Slc16a4 (solute carrier family 16, member 4) - Rat Genome Database

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Gene: Slc16a4 (solute carrier family 16, member 4) Rattus norvegicus
Analyze
Symbol: Slc16a4
Name: solute carrier family 16, member 4
RGD ID: 1359655
Description: Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in carboxylic acid transmembrane transport. Predicted to be active in plasma membrane. Orthologous to human SLC16A4 (solute carrier family 16 member 4); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295356; monocarboxylate transporter 5; similar to solute carrier family 16 (monocarboxylic acid transporters), member 4; solute carrier family 16 (monocarboxylic acid transporters), member 4; solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,593,738 - 197,621,569 (+)NCBIGRCr8
mRatBN7.22194,911,075 - 194,933,162 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,911,236 - 194,933,117 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,560,723 - 202,582,629 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,437,740 - 200,459,643 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,254,669 - 195,276,572 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,045,122 - 210,161,017 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,045,161 - 210,068,502 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,514,135 - 229,537,891 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42202,764,879 - 202,787,295 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12202,727,632 - 202,750,048 (+)NCBI
Celera2187,570,954 - 187,592,688 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium hexachloroplatinate  (ISO)
aristolochic acid A  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
furan  (EXP)
gentamycin  (EXP)
heptachlor  (EXP)
hexamethylene diisocyanate  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
methoxychlor  (EXP)
mirex  (EXP)
nitrofen  (EXP)
ozone  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
riddelliine  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Slc16a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,593,738 - 197,621,569 (+)NCBIGRCr8
mRatBN7.22194,911,075 - 194,933,162 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,911,236 - 194,933,117 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,560,723 - 202,582,629 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,437,740 - 200,459,643 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,254,669 - 195,276,572 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,045,122 - 210,161,017 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,045,161 - 210,068,502 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,514,135 - 229,537,891 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42202,764,879 - 202,787,295 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12202,727,632 - 202,750,048 (+)NCBI
Celera2187,570,954 - 187,592,688 (+)NCBICelera
Cytogenetic Map2q34NCBI
SLC16A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,362,857 - 110,391,026 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,362,851 - 110,391,082 (-)EnsemblGRCh38hg38GRCh38
GRCh371110,905,479 - 110,933,648 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,707,028 - 110,735,159 (-)NCBINCBI36Build 36hg18NCBI36
Build 341110,617,546 - 110,645,678NCBI
Celera1109,152,678 - 109,180,820 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,777,185 - 108,805,402 (-)NCBIHuRef
CHM1_11111,020,804 - 111,049,041 (-)NCBICHM1_1
T2T-CHM13v2.01110,377,933 - 110,406,181 (-)NCBIT2T-CHM13v2.0
Slc16a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,198,543 - 107,219,437 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,198,546 - 107,219,431 (+)EnsemblGRCm39 Ensembl
GRCm383107,291,230 - 107,312,115 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,291,230 - 107,312,115 (+)EnsemblGRCm38mm10GRCm38
MGSCv373107,094,210 - 107,115,033 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,419,348 - 107,440,171 (+)NCBIMGSCv36mm8
Celera3109,623,202 - 109,644,026 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.81NCBI
Slc16a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543513,865,958 - 13,892,684 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543513,865,956 - 13,892,687 (-)NCBIChiLan1.0ChiLan1.0
SLC16A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,648,956 - 116,683,991 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,796,555 - 115,831,580 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,011,906 - 113,040,494 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,302,041 - 127,330,254 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,302,041 - 127,330,254 (+)Ensemblpanpan1.1panPan2
SLC16A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1641,605,867 - 41,634,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl641,606,168 - 41,629,972 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,382,537 - 44,411,188 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0641,937,081 - 41,965,734 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl641,937,956 - 41,961,175 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1641,657,195 - 41,685,844 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0641,628,024 - 41,656,868 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,063,335 - 42,092,023 (+)NCBIUU_Cfam_GSD_1.0
Slc16a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,287,907 - 18,312,291 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367041,802,340 - 1,824,470 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367041,801,209 - 1,827,103 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC16A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,739,094 - 109,763,645 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,738,584 - 109,763,649 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,134,558 - 120,159,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC16A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,146,133 - 23,175,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2023,148,819 - 23,174,407 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603835,284,054 - 35,313,104 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc16a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247726,106,719 - 6,130,114 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247726,106,247 - 6,130,139 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc16a4
127 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:120
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000024455
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat

Markers in Region
AW146050  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22194,932,951 - 194,933,066 (+)MAPPERmRatBN7.2
Rnor_6.02210,068,412 - 210,068,526NCBIRnor6.0
Rnor_5.02229,537,231 - 229,537,345UniSTSRnor5.0
RGSC_v3.42202,787,129 - 202,787,243UniSTSRGSC3.4
Celera2187,592,522 - 187,592,636UniSTS
Cytogenetic Map2q34UniSTS
AI547803  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22194,932,606 - 194,932,810 (+)MAPPERmRatBN7.2
Rnor_6.02210,068,067 - 210,068,270NCBIRnor6.0
Rnor_5.02229,536,886 - 229,537,089UniSTSRnor5.0
RGSC_v3.42202,786,784 - 202,786,987UniSTSRGSC3.4
Celera2187,592,177 - 187,592,380UniSTS
RH 3.4 Map21378.5UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 45 113 91 90 59 25 59 6 214 93 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024455   ⟹   ENSRNOP00000024455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2194,911,236 - 194,933,117 (+)Ensembl
Rnor_6.0 Ensembl2210,045,161 - 210,068,502 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100305   ⟹   ENSRNOP00000092859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2194,911,236 - 194,933,117 (+)Ensembl
RefSeq Acc Id: NM_001013913   ⟹   NP_001013935
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,599,440 - 197,621,320 (+)NCBI
mRatBN7.22194,911,236 - 194,933,118 (+)NCBI
Rnor_6.02210,045,293 - 210,068,578 (+)NCBI
Rnor_5.02229,514,135 - 229,537,891 (+)NCBI
RGSC_v3.42202,764,879 - 202,787,295 (+)RGD
Celera2187,570,954 - 187,592,688 (+)RGD
Sequence:
RefSeq Acc Id: XM_008761389   ⟹   XP_008759611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,593,738 - 197,621,569 (+)NCBI
mRatBN7.22194,911,075 - 194,933,162 (+)NCBI
Rnor_6.02210,045,130 - 210,068,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102076   ⟹   XP_038958004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,593,738 - 197,621,569 (+)NCBI
mRatBN7.22194,911,080 - 194,933,162 (+)NCBI
RefSeq Acc Id: XM_063281656   ⟹   XP_063137726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,593,738 - 197,621,105 (+)NCBI
RefSeq Acc Id: NP_001013935   ⟸   NM_001013913
- UniProtKB: Q5U2P9 (UniProtKB/TrEMBL),   D3ZFJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759611   ⟸   XM_008761389
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AID2 (UniProtKB/TrEMBL),   A6HUT7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024455   ⟸   ENSRNOT00000024455
RefSeq Acc Id: XP_038958004   ⟸   XM_039102076
- Peptide Label: isoform X1
- UniProtKB: D3ZFJ5 (UniProtKB/TrEMBL),   Q5U2P9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092859   ⟸   ENSRNOT00000100305
RefSeq Acc Id: XP_063137726   ⟸   XM_063281656
- Peptide Label: isoform X2
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2P9-F1-model_v2 AlphaFold Q5U2P9 1-500 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691659
Promoter ID:EPDNEW_R2184
Type:initiation region
Name:Slc16a4_1
Description:solute carrier family 16, member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02210,045,297 - 210,045,357EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359655 AgrOrtholog
BioCyc Gene G2FUF-51678 BioCyc
Ensembl Genes ENSRNOG00000018131 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024455 ENTREZGENE
  ENSRNOT00000024455.7 UniProtKB/TrEMBL
  ENSRNOT00000100305 ENTREZGENE
  ENSRNOT00000100305.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108742 IMAGE-MGC_LOAD
InterPro MFS_1 UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  Proton-linked_MCT UniProtKB/TrEMBL
KEGG Report rno:295356 UniProtKB/TrEMBL
MGC_CLONE MGC:94829 IMAGE-MGC_LOAD
NCBI Gene 295356 ENTREZGENE
PANTHER MONOCARBOXYLATE TRANSPORTER UniProtKB/TrEMBL
  MONOCARBOXYLATE TRANSPORTER 5 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PhenoGen Slc16a4 PhenoGen
PROSITE MFS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018131 RatGTEx
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL
UniProt A0A8I6AID2 ENTREZGENE, UniProtKB/TrEMBL
  A6HUT7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFJ5 ENTREZGENE
  Q5U2P9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3ZFJ5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-02 Slc16a4  solute carrier family 16, member 4  Slc16a4  solute carrier family 16, member 4 (monocarboxylic acid transporter 5)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc16a4  solute carrier family 16, member 4 (monocarboxylic acid transporter 5)  Slc16a4  solute carrier family 16 (monocarboxylic acid transporters), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Slc16a4  solute carrier family 16 (monocarboxylic acid transporters), member 4      Symbol and Name updated 1299863 APPROVED
2005-07-29 LOC295356  similar to solute carrier family 16 (monocarboxylic acid transporters), member 4      Symbol and Name status set to provisional 70820 PROVISIONAL