Gene: Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) Rattus norvegicus
Analyze
Symbol:
Entpd2
Name:
ectonucleoside triphosphate diphosphohydrolase 2
Description:
Exhibits ATPase activity; adenosine-diphosphatase activity; and identical protein binding activity. Involved in cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and response to auditory stimulus. Localizes to cell body; cell projection membrane; and cell surface. Biomarker of hypertension. Human ortholog(s) of this gene implicated in malignant glioma. Orthologous to human ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
CD39 antigen-like 1; Cd39l1; ecto-ATP diphosphohydrolase 2; ecto-ATPase 2; ecto-ATPDase 2; NTPDase 2; NTPDase2; nucleoside triphosphate diphosphohydrolase 2; testicular ecto-ATPase
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Mus musculus (house mouse):
Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
entpd2a.2 (ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2)
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 3 2,617,795 - 2,623,818 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 2,617,805 - 2,623,445 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 2,599,211 - 2,605,231 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 3,564,380 - 3,569,801 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 3 3,564,379 - 3,569,800 (+) NCBI Celera 3 3,038,775 - 3,044,196 (+) NCBI Celera Cytogenetic Map 3 p13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
autosomal dominant non-syndromic intellectual disability 8 ISO RGD:733255 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant ClinVar PMID:28492532 Kleefstra syndrome 1 ISO RGD:733255 8554872 ClinVar Annotator: match by term: Kleefstra syndrome 1 ClinVar PMID:19264732 more ...
Imported Annotations - CTD
primary biliary cirrhosis ISO RGD:733255 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15651265
(-)-demecolcine increases expression ISO RGD:733255 6480464 Demecolcine results in increased expression of ENTPD2 mRNA CTD PMID:23649840 1,1-dichloroethene increases expression ISO RGD:735884 6480464 vinylidene chloride results in increased expression of ENTPD2 mRNA CTD PMID:26682919 1,2-dichloroethane decreases expression ISO RGD:735884 6480464 ethylene dichloride results in decreased expression of ENTPD2 mRNA CTD PMID:28960355 17alpha-ethynylestradiol increases activity EXP 6480464 Ethinyl Estradiol results in increased activity of ENTPD2 protein CTD PMID:10945241 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of ENTPD2 mRNA, Ethinyl Estradiol results in increased expression of ENTPD2 protein CTD PMID:10945241 17beta-estradiol multiple interactions ISO RGD:733255 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of ENTPD2 mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735884 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of ENTPD2 mRNA more ... CTD PMID:25975270 , PMID:9624117 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735884 6480464 Tetrachlorodibenzodioxin affects the expression of ENTPD2 mRNA CTD PMID:21570461 , PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735884 6480464 Tetrachlorodibenzodioxin results in increased expression of ENTPD2 mRNA, Tetrachlorodibenzodioxin results in increased expression of ENTPD2 protein CTD PMID:12392715 more ... 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO RGD:735884 6480464 Tetrachlorodibenzodioxin results in increased activity of ENTPD2 protein CTD PMID:9624117 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of ENTPD2 mRNA CTD PMID:21346803 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of ENTPD2 mRNA CTD PMID:24780913 acetylsalicylic acid increases expression EXP 6480464 Aspirin results in increased expression of ENTPD2 mRNA CTD PMID:12800193 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of ENTPD2 mRNA CTD PMID:28959563 aflatoxin B2 affects methylation ISO RGD:733255 6480464 aflatoxin B2 affects the methylation of ENTPD2 intron CTD PMID:30157460 alachlor increases expression EXP 6480464 alachlor results in increased expression of ENTPD2 mRNA CTD PMID:12419858 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ENTPD2 mRNA CTD PMID:16483693 antimycin A increases expression ISO RGD:735884 6480464 Antimycin A results in increased expression of ENTPD2 mRNA CTD PMID:19304788 Aroclor 1254 increases expression ISO RGD:735884 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of ENTPD2 mRNA CTD PMID:23650126 benzo[a]pyrene increases expression ISO RGD:733255 6480464 Benzo(a)pyrene results in increased expression of ENTPD2 mRNA CTD PMID:32234424 benzo[b]fluoranthene increases expression ISO RGD:735884 6480464 benzo(b)fluoranthene results in increased expression of ENTPD2 mRNA CTD PMID:26377693 Benzo[k]fluoranthene increases expression ISO RGD:735884 6480464 benzo(k)fluoranthene results in increased expression of ENTPD2 mRNA CTD PMID:26377693 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ENTPD2 mRNA CTD PMID:18164116 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ENTPD2 mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ENTPD2 mRNA CTD PMID:30816183 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of ENTPD2 gene CTD PMID:28505145 butyric acid increases expression EXP 6480464 Butyric Acid results in increased expression of ENTPD2 mRNA CTD PMID:12800193 calcitriol increases expression ISO RGD:733255 6480464 Calcitriol results in increased expression of ENTPD2 mRNA CTD PMID:26485663 carbon nanotube decreases expression ISO RGD:735884 6480464 Nanotubes, Carbon analog results in decreased expression of ENTPD2 mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:735884 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ENTPD2 mRNA CTD PMID:20938992 cisplatin multiple interactions ISO RGD:733255 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of ENTPD2 mRNA CTD PMID:27392435 cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of ENTPD2 protein CTD PMID:25100957 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of ENTPD2 mRNA CTD PMID:26033743 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of ENTPD2 mRNA CTD PMID:26033743 coumestrol decreases expression ISO RGD:733255 6480464 Coumestrol results in decreased expression of ENTPD2 mRNA CTD PMID:19167446 cyhalothrin increases expression EXP 6480464 cyhalothrin results in increased expression of ENTPD2 mRNA CTD PMID:31421116 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of ENTPD2 mRNA CTD PMID:23640034 diethylstilbestrol decreases expression ISO RGD:735884 6480464 Diethylstilbestrol results in decreased expression of ENTPD2 mRNA CTD PMID:15171707 diuron decreases expression EXP 6480464 Diuron results in decreased expression of ENTPD2 mRNA CTD PMID:25152437 ethanol increases expression ISO RGD:735884 6480464 Ethanol results in increased expression of ENTPD2 mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO RGD:733255 6480464 Ethyl Methanesulfonate results in increased expression of ENTPD2 mRNA CTD PMID:23649840 etoposide decreases expression ISO RGD:735884 6480464 Etoposide results in decreased expression of ENTPD2 mRNA CTD PMID:25270620 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of ENTPD2 mRNA CTD PMID:18035473 folic acid multiple interactions ISO RGD:735884 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ENTPD2 mRNA CTD PMID:20938992 fructose decreases expression EXP 6480464 Fructose results in decreased expression of ENTPD2 mRNA CTD PMID:15150374 furan decreases methylation EXP 6480464 furan results in decreased methylation of ENTPD2 gene CTD PMID:27387713 furan increases expression EXP 6480464 furan results in increased expression of ENTPD2 mRNA CTD PMID:27387713 L-methionine multiple interactions ISO RGD:735884 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ENTPD2 mRNA CTD PMID:20938992 methyl methanesulfonate increases expression ISO RGD:733255 6480464 Methyl Methanesulfonate results in increased expression of ENTPD2 mRNA CTD PMID:23649840 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ENTPD2 mRNA CTD PMID:18164116 N-nitrosodiethylamine increases expression ISO RGD:735884 6480464 Diethylnitrosamine results in increased expression of ENTPD2 mRNA CTD PMID:24535843 phenobarbital increases expression ISO RGD:735884 6480464 Phenobarbital results in increased expression of ENTPD2 mRNA CTD PMID:19482888 phenobarbital multiple interactions ISO RGD:735884 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ENTPD2 mRNA] CTD PMID:19482888 pirinixic acid increases expression ISO RGD:735884 6480464 pirinixic acid results in increased expression of ENTPD2 mRNA CTD PMID:18301758 , PMID:23811191 pravastatin decreases expression ISO RGD:735884 6480464 Pravastatin results in decreased expression of ENTPD2 mRNA CTD PMID:27225895 pravastatin increases expression EXP 6480464 Pravastatin results in increased expression of ENTPD2 mRNA CTD PMID:27225895 pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of ENTPD2 mRNA CTD PMID:19162173 raloxifene increases expression EXP 6480464 Raloxifene Hydrochloride results in increased expression of ENTPD2 mRNA CTD PMID:15576828 rotenone increases expression ISO RGD:735884 6480464 Rotenone results in increased expression of ENTPD2 mRNA CTD PMID:19304788 sodium fluoride decreases expression ISO RGD:735884 6480464 Sodium Fluoride results in decreased expression of ENTPD2 protein CTD PMID:28918527 Soman increases expression EXP 6480464 Soman results in increased expression of ENTPD2 mRNA CTD PMID:19281266 sulforaphane increases expression ISO RGD:735884 6480464 sulforafan results in increased expression of ENTPD2 mRNA CTD PMID:30529165 sulforaphane decreases expression ISO RGD:733255 6480464 sulforafan results in decreased expression of ENTPD2 mRNA CTD PMID:31838189 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of ENTPD2 mRNA CTD PMID:15651265 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of ENTPD2 mRNA CTD PMID:23411599 titanium dioxide affects expression ISO RGD:735884 6480464 titanium dioxide affects the expression of ENTPD2 mRNA CTD PMID:23557971 trimellitic anhydride decreases expression ISO RGD:735884 6480464 trimellitic anhydride results in decreased expression of ENTPD2 mRNA CTD PMID:19042947 valproic acid increases methylation ISO RGD:733255 6480464 Valproic Acid results in increased methylation of ENTPD2 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:733255 6480464 Valproic Acid results in increased expression of ENTPD2 mRNA CTD PMID:28001369 valproic acid affects expression ISO RGD:733255 6480464 Valproic Acid affects the expression of ENTPD2 mRNA CTD PMID:25979313 vincristine increases expression ISO RGD:733255 6480464 Vincristine results in increased expression of ENTPD2 mRNA CTD PMID:23649840 zaragozic acid A increases expression EXP 6480464 squalestatin 1 results in increased expression of ENTPD2 mRNA CTD PMID:27225895 zaragozic acid A decreases expression ISO RGD:735884 6480464 squalestatin 1 results in decreased expression of ENTPD2 mRNA CTD PMID:27225895
Biological Process cellular response to interferon-alpha IEP 9685490 RGD cellular response to interleukin-6 IMP 9685526 RGD cellular response to lipopolysaccharide IEP 9685490 RGD cellular response to tumor necrosis factor IEP 9685490 RGD G protein-coupled receptor signaling pathway ISO RGD:735884 1624291 (MGI:MGI:2178511, PMID:11929769) RGD MGI:MGI:2178511 , PMID:11929769 G protein-coupled receptor signaling pathway IEA UniProtKB:O55026 , ensembl:ENSMUSP000000283281600115 GO_REF:0000107 Ensembl GO_REF:0000107 platelet activation ISO RGD:735884 1624291 (MGI:MGI:2178511, PMID:11929769) RGD MGI:MGI:2178511 , PMID:11929769 platelet activation IEA UniProtKB:O55026 , ensembl:ENSMUSP000000283281600115 GO_REF:0000107 Ensembl GO_REF:0000107 purine ribonucleoside diphosphate catabolic process ISO RGD:735884 1624291 (MGI:MGI:2178511, PMID:11929769) RGD MGI:MGI:2178511 , PMID:11929769 purine ribonucleoside diphosphate catabolic process IEA UniProtKB:O55026 , ensembl:ENSMUSP000000283281600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to auditory stimulus IEP 9685459 RGD Cellular Component basement membrane ISO RGD:735884 1624291 (MGI:MGI:2178511, PMID:11929769) RGD MGI:MGI:2178511 , PMID:11929769 basement membrane IEA UniProtKB:O55026 , ensembl:ENSMUSP000000283281600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell body IDA 728486 RGD cell projection membrane IDA 728486 RGD cell surface IDA 9685525 RGD integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 plasma membrane ISO RGD:735884 1624291 (MGI:MGI:5557982, PMID:23010799) RGD MGI:MGI:5557982 , PMID:23010799 plasma membrane IEA UniProtKB:O55026 , ensembl:ENSMUSP000000283281600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane IDA 728486 RGD Molecular Function adenosine-diphosphatase activity IDA 9685525 RGD ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000043 UniProt GO_REF:0000043 ATPase activity IDA 9685525 RGD identical protein binding IPI RGD:69266 9685474 homooligomerization RGD nucleoside-diphosphatase activity ISO RGD:735884 1624291 (MGI:MGI:2178511, PMID:11929769) RGD MGI:MGI:2178511 , PMID:11929769 nucleoside-diphosphatase activity IEA UniProtKB:O55026 , ensembl:ENSMUSP000000283281600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoside-triphosphatase activity ISO RGD:735884 1624291 (MGI:MGI:2178511, PMID:11929769) RGD MGI:MGI:2178511 , PMID:11929769 nucleoside-triphosphatase activity IEA UniProtKB:O55026 , ensembl:ENSMUSP000000283281600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding ISO RGD:735884 1624291 PR:E9Q9D5 more ... RGD MGI:MGI:3609918 more ...
Gene-Chemical Interaction Annotations
