NT5E (5'-nucleotidase ecto) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: NT5E (5'-nucleotidase ecto) Canis lupus familiaris
Analyze
Symbol: NT5E
Name: 5'-nucleotidase ecto
RGD ID: 12082040
Description: ENCODES a protein that exhibits 5'-nucleotidase activity (ortholog); ferrous iron binding (ortholog); INVOLVED IN adenosine biosynthetic process (ortholog); adenosine metabolic process (ortholog); AMP catabolic process (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH Brain Injuries (ortholog); Disease Progression (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH carvedilol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 5'-nucleotidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11245,491,028 - 45,520,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1245,491,733 - 45,518,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1245,289,507 - 45,334,783 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01246,244,000 - 46,289,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1246,243,992 - 46,289,217 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11245,577,415 - 45,622,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01245,506,318 - 45,551,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01245,693,314 - 45,738,560 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
carvedilol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NT5E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11245,491,028 - 45,520,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1245,491,733 - 45,518,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1245,289,507 - 45,334,783 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01246,244,000 - 46,289,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1246,243,992 - 46,289,217 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11245,577,415 - 45,622,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01245,506,318 - 45,551,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01245,693,314 - 45,738,560 (+)NCBIUU_Cfam_GSD_1.0
NT5E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38685,450,083 - 85,495,784 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl685,449,584 - 85,495,791 (+)EnsemblGRCh38hg38GRCh38
GRCh37686,159,801 - 86,205,502 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36686,216,528 - 86,262,215 (+)NCBINCBI36Build 36hg18NCBI36
Build 34686,216,527 - 86,262,215NCBI
Celera686,586,482 - 86,632,679 (+)NCBICelera
Cytogenetic Map6q14.3NCBI
HuRef683,383,590 - 83,429,793 (+)NCBIHuRef
CHM1_1686,257,244 - 86,303,451 (+)NCBICHM1_1
T2T-CHM13v2.0686,666,882 - 86,712,587 (+)NCBIT2T-CHM13v2.0
Nt5e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39988,209,662 - 88,254,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl988,209,250 - 88,254,145 (+)EnsemblGRCm39 Ensembl
GRCm38988,327,609 - 88,372,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl988,327,197 - 88,372,092 (+)EnsemblGRCm38mm10GRCm38
MGSCv37988,222,447 - 88,266,927 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36988,125,533 - 88,169,982 (+)NCBIMGSCv36mm8
Celera985,354,734 - 85,399,137 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map947.24NCBI
Nt5e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8898,150,925 - 98,195,646 (+)NCBIGRCr8
mRatBN7.2889,271,046 - 89,314,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl889,270,696 - 89,314,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx894,940,630 - 94,984,431 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0893,139,844 - 93,183,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0890,998,970 - 91,042,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0895,969,002 - 96,012,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl895,968,652 - 96,012,696 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0895,464,591 - 95,508,322 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4893,591,630 - 93,635,481 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1893,610,734 - 93,654,911 (+)NCBI
Celera888,841,425 - 88,885,302 (+)NCBICelera
Cytogenetic Map8q31NCBI
Nt5e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541112,891,236 - 12,948,406 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541112,891,236 - 12,946,324 (+)NCBIChiLan1.0ChiLan1.0
NT5E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25105,532,410 - 105,584,140 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16103,429,147 - 103,478,675 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0683,333,428 - 83,379,585 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1686,615,409 - 86,661,594 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl686,615,409 - 86,661,601 (+)Ensemblpanpan1.1panPan2
Nt5e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494680,624,771 - 80,673,677 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365105,797,212 - 5,846,124 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365105,797,218 - 5,846,118 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NT5E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl154,400,810 - 54,448,742 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1154,400,786 - 54,450,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2160,831,831 - 60,881,527 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NT5E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11310,115,591 - 10,162,178 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1310,116,161 - 10,160,414 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040186,303,608 - 186,348,855 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nt5e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247998,765,711 - 8,845,778 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247998,766,608 - 8,845,296 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NT5E
361 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000004810   ⟹   ENSCAFP00000004456
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1245,491,733 - 45,518,405 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845023054   ⟹   ENSCAFP00845018086
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1246,243,992 - 46,289,217 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845023147   ⟹   ENSCAFP00845018148
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1246,243,992 - 46,289,217 (+)Ensembl
RefSeq Acc Id: XM_038492362   ⟹   XP_038348290
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11245,577,415 - 45,622,655 (+)NCBI
RefSeq Acc Id: XM_038554649   ⟹   XP_038410577
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01245,693,314 - 45,738,560 (+)NCBI
RefSeq Acc Id: XM_038618522   ⟹   XP_038474450
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01245,506,318 - 45,551,536 (+)NCBI
RefSeq Acc Id: XM_038675165   ⟹   XP_038531093
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1245,289,507 - 45,334,783 (+)NCBI
RefSeq Acc Id: XM_038684083   ⟹   XP_038540011
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01246,244,000 - 46,289,219 (+)NCBI
Ensembl Acc Id: ENSCAFP00000004456   ⟸   ENSCAFT00000004810
RefSeq Acc Id: XP_038348290   ⟸   XM_038492362
RefSeq Acc Id: XP_038474450   ⟸   XM_038618522
RefSeq Acc Id: XP_038540011   ⟸   XM_038684083
- UniProtKB: A0A8C0NBJ4 (UniProtKB/TrEMBL),   A0A8I3NIC2 (UniProtKB/TrEMBL),   A0A8C0KT91 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038531093   ⟸   XM_038675165
- UniProtKB: A0A8C0NBJ4 (UniProtKB/TrEMBL),   A0A8I3NIC2 (UniProtKB/TrEMBL),   A0A8C0KT91 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038410577   ⟸   XM_038554649
- UniProtKB: A0A8C0KT91 (UniProtKB/TrEMBL),   A0A8C0NBJ4 (UniProtKB/TrEMBL),   A0A8I3NIC2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845018086   ⟸   ENSCAFT00845023054
Ensembl Acc Id: ENSCAFP00845018148   ⟸   ENSCAFT00845023147
Protein Domains
5'-Nucleotidase C-terminal   Calcineurin-like phosphoesterase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002994 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015025 UniProtKB/TrEMBL
  ENSCAFG00040007790 UniProtKB/TrEMBL
  ENSCAFG00845012948 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004810.5 UniProtKB/TrEMBL
  ENSCAFT00000107397.1 UniProtKB/TrEMBL
  ENSCAFT00030027768.1 UniProtKB/TrEMBL
  ENSCAFT00030027817.1 UniProtKB/TrEMBL
  ENSCAFT00030027890.1 UniProtKB/TrEMBL
  ENSCAFT00030027990.1 UniProtKB/TrEMBL
  ENSCAFT00030028057.1 UniProtKB/TrEMBL
  ENSCAFT00030028097.1 UniProtKB/TrEMBL
  ENSCAFT00030028151.1 UniProtKB/TrEMBL
  ENSCAFT00040014490.1 UniProtKB/TrEMBL
  ENSCAFT00040014525.1 UniProtKB/TrEMBL
  ENSCAFT00040014564.1 UniProtKB/TrEMBL
  ENSCAFT00845023054 ENTREZGENE
  ENSCAFT00845023054.1 UniProtKB/TrEMBL
  ENSCAFT00845023147.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/TrEMBL
  3.90.780.10 UniProtKB/TrEMBL
InterPro 5'-Nucleotdase_C UniProtKB/TrEMBL
  5'-Nucleotdase_C_sf UniProtKB/TrEMBL
  5'-Nucleotdase_CS UniProtKB/TrEMBL
  5_nucleotidase/apyrase UniProtKB/TrEMBL
  Calcineurin-like_PHP_ApaH UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/TrEMBL
NCBI Gene NT5E ENTREZGENE
PANTHER 5'-NUCLEOTIDASE UniProtKB/TrEMBL
  PTHR11575 UniProtKB/TrEMBL
Pfam 5_nucleotid_C UniProtKB/TrEMBL
  Metallophos UniProtKB/TrEMBL
PRINTS APYRASEFAMLY UniProtKB/TrEMBL
PROSITE 5_NUCLEOTIDASE_1 UniProtKB/TrEMBL
  5_NUCLEOTIDASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55816 UniProtKB/TrEMBL
  SSF56300 UniProtKB/TrEMBL
UniProt A0A8C0KT91 ENTREZGENE
  A0A8C0NB61_CANLF UniProtKB/TrEMBL
  A0A8C0NBB2_CANLF UniProtKB/TrEMBL
  A0A8C0NBJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NG09_CANLF UniProtKB/TrEMBL
  A0A8C0NG45_CANLF UniProtKB/TrEMBL
  A0A8C0NGQ0_CANLF UniProtKB/TrEMBL
  A0A8C0NHC3_CANLF UniProtKB/TrEMBL
  A0A8I3NEG1_CANLF UniProtKB/TrEMBL
  A0A8I3NIC2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44000 ENTREZGENE