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Gene: Cpe (carboxypeptidase E) Mus musculus
Symbol: Cpe
Name: carboxypeptidase E
Description: This gene encodes carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the "fat mouse." Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin. [provided by RefSeq, Jan 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: carboxypeptidase H; CPH; Cph-1; Cph1; enkephalin convertase; fat; MGC7101; NF-alpha1; prohormone-processing carboxypeptidase; R74677
Homo sapiens (human) : CPE (carboxypeptidase E)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cpe (carboxypeptidase E)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cpe (carboxypeptidase E)
Pan paniscus (bonobo/pygmy chimpanzee) : CPE (carboxypeptidase E)
Canis lupus familiaris (dog) : CPE (carboxypeptidase E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cpe (carboxypeptidase E)
Sus scrofa (pig) : CPE (carboxypeptidase E)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38864,592,542 - 64,693,109 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37867,071,339 - 67,171,837 (-)NCBIGRCm37mm9NCBIm37
MGSCv36867,484,734 - 67,585,232 (-)NCBImm8
Celera867,161,674 - 67,256,578 (-)NCBICelera
Cytogenetic Map8 B3.1NCBI
cM Map832.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cpe
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732382
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-04-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.