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Gene: Aptx (aprataxin) Rattus norvegicus
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Symbol: Aptx
Name: aprataxin
Description: Predicted to have several functions, including DNA 5'-adenosine monophosphate hydrolase activity; DNA binding activity; and phosphatase activity. Predicted to be involved in DNA metabolic process; regulation of protein stability; and response to hydrogen peroxide. Predicted to colocalize with the nuclear chromatin. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 1 and olivopontocerebellar atrophy. Orthologous to human APTX (aprataxin); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH ammonium chloride; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: FHA-HIT; forkhead-associated domain histidine triad-like protein
Orthologs:
Homo sapiens (human) : APTX (aprataxin)  HGNC  Alliance
Mus musculus (house mouse) : Aptx (aprataxin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aptx (aprataxin)
Pan paniscus (bonobo/pygmy chimpanzee) : APTX (aprataxin)
Canis lupus familiaris (dog) : APTX (aprataxin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aptx (aprataxin)
Sus scrofa (pig) : APTX (aprataxin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0556,987,714 - 57,009,481 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0561,521,843 - 61,543,083 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4558,060,210 - 58,081,165 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1558,060,392 - 58,081,344 (-)NCBI
Celera554,414,271 - 54,435,214 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Aptx
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628740
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.