Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) - Rat Genome Database

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Gene: Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) Rattus norvegicus
Analyze
Symbol: Entpd2 (Ensembl: Npdc1)
Name: ectonucleoside triphosphate diphosphohydrolase 2 (Ensembl:neural proliferation, differentiation and control, 1)
RGD ID: 69266
Description: Enables ADP phosphatase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and response to auditory stimulus. Located in cell body; cell projection membrane; and cell surface. Biomarker of hypertension. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD39 antigen-like 1; Cd39l1; ecto-ATP diphosphohydrolase 2; ecto-ATPase 2; ecto-ATPDase 2; NTPDase 2; NTPDase2; nucleoside triphosphate diphosphohydrolase 2; testicular ecto-ATPase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,611,722 - 28,617,237 (+)NCBIGRCr8
mRatBN7.238,213,575 - 8,219,094 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,213,663 - 8,226,866 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,318,790 - 11,324,211 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,905,020 - 19,910,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,094,862 - 18,100,283 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,617,795 - 2,623,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,617,805 - 2,623,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,599,211 - 2,605,231 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,564,380 - 3,569,801 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,564,379 - 3,569,800 (+)NCBI
Celera33,038,775 - 3,044,196 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
aconitine  (EXP)
acrylamide  (EXP)
Aflatoxin B2 alpha  (ISO)
alachlor  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
butyric acid  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyhalothrin  (EXP)
decabromodiphenyl ether  (EXP)
diethylstilbestrol  (ISO)
diquat  (ISO)
diuron  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nitrofen  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
raloxifene  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Selective NTPDase2 expression modulates in vivo rat glioma growth. Braganhol E, etal., Cancer Sci. 2009 Aug;100(8):1434-42. doi: 10.1111/j.1349-7006.2009.01219.x. Epub 2009 May 18.
2. Expression of ecto-nucleoside triphosphate diphosphohydrolase1-3 (NTPDase1-3) by cortical astrocytes after exposure to pro-inflammatory factors in vitro. Brisevac D, etal., J Mol Neurosci. 2013 Nov;51(3):871-9. doi: 10.1007/s12031-013-0088-3. Epub 2013 Aug 29.
3. The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver. Dranoff JA, etal., Hepatology 2002 Nov;36(5):1135-44.
4. Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. Dranoff JA, etal., J Investig Med. 2004 Nov;52(7):475-82.
5. Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes. Failer BU, etal., Eur J Biochem. 2003 Apr;270(8):1802-9.
6. L-NAME-treatment alters ectonucleotidase activities in kidney membranes of rats. Furstenau CR, etal., Life Sci. 2010 Aug 28;87(9-10):325-32. doi: 10.1016/j.lfs.2010.07.008. Epub 2010 Jul 23.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain. Kegel B, etal., Neuropharmacology 1997 Sep;36(9):1189-200.
9. Ecto-ATPase mRNA is regulated by FSH in Sertoli cells. Lu Q, etal., J Androl 2001 Mar-Apr;22(2):289-301.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Evidence for alternative splicing of ecto-ATPase associated with termination of purinergic transmission. Vlajkovic SM, etal., Brain Res Mol Brain Res 1999 Nov 10;73(1-2):85-92.
18. Noise exposure induces up-regulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea. Vlajkovic SM, etal., Neuroscience. 2004;126(3):763-73.
19. Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes. Wink MR, etal., Neuroscience. 2006;138(2):421-32. Epub 2006 Jan 18.
20. IL-6 downregulates transcription of NTPDase2 via specific promoter elements. Yu J, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G748-56. doi: 10.1152/ajpgi.00208.2007. Epub 2008 Jan 17.
Additional References at PubMed
PMID:10510450   PMID:11929769   PMID:12477932   PMID:12832497   PMID:14730706   PMID:14764443   PMID:15004436   PMID:15362980   PMID:15799977   PMID:17574764   PMID:17910474   PMID:18201730  
PMID:18458329   PMID:19524108   PMID:21325440   PMID:22038661   PMID:23010799   PMID:23533145   PMID:23677997   PMID:23830739   PMID:26080748   PMID:35593054   PMID:38055119   PMID:38158780  


Genomics

Comparative Map Data
Entpd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,611,722 - 28,617,237 (+)NCBIGRCr8
mRatBN7.238,213,575 - 8,219,094 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,213,663 - 8,226,866 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,318,790 - 11,324,211 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,905,020 - 19,910,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,094,862 - 18,100,283 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,617,795 - 2,623,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,617,805 - 2,623,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,599,211 - 2,605,231 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,564,380 - 3,569,801 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,564,379 - 3,569,800 (+)NCBI
Celera33,038,775 - 3,044,196 (+)NCBICelera
Cytogenetic Map3p13NCBI
ENTPD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,048,107 - 137,054,061 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,048,107 - 137,054,061 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,942,559 - 139,948,513 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,062,374 - 139,068,326 (-)NCBINCBI36Build 36hg18NCBI36
Build 349137,218,389 - 137,224,342NCBI
Celera9110,455,967 - 110,461,919 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,402,078 - 109,408,246 (-)NCBIHuRef
CHM1_19140,091,345 - 140,097,263 (-)NCBICHM1_1
T2T-CHM13v2.09149,283,232 - 149,291,667 (-)NCBIT2T-CHM13v2.0
Entpd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,285,886 - 25,291,335 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,285,886 - 25,291,333 (+)EnsemblGRCm39 Ensembl
GRCm38225,395,874 - 25,401,323 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,395,874 - 25,401,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,251,394 - 25,256,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,217,967 - 25,223,327 (+)NCBIMGSCv36mm8
Celera225,123,341 - 25,128,787 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.22NCBI
Entpd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,068,875 - 5,075,098 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,070,050 - 5,075,098 (-)NCBIChiLan1.0ChiLan1.0
ENTPD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,344,532 - 2,350,408 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,346,687 - 2,352,742 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,108,780 - 108,114,806 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,077,207 - 137,083,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,077,207 - 137,083,031 (-)Ensemblpanpan1.1panPan2
ENTPD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,589,408 - 48,594,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,570,891 - 48,594,452 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,803,203 - 47,808,473 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,467,623 - 49,472,893 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,467,627 - 49,472,890 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,243,870 - 48,249,128 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,542,603 - 48,547,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,589,911 - 48,595,183 (+)NCBIUU_Cfam_GSD_1.0
Entpd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,468,293 - 202,475,008 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669901,104 - 906,782 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669901,192 - 906,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENTPD2
(Sus scrofa - pig)		 No map positions available.
ENTPD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,137,500 - 1,142,798 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,137,495 - 1,143,231 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,159,835 - 4,165,592 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Entpd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760859,637 - 866,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760859,598 - 865,194 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Entpd2
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:199
Count of miRNA genes:123
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000017829, ENSRNOT00000018560
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 9 4 3 27 19 27
Low 30 50 34 15 34 8 8 35 16 10 11 8
Below cutoff 4 7 7 7 12 4

Sequence


Ensembl Acc Id: ENSRNOT00000017829   ⟹   ENSRNOP00000017829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,213,663 - 8,220,040 (+)Ensembl
Rnor_6.0 Ensembl32,617,805 - 2,623,445 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000018927   ⟹   ENSRNOP00000018927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,220,678 - 8,226,866 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094013   ⟹   ENSRNOP00000086303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,213,663 - 8,226,862 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102806   ⟹   ENSRNOP00000091377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,214,833 - 8,220,040 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112091   ⟹   ENSRNOP00000096205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,220,678 - 8,226,866 (+)Ensembl
RefSeq Acc Id: NM_172030   ⟹   NP_742027
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,816 - 28,617,237 (+)NCBI
mRatBN7.238,213,673 - 8,219,094 (+)NCBI
Rnor_6.032,617,895 - 2,623,316 (+)NCBI
Rnor_5.032,599,211 - 2,605,231 (+)NCBI
RGSC_v3.433,564,380 - 3,569,801 (+)RGD
Celera33,038,775 - 3,044,196 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233644   ⟹   XP_006233706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,722 - 28,617,237 (+)NCBI
mRatBN7.238,213,576 - 8,219,041 (+)NCBI
Rnor_6.032,617,796 - 2,623,818 (+)NCBI
Rnor_5.032,599,211 - 2,605,231 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592023   ⟹   XP_017447512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,723 - 28,617,237 (+)NCBI
mRatBN7.238,213,575 - 8,219,041 (+)NCBI
Rnor_6.032,617,795 - 2,623,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592024   ⟹   XP_017447513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,725 - 28,617,184 (+)NCBI
mRatBN7.238,213,576 - 8,219,041 (+)NCBI
Rnor_6.032,617,796 - 2,623,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105790   ⟹   XP_038961718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,724 - 28,617,184 (+)NCBI
mRatBN7.238,213,576 - 8,219,041 (+)NCBI
RefSeq Acc Id: XM_063284518   ⟹   XP_063140588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,726 - 28,617,184 (+)NCBI
RefSeq Acc Id: XM_063284519   ⟹   XP_063140589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,613,238 - 28,617,237 (+)NCBI
RefSeq Acc Id: NP_742027   ⟸   NM_172030
- Peptide Label: precursor
- UniProtKB: O35795 (UniProtKB/Swiss-Prot),   Q9WVE7 (UniProtKB/Swiss-Prot),   Q9JHY5 (UniProtKB/Swiss-Prot),   Q5RJP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233706   ⟸   XM_006233644
- Peptide Label: isoform X2
- UniProtKB: F1M7N2 (UniProtKB/TrEMBL),   A0A8I6AFG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447512   ⟸   XM_017592023
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AFG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447513   ⟸   XM_017592024
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000017829   ⟸   ENSRNOT00000017829
RefSeq Acc Id: XP_038961718   ⟸   XM_039105790
- Peptide Label: isoform X3
- UniProtKB: Q9WVE7 (UniProtKB/Swiss-Prot),   Q9JHY5 (UniProtKB/Swiss-Prot),   O35795 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000091377   ⟸   ENSRNOT00000102806
Ensembl Acc Id: ENSRNOP00000096205   ⟸   ENSRNOT00000112091
Ensembl Acc Id: ENSRNOP00000086303   ⟸   ENSRNOT00000094013
Ensembl Acc Id: ENSRNOP00000018927   ⟸   ENSRNOT00000018927
RefSeq Acc Id: XP_063140588   ⟸   XM_063284518
- Peptide Label: isoform X5
- UniProtKB: Q9WVE7 (UniProtKB/Swiss-Prot),   Q9JHY5 (UniProtKB/Swiss-Prot),   O35795 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140589   ⟸   XM_063284519
- Peptide Label: isoform X6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35795-F1-model_v2 AlphaFold O35795 1-495 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691875
Promoter ID:EPDNEW_R2400
Type:initiation region
Name:Entpd2_1
Description:ectonucleoside triphosphate diphosphohydrolase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,617,851 - 2,617,911EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69266 AgrOrtholog
BioCyc Gene G2FUF-50457 BioCyc
Ensembl Genes ENSRNOG00000013102 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017829.5 UniProtKB/TrEMBL
  ENSRNOT00000094013.1 UniProtKB/TrEMBL
  ENSRNOT00000102806.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exopolyphosphatase. Domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7302083 IMAGE-MGC_LOAD
InterPro GDA1_CD39_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64467 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105301 IMAGE-MGC_LOAD
NCBI Gene 64467 ENTREZGENE
PANTHER ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11782 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GDA1_CD39 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Entpd2 PhenoGen
PROSITE GDA1_CD39_NTPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013102 RatGTEx
TIGR TC230447
UniProt A0A8I6A5S8_RAT UniProtKB/TrEMBL
  A0A8I6AFG9 ENTREZGENE, UniProtKB/TrEMBL
  A3FKJ7_RAT UniProtKB/TrEMBL
  ENTP2_RAT UniProtKB/Swiss-Prot
  F1M7N2 ENTREZGENE, UniProtKB/TrEMBL
  O35795 ENTREZGENE
  Q5RJP4 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHY5 ENTREZGENE
  Q9WVE7 ENTREZGENE
UniProt Secondary Q9JHY5 UniProtKB/Swiss-Prot
  Q9WVE7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Entpd2  ectonucleoside triphosphate diphosphohydrolase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in portal fibroblasts near hepatic bile duct epithelial basolateral membranes 728486