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Gene: Gla (galactosidase, alpha) Rattus norvegicus
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Symbol: Gla
Name: galactosidase, alpha
Description: Exhibits alpha-galactosidase activity and galactoside binding activity. Predicted to be involved in several processes, including glycosylceramide catabolic process; negative regulation of nitric oxide biosynthetic process; and negative regulation of nitric-oxide synthase activity. Localizes to the lysosome. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha); PARTICIPATES IN Fabry disease pathway; galactose metabolic pathway; galactosemia pathway; INTERACTS WITH amphetamine; bisphenol A; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-galactosidase A; galactosidase, alpha (mapped); Gla_mapped
Orthologs:
Homo sapiens (human) : GLA (galactosidase alpha)  HGNC  Alliance
Mus musculus (house mouse) : Gla (galactosidase, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gla (galactosidase alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : GLA (galactosidase alpha)
Canis lupus familiaris (dog) : GLA (galactosidase alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gla (galactosidase alpha)
Sus scrofa (pig) : GLA (galactosidase alpha)
more info ...
Allele / Splice: Glaem2Mcwi  
Genetic Models: DA-Glaem2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X105,405,915 - 105,417,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,406,792 - 105,417,323 (-)Ensembl
Rnor_5.0X105,295,029 - 105,306,686 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X122,044,703 - 122,056,327 (-)NCBIRGSC3.4rn4RGSC3.4
CeleraX98,809,769 - 98,821,187 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gla
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1589721
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.