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Gene: Gba2 (glucosylceramidase beta 2) Rattus norvegicus
Symbol: Gba2
Name: glucosylceramidase beta 2
RGD ID: 1305598
Description: Predicted to have glucosylceramidase activity; glucosyltransferase activity; and steryl-beta-glucosidase activity. Predicted to be involved in several processes, including glucosylceramide catabolic process; lipid glycosylation; and regulation of protein polymerization. Predicted to localize to cytosol; extrinsic component of organelle membrane; and integral component of membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; beta-naphthoflavone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-glucocerebrosidase 2; beta-glucosidase 2; bile acid beta-glucosidase; bile acid beta-glucosidase GBA2; bile acid glucosyl transferase GBA2; cholesterol glucosyltransferase GBA2; cholesteryl-beta-glucosidase GBA2; glucosidase beta 2; glucosylceramidase 2; LOC298399; NLGase; non-lysosomal glucosylceramidase
Homo sapiens (human) : GBA2 (glucosylceramidase beta 2)  HGNC  Alliance
Mus musculus (house mouse) : Gba2 (glucosidase beta 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gba2 (glucosylceramidase beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GBA2 (glucosylceramidase beta 2)
Canis lupus familiaris (dog) : GBA2 (glucosylceramidase beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gba2 (glucosylceramidase beta 2)
Sus scrofa (pig) : GBA2 (glucosylceramidase beta 2)
Chlorocebus sabaeus (African green monkey) : GBA2 (glucosylceramidase beta 2)
Heterocephalus glaber (naked mole-rat) : Gba2 (glucosylceramidase beta 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0559,068,081 - 59,079,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,068,081 - 59,079,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,592,675 - 63,604,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,045,397 - 60,057,035 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1560,045,575 - 60,057,254 (-)NCBI
Celera556,402,961 - 56,414,599 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Gba2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305598
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.