RGD Reference Report - The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. - Rat Genome Database

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The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump.

Authors: Sgambato-Faure, V  Xiong, Y  Berke, JD  Hyman, SE  Strehler, EE 
Citation: Sgambato-Faure V, etal., Biochem Biophys Res Commun. 2006 May 5;343(2):630-7. Epub 2006 Mar 15.
RGD ID: 1581788
Pubmed: PMID:16554037   (View Abstract at PubMed)
PMCID: PMC3873836   (View Article at PubMed Central)
DOI: DOI:10.1016/j.bbrc.2006.03.020   (Journal Full-text)

The Homer family of scaffold proteins couples NMDA receptors to metabotropic glutamate receptors and links extracellular signals to calcium release from intracellular stores. Ania-3 is a member of the Homer family and is rapidly inducible in brain in response to diverse stimuli. Here, we report the identification of the plasma membrane Ca2+ ATPase (PMCA) as a novel Ania-3/Homer-associated protein. Ania-3/Homer interacts with the b-splice forms of all PMCAs (PMCA1b, 2b, 3b, and 4b) via their PDZ domain-binding COOH-terminal tail. Ectopically expressed Ania-3 colocalized with the PMCA at the plasma membrane of polarized MDCK epithelial cells, and endogenous Ania-3/Homer and PMCA2 are co-expressed in the soma and dendrites of primary rat hippocampal neurons. The interaction between Ania-3/Homer and PMCAs may represent a novel mechanism by which local calcium signaling and hence synaptic function can be modulated in neurons.




Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Atp2b2Ratdendrite  IDA  RGD 
Homer1Ratdendrite  IDA  RGD 
Atp2b2Ratneuronal cell body  IDA  RGD 
Homer1Ratneuronal cell body  IDA  RGD 

Molecular Function

  


Genes (Rattus norvegicus)
Atp2b1  (ATPase plasma membrane Ca2+ transporting 1) Atp2b2  (ATPase plasma membrane Ca2+ transporting 2) Atp2b3  (ATPase plasma membrane Ca2+ transporting 3)
Atp2b4  (ATPase plasma membrane Ca2+ transporting 4) Grm5  (glutamate metabotropic receptor 5) Homer1  (homer scaffold protein 1)