Gla (galactosidase, alpha) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gla (galactosidase, alpha) Rattus norvegicus
Analyze
Symbol: Gla
Name: galactosidase, alpha
RGD ID: 1589721
Description: Enables alpha-galactosidase activity and galactoside binding activity. Involved in several processes, including glycosphingolipid catabolic process; platelet aggregation; and regulation of axon diameter. Predicted to be located in Golgi apparatus; extracellular space; and lysosome. Predicted to be active in cytoplasm. Used to study Fabry disease and lysosomal storage disease. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha); PARTICIPATES IN Fabry disease pathway; galactose metabolic pathway; galactosemia pathway; INTERACTS WITH 6-propyl-2-thiouracil; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-galactosidase A; galactosidase, alpha (mapped); Gla_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Glaem2Mcwi
Genetic Models: DA-Glaem2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,062,497 - 102,073,915 (-)NCBIGRCr8
mRatBN7.2X97,769,227 - 97,780,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,768,996 - 97,780,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,443,442 - 99,454,860 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,954,152 - 102,965,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X100,456,591 - 100,468,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X105,405,915 - 105,417,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,406,792 - 105,417,323 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,295,029 - 105,306,686 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X122,044,703 - 122,056,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX98,809,769 - 98,821,187 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hydralazine  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl methacrylate  (ISO)
migalastat  (ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
tremolite asbestos  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zalcitabine  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal circulating cytokine level  (IMP)
abnormal glycosphingolipid level  (IMP)
abnormal lens fiber morphology  (IMP)
abnormal lysosome morphology  (IMP)
abnormal megakaryocyte progenitor cell morphology  (IMP)
abnormal motor neuron morphology  (IMP)
abnormal myeloid cell number  (IMP)
abnormal myeloid leukocyte morphology  (IMP)
abnormal platelet activation  (IMP)
abnormal platelet aggregation  (IMP)
abnormal platelet morphology  (IMP)
abnormal proximal convoluted tubule morphology  (IMP)
abnormal reticulocyte cell number  (IMP)
abnormal reticulocyte morphology  (IMP)
abnormal retina blood vessel morphology  (IMP)
abnormal sebaceous gland morphology  (IMP)
abnormal sensory neuron morphology  (IMP)
abnormal sleep duration  (IMP)
abnormal sphingolipid level  (IMP)
abnormal survival  (IMP)
allodynia  (IMP)
alopecia  (IMP)
cornea opacity  (IMP)
decreased body weight  (IMP)
decreased cardiac muscle contractility  (IMP)
decreased circulating cholesterol level  (IMP)
decreased circulating glucose level  (IMP)
decreased circulating serum albumin level  (IMP)
decreased circulating total protein level  (IMP)
decreased grooming behavior  (IMP)
decreased heart left ventricle wall thickness  (IMP)
decreased locomotor activity  (IMP)
decreased mean corpuscular hemoglobin  (IMP)
decreased mean corpuscular volume  (IMP)
decreased mechanical nociceptive threshold  (IMP)
hyperresponsive to tactile stimuli  (IMP)
increased blood urea nitrogen level  (IMP)
increased body weight  (IMP)
increased circulating alkaline phosphatase level  (IMP)
increased circulating aspartate transaminase level  (IMP)
increased circulating interleukin-17 level  (IMP)
increased circulating potassium level  (IMP)
increased circulating tumor necrosis factor level  (IMP)
increased erythrocyte cell number  (IMP)
increased macrophage cell number  (IMP)
increased renal glomerular filtration rate  (IMP)
increased tongue size  (IMP)
increased urine calcium level  (IMP)
increased urine flow rate  (IMP)
increased urine glucose level  (IMP)
lipidosis  (IMP)
long tongue  (IMP)
lysosomal protein accumulation  (IMP)
nervous system inclusion bodies  (IMP)
neuron hypertrophy  (IMP)
renal glomerulus atrophy  (IMP)
rough coat  (IMP)
thick mitral valve  (IMP)
thrombocytosis  (IMP)
References

References - curated
# Reference Title Reference Citation
1. Fabry disease: six gene rearrangements and an exonic point mutation in the alpha-galactosidase gene. Bernstein HS, etal., J Clin Invest. 1989 Apr;83(4):1390-9.
2. HomeCageScan analysis reveals ongoing pain in Fabry rats. Burand AJ, etal., Neurobiol Pain. 2023 Jan 5;13:100113. doi: 10.1016/j.ynpai.2022.100113. eCollection 2023 Jan-Jul.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Platelet and myeloid cell phenotypes in a rat model of Fabry disease. Kanack AJ, etal., FASEB J. 2021 Aug;35(8):e21818. doi: 10.1096/fj.202001727RR.
5. α-Galactosidase A-deficient rats accumulate glycosphingolipids and develop cardiorenal phenotypes of Fabry disease. Miller JJ, etal., FASEB J. 2019 Jan;33(1):418-429. doi: 10.1096/fj.201800771R. Epub 2018 Jul 6.
6. Neuropathic pain in a Fabry disease rat model. Miller JJ, etal., JCI Insight. 2018 Mar 22;3(6). pii: 99171. doi: 10.1172/jci.insight.99171.
7. Rats deficient in α-galactosidase A develop ocular manifestations of Fabry disease. Miller JJ, etal., Sci Rep. 2019 Jun 28;9(1):9392. doi: 10.1038/s41598-019-45837-1.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Alterations in certain lysosomal glycohydrolases and cathepsins in rats on dexamethasone administration. Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1996 Jan 26;154(2):165-70.
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
16. Sensory-specific peripheral nerve pathology in a rat model of Fabry disease. Waltz TB, etal., Neurobiol Pain. 2021 Sep 2;10:100074. doi: 10.1016/j.ynpai.2021.100074. eCollection 2021 Aug-Dec.
Additional References at PubMed
PMID:39940   PMID:198184   PMID:205481   PMID:895843   PMID:1008807   PMID:1300216   PMID:1332979   PMID:2890215   PMID:2906327   PMID:3029062   PMID:6251472   PMID:6256390  
PMID:6852525   PMID:9122231   PMID:10840053   PMID:10841515   PMID:11115376   PMID:11752062   PMID:12938095   PMID:15629890   PMID:15668341   PMID:16372133   PMID:16697974   PMID:19710420  
PMID:23376485   PMID:23533145   PMID:27211852  


Genomics

Comparative Map Data
Gla
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,062,497 - 102,073,915 (-)NCBIGRCr8
mRatBN7.2X97,769,227 - 97,780,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,768,996 - 97,780,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,443,442 - 99,454,860 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,954,152 - 102,965,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X100,456,591 - 100,468,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X105,405,915 - 105,417,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,406,792 - 105,417,323 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,295,029 - 105,306,686 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X122,044,703 - 122,056,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX98,809,769 - 98,821,187 (-)NCBICelera
Cytogenetic MapXq32NCBI
GLA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,397,803 - 101,407,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX101,393,273 - 101,408,012 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,652,791 - 100,662,913 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,539,435 - 100,549,657 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X100,458,941 - 100,469,096NCBI
CeleraX101,172,239 - 101,182,459 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,459,075 - 90,468,889 (-)NCBIHuRef
CHM1_1X100,546,260 - 100,556,479 (-)NCBICHM1_1
T2T-CHM13v2.0X99,841,918 - 99,852,040 (-)NCBIT2T-CHM13v2.0
Gla
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,488,912 - 133,501,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,488,898 - 133,501,874 (-)EnsemblGRCm39 Ensembl
GRCm38X134,588,169 - 134,601,005 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,588,149 - 134,601,125 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,122,708 - 131,135,544 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,934,706 - 129,947,305 (-)NCBIMGSCv36mm8
CeleraX117,467,753 - 117,480,561 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX56.2NCBI
Gla
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555037,521,930 - 7,535,817 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555037,526,077 - 7,535,817 (-)NCBIChiLan1.0ChiLan1.0
GLA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X100,997,182 - 101,007,409 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X101,000,787 - 101,010,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X90,600,412 - 90,610,594 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X100,732,311 - 100,742,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,732,311 - 100,742,280 (-)Ensemblpanpan1.1panPan2
GLA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X75,311,536 - 75,320,391 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX75,311,536 - 75,320,249 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,731,752 - 76,740,708 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,731,752 - 76,740,486 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X74,296,077 - 74,305,030 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,956,280 - 75,965,243 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,718,710 - 75,727,662 (-)NCBIUU_Cfam_GSD_1.0
Gla
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,990,371 - 63,000,657 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936813474,949 - 484,760 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936813474,938 - 484,753 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX83,023,903 - 83,032,570 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X83,024,582 - 83,032,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GLA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,738,097 - 89,749,740 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX89,737,966 - 89,750,539 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606514,657,735 - 14,667,684 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gla
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,163,611 - 1,173,177 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,163,360 - 1,173,087 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gla
20 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:399
Count of miRNA genes:220
Interacting mature miRNAs:275
Transcripts:ENSRNOT00000015494
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
RH140281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X97,768,844 - 97,768,996 (+)MAPPERmRatBN7.2
Rnor_6.0X105,405,533 - 105,405,684NCBIRnor6.0
Rnor_5.0X105,294,887 - 105,295,038UniSTSRnor5.0
RGSC_v3.4X122,044,513 - 122,044,664UniSTSRGSC3.4
CeleraX98,809,387 - 98,809,538UniSTS
Cytogenetic MapXq34UniSTS
RH130891  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X102,062,296 - 102,062,483 (+)Marker Load Pipeline
mRatBN7.2X97,769,026 - 97,769,213 (+)MAPPERmRatBN7.2
Rnor_6.0X105,405,715 - 105,405,901NCBIRnor6.0
Rnor_5.0X105,295,069 - 105,295,255UniSTSRnor5.0
RGSC_v3.4X122,044,695 - 122,044,881UniSTSRGSC3.4
CeleraX98,809,569 - 98,809,755UniSTS
RH 3.4 Map1942.6UniSTS
Cytogenetic MapXq34UniSTS
BE118467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X97,770,604 - 97,770,788 (+)MAPPERmRatBN7.2
Rnor_6.0X105,407,293 - 105,407,476NCBIRnor6.0
Rnor_5.0X105,296,647 - 105,296,830UniSTSRnor5.0
RGSC_v3.4X122,046,273 - 122,046,456UniSTSRGSC3.4
CeleraX98,811,147 - 98,811,330UniSTS
RH 3.4 Map1943.1UniSTS
Cytogenetic MapXq34UniSTS


Genetic Models
This gene Gla is modified in the following models/strains:
DA-Glaem2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015494   ⟹   ENSRNOP00000015494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,768,996 - 97,780,664 (-)Ensembl
Rnor_6.0 EnsemblX105,406,792 - 105,417,323 (-)Ensembl
RefSeq Acc Id: NM_001108820   ⟹   NP_001102290
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X102,062,497 - 102,073,915 (-)NCBI
mRatBN7.2X97,769,227 - 97,780,646 (-)NCBI
Rnor_6.0X105,405,915 - 105,417,331 (-)NCBI
Rnor_5.0X105,295,029 - 105,306,686 (-)NCBI
RGSC_v3.4X122,044,703 - 122,056,327 (-)RGD
CeleraX98,809,769 - 98,821,187 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102290 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM07018 (Get FASTA)   NCBI Sequence Viewer  
  EDM07019 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015494
  ENSRNOP00000015494.6
RefSeq Acc Id: NP_001102290   ⟸   NM_001108820
- UniProtKB: D3ZJF9 (UniProtKB/TrEMBL),   A6IVG1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015494   ⟸   ENSRNOT00000015494
Protein Domains
Alpha galactosidase A C-terminal beta-sandwich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJF9-F1-model_v2 AlphaFold D3ZJF9 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701935
Promoter ID:EPDNEW_R12459
Type:multiple initiation site
Name:Gla_1
Description:galactosidase, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X105,417,343 - 105,417,403EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589721 AgrOrtholog
BioCyc Gene G2FUF-1680 BioCyc
BioCyc Pathway PWY0-1301 [melibiose degradation] BioCyc
BioCyc Pathway Image PWY0-1301 BioCyc
Ensembl Genes ENSRNOG00000011513 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015494 ENTREZGENE
  ENSRNOT00000015494.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1180 UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  Glyco_hydro_27 UniProtKB/TrEMBL
  Glyco_hydro_b UniProtKB/TrEMBL
  Glyco_hydro_catalytic_core UniProtKB/TrEMBL
  Glyco_hydro_GHD UniProtKB/TrEMBL
  Melibiase/NAGA_C UniProtKB/TrEMBL
KEGG Report rno:363494 UniProtKB/TrEMBL
NCBI Gene 363494 ENTREZGENE
PANTHER ALPHA-GALACTOSIDASE A UniProtKB/TrEMBL
  PTHR11452 UniProtKB/TrEMBL
Pfam Melibiase_2 UniProtKB/TrEMBL
  Melibiase_2_C UniProtKB/TrEMBL
PhenoGen Gla PhenoGen
PRINTS GLHYDRLASE27 UniProtKB/TrEMBL
PROSITE ALPHA_GALACTOSIDASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011513 RatGTEx
Superfamily-SCOP Glyco_hydro_cat UniProtKB/TrEMBL
  Glycosyl hydrolase domain UniProtKB/TrEMBL
UniProt A6IVG1 ENTREZGENE, UniProtKB/TrEMBL
  A6IVG2_RAT UniProtKB/TrEMBL
  D3ZJF9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   galactosidase, alpha  Gla  galactosidase, alpha (mapped)  Name updated 737654 APPROVED
2007-04-11 Gla  galactosidase, alpha (mapped)  Gla_mapped  galactosidase, alpha (mapped)  Data merged from RGD:2698 737654 APPROVED
2006-11-19 Gla  galactosidase, alpha (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Gla_mapped  galactosidase, alpha (mapped)  Gla  galactosidase, alpha  Symbol and Name updated 1556543 APPROVED
2002-06-10 Gla  Galactosidase, alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes Fabry disease, a disorder of glycosphingolipid catabolism 1300216