Dmgdh (dimethylglycine dehydrogenase) - Rat Genome Database

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Gene: Dmgdh (dimethylglycine dehydrogenase) Rattus norvegicus
Analyze
Symbol: Dmgdh
Name: dimethylglycine dehydrogenase
RGD ID: 620453
Description: Enables dimethylglycine dehydrogenase activity; flavin adenine dinucleotide binding activity; and folic acid binding activity. Involved in tetrahydrofolate interconversion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in dimethylglycine dehydrogenase deficiency. Orthologous to human DMGDH (dimethylglycine dehydrogenase); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dimethylglycine dehydrogenase precursor; dimethylglycine dehydrogenase, mitochondrial; Me2GlyDH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,647,540 - 26,722,496 (+)NCBIGRCr8
mRatBN7.2224,912,600 - 24,987,533 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl224,912,578 - 24,987,528 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx231,939,901 - 32,014,960 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0230,040,160 - 30,115,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,865,886 - 24,940,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0223,289,376 - 23,370,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl223,289,374 - 23,370,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0242,469,950 - 42,545,633 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4223,976,563 - 24,052,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1223,896,931 - 23,973,132 (+)NCBI
Celera220,986,895 - 21,062,849 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
indometacin  (EXP)
inulin  (ISO)
iodide salt  (EXP)
leflunomide  (EXP)
melatonin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
Ortho-topolin riboside  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
toluene  (ISO)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (IBA)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Over-expression in Escherichia coli, functional characterization and refolding of rat dimethylglycine dehydrogenase. Brizio C, etal., Protein Expr Purif 2004 Oct;37(2):434-42.
2. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat liver dimethylglycine dehydrogenase. Flavinylation of the enzyme in hepatocytes in primary culture and characterization of a cDNA clone. Lang H, etal., Eur J Biochem 1991 Jun 15;198(3):793-9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Biogenesis of the covalently flavinylated mitochondrial enzyme dimethylglycine dehydrogenase. Otto A, etal., J Biol Chem. 1996 Apr 19;271(16):9823-9.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810.
16. Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins. Wittwer AJ and Wagner C, J Biol Chem. 1981 Apr 25;256(8):4109-15.
17. Identification of folate binding protein of mitochondria as dimethylglycine dehydrogenase. Wittwer AJ and Wagner C, Proc Natl Acad Sci U S A. 1980 Aug;77(8):4484-8.
Additional References at PubMed
PMID:4055729   PMID:7513513   PMID:10102904   PMID:11231903   PMID:12477932   PMID:14651853   PMID:18423846   PMID:18614015   PMID:22658674   PMID:24858690   PMID:29476059  


Genomics

Comparative Map Data
Dmgdh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,647,540 - 26,722,496 (+)NCBIGRCr8
mRatBN7.2224,912,600 - 24,987,533 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl224,912,578 - 24,987,528 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx231,939,901 - 32,014,960 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0230,040,160 - 30,115,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,865,886 - 24,940,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0223,289,376 - 23,370,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl223,289,374 - 23,370,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0242,469,950 - 42,545,633 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4223,976,563 - 24,052,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1223,896,931 - 23,973,132 (+)NCBI
Celera220,986,895 - 21,062,849 (+)NCBICelera
Cytogenetic Map2q12NCBI
DMGDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38578,997,564 - 79,069,674 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl578,997,564 - 79,236,038 (-)EnsemblGRCh38hg38GRCh38
GRCh37578,293,387 - 78,365,497 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36578,329,185 - 78,401,205 (-)NCBINCBI36Build 36hg18NCBI36
Build 34578,329,185 - 78,401,205NCBI
Celera574,186,336 - 74,258,332 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef573,499,350 - 73,571,433 (-)NCBIHuRef
CHM1_1577,725,882 - 77,797,969 (-)NCBICHM1_1
T2T-CHM13v2.0579,478,676 - 79,550,778 (-)NCBIT2T-CHM13v2.0
Dmgdh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391393,810,944 - 93,889,331 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1393,810,941 - 93,889,341 (+)EnsemblGRCm39 Ensembl
GRCm381393,674,436 - 93,752,823 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1393,674,433 - 93,752,833 (+)EnsemblGRCm38mm10GRCm38
MGSCv371394,444,391 - 94,522,778 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361394,775,189 - 94,853,576 (+)NCBIMGSCv36mm8
Celera1397,280,488 - 97,360,770 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.88NCBI
Dmgdh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542522,045,993 - 22,102,852 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542522,045,977 - 22,103,381 (+)NCBIChiLan1.0ChiLan1.0
DMGDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2436,235,936 - 36,308,377 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1534,389,544 - 34,461,365 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0536,241,341 - 36,313,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1536,732,011 - 36,803,202 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl536,732,005 - 36,805,883 (+)Ensemblpanpan1.1panPan2
DMGDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1327,789,089 - 27,857,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl327,790,324 - 27,856,601 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha329,028,288 - 29,094,786 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0327,707,912 - 27,777,243 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl327,708,388 - 27,777,248 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1327,648,089 - 27,713,749 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0327,625,520 - 27,692,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0327,906,242 - 27,972,124 (+)NCBIUU_Cfam_GSD_1.0
Dmgdh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213183,959,062 - 184,020,082 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365496,839,295 - 6,899,911 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365496,838,773 - 6,899,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMGDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl287,791,943 - 87,866,679 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1287,791,827 - 87,867,189 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2289,475,706 - 89,593,728 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DMGDH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1473,217,523 - 73,339,646 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl473,216,579 - 73,290,268 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604922,063,950 - 22,136,314 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dmgdh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248693,500,293 - 3,576,245 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248693,498,851 - 3,576,341 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dmgdh
696 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:107
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000032783
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat

Markers in Region
RH130058  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2224,987,313 - 24,987,493 (+)MAPPERmRatBN7.2
Rnor_6.0223,370,141 - 23,370,320NCBIRnor6.0
Rnor_5.0242,544,841 - 42,545,020UniSTSRnor5.0
RGSC_v3.4224,052,547 - 24,052,726UniSTSRGSC3.4
Celera221,062,630 - 21,062,809UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 7 28 101 84 86 59 17 59 6 174 58 85 45 59 27

Sequence


Ensembl Acc Id: ENSRNOT00000032783   ⟹   ENSRNOP00000030481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,912,600 - 24,987,528 (+)Ensembl
Rnor_6.0 Ensembl223,289,391 - 23,370,353 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090666   ⟹   ENSRNOP00000075177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl224,912,578 - 24,987,528 (+)Ensembl
Rnor_6.0 Ensembl223,289,374 - 23,370,477 (+)Ensembl
RefSeq Acc Id: NM_139102   ⟹   NP_620802
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,647,575 - 26,722,496 (+)NCBI
mRatBN7.2224,912,600 - 24,987,533 (+)NCBI
Rnor_6.0223,289,391 - 23,370,360 (+)NCBI
Rnor_5.0242,469,950 - 42,545,633 (+)NCBI
RGSC_v3.4223,976,563 - 24,052,766 (+)RGD
Celera220,986,895 - 21,062,849 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101722   ⟹   XP_038957650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,647,559 - 26,722,496 (+)NCBI
mRatBN7.2224,912,617 - 24,987,533 (+)NCBI
RefSeq Acc Id: XM_039101723   ⟹   XP_038957651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,647,558 - 26,707,010 (+)NCBI
mRatBN7.2224,912,617 - 24,972,030 (+)NCBI
RefSeq Acc Id: XM_063281294   ⟹   XP_063137364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8226,647,540 - 26,707,007 (+)NCBI
RefSeq Acc Id: NP_620802   ⟸   NM_139102
- Peptide Label: precursor
- UniProtKB: Q63342 (UniProtKB/Swiss-Prot),   Q5RKL4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075177   ⟸   ENSRNOT00000090666
Ensembl Acc Id: ENSRNOP00000030481   ⟸   ENSRNOT00000032783
RefSeq Acc Id: XP_038957650   ⟸   XM_039101722
- Peptide Label: isoform X1
- UniProtKB: Q63342 (UniProtKB/Swiss-Prot),   A0A0G2K9Y2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957651   ⟸   XM_039101723
- Peptide Label: isoform X2
- UniProtKB: A6I4V9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137364   ⟸   XM_063281294
- Peptide Label: isoform X3
- UniProtKB: A6I4V9 (UniProtKB/TrEMBL)
Protein Domains
Aminomethyltransferase C-terminal   Aminomethyltransferase folate-binding   FAD dependent oxidoreductase   FAD dependent oxidoreductase central

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63342-F1-model_v2 AlphaFold Q63342 1-857 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691070
Promoter ID:EPDNEW_R1595
Type:initiation region
Name:Dmgdh_1
Description:dimethylglycine dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0223,289,402 - 23,289,462EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620453 AgrOrtholog
BioCyc Gene G2FUF-54842 BioCyc
BioCyc Pathway PWY-3661 [glycine betaine degradation I] BioCyc
  PWY-3661-1 [glycine betaine degradation II (mammalian)] BioCyc
BioCyc Pathway Image PWY-3661 BioCyc
  PWY-3661-1 BioCyc
Ensembl Genes ENSRNOG00000023588 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000032783 ENTREZGENE
  ENSRNOT00000090666 ENTREZGENE
  ENSRNOT00000132864 ENTREZGENE
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot
  Aminomethyltransferase beta-barrel domains UniProtKB/Swiss-Prot
  Aminomethyltransferase beta-barrel domains UniProtKB/Swiss-Prot
  D-Amino Acid Oxidase, subunit A, domain 2 UniProtKB/Swiss-Prot
  Probable tRNA modification gtpase trme, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108858 IMAGE-MGC_LOAD
InterPro FAD-dep_OxRdtase UniProtKB/Swiss-Prot
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  FAO_M UniProtKB/Swiss-Prot
  GCST/YgfZ/DmdA UniProtKB/Swiss-Prot
  GCV_T_C UniProtKB/Swiss-Prot
  GCV_T_N UniProtKB/Swiss-Prot
  GcvT/YgfZ_C UniProtKB/Swiss-Prot
  TrmE/GcvT_dom1 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93164 IMAGE-MGC_LOAD
NCBI Gene 245961 ENTREZGENE
PANTHER AMINOMETHYLTRANSFERASE UniProtKB/Swiss-Prot
  AMINOMETHYLTRANSFERASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam DAO UniProtKB/Swiss-Prot
  FAO_M UniProtKB/Swiss-Prot
  GCV_T UniProtKB/Swiss-Prot
  GCV_T_C UniProtKB/Swiss-Prot
PhenoGen Dmgdh PhenoGen
RatGTEx ENSRNOG00000023588 RatGTEx
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/Swiss-Prot
  Folate-binding domain UniProtKB/Swiss-Prot
  SSF101790 UniProtKB/Swiss-Prot
  SSF51905 UniProtKB/Swiss-Prot
UniProt A0A0G2K9Y2 ENTREZGENE, UniProtKB/TrEMBL
  A6I4V8_RAT UniProtKB/TrEMBL
  A6I4V9 ENTREZGENE, UniProtKB/TrEMBL
  M2GD_RAT UniProtKB/Swiss-Prot
  Q5RKL4 ENTREZGENE, UniProtKB/TrEMBL
  Q63342 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-16 Dmgdh  dimethylglycine dehydrogenase  Dmgdh  dimethylglycine dehydrogenase precursor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dmgdh  dimethylglycine dehydrogenase precursor      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dmgdh  dimethylglycine dehydrogenase precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the mitochondria 632576
gene_physical_interaction binds a FAD cofactor 632576
gene_protein 90 kDa 632576