Nt5e (5' nucleotidase, ecto) - Rat Genome Database

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Gene: Nt5e (5' nucleotidase, ecto) Rattus norvegicus
Analyze
Symbol: Nt5e
Name: 5' nucleotidase, ecto
RGD ID: 61956
Description: Enables 5'-nucleotidase activity and ferrous iron binding activity. Involved in nucleobase-containing small molecule metabolic process; positive regulation of lipid biosynthetic process; and response to aluminum ion. Located in cell surface and synaptic membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto); PARTICIPATES IN hypoxia inducible factor pathway; monoterpenoid biosynthetic pathway; niacin metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5 nucleotidase; 5 nucleotidase ecto; 5' nucleotidase ecto; 5'-deoxynucleotidase; 5'-NT; 5'-nucleotidase; CD73; ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; MGC112615; Nt5; thymidylate 5'-phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8898,150,925 - 98,195,646 (+)NCBIGRCr8
mRatBN7.2889,271,046 - 89,314,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl889,270,696 - 89,314,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx894,940,630 - 94,984,431 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0893,139,844 - 93,183,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0890,998,970 - 91,042,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0895,969,002 - 96,012,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl895,968,652 - 96,012,696 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0895,464,591 - 95,508,322 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4893,591,630 - 93,635,481 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1893,610,734 - 93,654,911 (+)NCBI
Celera888,841,425 - 88,885,302 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
adenosine  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antimycin A  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
betalain  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bucladesine  (ISO)
buspirone  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chloropicrin  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
homocysteine  (ISO)
hydrogen cyanide  (ISO)
indometacin  (EXP,ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP,ISO)
nitrites  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sotorasib  (ISO)
streptozocin  (ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP,ISO)
trametinib  (ISO)
trans-caffeic acid  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
withaferin A  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Evidence for the involvement of cytosolic 5'-nucleotidase (cN-II) in the synthesis of guanine nucleotides from xanthosine. Barsotti C, etal., J Biol Chem. 2005 Apr 8;280(14):13465-9. Epub 2005 Feb 6.
2. The ecto-enzymes CD73 and adenosine deaminase modulate 5'-AMP-derived adenosine in myofibroblasts of the rat small intestine. Bin A, etal., Purinergic Signal. 2018 Dec;14(4):409-421. doi: 10.1007/s11302-018-9623-6. Epub 2018 Sep 29.
3. Dynamic changes in the expression pattern of ecto-5'-nucleotidase in the rat model of cortical stab injury. Bjelobaba I, etal., J Neurosci Res. 2011 Jun;89(6):862-73. doi: 10.1002/jnr.22599. Epub 2011 Feb 17.
4. Ontogenetic profile of ectonucleotidase activities from brain synaptosomes of pilocarpine-treated rats. de Paula Cognato G, etal., Int J Dev Neurosci. 2005 Dec;23(8):703-9. Epub 2005 Nov 4.
5. 5'-Nucleotidase activity increases in aging rat brain. Fuchs JL, Neurobiol Aging. 1991 Sep-Oct;12(5):523-30. doi: 10.1016/0197-4580(91)90083-v.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. The effect of aluminium on NTPDase and 5'-nucleotidase activities from rat synaptosomes and platelets. Kaizer RR, etal., Int J Dev Neurosci. 2007 Oct;25(6):381-6. Epub 2007 Jul 10.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Oxidative modification of rat liver 5'-nucleotidase: the mechanisms for protection and re-activation. Kocic G, etal., Arch Physiol Biochem 2001 Oct;109(4):323-30.
11. Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. Mackiewicz M, etal., J Neurochem. 2003 Apr;85(2):348-57.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Primary structure of rat liver 5'-nucleotidase deduced from the cDNA. Presence of the COOH-terminal hydrophobic domain for possible post-translational modification by glycophospholipid. Misumi Y, etal., J Biol Chem 1990 Feb 5;265(4):2178-83.
14. Upregulation of Lipid Synthesis in Small Rat Adipocytes by Microvesicle-Associated CD73 From Large Adipocytes. Muller G, etal., Obesity (Silver Spring). 2011 Mar 3.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Ectonucleotidase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of streptozotocin-induced diabetic rats and treated with resveratrol. Schmatz R, etal., Brain Res Bull. 2009 Dec 16;80(6):371-6. Epub 2009 Aug 31.
23. Subcellular localization and properties of 5'-nucleotidase in the rat liver. Song CS and Bodansky O, J Biol Chem. 1967 Feb 25;242(4):694-9.
24. Ontogenetic profile of ecto-5'-nucleotidase in rat brain synaptic plasma membranes. Stanojevic I, etal., Int J Dev Neurosci. 2011 Jun;29(4):397-403. Epub 2011 Mar 23.
25. Effect of In-Vitro Passaging on the Stem Cell-related Properties of Tendon-Derived Stem Cells (TDSCs) - Implication in Tissue Engineering. Tan Q, etal., Stem Cells Dev. 2011 Jun 1.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2129526   PMID:2148114   PMID:7595232   PMID:11375348   PMID:12477932   PMID:15149841   PMID:15202768   PMID:15307889   PMID:15543949   PMID:15763893   PMID:16480902   PMID:16547283  
PMID:16672190   PMID:16705150   PMID:16718378   PMID:17119848   PMID:17574764   PMID:17619122   PMID:17619139   PMID:18201730   PMID:18223197   PMID:18256932   PMID:18636315   PMID:19056867  
PMID:19169047   PMID:19463911   PMID:19524108   PMID:19581412   PMID:19893081   PMID:20359849   PMID:20458337   PMID:21362503   PMID:22045065   PMID:22899823   PMID:23300031   PMID:23533145  
PMID:24894822   PMID:25833166   PMID:25907806   PMID:26080748   PMID:26303492   PMID:26499073   PMID:26987957   PMID:27102210   PMID:27694000   PMID:28363952   PMID:28560821   PMID:28684854  
PMID:30117104   PMID:30507864   PMID:30913879   PMID:31220343   PMID:35352799   PMID:37646205   PMID:38545102  


Genomics

Comparative Map Data
Nt5e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8898,150,925 - 98,195,646 (+)NCBIGRCr8
mRatBN7.2889,271,046 - 89,314,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl889,270,696 - 89,314,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx894,940,630 - 94,984,431 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0893,139,844 - 93,183,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0890,998,970 - 91,042,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0895,969,002 - 96,012,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl895,968,652 - 96,012,696 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0895,464,591 - 95,508,322 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4893,591,630 - 93,635,481 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1893,610,734 - 93,654,911 (+)NCBI
Celera888,841,425 - 88,885,302 (+)NCBICelera
Cytogenetic Map8q31NCBI
NT5E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38685,450,083 - 85,495,784 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl685,449,584 - 85,495,791 (+)EnsemblGRCh38hg38GRCh38
GRCh37686,159,801 - 86,205,502 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36686,216,528 - 86,262,215 (+)NCBINCBI36Build 36hg18NCBI36
Build 34686,216,527 - 86,262,215NCBI
Celera686,586,482 - 86,632,679 (+)NCBICelera
Cytogenetic Map6q14.3NCBI
HuRef683,383,590 - 83,429,793 (+)NCBIHuRef
CHM1_1686,257,244 - 86,303,451 (+)NCBICHM1_1
T2T-CHM13v2.0686,666,882 - 86,712,587 (+)NCBIT2T-CHM13v2.0
Nt5e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39988,209,662 - 88,254,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl988,209,250 - 88,254,145 (+)EnsemblGRCm39 Ensembl
GRCm38988,327,609 - 88,372,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl988,327,197 - 88,372,092 (+)EnsemblGRCm38mm10GRCm38
MGSCv37988,222,447 - 88,266,927 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36988,125,533 - 88,169,982 (+)NCBIMGSCv36mm8
Celera985,354,734 - 85,399,137 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map947.24NCBI
Nt5e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541112,891,236 - 12,948,406 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541112,891,236 - 12,946,324 (+)NCBIChiLan1.0ChiLan1.0
NT5E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25105,532,410 - 105,584,140 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16103,429,147 - 103,478,675 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0683,333,428 - 83,379,585 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1686,615,409 - 86,661,594 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl686,615,409 - 86,661,601 (+)Ensemblpanpan1.1panPan2
NT5E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11245,491,028 - 45,520,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1245,491,733 - 45,518,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1245,289,507 - 45,334,783 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01246,244,000 - 46,289,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1246,243,992 - 46,289,217 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11245,577,415 - 45,622,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01245,506,318 - 45,551,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01245,693,314 - 45,738,560 (+)NCBIUU_Cfam_GSD_1.0
Nt5e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494680,624,771 - 80,673,677 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365105,797,212 - 5,846,124 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365105,797,218 - 5,846,118 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NT5E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl154,400,810 - 54,448,742 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1154,400,786 - 54,450,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2160,831,831 - 60,881,527 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NT5E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11310,115,591 - 10,162,178 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1310,116,161 - 10,160,414 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040186,303,608 - 186,348,855 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nt5e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247998,765,711 - 8,845,778 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247998,766,608 - 8,845,296 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nt5e
252 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:318
Count of miRNA genes:216
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000015057
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat

Markers in Region
RH133920  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2889,314,499 - 89,314,714 (+)MAPPERmRatBN7.2
Rnor_6.0896,012,315 - 96,012,529NCBIRnor6.0
Rnor_5.0895,507,904 - 95,508,118UniSTSRnor5.0
RGSC_v3.4893,635,063 - 93,635,277UniSTSRGSC3.4
Celera888,884,884 - 88,885,098UniSTS
RH 3.4 Map81012.2UniSTS
Cytogenetic Map8q31UniSTS
RH144635  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2889,276,206 - 89,276,376 (+)MAPPERmRatBN7.2
Rnor_6.0895,974,163 - 95,974,332NCBIRnor6.0
Rnor_5.0895,469,752 - 95,469,921UniSTSRnor5.0
RGSC_v3.4893,596,791 - 93,596,960UniSTSRGSC3.4
Celera888,846,586 - 88,846,755UniSTS
RH 3.4 Map81020.8UniSTS
Cytogenetic Map8q31UniSTS
BF410734  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2889,272,455 - 89,272,557 (+)MAPPERmRatBN7.2
Rnor_6.0895,970,412 - 95,970,513NCBIRnor6.0
Rnor_5.0895,466,001 - 95,466,102UniSTSRnor5.0
RGSC_v3.4893,593,040 - 93,593,141UniSTSRGSC3.4
Celera888,842,835 - 88,842,936UniSTS
RH 3.4 Map81014.7UniSTS
Cytogenetic Map8q31UniSTS
BF399571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2889,308,091 - 89,308,252 (+)MAPPERmRatBN7.2
Rnor_6.0896,005,859 - 96,006,019NCBIRnor6.0
Rnor_5.0895,501,448 - 95,501,608UniSTSRnor5.0
RGSC_v3.4893,628,656 - 93,628,816UniSTSRGSC3.4
Celera888,878,476 - 88,878,636UniSTS
RH 3.4 Map81014.0UniSTS
Cytogenetic Map8q31UniSTS
Nt5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2889,312,610 - 89,312,737 (+)MAPPERmRatBN7.2
Rnor_6.0896,010,426 - 96,010,552NCBIRnor6.0
Rnor_5.0895,506,015 - 95,506,141UniSTSRnor5.0
RGSC_v3.4893,633,174 - 93,633,300UniSTSRGSC3.4
Celera888,882,995 - 88,883,121UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 40 25 19 25 11 21 23 11
Low 1 17 17 16 16 8 11 41 14 18 8
Below cutoff 22

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015057   ⟹   ENSRNOP00000015057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl889,270,696 - 89,314,881 (+)Ensembl
Rnor_6.0 Ensembl895,968,652 - 96,012,696 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107471   ⟹   ENSRNOP00000091985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl889,270,696 - 89,314,881 (+)Ensembl
RefSeq Acc Id: NM_021576   ⟹   NP_067587
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8898,150,925 - 98,194,794 (+)NCBI
mRatBN7.2889,271,046 - 89,314,918 (+)NCBI
Rnor_6.0895,969,002 - 96,012,733 (+)NCBI
Rnor_5.0895,464,591 - 95,508,322 (+)NCBI
RGSC_v3.4893,591,630 - 93,635,481 (+)RGD
Celera888,841,425 - 88,885,302 (+)RGD
Sequence:
RefSeq Acc Id: XM_063266046   ⟹   XP_063122116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8898,151,643 - 98,195,646 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_067587   ⟸   NM_021576
- Peptide Label: precursor
- UniProtKB: P21588 (UniProtKB/Swiss-Prot),   Q66HL0 (UniProtKB/TrEMBL),   Q4G083 (UniProtKB/TrEMBL),   F7EWJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015057   ⟸   ENSRNOT00000015057
RefSeq Acc Id: ENSRNOP00000091985   ⟸   ENSRNOT00000107471
RefSeq Acc Id: XP_063122116   ⟸   XM_063266046
- Peptide Label: isoform X1
Protein Domains
5'-Nucleotidase C-terminal   Calcineurin-like phosphoesterase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21588-F1-model_v2 AlphaFold P21588 1-576 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696167
Promoter ID:EPDNEW_R6692
Type:single initiation site
Name:Nt5e_2
Description:5' nucleotidase, ecto
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6693  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0895,968,630 - 95,968,690EPDNEW
RGD ID:13696168
Promoter ID:EPDNEW_R6693
Type:initiation region
Name:Nt5e_1
Description:5' nucleotidase, ecto
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6692  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0895,968,994 - 95,969,054EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61956 AgrOrtholog
BioCyc Gene G2FUF-29612 BioCyc
Ensembl Genes ENSRNOG00000011071 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015057 ENTREZGENE
  ENSRNOT00000015057.7 UniProtKB/TrEMBL
  ENSRNOT00000107471.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.780.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134340 IMAGE-MGC_LOAD
  IMAGE:7322840 IMAGE-MGC_LOAD
InterPro 5'-Nucleotdase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5'-Nucleotdase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5'-Nucleotdase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5_nucleotidase/apyrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58813 UniProtKB/TrEMBL
MGC_CLONE MGC:112615 IMAGE-MGC_LOAD
  MGC:93467 IMAGE-MGC_LOAD
NCBI Gene 58813 ENTREZGENE
PANTHER 5'-NUCLEOTIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11575 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 5_nucleotid_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NT5E RGD
PhenoGen Nt5e PhenoGen
PRINTS APYRASEFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 5_NUCLEOTIDASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5_NUCLEOTIDASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011071 RatGTEx
Superfamily-SCOP SSF55816 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228515
UniProt 5NTD_RAT UniProtKB/Swiss-Prot
  A0A8I6AV15_RAT UniProtKB/TrEMBL
  A6I1X9_RAT UniProtKB/TrEMBL
  F7EWJ6 ENTREZGENE, UniProtKB/TrEMBL
  P21588 ENTREZGENE
  Q4G083 ENTREZGENE
  Q66HL0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q4G083 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Nt5e  5' nucleotidase, ecto  Nt5  5 nucleotidase  Name updated 1299863 APPROVED
2002-06-10 Nt5  5 nucleotidase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the plasma membrane  
gene_protein 63.965 kDa