Nt5e (5' nucleotidase, ecto) - Rat Genome Database

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Gene: Nt5e (5' nucleotidase, ecto) Rattus norvegicus
Analyze
Symbol: Nt5e
Name: 5' nucleotidase, ecto
RGD ID: 61956
Description: Enables 5'-nucleotidase activity and ferrous iron binding activity. Involved in nucleobase-containing small molecule metabolic process; positive regulation of lipid biosynthetic process; and response to aluminum ion. Located in cell surface and synaptic membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto); PARTICIPATES IN hypoxia inducible factor pathway; monoterpenoid biosynthetic pathway; niacin metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5 nucleotidase; 5 nucleotidase ecto; 5' nucleotidase ecto; 5'-deoxynucleotidase; 5'-NT; 5'-nucleotidase; CD73; ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; MGC112615; Nt5; thymidylate 5'-phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8898,150,925 - 98,195,646 (+)NCBIGRCr8
GRCr8 Ensembl898,150,900 - 98,195,645 (+)EnsemblGRCr8 Ensembl
mRatBN7.2889,271,046 - 89,314,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl889,270,696 - 89,314,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx894,940,630 - 94,984,431 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0893,139,844 - 93,183,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0890,998,970 - 91,042,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0895,969,002 - 96,012,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl895,968,652 - 96,012,696 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0895,464,591 - 95,508,322 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4893,591,630 - 93,635,481 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera888,841,425 - 88,885,302 (+)NCBICelera
RGSC_v3.1893,610,734 - 93,654,911 (+)NCBI
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
adenosine  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antimycin A  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
betalain  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bucladesine  (ISO)
buspirone  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
homocysteine  (ISO)
hydrogen cyanide  (ISO)
indometacin  (EXP,ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP,ISO)
nitrites  (ISO)
Nivalenol  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
sodium dichromate  (EXP,ISO)
sotorasib  (ISO)
streptozocin  (ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
trametinib  (ISO)
trans-caffeic acid  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
withaferin A  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IDA)
cytosol  (IEA,ISO)
external side of plasma membrane  (IEA,ISO)
membrane  (IEA,ISO)
nucleoplasm  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO)
side of membrane  (IEA)
synaptic membrane  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Evidence for the involvement of cytosolic 5'-nucleotidase (cN-II) in the synthesis of guanine nucleotides from xanthosine. Barsotti C, etal., J Biol Chem. 2005 Apr 8;280(14):13465-9. Epub 2005 Feb 6.
2. The ecto-enzymes CD73 and adenosine deaminase modulate 5'-AMP-derived adenosine in myofibroblasts of the rat small intestine. Bin A, etal., Purinergic Signal. 2018 Dec;14(4):409-421. doi: 10.1007/s11302-018-9623-6. Epub 2018 Sep 29.
3. Dynamic changes in the expression pattern of ecto-5'-nucleotidase in the rat model of cortical stab injury. Bjelobaba I, etal., J Neurosci Res. 2011 Jun;89(6):862-73. doi: 10.1002/jnr.22599. Epub 2011 Feb 17.
4. Ontogenetic profile of ectonucleotidase activities from brain synaptosomes of pilocarpine-treated rats. de Paula Cognato G, etal., Int J Dev Neurosci. 2005 Dec;23(8):703-9. Epub 2005 Nov 4.
5. 5'-Nucleotidase activity increases in aging rat brain. Fuchs JL, Neurobiol Aging. 1991 Sep-Oct;12(5):523-30. doi: 10.1016/0197-4580(91)90083-v.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. The effect of aluminium on NTPDase and 5'-nucleotidase activities from rat synaptosomes and platelets. Kaizer RR, etal., Int J Dev Neurosci. 2007 Oct;25(6):381-6. Epub 2007 Jul 10.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Oxidative modification of rat liver 5'-nucleotidase: the mechanisms for protection and re-activation. Kocic G, etal., Arch Physiol Biochem 2001 Oct;109(4):323-30.
11. Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. Mackiewicz M, etal., J Neurochem. 2003 Apr;85(2):348-57.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Primary structure of rat liver 5'-nucleotidase deduced from the cDNA. Presence of the COOH-terminal hydrophobic domain for possible post-translational modification by glycophospholipid. Misumi Y, etal., J Biol Chem 1990 Feb 5;265(4):2178-83.
14. Upregulation of Lipid Synthesis in Small Rat Adipocytes by Microvesicle-Associated CD73 From Large Adipocytes. Muller G, etal., Obesity (Silver Spring). 2011 Mar 3.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Ectonucleotidase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of streptozotocin-induced diabetic rats and treated with resveratrol. Schmatz R, etal., Brain Res Bull. 2009 Dec 16;80(6):371-6. Epub 2009 Aug 31.
23. Subcellular localization and properties of 5'-nucleotidase in the rat liver. Song CS and Bodansky O, J Biol Chem. 1967 Feb 25;242(4):694-9.
24. Ontogenetic profile of ecto-5'-nucleotidase in rat brain synaptic plasma membranes. Stanojevic I, etal., Int J Dev Neurosci. 2011 Jun;29(4):397-403. Epub 2011 Mar 23.
25. Effect of In-Vitro Passaging on the Stem Cell-related Properties of Tendon-Derived Stem Cells (TDSCs) - Implication in Tissue Engineering. Tan Q, etal., Stem Cells Dev. 2011 Jun 1.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2129526   PMID:2148114   PMID:7595232   PMID:11375348   PMID:12477932   PMID:15149841   PMID:15202768   PMID:15307889   PMID:15543949   PMID:15763893   PMID:16480902   PMID:16547283  
PMID:16672190   PMID:16705150   PMID:16718378   PMID:17119848   PMID:17574764   PMID:17619122   PMID:17619139   PMID:18201730   PMID:18223197   PMID:18256932   PMID:18636315   PMID:19056867  
PMID:19169047   PMID:19463911   PMID:19524108   PMID:19581412   PMID:19893081   PMID:20359849   PMID:20458337   PMID:21362503   PMID:22045065   PMID:22899823   PMID:23300031   PMID:23533145  
PMID:24894822   PMID:25833166   PMID:25907806   PMID:26080748   PMID:26303492   PMID:26499073   PMID:26987957   PMID:27102210   PMID:27694000   PMID:28363952   PMID:28560821   PMID:28684854  
PMID:30117104   PMID:30507864   PMID:30913879   PMID:31220343   PMID:35352799   PMID:37646205   PMID:38545102  


Genomics

Comparative Map Data
Nt5e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8898,150,925 - 98,195,646 (+)NCBIGRCr8
GRCr8 Ensembl898,150,900 - 98,195,645 (+)EnsemblGRCr8 Ensembl
mRatBN7.2889,271,046 - 89,314,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl889,270,696 - 89,314,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx894,940,630 - 94,984,431 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0893,139,844 - 93,183,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0890,998,970 - 91,042,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0895,969,002 - 96,012,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl895,968,652 - 96,012,696 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0895,464,591 - 95,508,322 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4893,591,630 - 93,635,481 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera888,841,425 - 88,885,302 (+)NCBICelera
RGSC_v3.1893,610,734 - 93,654,911 (+)NCBI
Cytogenetic Map8q31NCBI
NT5E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38685,450,083 - 85,495,784 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl685,449,584 - 85,495,791 (+)EnsemblGRCh38hg38GRCh38
GRCh37686,159,801 - 86,205,502 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36686,216,528 - 86,262,215 (+)NCBINCBI36Build 36hg18NCBI36
Build 34686,216,527 - 86,262,215NCBI
Celera686,586,482 - 86,632,679 (+)NCBICelera
Cytogenetic Map6q14.3NCBI
HuRef683,383,590 - 83,429,793 (+)NCBIHuRef
CHM1_1686,257,244 - 86,303,451 (+)NCBICHM1_1
T2T-CHM13v2.0686,666,882 - 86,712,587 (+)NCBIT2T-CHM13v2.0
Nt5e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39988,209,662 - 88,254,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl988,209,250 - 88,254,145 (+)EnsemblGRCm39 Ensembl
GRCm38988,327,609 - 88,372,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl988,327,197 - 88,372,092 (+)EnsemblGRCm38mm10GRCm38
MGSCv37988,222,447 - 88,266,927 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36988,125,533 - 88,169,982 (+)NCBIMGSCv36mm8
Celera985,354,734 - 85,399,137 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map947.24NCBI
Nt5e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541112,891,236 - 12,948,406 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541112,891,236 - 12,946,324 (+)NCBIChiLan1.0ChiLan1.0
NT5E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25105,532,410 - 105,584,140 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16103,429,147 - 103,478,675 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0683,333,428 - 83,379,585 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1686,615,409 - 86,661,594 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl686,615,409 - 86,661,601 (+)Ensemblpanpan1.1panPan2
NT5E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11245,491,028 - 45,520,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1245,491,733 - 45,518,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1245,289,507 - 45,334,783 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01246,244,000 - 46,289,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1246,243,992 - 46,289,217 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11245,577,415 - 45,622,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01245,506,318 - 45,551,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01245,693,314 - 45,738,560 (+)NCBIUU_Cfam_GSD_1.0
Nt5e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494680,624,771 - 80,673,677 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365105,797,212 - 5,846,124 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365105,797,218 - 5,846,118 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NT5E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl154,400,810 - 54,448,742 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1154,400,786 - 54,450,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2160,831,831 - 60,881,527 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NT5E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11310,115,591 - 10,162,178 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1310,116,161 - 10,160,414 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040186,303,608 - 186,348,855 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nt5e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247998,765,711 - 8,845,778 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247998,766,608 - 8,845,296 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nt5e
249 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:318
Count of miRNA genes:216
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000015057
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH133920  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2889,314,499 - 89,314,714 (+)MAPPERmRatBN7.2
Rnor_6.0896,012,315 - 96,012,529NCBIRnor6.0
Rnor_5.0895,507,904 - 95,508,118UniSTSRnor5.0
RGSC_v3.4893,635,063 - 93,635,277UniSTSRGSC3.4
Celera888,884,884 - 88,885,098UniSTS
RH 3.4 Map81012.2UniSTS
Cytogenetic Map8q31UniSTS
RH144635  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2889,276,206 - 89,276,376 (+)MAPPERmRatBN7.2
Rnor_6.0895,974,163 - 95,974,332NCBIRnor6.0
Rnor_5.0895,469,752 - 95,469,921UniSTSRnor5.0
RGSC_v3.4893,596,791 - 93,596,960UniSTSRGSC3.4
Celera888,846,586 - 88,846,755UniSTS
RH 3.4 Map81020.8UniSTS
Cytogenetic Map8q31UniSTS
BF410734  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2889,272,455 - 89,272,557 (+)MAPPERmRatBN7.2
Rnor_6.0895,970,412 - 95,970,513NCBIRnor6.0
Rnor_5.0895,466,001 - 95,466,102UniSTSRnor5.0
RGSC_v3.4893,593,040 - 93,593,141UniSTSRGSC3.4
Celera888,842,835 - 88,842,936UniSTS
RH 3.4 Map81014.7UniSTS
Cytogenetic Map8q31UniSTS
BF399571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2889,308,091 - 89,308,252 (+)MAPPERmRatBN7.2
Rnor_6.0896,005,859 - 96,006,019NCBIRnor6.0
Rnor_5.0895,501,448 - 95,501,608UniSTSRnor5.0
RGSC_v3.4893,628,656 - 93,628,816UniSTSRGSC3.4
Celera888,878,476 - 88,878,636UniSTS
RH 3.4 Map81014.0UniSTS
Cytogenetic Map8q31UniSTS
Nt5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2889,312,610 - 89,312,737 (+)MAPPERmRatBN7.2
Rnor_6.0896,010,426 - 96,010,552NCBIRnor6.0
Rnor_5.0895,506,015 - 95,506,141UniSTSRnor5.0
RGSC_v3.4893,633,174 - 93,633,300UniSTSRGSC3.4
Celera888,882,995 - 88,883,121UniSTS
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015057   ⟹   ENSRNOP00000015057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl898,150,900 - 98,195,645 (+)Ensembl
mRatBN7.2 Ensembl889,270,696 - 89,314,881 (+)Ensembl
Rnor_6.0 Ensembl895,968,652 - 96,012,696 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107471   ⟹   ENSRNOP00000091985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl898,150,900 - 98,195,645 (+)Ensembl
mRatBN7.2 Ensembl889,270,696 - 89,314,881 (+)Ensembl
RefSeq Acc Id: NM_021576   ⟹   NP_067587
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8898,150,925 - 98,194,794 (+)NCBI
mRatBN7.2889,271,046 - 89,314,918 (+)NCBI
Rnor_6.0895,969,002 - 96,012,733 (+)NCBI
Rnor_5.0895,464,591 - 95,508,322 (+)NCBI
RGSC_v3.4893,591,630 - 93,635,481 (+)RGD
Celera888,841,425 - 88,885,302 (+)RGD
Sequence:
RefSeq Acc Id: XM_063266046   ⟹   XP_063122116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8898,151,643 - 98,195,646 (+)NCBI
RefSeq Acc Id: NP_067587   ⟸   NM_021576
- Peptide Label: precursor
- UniProtKB: P21588 (UniProtKB/Swiss-Prot),   Q66HL0 (UniProtKB/TrEMBL),   Q4G083 (UniProtKB/TrEMBL),   F7EWJ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015057   ⟸   ENSRNOT00000015057
Ensembl Acc Id: ENSRNOP00000091985   ⟸   ENSRNOT00000107471
RefSeq Acc Id: XP_063122116   ⟸   XM_063266046
- Peptide Label: isoform X1
- UniProtKB: P21588 (UniProtKB/Swiss-Prot)
Protein Domains
5'-Nucleotidase C-terminal   Calcineurin-like phosphoesterase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21588-F1-model_v2 AlphaFold P21588 1-576 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696167
Promoter ID:EPDNEW_R6692
Type:single initiation site
Name:Nt5e_2
Description:5' nucleotidase, ecto
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6693  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0895,968,630 - 95,968,690EPDNEW
RGD ID:13696168
Promoter ID:EPDNEW_R6693
Type:initiation region
Name:Nt5e_1
Description:5' nucleotidase, ecto
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6692  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0895,968,994 - 95,969,054EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61956 AgrOrtholog
BioCyc Gene G2FUF-29612 BioCyc
Ensembl Genes ENSRNOG00000011071 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015057 ENTREZGENE
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot
  3.90.780.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134340 IMAGE-MGC_LOAD
  IMAGE:7322840 IMAGE-MGC_LOAD
InterPro 5'-Nucleotdase_C UniProtKB/Swiss-Prot
  5'-Nucleotdase_C_sf UniProtKB/Swiss-Prot
  5'-Nucleotdase_CS UniProtKB/Swiss-Prot
  5_nucleotidase/apyrase UniProtKB/Swiss-Prot
  Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot
  Metallo-depent_PP-like UniProtKB/Swiss-Prot
MGC_CLONE MGC:112615 IMAGE-MGC_LOAD
  MGC:93467 IMAGE-MGC_LOAD
NCBI Gene 58813 ENTREZGENE
PANTHER 5'-NUCLEOTIDASE UniProtKB/Swiss-Prot
  PTHR11575 UniProtKB/Swiss-Prot
Pfam 5_nucleotid_C UniProtKB/Swiss-Prot
  Metallophos UniProtKB/Swiss-Prot
PharmGKB NT5E RGD
PhenoGen Nt5e PhenoGen
PRINTS APYRASEFAMLY UniProtKB/Swiss-Prot
PROSITE 5_NUCLEOTIDASE_1 UniProtKB/Swiss-Prot
  5_NUCLEOTIDASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011071 RatGTEx
Superfamily-SCOP SSF55816 UniProtKB/Swiss-Prot
  SSF56300 UniProtKB/Swiss-Prot
TIGR TC228515
UniProt 5NTD_RAT UniProtKB/Swiss-Prot
  A0A8I6AV15_RAT UniProtKB/TrEMBL
  A6I1X9_RAT UniProtKB/TrEMBL
  F7EWJ6 ENTREZGENE, UniProtKB/TrEMBL
  P21588 ENTREZGENE
  Q4G083 ENTREZGENE
  Q66HL0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Nt5e  5' nucleotidase, ecto  Nt5  5 nucleotidase  Name updated 1299863 APPROVED
2002-06-10 Nt5  5 nucleotidase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the plasma membrane  
gene_protein 63.965 kDa