Gla (galactosidase, alpha) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gla (galactosidase, alpha) Mus musculus
Analyze
Symbol: Gla
Name: galactosidase, alpha
RGD ID: 10650
MGI Page MGI
Description: Enables alpha-galactosidase activity. Involved in negative regulation of nitric oxide biosynthetic process and negative regulation of nitric-oxide synthase activity. Acts upstream of or within aorta development and glycosylceramide catabolic process. Located in extracellular space and lysosome. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and liver and biliary system. Used to study Fabry disease. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; Ags; alpha-D-galactosidase A; alpha-D-galactoside galactohydrolase; alpha-galactosidase A; galactosylgalactosylglucosylceramidase GLA; melibiase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,488,912 - 133,501,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,488,898 - 133,501,874 (-)EnsemblGRCm39 Ensembl
GRCm38X134,588,169 - 134,601,005 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,588,149 - 134,601,125 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,122,708 - 131,135,544 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,934,706 - 129,947,305 (-)NCBIMGSCv36mm8
CeleraX117,467,753 - 117,480,561 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX56.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
flutamide  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gentamycin  (ISO)
glucose  (EXP)
hydralazine  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl methacrylate  (EXP)
migalastat  (ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
serotonin  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thiram  (ISO)
tremolite asbestos  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zalcitabine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
extracellular region  (ISO,ISS)
extracellular space  (IDA)
Golgi apparatus  (ISO,ISS)
lysosome  (IDA,ISO,ISS)
membrane  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Fabry disease: six gene rearrangements and an exonic point mutation in the alpha-galactosidase gene. Bernstein HS, etal., J Clin Invest. 1989 Apr;83(4):1390-9.
2. Close linkage of the murine locus bare patches to the X-linked visual pigment gene: implications for mapping human X-linked dominant chondrodysplasia punctata. Herman GE and Walton SJ, Genomics 1990 Jul;7(3):307-12.
3. Platelet and myeloid cell phenotypes in a rat model of Fabry disease. Kanack AJ, etal., FASEB J. 2021 Aug;35(8):e21818. doi: 10.1096/fj.202001727RR.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. α-Galactosidase A-deficient rats accumulate glycosphingolipids and develop cardiorenal phenotypes of Fabry disease. Miller JJ, etal., FASEB J. 2019 Jan;33(1):418-429. doi: 10.1096/fj.201800771R. Epub 2018 Jul 6.
8. Neuropathic pain in a Fabry disease rat model. Miller JJ, etal., JCI Insight. 2018 Mar 22;3(6). pii: 99171. doi: 10.1172/jci.insight.99171.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Sensory-specific peripheral nerve pathology in a rat model of Fabry disease. Waltz TB, etal., Neurobiol Pain. 2021 Sep 2;10:100074. doi: 10.1016/j.ynpai.2021.100074. eCollection 2021 Aug-Dec.
Additional References at PubMed
PMID:198184   PMID:205481   PMID:895843   PMID:1008807   PMID:1235912   PMID:1674728   PMID:1675194   PMID:1889815   PMID:1964443   PMID:2110546   PMID:2563174   PMID:2571569  
PMID:2890215   PMID:2899541   PMID:2906327   PMID:3082971   PMID:3416629   PMID:6251472   PMID:6852525   PMID:7626884   PMID:8535076   PMID:8543175   PMID:8733892   PMID:9110171  
PMID:9122231   PMID:9196009   PMID:10339603   PMID:10349636   PMID:10840053   PMID:10841515   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11115376   PMID:11217851   PMID:11752062  
PMID:12370426   PMID:12460941   PMID:12477932   PMID:12538729   PMID:14610273   PMID:14681479   PMID:14684827   PMID:15489334   PMID:15511632   PMID:15539565   PMID:15629890   PMID:15668341  
PMID:15820316   PMID:16141072   PMID:16141073   PMID:16514103   PMID:16697974   PMID:16982810   PMID:16991089   PMID:17062978   PMID:17470787   PMID:17535804   PMID:17592721   PMID:17933476  
PMID:17967808   PMID:18287059   PMID:18381081   PMID:18425126   PMID:18456533   PMID:18565198   PMID:18799693   PMID:18848893   PMID:18986392   PMID:19202000   PMID:19628671   PMID:19642363  
PMID:19710420   PMID:19773742   PMID:19853240   PMID:20385825   PMID:20454522   PMID:20533258   PMID:20692233   PMID:20727792   PMID:20961863   PMID:20971723   PMID:21124789   PMID:21267068  
PMID:21677750   PMID:21747096   PMID:21873635   PMID:22425450   PMID:22472949   PMID:22574107   PMID:22875802   PMID:23007467   PMID:23472096   PMID:23754746   PMID:24094090   PMID:24158513  
PMID:24232002   PMID:24529306   PMID:25337704   PMID:25553976   PMID:25701874   PMID:26898341   PMID:27145802   PMID:27531673   PMID:27605553   PMID:28158561   PMID:28245920   PMID:28662189  
PMID:28769867   PMID:29553830   PMID:29617956   PMID:30013462   PMID:30333137   PMID:30879639   PMID:31120949   PMID:31999726   PMID:32179651   PMID:32428018   PMID:34339779   PMID:35628155  
PMID:36065186   PMID:37895103   PMID:38355793   PMID:38359115   PMID:38820517  


Genomics

Comparative Map Data
Gla
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,488,912 - 133,501,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,488,898 - 133,501,874 (-)EnsemblGRCm39 Ensembl
GRCm38X134,588,169 - 134,601,005 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,588,149 - 134,601,125 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,122,708 - 131,135,544 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,934,706 - 129,947,305 (-)NCBIMGSCv36mm8
CeleraX117,467,753 - 117,480,561 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX56.2NCBI
GLA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,397,803 - 101,407,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX101,393,273 - 101,408,012 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,652,791 - 100,662,913 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,539,435 - 100,549,657 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X100,458,941 - 100,469,096NCBI
CeleraX101,172,239 - 101,182,459 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,459,075 - 90,468,889 (-)NCBIHuRef
CHM1_1X100,546,260 - 100,556,479 (-)NCBICHM1_1
T2T-CHM13v2.0X99,841,918 - 99,852,040 (-)NCBIT2T-CHM13v2.0
Gla
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,062,497 - 102,073,915 (-)NCBIGRCr8
mRatBN7.2X97,769,227 - 97,780,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,768,996 - 97,780,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,443,442 - 99,454,860 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,954,152 - 102,965,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X100,456,591 - 100,468,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X105,405,915 - 105,417,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,406,792 - 105,417,323 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,295,029 - 105,306,686 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X122,044,703 - 122,056,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX98,809,769 - 98,821,187 (-)NCBICelera
Cytogenetic MapXq32NCBI
Gla
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555037,521,930 - 7,535,817 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555037,526,077 - 7,535,817 (-)NCBIChiLan1.0ChiLan1.0
GLA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X100,997,182 - 101,007,409 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X101,000,787 - 101,010,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X90,600,412 - 90,610,594 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X100,732,311 - 100,742,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,732,311 - 100,742,280 (-)Ensemblpanpan1.1panPan2
GLA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X75,311,536 - 75,320,391 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX75,311,536 - 75,320,249 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,731,752 - 76,740,708 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,731,752 - 76,740,486 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X74,296,077 - 74,305,030 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,956,280 - 75,965,243 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,718,710 - 75,727,662 (-)NCBIUU_Cfam_GSD_1.0
Gla
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,990,371 - 63,000,657 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936813474,949 - 484,760 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936813474,938 - 484,753 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX83,023,903 - 83,032,570 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X83,024,582 - 83,032,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GLA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,738,097 - 89,749,740 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX89,737,966 - 89,750,539 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606514,657,735 - 14,667,684 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gla
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,163,611 - 1,173,177 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,163,360 - 1,173,087 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gla
335 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1211
Count of miRNA genes:636
Interacting mature miRNAs:796
Transcripts:ENSMUST00000033621, ENSMUST00000153024
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse

Markers in Region
U34071  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X134,589,547 - 134,589,723UniSTSGRCm38
MGSCv37X131,124,086 - 131,124,262UniSTSGRCm37
CeleraX117,469,132 - 117,469,308UniSTS
Cytogenetic MapXE-F1UniSTS
Whitehead/MRC_RHX1484.93UniSTS
Whitehead_YACX UniSTS
Gla  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXE-F1UniSTS
cM MapX53.0UniSTS
U34071  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X134,589,772 - 134,589,855UniSTSGRCm38
MGSCv37X131,124,311 - 131,124,394UniSTSGRCm37
CeleraX117,469,357 - 117,469,440UniSTS
Cytogenetic MapXE-F1UniSTS
Whitehead/MRC_RHX1484.93UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK040081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB337527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB584184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX004852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L46651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U58105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000033621   ⟹   ENSMUSP00000033621
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,488,898 - 133,501,874 (-)Ensembl
GRCm38.p6 EnsemblX134,588,149 - 134,601,125 (-)Ensembl
Ensembl Acc Id: ENSMUST00000153024   ⟹   ENSMUSP00000123098
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,496,038 - 133,501,049 (-)Ensembl
GRCm38.p6 EnsemblX134,595,289 - 134,600,300 (-)Ensembl
Ensembl Acc Id: ENSMUST00000239113   ⟹   ENSMUSP00000159121
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,488,935 - 133,501,754 (-)Ensembl
GRCm38.p6 EnsemblX134,588,186 - 134,601,005 (-)Ensembl
RefSeq Acc Id: NM_013463   ⟹   NP_038491
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X133,488,912 - 133,501,707 (-)NCBI
GRCm38X134,588,169 - 134,601,005 (-)ENTREZGENE
MGSCv37X131,122,708 - 131,135,544 (-)RGD
CeleraX117,467,753 - 117,480,561 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NR_175282
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X133,488,912 - 133,501,707 (-)NCBI
RefSeq Acc Id: NP_038491   ⟸   NM_013463
- UniProtKB: P51569 (UniProtKB/Swiss-Prot),   Q8BGZ6 (UniProtKB/TrEMBL),   Q3TLY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000159121   ⟸   ENSMUST00000239113
Ensembl Acc Id: ENSMUSP00000033621   ⟸   ENSMUST00000033621
Ensembl Acc Id: ENSMUSP00000123098   ⟸   ENSMUST00000153024
Protein Domains
Alpha galactosidase A C-terminal beta-sandwich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51569-F1-model_v2 AlphaFold P51569 1-419 view protein structure

Promoters
RGD ID:6845745
Promoter ID:MM_KWN:61871
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000050331,   ENSMUST00000074950,   ENSMUST00000113202,   ENSMUST00000113203,   NM_019868,   OTTMUST00000046257,   OTTMUST00000046268
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X131,134,021 - 131,136,367 (-)MPROMDB
RGD ID:13681362
Promoter ID:EPDNEW_M24830
Type:multiple initiation site
Name:Gla_1
Description:Mus musculus galactosidase, alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X134,600,958 - 134,601,018EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347344 AgrOrtholog
Ensembl Genes ENSMUSG00000031266 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033621.8 UniProtKB/Swiss-Prot
  ENSMUST00000153024.2 UniProtKB/TrEMBL
  ENSMUST00000239113 ENTREZGENE
  ENSMUST00000239113.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_27/36_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Melibiase/NAGA_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11605 UniProtKB/TrEMBL
MGD MGI:1347344 ENTREZGENE
NCBI Gene 11605 ENTREZGENE
PANTHER ALPHA-GALACTOSIDASE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Melibiase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Melibiase_2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gla PhenoGen
PRINTS GLHYDRLASE27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALPHA_GALACTOSIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glycosyl hydrolase domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2BDV6_MOUSE UniProtKB/TrEMBL
  AGAL_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TLY5 ENTREZGENE, UniProtKB/TrEMBL
  Q3UM38_MOUSE UniProtKB/TrEMBL
  Q8BGZ6 ENTREZGENE, UniProtKB/TrEMBL