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Gene: Atp2b4 (ATPase plasma membrane Ca2+ transporting 4) Rattus norvegicus
Symbol: Atp2b4
Name: ATPase plasma membrane Ca2+ transporting 4
Description: Exhibits PDZ domain binding activity; calcium transmembrane transporter activity, phosphorylative mechanism; and protein kinase binding activity. Predicted to contribute to sodium channel regulator activity. Involved in several processes, including calcium ion transport; hippocampus development; and negative regulation of calcineurin-NFAT signaling cascade. Localizes to several cellular components, including basolateral plasma membrane; integral component of presynaptic active zone membrane; and sperm principal piece. Biomarker of dystonia. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: ATPase, Ca++ transporting, plasma membrane 4; plasma membrane Ca2+-ATPases 4; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 4; PMCA4
Homo sapiens (human) : ATP2B4 (ATPase plasma membrane Ca2+ transporting 4)  HGNC  Alliance
Mus musculus (house mouse) : Atp2b4 (ATPase, Ca++ transporting, plasma membrane 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp2b4 (ATPase plasma membrane Ca2+ transporting 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP2B4 (ATPase plasma membrane Ca2+ transporting 4)
Canis lupus familiaris (dog) : ATP2B4 (ATPase plasma membrane Ca2+ transporting 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp2b4 (ATPase plasma membrane Ca2+ transporting 4)
Sus scrofa (pig) : ATP2B4 (ATPase plasma membrane Ca2+ transporting 4)
Chlorocebus sabaeus (African green monkey) : ATP2B4 (ATPase plasma membrane Ca2+ transporting 4)
Heterocephalus glaber (naked mole-rat) : Atp2b4 (ATPase plasma membrane Ca2+ transporting 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01350,091,644 - 50,153,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,091,430 - 50,153,823 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,157,902 - 55,204,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,631,205 - 46,697,214 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,645,247 - 46,711,257 (-)NCBI
Celera1345,491,969 - 45,537,415 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Atp2b4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621305
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.