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Gene: Cpe (carboxypeptidase E) Rattus norvegicus
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Symbol: Cpe
Name: carboxypeptidase E
Description: Exhibits carboxypeptidase activity; cobalt ion binding activity; and protein domain specific binding activity. Involved in negative regulation of branching morphogenesis of a nerve and peptide metabolic process. Localizes to several cellular components, including the membrane raft; perikaryon; and secretory granule. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CPE (carboxypeptidase E); PARTICIPATES IN melanocortin system pathway; type 1 diabetes mellitus pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CARBE; carboxypeptidase H; Cph; enkephalin convertase; MGC93638; prohormone-processing carboxypeptidase
Orthologs:
Homo sapiens (human) : CPE (carboxypeptidase E)  HGNC  Alliance
Mus musculus (house mouse) : Cpe (carboxypeptidase E)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cpe (carboxypeptidase E)
Pan paniscus (bonobo/pygmy chimpanzee) : CPE (carboxypeptidase E)
Canis lupus familiaris (dog) : CPE (carboxypeptidase E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cpe (carboxypeptidase E)
Sus scrofa (pig) : CPE (carboxypeptidase E)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01626,906,716 - 27,014,811 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1626,906,716 - 27,014,813 (+)Ensembl
Rnor_5.01626,785,642 - 26,888,882 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11626,748,589 - 26,748,986 (+)NCBI
Celera1625,114,655 - 25,226,598 (+)NCBICelera
Cytogenetic Map16p13NCBI
RH 3.4 Map16298.1RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Cpe
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2394
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.