(+)-epicatechin-3-O-gallate multiple interactions ISO RGD:1348034 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CLOCK mRNA], [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CLOCK protein] CTD PMID:29061316 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1348034 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CLOCK mRNA] more ... CTD PMID:22079256 , PMID:29061316 17alpha-ethynylestradiol affects expression ISO RGD:1552430 6480464 Ethinyl Estradiol affects the expression of CLOCK mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression ISO RGD:1552430 6480464 Ethinyl Estradiol results in increased expression of CLOCK mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1552430 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLOCK mRNA CTD PMID:17942748 2,2',4,4',5,5'-hexachlorobiphenyl increases activity ISO RGD:1348034 6480464 2 more ... CTD PMID:27589886 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1552430 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,2',5,5'-tetrachlorobiphenyl increases expression ISO RGD:1348034 6480464 2 more ... CTD PMID:21703328 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1552430 6480464 Tetrachlorodibenzodioxin results in increased expression of CLOCK mRNA CTD PMID:17942748 , PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1552430 6480464 Tetrachlorodibenzodioxin results in decreased expression of CLOCK mRNA CTD PMID:18295293 , PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1552430 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:17942748 , PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1552430 6480464 Tetrachlorodibenzodioxin affects the expression of CLOCK mRNA CTD PMID:21570461 , PMID:28922406 2-amino-2-deoxy-D-glucopyranose decreases expression ISO RGD:1552430 6480464 Glucosamine results in decreased expression of CLOCK mRNA, Glucosamine results in decreased expression of CLOCK protein CTD PMID:24442997 20-HETE affects abundance ISO RGD:1552430 6480464 CLOCK protein affects the abundance of 20-hydroxy-5 more ... CTD PMID:22440902 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1552430 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of CLOCK mRNA CTD PMID:26251327 4,4'-diaminodiphenylmethane increases expression ISO RGD:1552430 6480464 4, 4'-diaminodiphenylmethane results in increased expression of CLOCK mRNA CTD PMID:18648102 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of CLOCK mRNA CTD PMID:30723492 aflatoxin B1 increases expression ISO RGD:1552430 6480464 Aflatoxin B1 results in increased expression of CLOCK mRNA CTD PMID:19770486 aldehydo-D-glucosamine decreases expression ISO RGD:1552430 6480464 Glucosamine results in decreased expression of CLOCK mRNA, Glucosamine results in decreased expression of CLOCK protein CTD PMID:24442997 all-trans-retinoic acid multiple interactions ISO RGD:1552430 6480464 RARA protein inhibits the reaction [Tretinoin results in increased activity of [CLOCK protein binds to ARNTL protein]], Tretinoin results in increased activity of [CLOCK protein binds to ARNTL protein] CTD PMID:17069763 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CLOCK mRNA CTD PMID:16483693 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of CLOCK mRNA CTD PMID:30779732 Aroclor 1254 decreases expression ISO RGD:1552430 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CLOCK mRNA CTD PMID:23650126 benzo[a]pyrene increases expression ISO RGD:1348034 6480464 Benzo(a)pyrene results in increased expression of CLOCK mRNA CTD PMID:17879257 benzo[a]pyrene increases expression ISO RGD:1552430 6480464 Benzo(a)pyrene results in increased expression of CLOCK mRNA CTD PMID:20127859 , PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:1552430 6480464 CLOCK gene mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:21978865 benzo[b]fluoranthene decreases expression ISO RGD:1552430 6480464 benzo(b)fluoranthene results in decreased expression of CLOCK mRNA CTD PMID:26377693 beta-D-glucosamine decreases expression ISO RGD:1552430 6480464 Glucosamine results in decreased expression of CLOCK mRNA, Glucosamine results in decreased expression of CLOCK protein CTD PMID:24442997 beta-naphthoflavone multiple interactions ISO RGD:1552430 6480464 beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to ARNTL protein], beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to PER1 promoter] CTD PMID:20106950 bezafibrate multiple interactions ISO RGD:1552430 6480464 [CLOCK protein binds to ARNTL protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA], CLOCK protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA] CTD PMID:20400680 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of CLOCK mRNA CTD PMID:28871463 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1552430 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CLOCK mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CLOCK mRNA CTD PMID:30816183 bisphenol A affects methylation ISO RGD:1552430 6480464 bisphenol A affects the methylation of CLOCK promoter CTD PMID:27334623 bisphenol A multiple interactions ISO RGD:1552430 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of CLOCK gene CTD PMID:28505145 butanal decreases expression ISO RGD:1348034 6480464 butyraldehyde results in decreased expression of CLOCK mRNA CTD PMID:26079696 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of CLOCK, Cadmium Chloride affects the expression of CLOCK mRNA CTD PMID:21442002 , PMID:23085516 cadmium dichloride multiple interactions EXP 6480464 Melatonin inhibits the reaction [Cadmium Chloride affects the expression of CLOCK] CTD PMID:23085516 cadmium dichloride affects methylation EXP 6480464 Cadmium Chloride affects the methylation of CLOCK promoter CTD PMID:22457795 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of CLOCK mRNA CTD PMID:20107868 carbon nanotube increases expression ISO RGD:1552430 6480464 Nanotubes, Carbon results in increased expression of CLOCK mRNA CTD PMID:25554681 , PMID:25620056 CGS-21680 increases expression ISO RGD:1348034 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of CLOCK mRNA CTD PMID:22923002 cisplatin decreases expression ISO RGD:1348034 6480464 Cisplatin results in decreased expression of CLOCK protein CTD PMID:21157427 clozapine affects response to substance ISO RGD:1348034 6480464 CLOCK gene SNP affects the susceptibility to Clozapine CTD PMID:15331141 cocaine increases expression ISO RGD:1552430 6480464 Cocaine results in increased expression of CLOCK mRNA CTD PMID:15994025 crocidolite asbestos decreases expression ISO RGD:1348034 6480464 Asbestos, Crocidolite results in decreased expression of CLOCK mRNA CTD PMID:29523930 DDE increases activity ISO RGD:1348034 6480464 Dichlorodiphenyl Dichloroethylene results in increased activity of CLOCK protein CTD PMID:27589886 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of CLOCK mRNA CTD PMID:23640034 dexamethasone affects expression ISO RGD:1348034 6480464 Dexamethasone affects the expression of CLOCK mRNA CTD PMID:23251369 dibenz[a,h]anthracene decreases expression ISO RGD:1552430 6480464 1 more ... CTD PMID:26377693 dichloromethane decreases expression ISO RGD:1552430 6480464 Methylene Chloride results in decreased expression of CLOCK mRNA CTD PMID:28392392 doxorubicin decreases expression ISO RGD:1348034 6480464 Doxorubicin results in decreased expression of CLOCK mRNA CTD PMID:29803840 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of CLOCK mRNA CTD PMID:29391264 fluoxetine increases expression ISO RGD:1552430 6480464 Fluoxetine results in increased expression of CLOCK mRNA CTD PMID:15994025 furan increases expression ISO RGD:1552430 6480464 furan results in increased expression of CLOCK mRNA CTD PMID:24183702 gallic acid multiple interactions ISO RGD:1348034 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CLOCK mRNA], [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CLOCK protein] CTD PMID:29061316 gallocatechin multiple interactions ISO RGD:1348034 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CLOCK mRNA], [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CLOCK protein] CTD PMID:29061316 hexadecanoic acid decreases expression ISO RGD:1552430 6480464 Palmitic Acid results in decreased expression of CLOCK mRNA, Palmitic Acid results in decreased expression of CLOCK protein CTD PMID:24442997 hydrogen peroxide multiple interactions ISO RGD:1348034 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CLOCK mRNA] more ... CTD PMID:29061316 , PMID:30316844 hydrogen peroxide affects expression ISO RGD:1348034 6480464 Hydrogen Peroxide affects the expression of CLOCK mRNA, Hydrogen Peroxide affects the expression of CLOCK protein CTD PMID:29061316 , PMID:30316844 lead(0) decreases expression ISO RGD:1348034 6480464 Lead results in decreased expression of CLOCK mRNA CTD PMID:19921347 lead(2+) decreases expression ISO RGD:1348034 6480464 Lead results in decreased expression of CLOCK mRNA CTD PMID:19921347 manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of CLOCK mRNA CTD PMID:28511934 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Cadmium Chloride affects the expression of CLOCK] CTD PMID:23085516 methylmercury chloride decreases expression ISO RGD:1348034 6480464 methylmercuric chloride results in decreased expression of CLOCK mRNA CTD PMID:28001369 N-nitrosodiethylamine multiple interactions ISO RGD:1552430 6480464 CLOCK protein promotes the reaction [Diethylnitrosamine results in increased activity of CASP3 protein] more ... CTD PMID:17942915 , PMID:21167249 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLOCK mRNA CTD PMID:20360939 N-nitrosodiethylamine increases response to substance ISO RGD:1552430 6480464 CLOCK protein results in increased susceptibility to Diethylnitrosamine CTD PMID:21167249 N-nitrosodiethylamine increases expression ISO RGD:1552430 6480464 Diethylnitrosamine results in increased expression of CLOCK mRNA CTD PMID:17942915 pentanal decreases expression ISO RGD:1348034 6480464 pentanal results in decreased expression of CLOCK mRNA CTD PMID:26079696 perfluorooctanoic acid increases expression ISO RGD:1348034 6480464 perfluorooctanoic acid results in increased expression of CLOCK mRNA CTD PMID:23146750 phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLOCK mRNA CTD PMID:20360939 phenobarbital decreases expression ISO RGD:1552430 6480464 Phenobarbital results in decreased expression of CLOCK mRNA CTD PMID:19270015 pirinixic acid increases expression ISO RGD:1552430 6480464 pirinixic acid results in increased expression of CLOCK mRNA CTD PMID:23811191 pirinixic acid multiple interactions ISO RGD:1552430 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CLOCK mRNA CTD PMID:19710929 potassium chromate decreases expression ISO RGD:1348034 6480464 potassium chromate(VI) results in decreased expression of CLOCK mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:1348034 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CLOCK mRNA CTD PMID:22079256 rotenone multiple interactions EXP 6480464 [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Rotenone] results in decreased expression of CLOCK mRNA, [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Rotenone] results in decreased expression of CLOCK protein CTD PMID:30328585 sodium arsenate increases expression ISO RGD:1552430 6480464 sodium arsenate results in increased expression of CLOCK mRNA CTD PMID:21795629 sodium arsenite decreases expression ISO RGD:1552430 6480464 sodium arsenite results in decreased expression of CLOCK mRNA CTD PMID:30130555 styrene decreases expression ISO RGD:1552430 6480464 Styrene results in decreased expression of CLOCK mRNA CTD PMID:28951217 sunitinib increases expression ISO RGD:1348034 6480464 Sunitinib results in increased expression of CLOCK mRNA CTD PMID:31533062 tamoxifen affects expression ISO RGD:1552430 6480464 Tamoxifen affects the expression of CLOCK mRNA CTD PMID:17555576 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CLOCK mRNA CTD PMID:31150632 tetraphene decreases expression ISO RGD:1552430 6480464 benz(a)anthracene results in decreased expression of CLOCK mRNA CTD PMID:26377693 trichloroethene decreases methylation EXP 6480464 Trichloroethylene results in decreased methylation of CLOCK gene CTD PMID:27618143 triphenyl phosphate decreases expression EXP 6480464 triphenyl phosphate results in decreased expression of CLOCK mRNA CTD PMID:30589522 valproic acid decreases expression ISO RGD:1348034 6480464 Valproic Acid results in decreased expression of CLOCK mRNA CTD PMID:23179753 , PMID:28001369 valproic acid decreases methylation ISO RGD:1348034 6480464 Valproic Acid results in decreased methylation of CLOCK gene CTD PMID:29154799 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of CLOCK mRNA CTD PMID:23034163
Biological Process cellular response to ionizing radiation ISO RGD:1348034 1624291 (PMID:21659603) RGD PMID:21659603 cellular response to ionizing radiation IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 circadian regulation of gene expression ISO RGD:1348034 1624291 (PMID:21980503), (PMID:24005054), (PMID:28985504) RGD PMID:21980503 more ... circadian regulation of gene expression ISO RGD:1552430 1624291 (MGI:MGI:2683983 more ... RGD MGI:MGI:2683983 more ... circadian regulation of gene expression ISS UniProtKB:O15516 1600115 GO_REF:0000024 UniProt GO_REF:0000024 circadian regulation of gene expression ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 circadian regulation of gene expression IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 circadian regulation of gene expression IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 circadian rhythm NAS 632379 RGD circadian rhythm ISO RGD:1552430 1624291 MGI:MGI:1861634 (MGI:MGI:2179885 more ... RGD MGI:MGI:2179885 more ... circadian rhythm IEP 10401879 RGD DNA damage checkpoint ISO RGD:1348034 1624291 (PMID:21659603) RGD PMID:21659603 DNA damage checkpoint IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 entrainment of circadian clock IEP 632379 RGD female pregnancy IEP 10401948 RGD histone acetylation IEA GO:0004402 1600115 GO_REF:0000108 GOC GO_REF:0000108 negative regulation of glucocorticoid receptor signaling pathway ISO RGD:1552430 1624291 (MGI:MGI:5567887, PMID:24378737) RGD MGI:MGI:5567887 , PMID:24378737 negative regulation of glucocorticoid receptor signaling pathway ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of glucocorticoid receptor signaling pathway IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription, DNA-templated ISO RGD:1552430 1624291 (MGI:MGI:5567887, PMID:24378737) RGD MGI:MGI:5567887 , PMID:24378737 negative regulation of transcription, DNA-templated ISS UniProtKB:Q9WTL8 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of transcription, DNA-templated IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of inflammatory response ISO RGD:1552430 1624291 (MGI:MGI:5574290, PMID:22894897) RGD MGI:MGI:5574290 , PMID:22894897 positive regulation of inflammatory response IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of NF-kappaB transcription factor activity ISO RGD:1552430 1624291 (MGI:MGI:5447078, PMID:22895791) RGD MGI:MGI:5447078 , PMID:22895791 positive regulation of NF-kappaB transcription factor activity ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of NF-kappaB transcription factor activity IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:1348034 1624291 UniProtKB:O00327 (PMID:9576906) RGD PMID:9576906 positive regulation of transcription by RNA polymerase II ISO RGD:1552430 1624291 MGI:MGI:1096381 (MGI:MGI:2683983 more ... RGD MGI:MGI:2683983 more ... positive regulation of transcription, DNA-templated ISO RGD:1552430 1624291 (MGI:MGI:2388855 more ... RGD MGI:MGI:2388855 more ... positive regulation of transcription, DNA-templated ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of transcription, DNA-templated IDA 8661632 PMID:22356123 UniProt positive regulation of transcription, DNA-templated ISO RGD:1348034 1624291 (PMID:23785138) RGD PMID:23785138 proteasome-mediated ubiquitin-dependent protein catabolic process ISO RGD:1552430 1624291 (MGI:MGI:5495336, PMID:23395176) RGD MGI:MGI:5495336 , PMID:23395176 proteasome-mediated ubiquitin-dependent protein catabolic process ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 proteasome-mediated ubiquitin-dependent protein catabolic process IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein acetylation ISO RGD:1348034 1624291 (PMID:28985504) RGD PMID:28985504 protein acetylation ISS UniProtKB:O15516 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein acetylation ISO RGD:1552430 1624291 (MGI:MGI:6103563, PMID:28985504) RGD MGI:MGI:6103563 , PMID:28985504 regulation of circadian rhythm IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of circadian rhythm ISO RGD:1552430 1624291 (MGI:MGI:6282958, PMID:30012868) RGD MGI:MGI:6282958 , PMID:30012868 regulation of circadian rhythm ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of hair cycle ISO RGD:1348034 1624291 (PMID:24005054) RGD PMID:24005054 regulation of hair cycle ISS UniProtKB:O15516 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of hair cycle IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of insulin secretion ISO RGD:1552430 1624291 (MGI:MGI:4819446, PMID:20562852) RGD MGI:MGI:4819446 , PMID:20562852 regulation of insulin secretion ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of insulin secretion IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of transcription, DNA-templated ISO RGD:1552430 1624291 (MGI:MGI:2179885 more ... RGD MGI:MGI:2179885 more ... regulation of transcription, DNA-templated IEA InterPro:IPR001067 , InterPro:IPR013767 1600115 GO_REF:0000002 InterPro GO_REF:0000002 regulation of transcription, DNA-templated ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of type B pancreatic cell development ISO RGD:1552430 1624291 (MGI:MGI:4819446, PMID:20562852) RGD MGI:MGI:4819446 , PMID:20562852 regulation of type B pancreatic cell development ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of type B pancreatic cell development IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to light stimulus IEP 10401879 RGD response to redox state ISO RGD:1348034 1624291 (PMID:11441146) RGD PMID:11441146 response to redox state ISS UniProtKB:O15516 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to redox state IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 spermatogenesis ISO RGD:1552430 1624291 (MGI:MGI:5447260, PMID:22900038) RGD MGI:MGI:5447260 , PMID:22900038 spermatogenesis ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 spermatogenesis IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component chromatoid body ISO RGD:1552430 1624291 (MGI:MGI:5447260, PMID:22900038) RGD MGI:MGI:5447260 , PMID:22900038 chromatoid body ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 chromatoid body IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromosome ISO RGD:1348034 1624291 (PMID:21659603) RGD PMID:21659603 chromosome IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm IEA InterPro:IPR001067 1600115 GO_REF:0000002 InterPro GO_REF:0000002 cytoplasm ISO RGD:1552430 1624291 (MGI:MGI:2669067 more ... RGD MGI:MGI:2669067 more ... cytosol ISO RGD:1348034 1624291 (PMID:28985504) RGD PMID:28985504 cytosol ISS UniProtKB:O15516 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cytosol IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 intracellular membrane-bounded organelle ISO RGD:1348034 1624291 RGD GO_REF:0000052 nucleolus IDA 10401943 RGD nucleoplasm IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:1348034 1624291 RGD GO_REF:0000052 nucleus IDA 8661632 PMID:22356123 UniProt nucleus IEA UniProtKB-SubCell:SL-0191 1600115 GO_REF:0000044 UniProt GO_REF:0000044 nucleus ISO RGD:1552430 1624291 (MGI:MGI:2669067 more ... RGD MGI:MGI:2669067 more ... nucleus ISO RGD:1348034 1624291 (PMID:14645221), (PMID:28985504) RGD PMID:14645221 , PMID:28985504 perichromatin fibrils IDA 10401943 RGD rough endoplasmic reticulum IDA 10401943 RGD transcription regulator complex IEA InterPro:IPR001067 1600115 GO_REF:0000002 InterPro GO_REF:0000002 transcription regulator complex ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 transcription regulator complex IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription regulator complex ISO RGD:1348034 1624291 UniProtKB:O00327 (PMID:9576906) RGD PMID:9576906 transcription regulator complex IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription regulator complex ISO RGD:1552430 1624291 (MGI:MGI:3625767 more ... RGD MGI:MGI:3625767 more ... Molecular Function chromatin DNA binding ISO RGD:1552430 1624291 (MGI:MGI:5568183, PMID:24610784) RGD MGI:MGI:5568183 , PMID:24610784 chromatin DNA binding ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 chromatin DNA binding IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA binding ISO RGD:1348034 1624291 (PMID:11441146) RGD PMID:11441146 DNA binding IEA UniProtKB-KW:KW-0238 1600115 GO_REF:0000043 UniProt GO_REF:0000043 DNA binding ISS UniProtKB:O15516 1600115 GO_REF:0000024 UniProt GO_REF:0000024 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:1552430 1624291 (MGI:MGI:5306311, PMID:15560782) RGD MGI:MGI:5306311 , PMID:15560782 DNA-binding transcription factor activity IEA InterPro:IPR001067 1600115 GO_REF:0000002 InterPro GO_REF:0000002 DNA-binding transcription factor activity ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 DNA-binding transcription factor activity ISO RGD:1552430 1624291 (MGI:MGI:2179885 more ... RGD MGI:MGI:2179885 more ... DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:1552430 1624291 (MGI:MGI:5297789, PMID:15147242) RGD MGI:MGI:5297789 , PMID:15147242 E-box binding ISO RGD:1348034 1624291 (PMID:18411297), (PMID:23785138) RGD PMID:18411297 , PMID:23785138 E-box binding ISO RGD:1552430 1624291 (MGI:MGI:4410413 more ... RGD MGI:MGI:4410413 more ... E-box binding ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 E-box binding IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 E-box binding IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 histone acetyltransferase activity ISO RGD:1348034 1624291 (PMID:21980503), (PMID:28985504) RGD PMID:21980503 , PMID:28985504 histone acetyltransferase activity ISS UniProtKB:O15516 1600115 GO_REF:0000024 UniProt GO_REF:0000024 histone acetyltransferase activity IEA UniProtKB:O08785 , ensembl:ENSMUSP000001439391600115 GO_REF:0000107 Ensembl GO_REF:0000107 histone acetyltransferase activity ISO RGD:1552430 1624291 (MGI:MGI:3843754, PMID:19141540) RGD MGI:MGI:3843754 , PMID:19141540 histone acetyltransferase activity IEA UniProtKB:O15516 , ensembl:ENSP000004269831600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding ISO RGD:1348034 1624291 UniProtKB:O00327 more ... RGD PMID:11018023 more ... protein binding ISO RGD:1552430 1624291 PR:P45481 more ... RGD MGI:MGI:1276614 more ... protein dimerization activity IEA InterPro:IPR011598 , InterPro:IPR036638 1600115 GO_REF:0000002 InterPro GO_REF:0000002 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1348034 1624291 (PMID:18411297) RGD PMID:18411297 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1552430 1624291 (MGI:MGI:3843127 more ... RGD MGI:MGI:3843127 more ... RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024 sequence-specific DNA binding ISO RGD:1552430 1624291 (MGI:MGI:5567903, PMID:21613214) RGD MGI:MGI:5567903 , PMID:21613214 sequence-specific DNA binding ISS UniProtKB:O08785 1600115 GO_REF:0000024 UniProt GO_REF:0000024
Gene-Chemical Interaction Annotations
