Adam2 (ADAM metallopeptidase domain 2) - Rat Genome Database

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Gene: Adam2 (ADAM metallopeptidase domain 2) Heterocephalus glaber
Analyze
Symbol: Adam2
Name: ADAM metallopeptidase domain 2
RGD ID: 18913521
Description: ENCODES a protein that exhibits metalloendopeptidase activity (inferred); metallopeptidase activity (inferred); INVOLVED IN adult behavior (ortholog); cell adhesion (ortholog); gene expression (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Kidney Reperfusion Injury (ortholog); FOUND IN acrosomal vesicle (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 2; disintegrin and metalloproteinase domain-containing protein 2 preproprotein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,317,961 - 22,383,736 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,318,565 - 22,384,360 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adam2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,317,961 - 22,383,736 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,318,565 - 22,384,360 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ADAM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38839,743,735 - 39,838,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl839,743,735 - 39,838,227 (-)EnsemblGRCh38hg38GRCh38
GRCh37839,601,254 - 39,695,746 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36839,720,411 - 39,814,936 (-)NCBINCBI36Build 36hg18NCBI36
Build 34839,720,413 - 39,814,936NCBI
Celera838,553,126 - 38,647,899 (-)NCBICelera
Cytogenetic Map8p11.22NCBI
HuRef838,134,819 - 38,229,371 (-)NCBIHuRef
CHM1_1839,648,176 - 39,742,718 (-)NCBICHM1_1
T2T-CHM13v2.0840,020,946 - 40,115,447 (-)NCBIT2T-CHM13v2.0
Adam2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,264,778 - 66,315,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,264,778 - 66,315,182 (-)EnsemblGRCm39 Ensembl
GRCm381466,027,322 - 66,077,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,027,329 - 66,077,733 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,646,166 - 66,696,570 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,981,442 - 65,039,019 (-)NCBIMGSCv36mm8
Celera1463,775,697 - 63,826,131 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Adam2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,418,191 - 44,459,570 (-)NCBIGRCr8
mRatBN7.21540,242,651 - 40,284,025 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,242,783 - 40,283,952 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,107,929 - 42,148,828 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,258,129 - 43,299,026 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,703,086 - 41,744,269 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,708,536 - 42,751,281 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,708,387 - 42,751,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,842,808 - 48,883,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,449,574 - 45,491,663 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,465,353 - 45,507,443 (-)NCBI
Celera1539,914,632 - 39,955,090 (-)NCBICelera
Cytogenetic Map15p12NCBI
Adam2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,046,004 - 50,117,201 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,046,262 - 50,115,004 (+)NCBIChiLan1.0ChiLan1.0
ADAM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2758,199,433 - 58,295,832 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1833,916,514 - 34,012,905 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0838,939,413 - 39,034,142 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1836,448,201 - 36,542,784 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl836,448,201 - 36,542,784 (-)Ensemblpanpan1.1panPan2
ADAM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11625,781,508 - 25,912,988 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1625,782,267 - 25,912,891 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1626,296,840 - 26,434,482 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01627,604,238 - 27,740,761 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1627,605,309 - 27,722,734 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11625,906,520 - 26,037,639 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01626,466,004 - 26,599,845 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01626,520,781 - 26,651,970 (-)NCBIUU_Cfam_GSD_1.0
Adam2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,134,275 - 8,190,300 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675397,161 - 451,153 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675393,160 - 451,851 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1547,207,722 - 47,278,315 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11547,207,727 - 47,278,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21554,055,205 - 54,124,179 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1837,758,276 - 37,884,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660524,067,374 - 4,172,869 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000010822   ⟹   ENSHGLP00000010700
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475822,317,961 - 22,383,736 (+)Ensembl
RefSeq Acc Id: XM_004848391   ⟹   XP_004848448
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475822,318,565 - 22,384,360 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004848448 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000010700
GenBank Protein JAN99380 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004848448   ⟸   XM_004848391
- UniProtKB: A0AAX6PCD9 (UniProtKB/TrEMBL),   A0A0P6J703 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000010700   ⟸   ENSHGLT00000010822


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007670 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000010822 ENTREZGENE
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene Adam2 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  PTHR11905:SF108 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A0P6J703 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6PCD9 ENTREZGENE, UniProtKB/TrEMBL