Ugt2b (UDP glycosyltransferase 2 family, polypeptide B)

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Gene: Ugt2b (UDP glycosyltransferase 2 family, polypeptide B) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Ugt2b

Name:

UDP glycosyltransferase 2 family, polypeptide B

RGD ID:

3936

Description:

ENCODES a protein that exhibits glucuronosyltransferase activity; PARTICIPATES IN ascorbate and aldarate metabolic pathway; O-linked glycan biosynthetic pathway; pentose and glucuronate interconversion pathway; ASSOCIATED WITH Experimental Liver Cirrhosis; FOUND IN endoplasmic reticulum membrane (inferred); integral component of membrane (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,4,7,8-Pentachlorodibenzofuran

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

3-hydroxyandrogen specific; 3-hydroxyandrogen-specific UDPGT; Androsterone UDP-glucuronosyltransferase; LOC688226; RLUG23; UDP glucuronosyltransferase; UDP-glucuronosyltransferase 2B2; UDPGT 2B2; UDPGTr-4; Ugt2b2

RGD Orthologs

Alliance Genes

More Info

homologs ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	20,630,572 - 20,665,062 (+)	NCBI
Rnor_6.0 Ensembl	14	22,375,955 - 22,534,720 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	22,323,542 - 22,344,064 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	22,154,370 - 22,178,222 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	14	22,066,518 - 22,177,852 (+)	NCBI
Cytogenetic Map	14	p22-p21.2	NCBI

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (EXP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

2,3,4,7,8-Pentachlorodibenzofuran (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4,5,3',4',5'-Hexachlorobiphenyl (EXP)

3alpha-hydroxy-5beta-androstan-17-one (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (EXP)

9-cis-retinoic acid (EXP)

acetamide (EXP)

all-trans-retinoic acid (EXP)

alpha-hexachlorocyclohexane (EXP)

androsterone (EXP)

beta-naphthoflavone (EXP)

bexarotene (EXP)

bisphenol A (EXP)

clofibrate (EXP)

coumarin (EXP)

decabromodiphenyl ether (EXP)

dexamethasone (EXP)

Diallyl sulfide (EXP)

glutathione (EXP)

indole-3-methanol (EXP)

indometacin (EXP)

lithocholic acid (EXP)

N-nitrosodimethylamine (EXP)

perfluorooctanoic acid (EXP)

phenobarbital (EXP)

pirinixic acid (EXP)

propranolol (EXP)

tauroursodeoxycholic acid (EXP)

tetrachloromethane (EXP)

troglitazone (EXP)

vitamin E (EXP)

zearalenone (EXP)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

endoplasmic reticulum membrane (IEA)

integral component of membrane (IEA)

intracellular membrane-bounded organelle (IBA)

Molecular Function

glucuronosyltransferase activity (IDA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ascorbate and aldarate metabolic pathway (IEA)

O-linked glycan biosynthetic pathway (IEA)

pentose and glucuronate interconversion pathway (IEA)

phase I biotransformation pathway via cytochrome P450 (IEA)

porphyrin and chlorophyll metabolic pathway (IEA)

retinol metabolic pathway (IEA)

starch and sucrose metabolic pathway (IEA)

steroid hormone biosynthetic pathway (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Jackson MR and Burchell B, Nucleic Acids Res 1986 Jan 24;14(2):779-95.
3.	KEGG
4.	Mackenzie PI J Biol Chem 1986 Oct 25;261(30):14112-7.
5.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Pipeline to import KEGG annotations from KEGG into RGD
7.	RGD automated data pipeline
8.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1909872	PMID:7492328	PMID:12477932	PMID:17435758	PMID:23230277

Genomics

Position Markers

RH127922

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	14	22,157,582 - 22,157,799	NCBI	Rnor6.0
Rnor_6.0	14	22,438,390 - 22,438,607	NCBI	Rnor6.0
Rnor_5.0	14	22,344,386 - 22,344,603	UniSTS	Rnor5.0
Rnor_5.0	14	22,071,655 - 22,071,872	UniSTS	Rnor5.0
RGSC_v3.4	14	22,179,529 - 22,179,746	UniSTS	RGSC3.4
RGSC_v3.4	14	22,178,177 - 22,179,746	UniSTS	RGSC3.4
Cytogenetic Map	14	p22-p21.2	UniSTS

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	46
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000052369
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC089792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ351215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EX489691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ102904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ240959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J02589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M74439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X03478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_031533 ⟹ NP_113721

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	20,630,591 - 20,651,409 (+)	NCBI
Rnor_5.0	14	22,323,542 - 22,344,064 (+)	NCBI
RGSC_v3.4	14	22,154,370 - 22,178,222 (+)	RGD

Sequence:

show sequence

ACACACTGTGACCAGAAGGACTTTGATGTTCAAAATGCCCAGAAAGTGGATTTCTGCTCTGTTC
CTGCTACAGATAAGTTACTGTTTCAAATCTGGGCACTGTGGGAAGGTGTTGGTGTGGCCGATGG
ACTTTAGTCACTGGATGAATATAAAAATAATCCTTGATGAACTTGTACAGAGGGGCCATGAGGT
CACTGTTCTGAAACCTTCGGCTTACTTTTTTCTTGATCCGAAAAAATCGTCTGACCTTAAGTTT
GAAATTTTTCCTACATCTATCAGTAAAGATGAGCTGCAAAATCATTTCATAAAACTTTTGGATG
TGTGGACTTATGAGTTGCCAAGAGATACATGTTTGTCATATTCTCCTATCCTTCAAAATCTAGT
TTATGAATTTTCTTATTTTTATCTAAGTATTTGTAAAGACGCTGTTTCAAACAAGCAGCTCATG
ACAAAACTACAGGAATCCAAGTTTGATGTTCTTTTCGCAGATCCTGTGGCTTCCTGTGGGGATC
TGATAGCTGAACTGCTCCACATTCCTTTTCTGTACAGTCTTAGCTTCTCTCCAGGCCACAAACT
TGAAAAGTCCATTGGAAAATTTATACTCCCTCCATCTTATGTGCCTGTAATTTTGTCGGGACTG
GCTGGCAAAATGACATTCATAGACAGGGTAAAAAATATGATATGTATGCTTTATTTCGACTTTT
GGTTCGAGAGACTTAGACACAAGGAATGGGACACATTTTACAGTGAGATTTTGGGAAGGCCCAC
CACCGTAGATGAGACAATGAGCAAAGTAGAAATATGGCTTATTAGATCCTATTGGGATTTGAAA
TTTCCCCACCCAACATTACCAAATGTTGACTATATTGGAGGACTCCATTGCAAACCTGCTAAAC
CCTTGCCTAAGGATATGGAAGAATTTGTCCAGAGCTCTGGAGAGCACGGTGTGGTGGTGTTTTC
TCTGGGGTCAATGGTCAGCAACATGACAGAAGAAAAGGCCAACGCAATTGCATGGGCCCTTGCC
CAGATTCCACAAAAGGTTCTTTGGAAATTTGATGGCAAAACCCCAGCAACATTAGGACCCAATA
CCAGAGTCTACAAGTGGCTCCCGCAGAATGACATCCTGGGTCACCCAAAAACCAAAGCCTTTGT
AACTCATGGTGGAGCCAATGGCCTCTATGAGGCAATCTATCATGGAATCCCTATGATTGGCATT
CCTCTGTTTGGAGATCAACCTGATAATATTGCCCACATGGTGGCCAAAGGAGCAGCTGTTTCAT
TGAATATCAGGACAATGTCAAAGTTAGATTTTCTCAGTGCACTGGAGGAAGTCATAGACAATCC
GTTCTATAAAAAAAATGTTATGTTGTTGTCAACCATTCACCATGACCAGCCTATGAAGCCCCTG
GACAGAGCTGTCTTCTGGATTGAGTTTATCATGCGCCACAAAGGGGCCAAGCACCTGAGACCAC
TTGGACATAACCTTCCCTGGTACCAGTACCACTCTCTGGATGTGATTGGATTCCTGCTCACCTG
TTTTGCAGTCATTGCAGCTCTTACTGTAAAATGTCTCTTGTTCATGTACCGATTCTTTGTAAAG
AAGGAAAAGAAAATGAAGAATGAGTAGAGCTCATTGACAATGCACTACAGAAATGAAATTTCAG
CGACATTCTAATTTATGAACCACCTTCTAAAAATTACTAATTTTTTATCAAGGTAGATAACCTT
TGTAGGAAGACATATAACTCCGTGAATACTGATATGTACTCAAAAATCCATCATTTTTAAATTT
TAAAACCACTTAATGTAAAAGTTACATTGTAGAAAAATGTGCAGAATAAAATTATTCTTGATAG
AGTCCAAATAATCAAAGTATTAACCTTAAAATATTTGAATAGTGTCCATTAGCTTCTTTGTCTA
ATACTGAATCTGTAGCTTTCATACAATAAAATGTAGATAACTTGTACACGATAAA

hide sequence

RefSeq Acc Id:

XM_039091621 ⟹ XP_038947549

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	20,630,572 - 20,665,062 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_113721	(Get FASTA)	NCBI Sequence Viewer
	XP_038947549	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA42314	(Get FASTA)	NCBI Sequence Viewer
	AAH89792	(Get FASTA)	NCBI Sequence Viewer
	AAM51149	(Get FASTA)	NCBI Sequence Viewer
	ABC71921	(Get FASTA)	NCBI Sequence Viewer
	CAA27198	(Get FASTA)	NCBI Sequence Viewer
	P08541	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_113721 ⟸ NM_031533

- Peptide Label:

precursor

- Sequence:

show sequence

MPRKWISALFLLQISYCFKSGHCGKVLVWPMDFSHWMNIKIILDELVQRGHEVTVLKPSAYFFL
DPKKSSDLKFEIFPTSISKDELQNHFIKLLDVWTYELPRDTCLSYSPILQNLVYEFSYFYLSIC
KDAVSNKQLMTKLQESKFDVLFADPVASCGDLIAELLHIPFLYSLSFSPGHKLEKSIGKFILPP
SYVPVILSGLAGKMTFIDRVKNMICMLYFDFWFERLRHKEWDTFYSEILGRPTTVDETMSKVEI
WLIRSYWDLKFPHPTLPNVDYIGGLHCKPAKPLPKDMEEFVQSSGEHGVVVFSLGSMVSNMTEE
KANAIAWALAQIPQKVLWKFDGKTPATLGPNTRVYKWLPQNDILGHPKTKAFVTHGGANGLYEA
IYHGIPMIGIPLFGDQPDNIAHMVAKGAAVSLNIRTMSKLDFLSALEEVIDNPFYKKNVMLLST
IHHDQPMKPLDRAVFWIEFIMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCFAVIAALTVKC
LLFMYRFFVKKEKKMKNE

hide sequence

RefSeq Acc Id:	XP_038947549 ⟸ XM_039091621
- Peptide Label:	isoform X1

Protein Domains

UDPGT

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
14	22323705	22323706	G	T	snv	Crl:SD (UDEL)
14	22323800	22323801	A	C	snv	SBH/Ygl (MCW), FHL/EurMcwi (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), COP/CrCrl (MCW & UW), SDLEF7/Barth (UDEL), Crl:SD (UDEL)
14	22324124	22324125	G	T	snv	LE/Stm (KyushuU)
14	22342303	22342304	A	T	snv	LEC/Tj (KyushuU), BUF/MNa (KyushuU), Crl:SD (UDEL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSRNOG00000046540	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000043239	UniProtKB/TrEMBL
	ENSRNOP00000063270	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000052369	UniProtKB/TrEMBL
	ENSRNOT00000063915	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7370057	IMAGE-MGC_LOAD
InterPro	UDP_glucos_trans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UDP_glycos_trans_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24862	UniProtKB/TrEMBL
MGC_CLONE	MGC:108656	IMAGE-MGC_LOAD
NCBI Gene	24862	ENTREZGENE
Pfam	UDPGT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ugt2b	PhenoGen
PROSITE	UDPGT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A1XF83_RAT	UniProtKB/TrEMBL
	F1LM22_RAT	UniProtKB/TrEMBL
	F1M3E3_RAT	UniProtKB/TrEMBL
	P08541	ENTREZGENE
	Q5EBC8_RAT	UniProtKB/TrEMBL
	UD2B2_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-03-29	Ugt2b	UDP glycosyltransferase 2 family, polypeptide B	LOC688226	similar to UDP-glucuronosyltransferase 2B2 precursor (UDPGT) (3-hydroxyandrogen specific) (UDPGTr-4) (RLUG23)	Data Merged	737654	PROVISIONAL
2006-11-20	LOC688226	similar to UDP-glucuronosyltransferase 2B2 precursor (UDPGT) (3-hydroxyandrogen specific) (UDPGTr-4) (RLUG23)			Symbol and Name status set to provisional	70820	PROVISIONAL
2003-04-09	Ugt2b	UDP glycosyltransferase 2 family, polypeptide B	Ugt2b2	Androsterone UDP-glucuronosyltransferase	Symbol and Name updated	629477	APPROVED
2002-06-10	Ugt2b2	Androsterone UDP-glucuronosyltransferase			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)