F5 (coagulation factor V) - Rat Genome Database

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Gene: F5 (coagulation factor V) Rattus norvegicus
Analyze
Symbol: F5
Name: coagulation factor V
RGD ID: 1589758
Description: Predicted to enable oxidoreductase activity. Involved in blood coagulation and response to vitamin K. Located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Used to study membranoproliferative glomerulonephritis. Biomarker of hepatitis and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal disease; factor V deficiency; liver disease (multiple); and non-arteritic anterior ischemic optic neuropathy. Orthologous to human F5 (coagulation factor V); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ac2-120; coagulation factor 5; coagulation factor 5 (mapped); coagulation factor V (proaccelerin, labile factor); F5_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21376,513,463 - 76,583,106 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,513,255 - 76,582,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,142,948 - 79,200,967 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01380,446,925 - 80,504,974 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01377,701,514 - 77,759,605 (+)NCBIRnor_WKY
Rnor_6.01382,479,997 - 82,535,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,479,998 - 82,535,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,355,980 - 87,417,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,934,956 - 79,997,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1376,256,969 - 76,316,731 (+)NCBICelera
Cytogenetic Map13q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
1q24 Deletion Syndrome  (ISO)
Acute Liver Failure  (ISO)
Behcet's disease  (ISO)
blood coagulation disease  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Budd-Chiari syndrome  (ISO)
cerebral infarction  (ISO)
Colonic Neoplasms  (IEP,ISO)
colorectal adenoma  (ISO)
COVID-19  (ISO)
Dysarthria  (ISO)
Dyspnea  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP)
Experimental Liver Cirrhosis  (IEP)
factor V deficiency  (ISO)
familial adenomatous polyposis  (ISO)
Femur Head Necrosis  (ISO)
Fetal Death  (ISO)
gastrointestinal stromal tumor  (ISO)
Habitual Abortions  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
hepatitis  (IEP,ISO)
Hereditary Thrombophilia  (ISO)
Hirschsprung's disease  (ISO)
hypereosinophilic syndrome  (ISO)
liver cirrhosis  (ISO)
membranoproliferative glomerulonephritis  (IMP)
Mesenteric Ischemia  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
parathyroid carcinoma  (ISO)
Peritoneal Fibrosis  (IEP)
portal hypertension  (IEP)
pre-eclampsia  (ISO)
prostate cancer  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
retinal artery occlusion  (ISO)
retinal vein occlusion  (ISO)
sagittal sinus thrombosis  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (IMP,ISO)
Septic Peritonitis  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (ISO)
Thromboembolism  (ISO)
thrombophilia due to activated protein C resistance  (ISO)
thrombophilia due to thrombin defect  (ISO)
thrombosis  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acenocoumarol  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspalathin  (ISO)
atorvastatin calcium  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chromium atom  (ISO)
chrysene  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clomiphene  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
Ethyl icosapentate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
glycidol  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP)
levonorgestrel  (ISO)
lithium chloride  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenprocoumon  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quinapril hydrochloride  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
warfarin  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Predictors of vascular access thrombosis among patients on the cadaveric renal transplantation waiting list. Akman B, etal., Transplant Proc. 2006 Mar;38(2):413-5.
2. Quercetin prevents oxidative stress in cirrhotic rats. Amalia PM, etal., Dig Dis Sci. 2007 Oct;52(10):2616-21. Epub 2007 Apr 12.
3. Increased prevalence of factor V Leiden in patients with retinal vein occlusion and under 60 years of age. Arsene S, etal., Thromb Haemost. 2005 Jul;94(1):101-6.
4. Disseminated intravascular coagulation in liver cirrhosis: fact or fiction? Ben-Ari Z, etal., Am J Gastroenterol. 1999 Oct;94(10):2977-82. doi: 10.1111/j.1572-0241.1999.01446.x.
5. Influence of the factor V Leiden mutation on infectious disease susceptibility and outcome: a population-based study. Benfield TL, etal., J Infect Dis. 2005 Nov 15;192(10):1851-7. Epub 2005 Oct 12.
6. Lack of association between inherited thrombophilic risk factors and idiopathic sudden sensorineural hearing loss in Italian patients. Cadoni G, etal., Ann Otol Rhinol Laryngol. 2006 Mar;115(3):195-200.
7. Genetic and acquired prothrombotic risk factors and sudden hearing loss. Capaccio P, etal., Laryngoscope. 2007 Mar;117(3):547-51.
8. Factor V Leiden: a disorder of factor V anticoagulant function. Castoldi E and Rosing J, Curr Opin Hematol. 2004 May;11(3):176-81.
9. Prevalence and association of the factor V Leiden and prothrombin G20210A in healthy subjects and patients with venous thromboembolism. Coen D, etal., Croat Med J. 2001 Aug;42(4):488-92.
10. Hyperhomocysteinaemia and factor V Leiden mutation are associated with Budd-Chiari syndrome. Colak Y, etal., Eur J Gastroenterol Hepatol. 2006 Aug;18(8):917-20.
11. Rat coagulation factor V purification and production of the monospecific antiserum. Cornillon B, etal., Comp Biochem Physiol B. 1986;83(2):397-401.
12. Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Cui J, etal., Blood. 2000 Dec 15;96(13):4222-6.
13. Coagulation factor V. Duga S, etal., Int J Biochem Cell Biol. 2004 Aug;36(8):1393-9.
14. Thrombophilia and avascular necrosis of femoral head in kidney allograft recipients. Ekmekci Y, etal., Nephrol Dial Transplant. 2006 Dec;21(12):3555-8. Epub 2006 Sep 12.
15. Association of factor V Leiden, Janus kinase 2, prothrombin, and MTHFR mutations with primary Budd-Chiari syndrome in Egyptian patients. El Sebay HM, etal., J Gastroenterol Hepatol. 2016 Jan;31(1):235-40. doi: 10.1111/jgh.13066.
16. Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery. Emiroglu O, etal., J Cardiothorac Surg. 2011 Sep 28;6:120.
17. Hypereosinophilic syndrome associated with heterozygous factor V gene mutation: an unusual combination resulting in an acute coronary syndrome and recurrent cerebral stroke-a case report. Engelmann MG, etal., Angiology. 2004 Mar-Apr;55(2):221-5.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Renal vascular sclerosis is associated with inherited thrombophilias. Goforth RL, etal., Kidney Int. 2006 Aug;70(4):743-50. Epub 2006 Jun 7.
20. The role of factor V Leiden and prothrombin G20210A mutations in sudden sensorineural hearing loss. Gorur K, etal., Otol Neurotol. 2005 Jul;26(4):599-601.
21. Incidence of factor V Leiden in patients with acute myocardial infarction. Gowda MS, etal., J Thromb Thrombolysis. 2000 Jan;9(1):43-5.
22. The relationship between the levels and function of endothelial progenitor cells and factor V Leiden and protein C deficiency in patients with primary Budd-Chiari syndrome. Guan ZY, etal., Eur Rev Med Pharmacol Sci. 2018 May;22(9):2742-2750. doi: 10.26355/eurrev_201805_14971.
23. Coagulation factor V gene mutation increases the risk of venous thrombosis in behcet's disease. Gul A, etal., Br J Rheumatol. 1996 Nov;35(11):1178-80.
24. Arterial thrombosis resulting in amputation in a child with poorly controlled type 1 diabetes and heterozygous Factor V Leiden mutation. Haller MJ, etal., Pediatr Diabetes. 2006 Aug;7(4):229-31.
25. Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: a multicenter study. Hefler L, etal., J Soc Gynecol Investig. 2004 Jan;11(1):42-4.
26. The factor V Leiden (R506Q) mutation and risk of thrombosis in renal transplant recipients. Irish AB, etal., Transplantation. 1997 Aug 27;64(4):604-7.
27. The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. Ivancic MM, etal., Cancer Prev Res (Phila). 2014 Nov;7(11):1160-9. doi: 10.1158/1940-6207.CAPR-14-0056. Epub 2014 Sep 8.
28. Conserved serum protein biomarkers associated with growing early colorectal adenomas. Ivancic MM, etal., Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8471-8480. doi: 10.1073/pnas.1813212116. Epub 2019 Apr 10.
29. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Juul K, etal., Ann Intern Med. 2004 Mar 2;140(5):330-7.
30. Factor V leiden homozygosity, dyspnea, and reduced pulmonary function. Juul K, etal., Arch Intern Med. 2005 Sep 26;165(17):2032-6.
31. Genetic risk factors for thrombosis in systemic lupus erythematosus. Kaiser R, etal., J Rheumatol. 2012 Aug;39(8):1603-10. Epub 2012 Jun 15.
32. Factor V Leiden and prothrombin 20210 A mutations in patients with central and branch retinal vein occlusion. Kalayci D, etal., Acta Ophthalmol Scand. 1999 Dec;77(6):622-4.
33. Survival advantage of heterozygous factor V Leiden carriers in murine sepsis. Kerschen E, etal., J Thromb Haemost. 2015 Jun;13(6):1073-80. doi: 10.1111/jth.12876. Epub 2015 Mar 31.
34. Thrombophilic disorders: a real threat to patients with end-stage renal disease on hemodialysis and at the time of renal transplantation. Klai S, etal., Blood Coagul Fibrinolysis. 2012 Jul;23(5):406-10.
35. Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. Laudes IJ, etal., Am J Pathol. 2002 May;160(5):1867-75.
36. Coagulation in the mesangial area promotes ECM accumulation through factor V expression in MsPGN in rats. Liu N, etal., Am J Physiol Renal Physiol. 2004 Oct;287(4):F612-20. Epub 2004 Jun 1.
37. Factor V Leiden mutation is a risk factor for cerebral venous thrombosis: a case-control study of 55 patients. Ludemann P, etal., Stroke. 1998 Dec;29(12):2507-10.
38. Prevalence of the factor V Leiden mutation in hepatic and portal vein thrombosis. Mahmoud AE, etal., Gut. 1997 Jun;40(6):798-800. doi: 10.1136/gut.40.6.798.
39. Biosynthesis of factor V by normal adult rat hepatocytes. Mazzorana M, etal., Thromb Res. 1989 Jun 15;54(6):655-75.
40. Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study. Mello G, etal., Hypertension. 2005 Dec;46(6):1270-4. Epub 2005 Oct 24.
41. Prevalence of resistance against activated protein C resulting from factor V Leiden is significantly increased in myocardial infarction: investigation of 507 patients with myocardial infarction. Middendorf K, etal., Am Heart J. 2004 May;147(5):897-904.
42. Activated protein C resistance in anterior ischaemic optic neuropathy. Nagy V, etal., Acta Ophthalmol Scand. 2004 Apr;82(2):140-3.
43. Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats. Nobukata H, etal., Toxicol Lett. 1999 Jan 11;104(1-2):93-101.
44. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
45. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
46. Rat coagulation factors V, VIII, XI, and XII: vitamin K dependent. Owen CA Jr and Bowie EJ, Haemostasis. 1978;7(4):189-201.
47. Coagulation factor V and VIII/V ratio as predictors of outcome in paracetamol induced fulminant hepatic failure: relation to other prognostic indicators. Pereira LM, etal., Gut. 1992 Jan;33(1):98-102. doi: 10.1136/gut.33.1.98.
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
50. Prothrombotic genetic risk factors are associated with an increased risk of liver fibrosis in the general population: The Rotterdam Study. Plompen EP, etal., J Hepatol. 2015 Dec;63(6):1459-65. doi: 10.1016/j.jhep.2015.07.026. Epub 2015 Jul 27.
51. GOA pipeline RGD automated data pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Comprehensive gene review and curation RGD comprehensive gene curation
55. Tissue factor and factor v involvement in rat peritoneal fibrosis. Saito H, etal., Perit Dial Int. 2009 May-Jun;29(3):340-51.
56. Prevalence of Hereditary Thrombophilia in Patients Older Than 75 Years With Venous Thromboembolism Referred for Thrombophilia Screening. Siguret V, etal., J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):977-81. doi: 10.1093/gerona/glu240. Epub 2015 Feb 9.
57. Factor V Leiden and prothrombin gene G20210A mutations in Italian patients with Behcet's disease and deep vein thrombosis. Silingardi M, etal., Arthritis Rheum. 2004 Apr 15;51(2):177-83.
58. Treatment of fulminant viral hepatic failure with prostaglandin E. A preliminary report. Sinclair SB and Levy GA, Dig Dis Sci. 1991 Jun;36(6):791-800. doi: 10.1007/bf01311239.
59. How it all starts: Initiation of the clotting cascade. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
60. Plasminogen activator inhibitor-1 4G/5G polymorphism, factor V Leiden, prothrombin mutations and the risk of VTE recurrence. Sundquist K, etal., Thromb Haemost. 2015 Nov 25;114(6):1156-64. doi: 10.1160/TH15-01-0031. Epub 2015 Aug 6.
61. Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study. Tinholt M, etal., BMC Cancer. 2014 Nov 19;14:845. doi: 10.1186/1471-2407-14-845.
62. Role of thrombotic risk factors in end-stage renal disease. Tripathi G, etal., Clin Appl Thromb Hemost. 2010 Apr;16(2):132-40. Epub 2009 Jun 10.
63. Portal hypertension and ascites in acute hepatitis: clinical, hemodynamic and histological correlations. Valla D, etal., Hepatology. 1989 Oct;10(4):482-7.
64. Coexistence of a novel homozygous nonsense mutation in exon 13 of the factor V gene with the homozygous Leiden mutation in two unrelated patients with severe factor V deficiency. van Wijk R, etal., Br J Haematol. 2001 Sep;114(4):871-4.
65. Factor V Leiden mutation is associated with ocular involvement in Behcet disease. Verity DH, etal., Am J Ophthalmol. 1999 Sep;128(3):352-6.
66. Role of factor V Leiden and prothrombin 20210A in patients with retinal artery occlusion. Weger M, etal., Eye. 2003 Aug;17(6):731-4.
67. Prothrombin and risk of venous thromboembolism, ischemic heart disease and ischemic cerebrovascular disease in the general population. Weischer M, etal., Atherosclerosis. 2010 Feb;208(2):480-3. Epub 2009 May 21.
68. Hereditary and acquired thrombotic risk factors for chronic thromboembolic pulmonary hypertension. Wong CL, etal., Blood Coagul Fibrinolysis. 2010 Apr;21(3):201-6.
69. Pulmonary fibrosis is increased in mice carrying the factor V Leiden mutation following bleomycin injury. Xu Z, etal., Thromb Haemost. 2001 Mar;85(3):441-4.
70. Preferential consumption of coagulation factors I, V, and VIII in rat endotoxemia. Yamaguchi K, etal., Shock. 2000 Nov;14(5):535-43.
71. [Detection of coagulation factor V in patients with severe hepatitis and its clinical significance]. Zou ZS, etal., Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003 Sep;17(3):274-6.
Additional References at PubMed
PMID:8900278   PMID:10669158   PMID:12816857   PMID:12855561   PMID:19946888   PMID:20664909   PMID:24769233   PMID:31904090  


Genomics

Comparative Map Data
F5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21376,513,463 - 76,583,106 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,513,255 - 76,582,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1379,142,948 - 79,200,967 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01380,446,925 - 80,504,974 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01377,701,514 - 77,759,605 (+)NCBIRnor_WKY
Rnor_6.01382,479,997 - 82,535,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,479,998 - 82,535,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,355,980 - 87,417,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,934,956 - 79,997,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1376,256,969 - 76,316,731 (+)NCBICelera
Cytogenetic Map13q23NCBI
F5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,511,951 - 169,586,481 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1169,511,951 - 169,586,588 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,481,189 - 169,555,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,747,816 - 167,822,393 (-)NCBINCBI36Build 36hg18NCBI36
Build 341166,215,066 - 166,287,379NCBI
Celera1142,590,970 - 142,665,548 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1140,703,881 - 140,778,453 (-)NCBIHuRef
CHM1_11170,903,222 - 170,977,927 (-)NCBICHM1_1
T2T-CHM13v2.01168,867,198 - 168,942,366 (-)NCBIT2T-CHM13v2.0
F5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,979,404 - 164,047,846 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1163,979,407 - 164,047,846 (+)EnsemblGRCm39 Ensembl
GRCm381164,151,835 - 164,220,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,151,838 - 164,220,277 (+)EnsemblGRCm38mm10GRCm38
MGSCv371166,081,990 - 166,150,405 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361165,988,633 - 166,056,215 (+)NCBIMGSCv36mm8
Celera1166,589,960 - 166,658,650 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.46NCBI
F5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554627,694,939 - 7,757,463 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554627,695,004 - 7,757,832 (+)NCBIChiLan1.0ChiLan1.0
F5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11148,718,748 - 148,791,049 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,718,897 - 148,790,915 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01144,996,757 - 145,070,046 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
F5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,999,481 - 29,069,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,999,512 - 29,069,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,531,164 - 28,601,084 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0728,801,509 - 28,871,406 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl728,801,237 - 28,871,399 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1728,649,506 - 28,719,863 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0728,685,240 - 28,755,563 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0728,922,027 - 28,992,360 (+)NCBIUU_Cfam_GSD_1.0
F5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,267,628 - 99,332,463 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648117,114,441 - 17,178,902 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,403,274 - 81,485,066 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1481,403,273 - 81,484,908 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2489,027,936 - 89,109,573 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,465,610 - 59,539,022 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2559,466,378 - 59,538,872 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605561,142,905 - 61,215,886 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248267,438,682 - 7,507,012 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248267,438,632 - 7,507,322 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F5
559 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:66
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000033157
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat

Markers in Region
AI173222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,580,791 - 76,580,882 (+)MAPPERmRatBN7.2
Rnor_6.01382,534,017 - 82,534,107NCBIRnor6.0
Rnor_5.01387,416,163 - 87,416,253UniSTSRnor5.0
RGSC_v3.41379,995,762 - 79,995,852UniSTSRGSC3.4
Celera1376,315,208 - 76,315,298UniSTS
Cytogenetic Map13q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 41 6 41 4 7 1
Low 2 38 16 13 1 1 59 28 27 11 1
Below cutoff 1 5 7 9 11 13 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000079872   ⟹   ENSRNOP00000070280
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,524,340 - 76,582,315 (+)Ensembl
Rnor_6.0 Ensembl1382,479,998 - 82,528,172 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080759   ⟹   ENSRNOP00000072800
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1376,513,255 - 76,582,317 (+)Ensembl
Rnor_6.0 Ensembl1382,496,022 - 82,535,534 (+)Ensembl
RefSeq Acc Id: NM_001047878   ⟹   NP_001041343
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21376,524,340 - 76,582,315 (+)NCBI
Rnor_6.01382,479,997 - 82,535,540 (+)NCBI
Rnor_5.01387,355,980 - 87,417,686 (+)NCBI
RGSC_v3.41379,934,956 - 79,997,285 (+)RGD
Celera1376,256,969 - 76,316,731 (+)RGD
Sequence:
RefSeq Acc Id: XM_039090783   ⟹   XP_038946711
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21376,513,463 - 76,583,106 (+)NCBI
RefSeq Acc Id: XM_039090784   ⟹   XP_038946712
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21376,524,094 - 76,583,106 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001041343 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946711 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946712 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP86265 (Get FASTA)   NCBI Sequence Viewer  
  EDM09360 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001041343   ⟸   NM_001047878
- UniProtKB: Q7TPK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072800   ⟸   ENSRNOT00000080759
RefSeq Acc Id: ENSRNOP00000070280   ⟸   ENSRNOT00000079872
RefSeq Acc Id: XP_038946711   ⟸   XM_039090783
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946712   ⟸   XM_039090784
- Peptide Label: isoform X2
Protein Domains
F5/8 type C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JXI1-F1-model_v2 AlphaFold A0A0G2JXI1 1-1833 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589758 AgrOrtholog
BioCyc Gene G2FUF-17601 BioCyc
Ensembl Genes ENSRNOG00000057855 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070280 ENTREZGENE
  ENSRNOP00000070280.2 UniProtKB/TrEMBL
  ENSRNOP00000072800 ENTREZGENE
  ENSRNOP00000072800.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079872 ENTREZGENE
  ENSRNOT00000079872.2 UniProtKB/TrEMBL
  ENSRNOT00000080759 ENTREZGENE
  ENSRNOT00000080759.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.420 UniProtKB/TrEMBL
InterPro Coagulation_fac_5/8-C_type_dom UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/TrEMBL
  Cu_oxidase_CS UniProtKB/TrEMBL
  Cupredoxin UniProtKB/TrEMBL
  Factor_5/8_like UniProtKB/TrEMBL
  Galactose-bd-like UniProtKB/TrEMBL
KEGG Report rno:304929 UniProtKB/TrEMBL
NCBI Gene 304929 ENTREZGENE
Pfam Cu-oxidase_3 UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/TrEMBL
PharmGKB F5 RGD
PhenoGen F5 PhenoGen
PIRSF Factors_V_VIII UniProtKB/TrEMBL
PROSITE FA58C_1 UniProtKB/TrEMBL
  FA58C_2 UniProtKB/TrEMBL
  FA58C_3 UniProtKB/TrEMBL
  MULTICOPPER_OXIDASE1 UniProtKB/TrEMBL
SMART FA58C UniProtKB/TrEMBL
Superfamily-SCOP Cupredoxin UniProtKB/TrEMBL
  Gal_bind_like UniProtKB/TrEMBL
UniProt A0A0G2K3W2_RAT UniProtKB/TrEMBL
  Q7TPK2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2JXI1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 F5  coagulation factor V  F5  coagulation factor V  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 F5  coagulation factor V  F5  coagulation factor V  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 F5  coagulation factor V  F5  coagulation factor V (proaccelerin, labile factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 F5  coagulation factor V (proaccelerin, labile factor)  F5  coagulation factor V  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 F5  coagulation factor V  F5  coagulation factor 5 (mapped)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-06 F5  coagulation factor 5 (mapped)  F5_mapped  coagulation factor 5 (mapped)  Data Merged 737654 PROVISIONAL
2006-11-19 F5  coagulation factor 5 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 F5_mapped  coagulation factor 5 (mapped)  F5  coagulation factor 5   Symbol and Name updated 1556543 APPROVED
2003-04-09 F5  coagulation factor 5     Coagulation factor V (proaccelerin, labile factor)  Name updated 629478 APPROVED
2002-06-10 F5  Coagulation factor V (proaccelerin, labile factor)      Symbol and Name status set to approved 70586 APPROVED