Gene: F5 (coagulation factor V) Rattus norvegicus
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Symbol:
F5
Name:
coagulation factor V
Description:
Predicted to have ferroxidase activity. Involved in blood coagulation and response to vitamin K. Localizes to the Golgi apparatus; endoplasmic reticulum; and extracellular space. Used to study Budd-Chiari syndrome; liver cirrhosis; and membranoproliferative glomerulonephritis. Biomarker of colon adenoma; hepatitis; liver cirrhosis; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal failure; factor V deficiency; liver disease (multiple); and non-arteritic anterior ischemic optic neuropathy. Orthologous to human F5 (coagulation factor V); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Ac2-120; coagulation factor 5; coagulation factor 5 (mapped); coagulation factor V (proaccelerin, labile factor); F5_mapped
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
F5 (coagulation factor V) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):
F5 (coagulation factor V) HGNC
NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
F5 (coagulation factor V) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
F5 (coagulation factor V) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
F5 (coagulation factor V) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
F5 (coagulation factor V) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
F5 (coagulation factor V) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
F5 (coagulation factor V) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
F5 (coagulation factor V) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
F5 (coagulation factor V)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, PhylomeDB)
Homo sapiens (human):
F5 (coagulation factor V)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, PhylomeDB)
Danio rerio (zebrafish):
f5 (coagulation factor V)
Alliance
DIOPT (Ensembl Compara, OMA, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 13 82,479,997 - 82,535,540 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 82,479,998 - 82,535,534 (+) Ensembl Rnor_5.0 13 87,355,980 - 87,417,686 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 79,934,956 - 79,997,285 (+) NCBI RGSC3.4 rn4 RGSC3.4 Celera 13 76,256,969 - 76,316,731 (+) NCBI Celera Cytogenetic Map 13 q23 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
Acute Liver Failure severity ISO 14700653 protein:altered expression (human) RGD Behcet's disease no_association ISO RGD:1344593 7394769 DNA:mutation: :1691G>A (human) RGD breast cancer ISO RGD:1344593 10449101 DNA:SNPs: :multiple RGD breast cancer no_association ISO RGD:1344593 10449101 DNA:SNPs: :rs6025 (human) RGD Budd-Chiari syndrome severity ISO 14700660 RGD Budd-Chiari syndrome susceptibility ISO RGD:1344593 15036813 DNA:missense mutation:cds:R506Q (human) RGD Budd-Chiari syndrome disease_progression ISO RGD:1344593 11537993 DNA:missense mutation:cds:R506Q (human) RGD Budd-Chiari syndrome severity ISO RGD:1344593 14700661 associated with hyperhomocysteinemia:DNA:missense mutation:cds: (R506Q) (human) RGD colon adenoma IEP 10449102 protein:increased expression:serum RGD Dysarthria ISO RGD:1344593 1580361 RGD Dyspnea ISO RGD:1344593 4892656 RGD end stage renal failure ISO RGD:1344593 6893522 DNA:mutation: :1691G>A(human) RGD Endotoxemia IEP 7394782 RGD Experimental Liver Cirrhosis treatment IEP 7394781 RGD factor V deficiency ISO RGD:1344593 11564334 DNA:nonsense, misense mutations:cds:c.3571C>T, c.1691G>A(human) RGD Femur Head Necrosis ISO RGD:1344593 6902907 associated with kidney transplantation, 1691G>A(human) RGD Fetal Death no_association ISO RGD:1344593 1580130 RGD hepatitis treatment ISO 14700657 RGD hepatitis severity IEP 14700682 protein:decreased expression:plasma (human) RGD hypereosinophilic syndrome ISO RGD:1344593 1580361 RGD liver cirrhosis susceptibility ISO 14700659 RGD liver cirrhosis disease_progression ISO RGD:1344593 14700663 RGD membranoproliferative glomerulonephritis IMP 1601118 RGD myocardial infarction susceptibility ISO RGD:1344593 11564335 DNA:mutation:cds:1691G>A (human) RGD myocardial infarction no_association ISO RGD:1344593 11564337 DNA:mutation:cds:1691G>A (human) RGD Myocardial Ischemia ISO RGD:1344593 4892673 DNA:mutation, haplotype: :1691G>A (human) RGD non-arteritic anterior ischemic optic neuropathy ISO RGD:1344593 7394764 DNA:missense mutation:cds:p.R506Q (1691G>A) (human) RGD Peritoneal Fibrosis IEP 7394780 RGD portal hypertension IEP 14700665 associated with Acute Hepatitis, protein:decreased expression:serum (human) RGD pre-eclampsia severity ISO RGD:1344593 6893628 DNA:mutation: :1691G>A(human) RGD pulmonary embolism ISO RGD:1344593 4892657 RGD pulmonary fibrosis severity ISO RGD:10557 11564339 RGD pulmonary hypertension ISO RGD:1344593 4892669 Chronic thromboembolic pulmonary hypertension (CTEPH) RGD retinal artery occlusion no_association ISO RGD:1344593 1580362 RGD retinal vein occlusion ISO RGD:1344593 7394767 associated with Behcet Syndrome, DNA:missense mutation:cds:p.R506Q (human) RGD retinal vein occlusion onset ISO RGD:1344593 7394778 DNA:missense mutation:cds:1691G>A (human) RGD retinal vein occlusion no_association ISO RGD:1344593 7394773 DNA:SNP:cds:1691G>A (human) RGD sensorineural hearing loss ISO RGD:1344593 7387260 DNA:mutation RGD sensorineural hearing loss no_association ISO RGD:1344593 7387240 DNA:SNP: :1691G>A (human) RGD sensorineural hearing loss ISO RGD:1344593 7387261 DNA:transition: :1691G>A (human) RGD Sepsis severity ISO RGD:1344593 4892622 RGD Sepsis treatment IMP 1598921 RGD Septic Peritonitis disease_progression ISO RGD:10557 11564333 RGD Thromboembolism ISO RGD:1344593 6893596 associated with coronary artery disease, DNA:mutation: : RGD Thromboembolism ISO RGD:1344593 1580340 RGD thrombosis ISO RGD:1344593 6893627 associated with kidney failure, chronic, DNA:mutation: :1691G>A(human) RGD thrombosis ISO RGD:10557 11564340 RGD Venous Thromboembolism ISO RGD:1344593 10449100 DNA:mutation: :1691G>A (human) RGD Venous Thromboembolism disease_progression ISO RGD:1344593 11536892 DNA:SNP: :rs6025(human) RGD Venous Thrombosis ISO RGD:1344593 6893601 DNA:missense mutation:cds:p.R506Q (human) RGD Venous Thrombosis ISO RGD:1344593 7394779 DNA:mutation: :1691G>A (human) RGD Venous Thrombosis ISO RGD:1344593 7394762 associated with Behcet Syndrome, DNA:SNP: :1691G>A (human) RGD Venous Thrombosis ISO RGD:1344593 6893602 associated with lupus erythematosus, systemic, DNA:polymorphism:cds:rs6025(human) RGD
Imported Annotations - ClinVar
1q24 Deletion Syndrome ISO RGD:1344593 8554872 ClinVar Annotator: match by term: 1q24q25 microdeletion syndrome ClinVar PMID:25741868 Activated Protein C Resistance ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia due to activated protein C resistance ClinVar PMID:28492532 Activated Protein C Resistance ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia due to activated protein C resistance ClinVar PMID:25741868 , PMID:28492532 Activated Protein C Resistance ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia due to activated protein C resistance ClinVar PMID:9454742 Activated Protein C Resistance ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia due to activated protein C resistance ClinVar PMID:14617013 Activated Protein C Resistance ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia due to activated protein C resistance ClinVar PMID:24033266 , PMID:25741868 Activated Protein C Resistance ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia due to activated protein C resistance ClinVar PMID:14617013 , PMID:14695241 Activated Protein C Resistance ISO RGD:1344593 8554872 ClinVar Annotator: match by term: APC RESISTANCE ClinVar PMID:10328130 more ... Activated Protein C Resistance ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia due to activated protein C resistance ClinVar PMID:25741868 Activated Protein C Resistance ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia due to activated protein C resistance ClinVar Budd-Chiari syndrome ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Budd-Chiari syndrome ClinVar PMID:28492532 Budd-Chiari syndrome ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Budd-Chiari syndrome ClinVar PMID:25741868 , PMID:28492532 Budd-Chiari syndrome ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Budd-Chiari syndrome ClinVar PMID:24033266 , PMID:25741868 Budd-Chiari syndrome ISO RGD:1344593 8554872 ClinVar Annotator: match by OMIM:600880 ClinVar Budd-Chiari syndrome ISO RGD:1344593 8554872 ClinVar Annotator: match by OMIM:600880 ClinVar PMID:25741868 cerebral infarction ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Ischemic stroke, susceptibility to ClinVar PMID:10328130 more ... factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by null ClinVar PMID:11781258 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar PMID:12816860 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar PMID:10942390 more ... factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar PMID:25741868 , PMID:28492532 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar PMID:24033266 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar PMID:28492532 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar PMID:12393490 , PMID:25741868 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar PMID:19486170 more ... factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar PMID:24033266 , PMID:25741868 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by OMIM:227400 ClinVar PMID:12816860 more ... factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar PMID:25741868 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Factor V deficiency ClinVar PMID:10328130 more ... factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by null ClinVar PMID:10494770 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by OMIM:227400 ClinVar PMID:11564077 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by OMIM:227400 ClinVar PMID:11435304 , PMID:9488630 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by OMIM:227400 ClinVar PMID:10942390 , PMID:11435304 factor V deficiency ISO RGD:1344593 8554872 ClinVar Annotator: match by null ClinVar PMID:9576178 Habitual Abortions ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Recurrent abortion ClinVar PMID:10328130 more ... hemorrhagic disease ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Hemorrhagic diathesis ClinVar PMID:25741868 Hirschsprung's disease ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Hirschsprung disease ClinVar prostate cancer ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Prostate cancer ClinVar PMID:23265383 Spontaneous Abortions ISO RGD:1344593 8554872 ClinVar Annotator: match by term: FETAL LOSS, RECURRENT, SUSCEPTIBILITY TO ClinVar PMID:10328130 more ... Thromboembolism ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thromboembolism ClinVar PMID:25741868 thrombophilia ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia ClinVar PMID:25741868 thrombophilia ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Venous thrombosis ClinVar PMID:28492532 thrombophilia ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Venous thrombosis ClinVar PMID:25741868 , PMID:28492532 thrombophilia ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia ClinVar PMID:24033266 , PMID:25741868 thrombophilia ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Thrombophilia ClinVar Venous Thrombosis ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Venous thrombosis ClinVar PMID:28492532 Venous Thrombosis ISO RGD:1344593 8554872 ClinVar Annotator: match by term: Venous thrombosis ClinVar PMID:25741868 , PMID:28492532 Venous Thrombosis ISO RGD:1344593 8554872 ClinVar Annotator: match by term: VENOUS THROMBOSIS ClinVar PMID:24033266 , PMID:25741868 Venous Thrombosis ISO RGD:1344593 8554872 ClinVar Annotator: match by term: VENOUS THROMBOSIS ClinVar PMID:25741868 Venous Thrombosis ISO RGD:1344593 8554872 ClinVar Annotator: match by term: VENOUS THROMBOSIS ClinVar
Imported Annotations - CTD
blood coagulation disease ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17721328 brain ischemia ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15534175 Colonic Neoplasms ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25200834 familial adenomatous polyposis ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25200834 Hereditary Thrombophilia ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9136971 liver cirrhosis ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18485088 Mesenteric Ischemia ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24282370 myocardial infarction ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9531249 retinal vein occlusion ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12022286 sagittal sinus thrombosis ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18382986 Spontaneous Abortions ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD Stroke ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15534175 Thromboembolism ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14693181 , PMID:20554945 thrombosis ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9164807 , PMID:11132655 Venous Thromboembolism ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7500743 , PMID:9149031 Venous Thrombosis ISO RGD:1344593 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12296757 more ... Imported Annotations - OMIM
Activated Protein C Resistance ISO RGD:1344593 7240710 OMIM Budd-Chiari syndrome ISO RGD:1344593 7240710 OMIM cerebral infarction ISO RGD:1344593 7240710 OMIM factor V deficiency ISO RGD:1344593 7240710 OMIM Spontaneous Abortions susceptibility ISO RGD:1344593 7240710 OMIM
(-)-demecolcine increases expression ISO RGD:1344593 6480464 Demecolcine results in increased expression of F5 mRNA CTD PMID:23649840 1-naphthyl isothiocyanate multiple interactions ISO RGD:1344593 6480464 [1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of F5 mRNA CTD PMID:27344345 17alpha-ethynylestradiol multiple interactions ISO RGD:1344593 6480464 F5 gene polymorphism inhibits the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of C4BPB protein] CTD PMID:14551147 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of F5 mRNA CTD PMID:29097150 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1344593 6480464 Dihydrotestosterone results in increased expression of F5 mRNA CTD PMID:29581250 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10557 6480464 Tetrachlorodibenzodioxin results in decreased expression of F5 mRNA CTD PMID:19770486 2,3-dimethoxynaphthalene-1,4-dione decreases expression ISO RGD:1344593 6480464 2 more ... CTD PMID:17547211 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of F5 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of F5 mRNA CTD PMID:21346803 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:10557 6480464 3 more ... CTD PMID:19467301 4,4'-diaminodiphenylmethane increases expression ISO RGD:10557 6480464 4, 4'-diaminodiphenylmethane results in increased expression of F5 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases expression ISO RGD:10557 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of F5 mRNA CTD PMID:30951980 acenocoumarol decreases activity EXP 6480464 Acenocoumarol results in decreased activity of F5 protein CTD PMID:3490277 acrylamide affects expression EXP 6480464 Acrylamide affects the expression of F5 mRNA CTD PMID:28959563 aflatoxin B1 affects expression ISO RGD:1344593 6480464 Aflatoxin B1 affects the expression of F5 protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:1344593 6480464 Aflatoxin B1 results in decreased methylation of F5 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:10557 6480464 Aflatoxin B1 results in decreased expression of F5 mRNA CTD PMID:19770486 all-trans-retinoic acid decreases response to substance ISO RGD:1344593 6480464 F5 protein results in decreased susceptibility to Tretinoin CTD PMID:10734661 antimony(0) decreases expression ISO RGD:1344593 6480464 Antimony results in decreased expression of F5 mRNA CTD PMID:17547211 antirheumatic drug decreases expression ISO RGD:1344593 6480464 Antirheumatic Agents results in decreased expression of F5 mRNA CTD PMID:24449571 arsane decreases expression ISO RGD:10557 6480464 Arsenic results in decreased expression of F5 mRNA CTD PMID:19654921 arsenic atom decreases expression ISO RGD:10557 6480464 Arsenic results in decreased expression of F5 mRNA CTD PMID:19654921 arsenous acid increases expression ISO RGD:1344593 6480464 Arsenic Trioxide results in increased expression of F5 mRNA CTD PMID:20458559 aspalathin multiple interactions ISO RGD:1344593 6480464 aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein] CTD PMID:25325928 atorvastatin calcium decreases activity ISO RGD:1344593 6480464 Atorvastatin results in decreased activity of F5 protein CTD PMID:16907931 benzene increases expression ISO RGD:10557 6480464 Benzene results in increased expression of F5 mRNA CTD PMID:15120971 , PMID:15122651 benzo[a]pyrene decreases expression ISO RGD:10557 6480464 Benzo(a)pyrene results in decreased expression of F5 mRNA CTD PMID:19770486 benzo[a]pyrene increases expression ISO RGD:10557 6480464 Benzo(a)pyrene results in increased expression of F5 mRNA CTD PMID:27195522 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1344593 6480464 7 more ... CTD PMID:26238291 bisphenol A decreases expression ISO RGD:10557 6480464 bisphenol A results in decreased expression of F5 mRNA CTD PMID:21932408 bisphenol A increases expression ISO RGD:10557 6480464 bisphenol A results in increased expression of F5 mRNA CTD PMID:30951980 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of F5 gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of F5 mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:10557 6480464 bisphenol F results in increased expression of F5 mRNA CTD PMID:30951980 buta-1,3-diene decreases expression ISO RGD:10557 6480464 1, 3-butadiene results in decreased expression of F5 mRNA CTD PMID:29038090 butanal decreases expression ISO RGD:1344593 6480464 butyraldehyde results in decreased expression of F5 mRNA CTD PMID:26079696 cadmium atom affects binding ISO RGD:1344593 6480464 F5 protein binds to Cadmium CTD PMID:23896426 calcitriol increases expression ISO RGD:1344593 6480464 Calcitriol results in increased expression of F5 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1344593 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of F5 mRNA CTD PMID:21592394 calcium dichloride multiple interactions ISO RGD:1344593 6480464 [F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein more ... CTD PMID:25325928 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of F5 mRNA CTD PMID:23125180 chromium atom decreases expression ISO RGD:1344593 6480464 Chromium results in decreased expression of F5 mRNA CTD PMID:17547211 chrysene increases expression ISO RGD:10557 6480464 chrysene results in increased expression of F5 mRNA CTD PMID:26377693 clofibrate multiple interactions ISO RGD:10557 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of F5 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of F5 mRNA] CTD PMID:17585979 clofibrate decreases expression ISO RGD:10557 6480464 Clofibrate results in decreased expression of F5 mRNA CTD PMID:23811191 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of F5 mRNA CTD PMID:12851107 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of F5 mRNA CTD PMID:17602206 clomiphene affects response to substance ISO RGD:1344593 6480464 F5 gene polymorphism affects the susceptibility to Clomiphene CTD PMID:19371211 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of F5 mRNA CTD PMID:24386269 cyclosporin A decreases expression ISO RGD:10557 6480464 Cyclosporine results in decreased expression of F5 mRNA CTD PMID:19770486 cyclosporin A decreases expression ISO RGD:1344593 6480464 Cyclosporine results in decreased expression of F5 mRNA CTD PMID:20106945 , PMID:25562108 cyproconazole decreases expression ISO RGD:10557 6480464 cyproconazole results in decreased expression of F5 mRNA CTD PMID:22334560 dextran sulfate multiple interactions ISO RGD:10557 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of F5 mRNA CTD PMID:29950665 diarsenic trioxide increases expression ISO RGD:1344593 6480464 Arsenic Trioxide results in increased expression of F5 mRNA CTD PMID:20458559 diazinon decreases expression EXP 6480464 Diazinon results in decreased expression of F5 mRNA CTD PMID:29108742 dichloroacetic acid decreases expression ISO RGD:10557 6480464 Dichloroacetic Acid results in decreased expression of F5 mRNA CTD PMID:28962523 dicrotophos increases expression ISO RGD:1344593 6480464 dicrotophos results in increased expression of F5 mRNA CTD PMID:28302478 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate decreases expression ISO RGD:1344593 6480464 Antimony Potassium Tartrate results in decreased expression of F5 mRNA CTD PMID:17547211 dorsomorphin multiple interactions ISO RGD:1344593 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 entinostat increases expression ISO RGD:1344593 6480464 entinostat results in increased expression of F5 mRNA CTD PMID:26272509 , PMID:27188386 entinostat multiple interactions ISO RGD:1344593 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F5 mRNA CTD PMID:27188386 epoxiconazole decreases expression ISO RGD:10557 6480464 epoxiconazole results in decreased expression of F5 mRNA CTD PMID:22334560 Ethyl icosapentate decreases activity EXP 6480464 eicosapentaenoic acid ethyl ester results in decreased activity of F5 protein CTD PMID:14614217 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of F5 mRNA CTD PMID:24793618 furan increases methylation EXP 6480464 furan results in increased methylation of F5 gene CTD PMID:22079235 furan decreases expression EXP 6480464 furan results in decreased expression of F5 mRNA CTD PMID:25539665 glycidol increases expression EXP 6480464 glycidol results in increased expression of F5 mRNA CTD PMID:24395379 lead diacetate affects expression EXP 6480464 lead acetate affects the expression of F5 mRNA CTD PMID:22641619 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of F5 mRNA CTD PMID:24136188 levonorgestrel multiple interactions ISO RGD:1344593 6480464 F5 gene polymorphism inhibits the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of C4BPB protein] CTD PMID:14551147 lithium chloride increases expression ISO RGD:1344593 6480464 Lithium Chloride results in increased expression of F5 mRNA CTD PMID:23527032 mercury atom decreases expression ISO RGD:1344593 6480464 Mercury results in decreased expression of F5 mRNA CTD PMID:17547211 mercury dibromide increases expression ISO RGD:1344593 6480464 mercuric bromide results in increased expression of F5 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:1344593 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F5 mRNA CTD PMID:27188386 mercury(0) decreases expression ISO RGD:1344593 6480464 Mercury results in decreased expression of F5 mRNA CTD PMID:17547211 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of F5 mRNA CTD PMID:30467583 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of F5 mRNA CTD PMID:17602206 N-nitrosodimethylamine decreases expression ISO RGD:1344593 6480464 Dimethylnitrosamine results in decreased expression of F5 mRNA CTD PMID:17547211 nickel atom decreases expression ISO RGD:1344593 6480464 Nickel results in decreased expression of F5 mRNA CTD PMID:25583101 nickel dichloride decreases expression ISO RGD:1344593 6480464 nickel chloride results in decreased expression of F5 mRNA CTD PMID:17547211 ochratoxin A decreases expression ISO RGD:1344593 6480464 ochratoxin A results in decreased expression of F5 mRNA CTD PMID:19287073 p-chloromercuribenzoic acid increases expression ISO RGD:1344593 6480464 p-Chloromercuribenzoic Acid results in increased expression of F5 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:1344593 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F5 mRNA CTD PMID:27188386 paracetamol multiple interactions ISO RGD:10557 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of F5 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of F5 mRNA] CTD PMID:17585979 paracetamol decreases expression ISO RGD:1344593 6480464 Acetaminophen results in decreased expression of F5 mRNA CTD PMID:29067470 paracetamol affects expression ISO RGD:10557 6480464 Acetaminophen affects the expression of F5 mRNA CTD PMID:17562736 pentanal decreases expression ISO RGD:1344593 6480464 pentanal results in decreased expression of F5 mRNA CTD PMID:26079696 perfluorooctane-1-sulfonic acid affects expression ISO RGD:10557 6480464 perfluorooctane sulfonic acid affects the expression of F5 mRNA CTD PMID:19429403 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:10557 6480464 perfluorooctane sulfonic acid results in decreased expression of F5 mRNA CTD PMID:20936131 perfluorooctanoic acid affects expression ISO RGD:10557 6480464 perfluorooctanoic acid affects the expression of F5 mRNA CTD PMID:19429403 phenobarbital affects expression ISO RGD:10557 6480464 Phenobarbital affects the expression of F5 mRNA CTD PMID:23091169 phenprocoumon decreases activity EXP 6480464 Phenprocoumon results in decreased activity of F5 protein CTD PMID:3490277 phenylmercury acetate increases expression ISO RGD:1344593 6480464 Phenylmercuric Acetate results in increased expression of F5 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1344593 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F5 mRNA CTD PMID:27188386 pirinixic acid multiple interactions ISO RGD:10557 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of F5 mRNA, PPARA protein promotes the reaction [pirinixic acid results in decreased expression of F5 mRNA] CTD PMID:18467677 , PMID:19710929 pirinixic acid decreases expression ISO RGD:10557 6480464 pirinixic acid results in decreased expression of F5 mRNA CTD PMID:18467677 , PMID:23811191 potassium dichromate decreases expression ISO RGD:1344593 6480464 Potassium Dichromate results in decreased expression of F5 mRNA CTD PMID:17547211 propanal decreases expression ISO RGD:1344593 6480464 propionaldehyde results in decreased expression of F5 mRNA CTD PMID:26079696 propiconazole decreases expression ISO RGD:10557 6480464 propiconazole results in decreased expression of F5 mRNA CTD PMID:21278054 , PMID:22334560 quinapril hydrochloride decreases activity ISO RGD:1344593 6480464 Quinapril results in decreased activity of F5 protein CTD PMID:16907931 rotenone affects expression EXP 6480464 Rotenone affects the expression of F5 mRNA CTD PMID:28374803 SB 431542 multiple interactions ISO RGD:1344593 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenite decreases expression ISO RGD:1344593 6480464 sodium arsenite results in decreased expression of F5 mRNA CTD PMID:29301061 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of F5 mRNA CTD PMID:22110744 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of F5 mRNA CTD PMID:21515302 testosterone multiple interactions ISO RGD:1344593 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of F5 mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:1344593 6480464 Testosterone results in increased expression of F5 mRNA CTD PMID:21592394 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of F5 mRNA CTD PMID:31150632 titanium dioxide multiple interactions ISO RGD:10557 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of F5 mRNA CTD PMID:29950665 tolcapone increases expression EXP 6480464 tolcapone results in increased expression of F5 mRNA CTD PMID:24136188 trichostatin A increases expression ISO RGD:1344593 6480464 trichostatin A results in increased expression of F5 mRNA CTD PMID:24935251 valproic acid affects expression ISO RGD:1344593 6480464 Valproic Acid affects the expression of F5 mRNA CTD PMID:25979313 valproic acid multiple interactions ISO RGD:1344593 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F5 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1344593 6480464 Valproic Acid results in increased expression of F5 mRNA CTD PMID:23179753 more ... vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of F5 mRNA CTD PMID:23034163 warfarin affects response to substance ISO RGD:1344593 6480464 F5 gene polymorphism affects the susceptibility to Warfarin, F5 protein affects the susceptibility to Warfarin CTD PMID:19752777 warfarin decreases activity EXP 6480464 Warfarin results in decreased activity of F5 protein CTD PMID:3490277 zinc atom increases expression ISO RGD:10557 6480464 Zinc deficiency results in increased expression of F5 mRNA CTD PMID:20857495 zinc atom increases expression ISO RGD:1344593 6480464 Zinc deficiency results in increased expression of F5 mRNA CTD PMID:22171008 zinc(0) increases expression ISO RGD:10557 6480464 Zinc deficiency results in increased expression of F5 mRNA CTD PMID:20857495 zinc(0) increases expression ISO RGD:1344593 6480464 Zinc deficiency results in increased expression of F5 mRNA CTD PMID:22171008
Gene-Chemical Interaction Annotations
