Atp2b2 (ATPase plasma membrane Ca2+ transporting 2) - Rat Genome Database

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Gene: Atp2b2 (ATPase plasma membrane Ca2+ transporting 2) Rattus norvegicus
Analyze
Symbol: Atp2b2
Name: ATPase plasma membrane Ca2+ transporting 2
RGD ID: 2176
Description: Enables several functions, including ATP binding activity; P-type calcium transporter activity; and PDZ domain binding activity. Involved in brain development and neural retina development. Located in several cellular components, including apical plasma membrane; dendritic spine membrane; and neuronal cell body membrane. Is active in several cellular components, including GABA-ergic synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATPase isoform 2 Na+K+ transporting beta polypeptide 2; ATPase isoform 2, Na+K+ transporting, beta polypeptide 2; ATPase, Ca++ transporting, plasma membrane 2; plasma membrane Ca++-ATPase; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 2; PMCA2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24146,896,332 - 147,140,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,896,332 - 147,140,665 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4152,279,141 - 152,592,499 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04148,060,008 - 148,373,376 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04146,688,239 - 147,002,829 (-)NCBIRnor_WKY
Rnor_6.04145,704,779 - 145,948,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,703,046 - 146,016,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04209,001,178 - 209,242,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,655,651 - 149,907,813 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,903,289 - 150,220,388 (-)NCBI
Celera4135,451,009 - 135,760,704 (-)NCBICelera
RH 3.4 Map4948.3RGD
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium acetate  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
dicrotophos  (ISO)
dopamine  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenoldopam  (EXP)
folic acid  (ISO)
furan  (ISO)
indole-3-methanol  (EXP)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
orphenadrine  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (EXP)
propiconazole  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
2. Expression of plasma membrane calcium-pumping ATPase mRNAs in developing rat brain and adult brain subregions: evidence for stage-specific expression. Brandt P and Neve RL, J Neurochem. 1992 Oct;59(4):1566-9.
3. Calcium pumps in health and disease. Brini M and Carafoli E, Physiol Rev. 2009 Oct;89(4):1341-78. doi: 10.1152/physrev.00032.2008.
4. Perisynaptic organization of plasma membrane calcium pumps in cerebellar cortex. Burette A and Weinberg RJ, J Comp Neurol. 2007 Feb 20;500(6):1127-35. doi: 10.1002/cne.21237.
5. A plasma membrane Ca2+ ATPase isoform at the postsynaptic density. Burette AC, etal., Neuroscience. 2010 Sep 1;169(3):987-93. doi: 10.1016/j.neuroscience.2010.05.062. Epub 2010 Jun 3.
6. Molecular interactions of the plasma membrane calcium ATPase 2 at pre- and post-synaptic sites in rat cerebellum. Garside ML, etal., Neuroscience. 2009 Aug 18;162(2):383-95. Epub 2009 May 3.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. PMCA2 via PSD-95 controls calcium signaling by alpha7-containing nicotinic acetylcholine receptors on aspiny interneurons. Gomez-Varela D, etal., J Neurosci. 2012 May 16;32(20):6894-905. doi: 10.1523/JNEUROSCI.5972-11.2012.
10. Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells. Grati M, etal., J Cell Sci. 2006 Jul 15;119(Pt 14):2995-3007. Epub 2006 Jun 27.
11. Rapid turnover of stereocilia membrane proteins: evidence from the trafficking and mobility of plasma membrane Ca(2+)-ATPase 2. Grati M, etal., J Neurosci. 2006 Jun 7;26(23):6386-95.
12. Partitioning of the plasma membrane Ca2+-ATPase into lipid rafts in primary neurons: effects of cholesterol depletion. Jiang L, etal., J Neurochem. 2007 Jul;102(2):378-88.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. Ontogeny of plasma membrane Ca2+ ATPase isoforms in the neural retina of the postnatal rat. Renteria RC, etal., Vis Neurosci. 2005 May-Jun;22(3):263-74.
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. Sgambato-Faure V, etal., Biochem Biophys Res Commun. 2006 May 5;343(2):630-7. Epub 2006 Mar 15.
22. Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases. Shull GE and Greeb J, J Biol Chem 1988 Jun 25;263(18):8646-57.
Additional References at PubMed
PMID:1315513   PMID:2765934   PMID:3038581   PMID:7518067   PMID:7683393   PMID:7929331   PMID:8428948   PMID:9325047   PMID:9668038   PMID:9697703   PMID:10441500   PMID:10687933  
PMID:11259493   PMID:11786550   PMID:11875276   PMID:11950541   PMID:11985881   PMID:12624087   PMID:15302868   PMID:15350283   PMID:15765049   PMID:15829536   PMID:16529873   PMID:16763025  
PMID:16845470   PMID:16880690   PMID:17170045   PMID:17234811   PMID:17409239   PMID:17823248   PMID:17970729   PMID:18570454   PMID:18643776   PMID:19025983   PMID:19120150   PMID:19410650  
PMID:19653992   PMID:20398509   PMID:20489728   PMID:21798237   PMID:22672315   PMID:22871113   PMID:24269647   PMID:25014339   PMID:25276815   PMID:25315779   PMID:28153703   PMID:29476059  
PMID:31032369  


Genomics

Comparative Map Data
Atp2b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24146,896,332 - 147,140,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,896,332 - 147,140,665 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4152,279,141 - 152,592,499 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04148,060,008 - 148,373,376 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04146,688,239 - 147,002,829 (-)NCBIRnor_WKY
Rnor_6.04145,704,779 - 145,948,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,703,046 - 146,016,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04209,001,178 - 209,242,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,655,651 - 149,907,813 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,903,289 - 150,220,388 (-)NCBI
Celera4135,451,009 - 135,760,704 (-)NCBICelera
RH 3.4 Map4948.3RGD
Cytogenetic Map4q42NCBI
ATP2B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38310,324,023 - 10,708,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl310,324,023 - 10,708,007 (-)EnsemblGRCh38hg38GRCh38
GRCh37310,365,707 - 10,661,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,342,744 - 10,466,546 (-)NCBINCBI36Build 36hg18NCBI36
Build 34310,342,744 - 10,466,546NCBI
Celera310,301,512 - 10,482,740 (-)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef310,301,047 - 10,335,597 (-)NCBIHuRef
HuRef310,348,273 - 10,482,006 (-)NCBIHuRef
CHM1_1310,315,744 - 10,497,280 (-)NCBICHM1_1
T2T-CHM13v2.0310,317,333 - 10,614,270 (-)NCBIT2T-CHM13v2.0
Atp2b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,720,792 - 114,019,574 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6113,720,792 - 114,019,574 (-)EnsemblGRCm39 Ensembl
GRCm386113,743,831 - 114,042,613 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,743,831 - 114,042,613 (-)EnsemblGRCm38mm10GRCm38
MGSCv376113,695,662 - 113,992,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366113,711,445 - 114,007,621 (-)NCBIMGSCv36mm8
Celera6115,571,179 - 115,799,955 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.85NCBI
Atp2b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,727,935 - 1,851,907 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,727,935 - 1,851,907 (-)NCBIChiLan1.0ChiLan1.0
ATP2B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1310,611,619 - 10,979,238 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl310,611,619 - 10,738,006 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0310,260,556 - 10,643,346 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ATP2B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1207,665,468 - 8,037,407 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl207,749,807 - 8,034,474 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha207,700,708 - 8,073,696 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0207,695,736 - 8,069,081 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl207,695,764 - 8,067,042 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1207,411,304 - 7,790,973 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0207,763,652 - 8,136,675 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0207,736,523 - 8,110,287 (+)NCBIUU_Cfam_GSD_1.0
Atp2b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,898,661 - 16,164,953 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366022,744,759 - 3,007,940 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366022,744,757 - 3,011,051 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP2B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,528,323 - 66,897,128 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11366,526,508 - 66,897,125 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ATP2B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12246,360,306 - 46,742,446 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2246,368,243 - 46,662,220 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041119,794,423 - 120,176,947 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp2b2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247315,029,421 - 5,190,996 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247314,836,109 - 5,190,990 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp2b2
1021 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3430
Count of miRNA genes:316
Interacting mature miRNAs:414
Transcripts:ENSRNOT00000043476, ENSRNOT00000044110, ENSRNOT00000049290, ENSRNOT00000050928, ENSRNOT00000064541, ENSRNOT00000067931
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat

Markers in Region
D3S3990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,899,207 - 146,899,383 (+)MAPPERmRatBN7.2
Rnor_6.04145,707,654 - 145,707,829NCBIRnor6.0
Rnor_5.04209,004,053 - 209,004,228UniSTSRnor5.0
RGSC_v3.44149,658,526 - 149,658,701UniSTSRGSC3.4
Celera4135,453,884 - 135,454,059UniSTS
Cytogenetic Map4q41.3-q42.1UniSTS
RH142691  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24147,029,203 - 147,029,303 (+)MAPPERmRatBN7.2
Rnor_6.04145,837,969 - 145,838,068NCBIRnor6.0
Rnor_5.04209,132,438 - 209,132,537UniSTSRnor5.0
RGSC_v3.44149,793,065 - 149,793,164UniSTSRGSC3.4
Celera4135,581,970 - 135,582,069UniSTS
RH 3.4 Map4950.7UniSTS
Cytogenetic Map4q41.3-q42.1UniSTS
RH94465  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,898,953 - 146,899,126 (+)MAPPERmRatBN7.2
Rnor_6.04145,707,400 - 145,707,572NCBIRnor6.0
Rnor_5.04209,003,799 - 209,003,971UniSTSRnor5.0
RGSC_v3.44149,658,272 - 149,658,444UniSTSRGSC3.4
Celera4135,453,630 - 135,453,802UniSTS
RH 3.4 Map4948.3UniSTS
Cytogenetic Map4q41.3-q42.1UniSTS
RH141415  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,926,607 - 146,926,799 (+)MAPPERmRatBN7.2
Rnor_6.04145,735,055 - 145,735,246NCBIRnor6.0
Rnor_5.04209,031,113 - 209,031,304UniSTSRnor5.0
RGSC_v3.44149,687,765 - 149,687,956UniSTSRGSC3.4
Celera4135,481,137 - 135,481,328UniSTS
RH 3.4 Map4947.1UniSTS
Cytogenetic Map4q41.3-q42.1UniSTS
Atp2b2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,896,756 - 146,897,034 (+)MAPPERmRatBN7.2
Rnor_6.04145,705,204 - 145,705,480NCBIRnor6.0
Rnor_5.04209,001,603 - 209,001,879UniSTSRnor5.0
RGSC_v3.44149,656,076 - 149,656,352UniSTSRGSC3.4
Celera4135,451,434 - 135,451,710UniSTS
Cytogenetic Map4q41.3-q42.1UniSTS
D6Mit141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24147,171,223 - 147,171,953 (+)MAPPERmRatBN7.2
Rnor_6.04145,979,550 - 145,980,279NCBIRnor6.0
Rnor_5.04209,273,413 - 209,274,142UniSTSRnor5.0
RGSC_v3.44149,938,366 - 149,939,095UniSTSRGSC3.4
Celera4135,723,972 - 135,724,701UniSTS
Cytogenetic Map4q41.3-q42.1UniSTS
D3S2930E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,898,106 - 146,898,299 (+)MAPPERmRatBN7.2
Rnor_6.04145,706,553 - 145,706,745NCBIRnor6.0
Rnor_5.04209,002,952 - 209,003,144UniSTSRnor5.0
RGSC_v3.44149,657,425 - 149,657,617UniSTSRGSC3.4
Celera4135,452,783 - 135,452,975UniSTS
Cytogenetic Map4q41.3-q42.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 62 1
Low 42 43 35 5 35 3 3 12 27 24 3 3
Below cutoff 3 1 14 6 14 6 5 7 6 16 8 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000043476   ⟹   ENSRNOP00000045983
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,896,334 - 147,140,665 (-)Ensembl
Rnor_6.0 Ensembl4145,703,046 - 145,948,996 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000067931   ⟹   ENSRNOP00000060489
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,896,332 - 147,140,665 (-)Ensembl
Rnor_6.0 Ensembl4145,704,779 - 146,016,325 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094304   ⟹   ENSRNOP00000097553
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,896,334 - 147,140,665 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095628   ⟹   ENSRNOP00000090928
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,896,332 - 147,140,665 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098532   ⟹   ENSRNOP00000081850
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,896,334 - 147,140,665 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111682   ⟹   ENSRNOP00000090223
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,896,334 - 147,140,665 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115111   ⟹   ENSRNOP00000091175
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,896,332 - 147,140,665 (-)Ensembl
RefSeq Acc Id: NM_012508   ⟹   NP_036640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24146,896,332 - 147,140,665 (-)NCBI
Rnor_6.04145,704,779 - 145,948,997 (-)NCBI
Rnor_5.04209,001,178 - 209,242,860 (-)NCBI
RGSC_v3.44149,655,651 - 149,907,813 (-)RGD
Celera4135,451,009 - 135,760,704 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036640 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA74219 (Get FASTA)   NCBI Sequence Viewer  
  AAB60703 (Get FASTA)   NCBI Sequence Viewer  
  EDL91561 (Get FASTA)   NCBI Sequence Viewer  
  EDL91562 (Get FASTA)   NCBI Sequence Viewer  
  P11506 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036640   ⟸   NM_012508
- UniProtKB: P11506 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000045983   ⟸   ENSRNOT00000043476
RefSeq Acc Id: ENSRNOP00000060489   ⟸   ENSRNOT00000067931
RefSeq Acc Id: ENSRNOP00000091175   ⟸   ENSRNOT00000115111
RefSeq Acc Id: ENSRNOP00000090223   ⟸   ENSRNOT00000111682
RefSeq Acc Id: ENSRNOP00000090928   ⟸   ENSRNOT00000095628
RefSeq Acc Id: ENSRNOP00000081850   ⟸   ENSRNOT00000098532
RefSeq Acc Id: ENSRNOP00000097553   ⟸   ENSRNOT00000094304
Protein Domains
Cation_ATPase_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11506-F1-model_v2 AlphaFold P11506 1-1243 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2176 AgrOrtholog
BioCyc Gene G2FUF-43362 BioCyc
Ensembl Genes ENSRNOG00000030269 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000045983.5 UniProtKB/TrEMBL
  ENSRNOP00000060489.4 UniProtKB/TrEMBL
  ENSRNOP00000081850.1 UniProtKB/TrEMBL
  ENSRNOP00000090223.1 UniProtKB/TrEMBL
  ENSRNOP00000090928 UniProtKB/Swiss-Prot
  ENSRNOP00000091175 ENTREZGENE
  ENSRNOP00000091175.1 UniProtKB/TrEMBL
  ENSRNOP00000097553.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043476.6 UniProtKB/TrEMBL
  ENSRNOT00000067931.4 UniProtKB/TrEMBL
  ENSRNOT00000094304.1 UniProtKB/TrEMBL
  ENSRNOT00000095628 UniProtKB/Swiss-Prot
  ENSRNOT00000098532.1 UniProtKB/TrEMBL
  ENSRNOT00000111682.1 UniProtKB/TrEMBL
  ENSRNOT00000115111 ENTREZGENE
  ENSRNOT00000115111.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATP2B2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_Ca_trans_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-type_ATPase_IIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24215 UniProtKB/Swiss-Prot
NCBI Gene 24215 ENTREZGENE
PANTHER PTHR24093:SF377 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP_Ca_trans_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation_ATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp2b2 PhenoGen
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Cation_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81653 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs ATPase-IIB_Ca UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZSI6_RAT UniProtKB/TrEMBL
  A0A8I6ADD4_RAT UniProtKB/TrEMBL
  A0A8I6AF36_RAT UniProtKB/TrEMBL
  A0A8I6ANJ1_RAT UniProtKB/TrEMBL
  A0A8L2QTH1_RAT UniProtKB/TrEMBL
  AT2B2_RAT UniProtKB/Swiss-Prot
  D4A8B3_RAT UniProtKB/TrEMBL
  P11506 ENTREZGENE
UniProt Secondary Q63443 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp2b2  ATPase plasma membrane Ca2+ transporting 2  Atp2b2  ATPase, Ca++ transporting, plasma membrane 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Atp2b2  ATPase, Ca++ transporting, plasma membrane 2    ATPase isoform 2, Na+K+ transporting, beta polypeptide 2  Name updated 629478 APPROVED
2002-06-10 Atp2b2  ATPase isoform 2, Na+K+ transporting, beta polypeptide 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to plasma membrane 631720
gene_function Ca2+ ATPase 631720
gene_process plays an essential role in the regulation of intracellular Ca2+ levels 631720