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Gene: ADAM2 (ADAM metallopeptidase domain 2) Homo sapiens
Symbol: ADAM2
Name: ADAM metallopeptidase domain 2
Description: Predicted to have integrin binding activity and metallopeptidase activity. Predicted to be involved in binding activity of sperm to zona pellucida and fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to localize to the integral component of plasma membrane. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADAM 2; cancer/testis antigen 15; CRYN1; CRYN2; CT15; disintegrin and metalloproteinase domain-containing protein 2; fertilin beta; fertilin subunit beta; FTNB; PH-30; PH-30b; PH30; PH30-beta
Mus musculus (house mouse) : Adam2 (a disintegrin and metallopeptidase domain 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Adam2 (ADAM metallopeptidase domain 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam2 (ADAM metallopeptidase domain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM2 (ADAM metallopeptidase domain 2)
Canis lupus familiaris (dog) : ADAM2 (ADAM metallopeptidase domain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam2 (ADAM metallopeptidase domain 2)
Sus scrofa (pig) : ADAM2 (ADAM metallopeptidase domain 2)
Chlorocebus sabaeus (green monkey) : ADAM2 (ADAM metallopeptidase domain 2)
Heterocephalus glaber (naked mole-rat) : Adam2 (ADAM metallopeptidase domain 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl839,743,735 - 39,838,289 (-)Ensembl
GRCh38839,743,735 - 39,838,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37839,601,254 - 39,695,808 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36839,720,411 - 39,814,936 (-)NCBINCBI36hg18NCBI36
Build 34839,720,413 - 39,814,936NCBI
Celera838,553,126 - 38,647,899 (-)NCBI
Cytogenetic Map8p11.22NCBI
HuRef838,134,819 - 38,229,371 (-)NCBIHuRef
CHM1_1839,648,176 - 39,742,718 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ADAM2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69085
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.