Emx2 (empty spiracles homeobox 2) - Rat Genome Database

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Gene: Emx2 (empty spiracles homeobox 2) Rattus norvegicus
Analyze
Symbol: Emx2
Name: empty spiracles homeobox 2
RGD ID: 1564797
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in nervous system development; regulation of transcription by RNA polymerase II; and stereocilium bundle organization. Predicted to act upstream of or within several processes, including forebrain development; neuron migration; and ureter morphogenesis. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and stomach cancer. Orthologous to human EMX2 (empty spiracles homeobox 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: empty spiracles homolog 2; homeobox protein EMX2; LOC499380; RGD1564797; similar to empty spiracles-like protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81268,612,663 - 268,619,671 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1268,612,663 - 268,619,671 (+)EnsemblGRCr8
mRatBN7.21258,626,584 - 258,633,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1258,626,584 - 258,633,594 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1266,832,393 - 266,839,395 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01273,538,418 - 273,545,420 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01266,179,101 - 266,186,108 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01280,633,938 - 280,640,946 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1280,633,938 - 280,640,946 (+)Ensemblrn6Rnor6.0
Rnor_5.01287,993,648 - 288,000,656 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41266,004,257 - 266,011,265 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1254,275,943 - 254,282,950 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
15-acetyldeoxynivalenol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arotinoid acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
CHIR 99021  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
picoxystrobin  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. EMX2 gene expression predicts liver metastasis and survival in colorectal cancer. Aykut B, etal., BMC Cancer. 2017 Aug 22;17(1):555. doi: 10.1186/s12885-017-3556-2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma. Giroux Leprieur E, etal., Lung Cancer. 2014 Sep;85(3):465-71. doi: 10.1016/j.lungcan.2014.06.018. Epub 2014 Jun 30.
4. Adenoviral delivery of the EMX2 gene suppresses growth in human gastric cancer. Li J, etal., PLoS One. 2012;7(9):e45970. doi: 10.1371/journal.pone.0045970. Epub 2012 Sep 21.
5. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients. Okamoto J, etal., Clin Lung Cancer. 2011 Jul;12(4):237-44. doi: 10.1016/j.cllc.2011.03.025. Epub 2011 Apr 24.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. EMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma. Wang L, etal., Oncol Rep. 2019 Nov;42(5):2169-2178. doi: 10.3892/or.2019.7284. Epub 2019 Aug 20.
10. EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas. Yue D, etal., PLoS One. 2015 Jul 1;10(7):e0132134. doi: 10.1371/journal.pone.0132134. eCollection 2015.
11. Empty Spiracles Homeobox 2 (EMX2) Inhibits the Invasion and Tumorigenesis in Colorectal Cancer Cells. Zhang Y, etal., Oncol Res. 2017 Apr 14;25(4):537-544. doi: 10.3727/096504016X14756640150695. Epub 2016 Oct 5.
Additional References at PubMed
PMID:9098922   PMID:10729342   PMID:12091317   PMID:12196586   PMID:12209834   PMID:12561075   PMID:12764040   PMID:15147765   PMID:15294144   PMID:15917450   PMID:16919471   PMID:21731775  


Genomics

Comparative Map Data
Emx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81268,612,663 - 268,619,671 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1268,612,663 - 268,619,671 (+)EnsemblGRCr8
mRatBN7.21258,626,584 - 258,633,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1258,626,584 - 258,633,594 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1266,832,393 - 266,839,395 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01273,538,418 - 273,545,420 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01266,179,101 - 266,186,108 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01280,633,938 - 280,640,946 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1280,633,938 - 280,640,946 (+)Ensemblrn6Rnor6.0
Rnor_5.01287,993,648 - 288,000,656 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41266,004,257 - 266,011,265 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1254,275,943 - 254,282,950 (+)NCBICelera
Cytogenetic Map1q55NCBI
EMX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810117,542,746 - 117,549,546 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10117,542,445 - 117,549,546 (+)Ensemblhg38GRCh38
GRCh3710119,302,257 - 119,309,057 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610119,291,946 - 119,299,043 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410119,291,945 - 119,299,043NCBI
Celera10113,031,949 - 113,039,046 (+)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10112,930,193 - 112,937,289 (+)NCBIHuRef
CHM1_110119,586,078 - 119,593,194 (+)NCBICHM1_1
T2T-CHM13v2.010118,437,136 - 118,443,925 (+)NCBIT2T-CHM13v2.0
Emx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391959,447,122 - 59,453,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1959,446,804 - 59,453,789 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381959,458,690 - 59,465,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1959,458,372 - 59,465,357 (+)Ensemblmm10GRCm38
MGSCv371959,533,180 - 59,539,847 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361959,511,622 - 59,518,607 (+)NCBIMGSCv36mm8
Celera1961,658,178 - 61,664,837 (+)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.28NCBI
Emx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543122,192,446 - 22,199,279 (+)Ensembl
ChiLan1.0NW_00495543122,192,446 - 22,199,141 (+)NCBIChiLan1.0ChiLan1.0
EMX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28129,405,618 - 129,419,620 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110129,417,530 - 129,424,956 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010114,124,759 - 114,132,109 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110117,551,451 - 117,557,972 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10117,551,451 - 117,557,972 (+)EnsemblpanPan2panpan1.1
EMX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12828,002,966 - 28,009,955 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2828,003,710 - 28,009,035 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2828,146,341 - 28,153,333 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02828,532,618 - 28,539,604 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2828,532,897 - 28,538,743 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12828,094,345 - 28,101,342 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02828,108,855 - 28,115,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02828,303,055 - 28,310,050 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Emx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721318,241,303 - 18,247,914 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364867,313,190 - 7,319,995 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364867,313,689 - 7,319,971 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EMX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14127,650,688 - 127,655,706 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114127,649,675 - 127,656,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214139,052,130 - 139,055,522 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EMX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19110,347,043 - 110,353,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9110,347,379 - 110,353,643 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604871,602,815 - 71,610,687 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Emx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473729,103,279 - 29,110,344 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473729,103,378 - 29,110,356 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:449
Count of miRNA genes:242
Interacting mature miRNAs:287
Transcripts:ENSRNOT00000012564
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1263946994269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
D1Mit14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21258,625,162 - 258,625,266 (+)MAPPERmRatBN7.2
Rnor_6.01280,632,517 - 280,632,620NCBIRnor6.0
Rnor_5.01287,992,227 - 287,992,330UniSTSRnor5.0
RGSC_v3.41266,002,835 - 266,002,939RGDRGSC3.4
RGSC_v3.41266,002,836 - 266,002,939UniSTSRGSC3.4
Celera1254,274,522 - 254,274,625UniSTS
RGSC_v3.11266,213,881 - 266,213,984RGD
RH 3.4 Map11706.6UniSTS
RH 3.4 Map11706.6RGD
RH 2.0 Map11324.4999RGD
FHH x ACI Map1132.1799RGD
Cytogenetic Map1q55UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 11 56 137 65 64 33 29 33 6 252 117 10 109 81 92 31 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000012564   ⟹   ENSRNOP00000012564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1268,612,663 - 268,619,671 (+)Ensembl
mRatBN7.2 Ensembl1258,626,584 - 258,633,594 (+)Ensembl
Rnor_6.0 Ensembl1280,633,938 - 280,640,946 (+)Ensembl
RefSeq Acc Id: NM_001109169   ⟹   NP_001102639
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81268,612,663 - 268,619,671 (+)NCBI
mRatBN7.21258,626,584 - 258,633,594 (+)NCBI
Rnor_6.01280,633,938 - 280,640,946 (+)NCBI
Rnor_5.01287,993,648 - 288,000,656 (+)NCBI
RGSC_v3.41266,004,257 - 266,011,265 (+)RGD
Celera1254,275,943 - 254,282,950 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271792   ⟹   XP_063127862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81268,613,298 - 268,618,267 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102639 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127862 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94560 (Get FASTA)   NCBI Sequence Viewer  
  EDL94561 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012564
  ENSRNOP00000012564.3
RefSeq Acc Id: NP_001102639   ⟸   NM_001109169
- UniProtKB: D3ZCK7 (UniProtKB/TrEMBL),   A6JI86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012564   ⟸   ENSRNOT00000012564
RefSeq Acc Id: XP_063127862   ⟸   XM_063271792
- Peptide Label: isoform X1
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCK7-F1-model_v2 AlphaFold D3ZCK7 1-253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691015
Promoter ID:EPDNEW_R1540
Type:single initiation site
Name:Emx2_1
Description:empty spiracles homeobox 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01280,633,971 - 280,634,031EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564797 AgrOrtholog
BioCyc Gene G2FUF-55248 BioCyc
Ensembl Genes ENSRNOG00000009482 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012564 ENTREZGENE
  ENSRNOT00000012564.4 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro EMX-VAX-Noto_Homeobox_TFs UniProtKB/TrEMBL
  Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_region UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  HTH_lambrepressr UniProtKB/TrEMBL
KEGG Report rno:499380 UniProtKB/TrEMBL
NCBI Gene 499380 ENTREZGENE
PANTHER HOMEOBOX PROTEIN EMX-RELATED UniProtKB/TrEMBL
  HOMEOBOX PROTEIN EMX2 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Emx2 PhenoGen
PRINTS HOMEOBOX UniProtKB/TrEMBL
  HTHREPRESSR UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009482 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A6JI86 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCK7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Emx2  empty spiracles homeobox 2  RGD1564797_predicted  similar to empty spiracles-like protein 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564797_predicted  similar to empty spiracles-like protein 2 (predicted)  LOC499380  similar to empty spiracles-like protein 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499380  similar to empty spiracles-like protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL