Adam2 (ADAM metallopeptidase domain 2) - Rat Genome Database

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Gene: Adam2 (ADAM metallopeptidase domain 2) Rattus norvegicus
Analyze
Symbol: Adam2
Name: ADAM metallopeptidase domain 2
RGD ID: 69299
Description: Predicted to enable metalloendopeptidase activity. Involved in male gonad development and spermatogenesis. Located in acrosomal vesicle. Orthologous to human ADAM2 (ADAM metallopeptidase domain 2); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 2; a disintegrin and metalloprotease domain (ADAM) 2; a disintegrin and metalloprotease domain 2; A disintegrin and metalloprotease domain 2 (Fertilin beta); ADAM 2; beta; disintegrin and metalloproteinase domain-containing protein 2; fertilin beta; fertilin subunit beta; Ftnb; PH-30; PH30; PH30-beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,418,191 - 44,459,570 (-)NCBIGRCr8
mRatBN7.21540,242,651 - 40,284,025 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,242,783 - 40,283,952 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,107,929 - 42,148,828 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,258,129 - 43,299,026 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,703,086 - 41,744,269 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,708,536 - 42,751,281 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,708,387 - 42,751,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,842,808 - 48,883,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,449,574 - 45,491,663 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,465,353 - 45,507,443 (-)NCBI
Celera1539,914,632 - 39,955,090 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Altered cell-matrix associated ADAM proteins in Alzheimer disease. Gerst JL, etal., J Neurosci Res. 2000 Mar 1;59(5):680-4.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Cloning and sequence analysis of rat fertilin alpha and beta--developmental expression, processing and immunolocalization. McLaughlin EA, etal., Mol Hum Reprod 1997 Sep;3(9):801-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2). Rosselot C, etal., Dev Dyn. 2003 Jul;227(3):458-67.
12. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
13. Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. Yoshida T, etal., Kidney Int. 2002 May;61(5):1646-54.
Additional References at PubMed
PMID:16504143   PMID:19129510   PMID:21060781   PMID:21273369   PMID:30396079  


Genomics

Comparative Map Data
Adam2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,418,191 - 44,459,570 (-)NCBIGRCr8
mRatBN7.21540,242,651 - 40,284,025 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,242,783 - 40,283,952 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,107,929 - 42,148,828 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,258,129 - 43,299,026 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,703,086 - 41,744,269 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,708,536 - 42,751,281 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,708,387 - 42,751,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,842,808 - 48,883,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,449,574 - 45,491,663 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,465,353 - 45,507,443 (-)NCBI
Celera1539,914,632 - 39,955,090 (-)NCBICelera
Cytogenetic Map15p12NCBI
ADAM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38839,743,735 - 39,838,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl839,743,735 - 39,838,227 (-)EnsemblGRCh38hg38GRCh38
GRCh37839,601,254 - 39,695,746 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36839,720,411 - 39,814,936 (-)NCBINCBI36Build 36hg18NCBI36
Build 34839,720,413 - 39,814,936NCBI
Celera838,553,126 - 38,647,899 (-)NCBICelera
Cytogenetic Map8p11.22NCBI
HuRef838,134,819 - 38,229,371 (-)NCBIHuRef
CHM1_1839,648,176 - 39,742,718 (-)NCBICHM1_1
T2T-CHM13v2.0840,020,946 - 40,115,447 (-)NCBIT2T-CHM13v2.0
Adam2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,264,778 - 66,315,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,264,778 - 66,315,182 (-)EnsemblGRCm39 Ensembl
GRCm381466,027,322 - 66,077,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,027,329 - 66,077,733 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,646,166 - 66,696,570 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,981,442 - 65,039,019 (-)NCBIMGSCv36mm8
Celera1463,775,697 - 63,826,131 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Adam2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,046,004 - 50,117,201 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,046,262 - 50,115,004 (+)NCBIChiLan1.0ChiLan1.0
ADAM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2758,199,433 - 58,295,832 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1833,916,514 - 34,012,905 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0838,939,413 - 39,034,142 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1836,448,201 - 36,542,784 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl836,448,201 - 36,542,784 (-)Ensemblpanpan1.1panPan2
ADAM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11625,781,508 - 25,912,988 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1625,782,267 - 25,912,891 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1626,296,840 - 26,434,482 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01627,604,238 - 27,740,761 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1627,605,309 - 27,722,734 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11625,906,520 - 26,037,639 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01626,466,004 - 26,599,845 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01626,520,781 - 26,651,970 (-)NCBIUU_Cfam_GSD_1.0
Adam2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,134,275 - 8,190,300 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675397,161 - 451,153 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675393,160 - 451,851 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1547,207,722 - 47,278,315 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11547,207,727 - 47,278,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21554,055,205 - 54,124,179 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1837,758,276 - 37,884,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660524,067,374 - 4,172,869 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,317,961 - 22,383,736 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,318,565 - 22,384,360 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam2
345 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:20
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000066478
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
Adam2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,242,712 - 40,242,898 (+)MAPPERmRatBN7.2
Rnor_6.01542,708,466 - 42,708,651NCBIRnor6.0
Rnor_5.01548,883,722 - 48,883,907UniSTSRnor5.0
RGSC_v3.41545,449,504 - 45,449,689UniSTSRGSC3.4
Celera1539,914,562 - 39,914,747UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 6 6 6 2 2 5 5 2
Below cutoff 1 28 24 6 24 3 5 22 2 18 4 3

Sequence


RefSeq Acc Id: ENSRNOT00000066478   ⟹   ENSRNOP00000061122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,242,783 - 40,283,952 (-)Ensembl
Rnor_6.0 Ensembl1542,708,387 - 42,751,330 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118188   ⟹   ENSRNOP00000084478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,244,203 - 40,283,952 (-)Ensembl
RefSeq Acc Id: NM_020077   ⟹   NP_064462
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,418,199 - 44,459,516 (-)NCBI
mRatBN7.21540,242,651 - 40,283,970 (-)NCBI
Rnor_6.01542,708,536 - 42,751,281 (-)NCBI
Rnor_5.01548,842,808 - 48,883,837 (+)NCBI
RGSC_v3.41545,449,574 - 45,491,663 (-)RGD
Celera1539,914,632 - 39,955,090 (-)RGD
Sequence:
RefSeq Acc Id: XM_039093614   ⟹   XP_038949542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,418,191 - 44,459,570 (-)NCBI
mRatBN7.21540,242,784 - 40,284,025 (-)NCBI
RefSeq Acc Id: XM_039093615   ⟹   XP_038949543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,418,191 - 44,455,137 (-)NCBI
mRatBN7.21540,242,784 - 40,279,592 (-)NCBI
RefSeq Acc Id: XM_039093616   ⟹   XP_038949544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,418,191 - 44,445,557 (-)NCBI
mRatBN7.21540,242,784 - 40,269,999 (-)NCBI
RefSeq Acc Id: XM_039093617   ⟹   XP_038949545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,418,191 - 44,443,240 (-)NCBI
mRatBN7.21540,242,784 - 40,267,719 (-)NCBI
RefSeq Acc Id: XM_063274593   ⟹   XP_063130663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,418,191 - 44,455,133 (-)NCBI
RefSeq Acc Id: NP_064462   ⟸   NM_020077
- Peptide Label: precursor
- UniProtKB: A6K6L5 (UniProtKB/TrEMBL),   F1M6W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061122   ⟸   ENSRNOT00000066478
RefSeq Acc Id: XP_038949542   ⟸   XM_039093614
- Peptide Label: isoform X1
- UniProtKB: F1M6W4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949543   ⟸   XM_039093615
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949544   ⟸   XM_039093616
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949545   ⟸   XM_039093617
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000084478   ⟸   ENSRNOT00000118188
RefSeq Acc Id: XP_063130663   ⟸   XM_063274593
- Peptide Label: isoform X2
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63202-F1-model_v2 AlphaFold Q63202 1-737 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699754
Promoter ID:EPDNEW_R10277
Type:multiple initiation site
Name:Adam2_1
Description:ADAM metallopeptidase domain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01542,751,310 - 42,751,370EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69299 AgrOrtholog
BioCyc Gene G2FUF-13333 BioCyc
Ensembl Genes ENSRNOG00000017027 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066478.4 UniProtKB/TrEMBL
  ENSRNOT00000118188.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56806 UniProtKB/Swiss-Prot
NCBI Gene 56806 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11905:SF108 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam2 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017027 RatGTEx
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZZF4_RAT UniProtKB/TrEMBL
  A6K6L5 ENTREZGENE, UniProtKB/TrEMBL
  ADAM2_RAT UniProtKB/Swiss-Prot
  F1M6W4 ENTREZGENE, UniProtKB/TrEMBL
  Q63202 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adam2  ADAM metallopeptidase domain 2  Adam2  a disintegrin and metallopeptidase domain 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Adam2  a disintegrin and metallopeptidase domain 2  Adam2  a disintegrin and metalloprotease domain 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Adam2  a disintegrin and metalloprotease domain 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the acrosomal cap of spermatozoa and elongating spermatids 68863
gene_process sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; may have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct 724707
gene_product member of the MDC (metalloproteinase-like, disintegrin-like, cysteine-rich) protein family; non catalytic 724707
gene_regulation interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg 68863