCTTACCGAGAGCCGTG
CAAACCGTCTGATGCCTGTGGCCTGATCCGGTGGCTGTTAATGGTGAATCCCATCCGTCGGGCC
ACTCTGGAGGATGTAGCCAGTCATTGGTGGGTCAACTGGGGTTACAGCACCCGAATTGGGGAAC
AGGAAGCTCTGCGAGAGGGTGGGCACCCTAGCGGTGACTCTGGCCGGGCCTCTATGGCGGACTG
GTTACGTCGCTCCTCCCGCCCCCTCCTGGAGAATGGAGCCAAAGTGTGTAGCTTCTTCAAGCAG
CATGTGCCGGGAGGTGGAAGCACGGGACCGGGGCTGGAGCGGCAACATTCTCTTAAGAAGTCCC
GCAAGGAGAATGACATGGCTCAGACTCTGCAGAATGACCCAGCTGAAGATACTTCCTCTCGCCC
TGGCAAGAACAGCCTCAAGCTTCCGAAAGGTATCCTCAAGAAAAAGGCCTCTCCCTCATCGGGG
GAGGTACAGGAGGGCCCTCAGGAACTCAGACCAGTGTCCAATACCCCAGGGCAGCCTGTCCCTG
CTATACCCCTGCTCCCAAGGAAGGGCATTCTTAAGAAGTCTCGGCAGCGTGAATCTGGTTACTA
CTCCTCTCCAGAGCCCAGTGAGTCTGGGGAACTCTTAGACGCAGGTGATGTGTTTGTGAGTGGG
GACCCCATGGAGCAGAAGTCTCCACAAGCTTCAGGGCGCCTCCATCGCAAGGGCATCCTCAAAC
TCAATGGCAAGTTTTCCCGCACAGCCTTAGAAGGCACTGCCCCTAGCACCTTTGGCTCCCTAGA
CCAACTGGCCTCCCCTCATCCTACAGCCCGGGCCAGCCGTCCCTCGGGAGCTGTGAGTGAGGAC
AGCATCCTGTCCTCCGAGTCCTTTGACCAATTGGACTTGCCCGAGCGGCTTCCCGAAACCCCAC
TGAGGGGCTGTGTGTCTGTGGACAACCTGAGGAGGCTTGAGCAGCCTCCCTCAGAAGGCCTAAA
ACGATGGTGGCAGGAATCCTTGGGGGATAGCTGCTTTTCTCTGACAGACTGCCAAGAGGTGACA
GCAGCCTACAGACAAGCCCTAGGAATCTGCTCGAAGCTCAGCTGAGGAGGAGAGGCAGTGCCCC
AGTGATGGGGTAGACTCTGAGAGGGGTTTGCAGAGGAACCCTGGGTAGGATTCCCCAGGGGAGT
AGAGTACATCAAGAACTCTCTCTCTGTCTTCAGCCTGATTGAACCTGGAGGCTGAGAGAAATAG
CAGAGATATGGAAAGGACTGACCTACAGAGTCCTGACTGCCAGAATGTTCAAGCGGGGCCACAG
AGACCTGAAAGTGCCTACCTCCTTTATGCTGAGTGCTACCCATGGCATCTCCCCCCTGCTCTCT
GCCAGTGTCAGGGTGTACCCACATAAGTTCCTGTTCGCATCGACCACCAGGGTTAGAACCCTGA
CATCCCTGGAAGTAATGTGGAGCAACCTCGCTTATTTAAAGAGGAAACAGCCTCTGGTTTCCAT
CTCTGCTGCTGTGCATCTCAAAGACCTAGAAAGACTCAACTGCTGTTTCACTTCATCTCAAGGG
GACCTCAGAGACCTGAGCCTTGAAGCTGTTCCTGATAACCAGACTATGATGGATATGTCTGTTT
CTCAGGCCAGCAGGACCCAGAATGTGCTGACTTATTTATTTTTGTGATTCTCACTTCTGGTTTC
TGTTTCGTTTTTTCTGTTGTTGGTTTTGTTGTTGTCGTTTGTTTCTTGTTTTTTGTTTGTTTGT
TTGTTTTTTAAAGTGAATTTTGCTGCTTTCGGTAATGTGAATGCTGTGTTCTGGGGAAAGCCAC
TGTGTCATTGAAGTGTGTGTACAGAGAAGTATTTGGCAGTGATTCCTTCTAATGGGGGGTGGCT
TTTTCAGATGTATGTCTTGAGCACTGTCTGGATTGGGTCTCCTGTCCCCTCACACCAGAGGCTG
TCCACCCTCCCTCATCTGTGGCCAAAAAAAACCTCATTAAAACCAGCAACGGCAACTGGAAAAA
AAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039090614 ⟹ XP_038946542

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	43,753,454 - 43,770,604 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001007618	(Get FASTA)	NCBI Sequence Viewer
	XP_038946542	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81899	(Get FASTA)	NCBI Sequence Viewer
	EDM09799	(Get FASTA)	NCBI Sequence Viewer
	Q66HE5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001007618 ⟸ NM_001007617

- UniProtKB:

Q66HE5 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MESVALHRRGNLAPSASALATESARPLADRLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLG
KGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIHEVFENSSK
IVIVMEYASRGDLYDYISERPRLNERDARHFFRQIVSALHYCHQNGIVHRDLKLENILLDASGN
IKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTMPFDG
QDHKTLVKQISSGAYREPCKPSDACGLIRWLLMVNPIRRATLEDVASHWWVNWGYSTRIGEQEA
LREGGHPSGDSGRASMADWLRRSSRPLLENGAKVCSFFKQHVPGGGSTGPGLERQHSLKKSRKE
NDMAQTLQNDPAEDTSSRPGKNSLKLPKGILKKKASPSSGEVQEGPQELRPVSNTPGQPVPAIP
LLPRKGILKKSRQRESGYYSSPEPSESGELLDAGDVFVSGDPMEQKSPQASGRLHRKGILKLNG
KFSRTALEGTAPSTFGSLDQLASPHPTARASRPSGAVSEDSILSSESFDQLDLPERLPETPLRG
CVSVDNLRRLEQPPSEGLKRWWQESLGDSCFSLTDCQEVTAAYRQALGICSKLS

hide sequence

RefSeq Acc Id:

ENSRNOP00000000039 ⟸ ENSRNOT00000000039

RefSeq Acc Id:	XP_038946542 ⟸ XM_039090614
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000096256 ⟸ ENSRNOT00000109571

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66HE5-F1-model_v2	AlphaFold	Q66HE5	1-630	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698812

Promoter ID:

EPDNEW_R9335

Type:

multiple initiation site

Name:

Nuak2_1

Description:

NUAK family kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	49,092,285 - 49,092,345	EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)

ACI/EurMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Damaging Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
13	49107973	49107974	G	A	snv	FXLE16/Stm (2020), LEW/Crl (2019), F344/N (2020), F344/NCrl (2019), F344/DuCrl (2019), SS/JrHsdMcwi (RGD), SS/Jr (RGD), LN/MavRrrc (RGD), LEW/NCrlBR (RGD), F344/NCrl (RGD), M520/N (MCW), F344/NRrrc (MCW), SS/JrHsdMcwi (MCW), SS/JrHsdMcwi (2019), PVG/Seac (2019), M520/N (2020), M520/NRrrcMcwi (2019), LN/MavRrrcAek (2020), LEXF3/Stm (2020), LEXF2B/Stm (2019), LEXF1C/Stm (2019), LEXF1A/Stm (2019), F344/Stm (2019)
13	49108063	49108064	T	C	snv	SS/JrHsdMcwi (2019), WKY/N (2020), CDR, FHL/EurMcwi (MCW), GH/OmrMcwi (MCW), WKY/N (MCW), FHL/EurMcwi (RGD), GK/Ox (RGD), LEW/Crl (RGD), SS/Jr (RGD), WKY/NCrl (RGD), WKY/NHsd (RGD), FHH/EurMcwi (2019), GK/FarMcwi (2019), PVG/Seac (2019), M520/N (2020), M520/NRrrcMcwi (2019), LN/MavRrrcAek (2020), LEXF3/Stm (2020), LEXF2B/Stm (2019), LEXF1C/Stm (2019), LEXF1A/Stm (2019), LEW/Crl (2019), FXLE16/Stm (2020), F344/Stm (2019), F344/N (2020), F344/NCrl (2019), F344/DuCrl (2019), SS/JrHsdMcwi (RGD), WKY/NCrl (2019), LEW/NCrlBR (RGD), FHH/EurMcwi (RGD), F344/NCrl (RGD), M520/N (MCW), F344/NRrrc (MCW), SS/JrHsdMcwi (MCW), FHH/EurMcwi (MCW), LN/MavRrrc (RGD)

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
13	54176662	54176663	G	A	snv	SDLEF7/Barth (UDEL), F344/NRrrc (Illumina) (KNAW), M520/N (KNAW), LEW/NCrl (KNAW), LEW/Crl (KNAW), F344/NHsd (KNAW), LE/OrlBarth (UDEL), F344/NRrrc (SOLiD) (KNAW), SS/JrHsdMcwi (KNAW), SS/Jr (KNAW), LN/MavRrrc (KNAW), SS/JrHsdMcwi (MCW), F344/NCrl (KNAW)
13	54176752	54176753	T	C	snv	LEW/NCrl (KNAW), M520/N (KNAW), F344/NRrrc (Illumina) (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), Crl:SD (UDEL), IS/Kyo (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), F344/Stm (KyushuU), F344/Jcl (KyushuU), DOB/Oda (KyushuU), LEW/Crl (KNAW), GK/Ox (KNAW), FHL/EurMcwi (KNAW), FHH/EurMcwi (KNAW), F344/NHsd (KNAW), F344/NCrl (KNAW), F344/NRrrc (SOLiD) (KNAW), SS/JrHsdMcwi (KNAW), SS/Jr (KNAW), LN/MavRrrc (KNAW), SS/JrHsdMcwi (MCW), GH/OmrMcwi (MCW), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW)

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
13	45221240	45221241	G	A	snv	LCR/2Mco (UMich), HCR/2Mco (UMich), HCR/1Mco (UMich), SS/JrHsdMcwi (ICL), SS/Jr (ICL), LN/MavRrrc (ICL), F344/NHsd (ICAHN), LEW/Crl (ICL), F344/NCrl (ICL), M520/N (KNAW), F344/NRrrc (KNAW), SS/JrHsdMcwi (MDC), SS/JrHsdMcwi (MCW), LEW/NCrl (ICL)
13	45221330	45221331	T	C	snv	LN/MavRrrc (ICL), SS/Jr (ICL), SS/JrHsdMcwi (ICL), WKY/NCrl (ICL), WKY/NHsd (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), LCR/2Mco (UMich), F344/NHsd (ICAHN), LEW/NCrl (ICL), LEW/Crl (ICL), GK/Ox (ICL), FHL/EurMcwi (ICL), FHH/EurMcwi (ICL), F344/NCrl (ICL), GH/OmrMcwi (MCW), WKY/N (KNAW), M520/N (KNAW), F344/NRrrc (KNAW), SS/JrHsdMcwi (MDC), FHH/EurMcwi (MDC), SS/JrHsdMcwi (MCW), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359167	AgrOrtholog
BioCyc Gene	G2FUF-18321	BioCyc
Ensembl Genes	ENSRNOG00000000034	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000000039	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000096256.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000039	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000109571.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7110518	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:289419	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93817	IMAGE-MGC_LOAD
NCBI Gene	289419	ENTREZGENE
Pfam	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Nuak2	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AQK6_RAT	UniProtKB/TrEMBL
	NUAK2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-17	Nuak2	NUAK family kinase 2	Nuak2	NUAK family, SNF1-like kinase, 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Nuak2	NUAK family, SNF1-like kinase, 2	1200013b22rik	SNF1/AMP-activated protein kinase	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM