NUAK2 (NUAK family kinase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: NUAK2 (NUAK family kinase 2) Chlorocebus sabaeus
Analyze
Symbol: NUAK2
Name: NUAK family kinase 2
RGD ID: 18771447
Description: ENCODES a protein that exhibits magnesium ion binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cellular response to glucose starvation (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH Anencephaly 2 (ortholog); autistic disorder (ortholog); familial adult myoclonic epilepsy 5 (ortholog); FOUND IN nuclear speck (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NUAK family SNF1-like kinase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12524,016,909 - 24,036,640 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2524,016,930 - 24,036,641 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605524,716,229 - 24,735,961 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nuclear speck  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NUAK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12524,016,909 - 24,036,640 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2524,016,930 - 24,036,641 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605524,716,229 - 24,735,961 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NUAK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381205,302,063 - 205,321,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1205,302,063 - 205,321,745 (-)EnsemblGRCh38hg38GRCh38
GRCh371205,271,191 - 205,290,873 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361203,537,814 - 203,557,506 (-)NCBINCBI36Build 36hg18NCBI36
Celera1178,406,280 - 178,425,974 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1176,436,830 - 176,456,534 (-)NCBIHuRef
CHM1_11206,694,514 - 206,714,205 (-)NCBICHM1_1
T2T-CHM13v2.01204,566,371 - 204,586,053 (-)NCBIT2T-CHM13v2.0
Nuak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,243,827 - 132,261,233 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,243,864 - 132,261,226 (+)EnsemblGRCm39 Ensembl
GRCm381132,316,125 - 132,333,488 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,316,126 - 132,333,488 (+)EnsemblGRCm38mm10GRCm38
MGSCv371134,212,715 - 134,230,065 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,143,684 - 134,161,034 (+)NCBIMGSCv36mm8
Celera1134,923,119 - 134,940,418 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.24NCBI
Nuak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81346,305,744 - 46,322,755 (+)NCBIGRCr8
mRatBN7.21343,753,454 - 43,770,604 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,753,832 - 43,770,604 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1346,360,867 - 46,377,614 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01347,649,007 - 47,665,754 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0PNS010002779.13,843 - 20,310 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01349,092,306 - 49,109,055 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,092,306 - 49,109,050 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01354,159,277 - 54,177,744 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41345,205,573 - 45,222,322 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11345,219,615 - 45,236,360 (+)NCBI
Celera1344,088,713 - 44,105,461 (+)NCBICelera
Cytogenetic Map13q13NCBI
Nuak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540641,051,419 - 41,069,066 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540641,050,396 - 41,069,066 (-)NCBIChiLan1.0ChiLan1.0
NUAK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2144,047,631 - 44,067,821 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1144,012,907 - 44,033,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01180,910,956 - 180,931,147 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,197,675 - 185,217,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,197,678 - 185,217,264 (-)Ensemblpanpan1.1panPan2
NUAK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1381,797,899 - 1,816,087 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl381,798,802 - 1,816,185 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha381,891,562 - 1,909,750 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0381,794,369 - 1,812,549 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl381,795,278 - 1,812,621 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1381,790,360 - 1,808,543 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,181,580 - 2,199,756 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0382,381,515 - 2,399,704 (-)NCBIUU_Cfam_GSD_1.0
Nuak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934469,839,564 - 69,864,148 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365577,085,719 - 7,104,443 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365577,085,777 - 7,104,430 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUAK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl965,980,041 - 66,001,764 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1965,980,035 - 66,001,665 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2972,201,232 - 72,222,949 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nuak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248075,850,600 - 5,869,547 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248075,850,857 - 5,869,284 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 10 13 10
Low 26 7 34
Below cutoff 16

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007988753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000012714   ⟹   ENSCSAP00000010744
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2524,016,930 - 24,036,641 (+)Ensembl
RefSeq Acc Id: XM_007988753   ⟹   XP_007986944
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12524,016,909 - 24,036,640 (+)NCBI
Vero_WHO_p1.0NW_02366605524,716,229 - 24,735,961 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007986944 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010744.1
Reference Protein Sequences
RefSeq Acc Id: XP_007986944   ⟸   XM_007988753
- UniProtKB: A0A0D9RQ55 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000010744   ⟸   ENSCSAT00000012714


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014618 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012714.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report csab:103230233 UniProtKB/TrEMBL
NCBI Gene NUAK2 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  NUAK FAMILY SNF1-LIKE KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RQ55 ENTREZGENE, UniProtKB/TrEMBL