Atp2b4 (ATPase plasma membrane Ca2+ transporting 4) - Rat Genome Database
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Gene: Atp2b4 (ATPase plasma membrane Ca2+ transporting 4) Rattus norvegicus
Analyze
Symbol: Atp2b4
Name: ATPase plasma membrane Ca2+ transporting 4
RGD ID: 621305
Description: Exhibits PDZ domain binding activity; calcium transmembrane transporter activity, phosphorylative mechanism; and protein kinase binding activity. Predicted to contribute to sodium channel regulator activity. Involved in several processes, including calcium ion transport; hippocampus development; and negative regulation of calcineurin-NFAT signaling cascade. Localizes to several cellular components, including basolateral plasma membrane; integral component of presynaptic active zone membrane; and sperm principal piece. Biomarker of dystonia. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATPase, Ca++ transporting, plasma membrane 4; plasma membrane Ca2+-ATPases 4; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 4; PMCA4
Orthologs:
Homo sapiens (human) : ATP2B4 (ATPase plasma membrane Ca2+ transporting 4)  HGNC  Alliance
Mus musculus (house mouse) : Atp2b4 (ATPase, Ca++ transporting, plasma membrane 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp2b4 (ATPase plasma membrane Ca2+ transporting 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP2B4 (ATPase plasma membrane Ca2+ transporting 4)
Canis lupus familiaris (dog) : ATP2B4 (ATPase plasma membrane Ca2+ transporting 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp2b4 (ATPase plasma membrane Ca2+ transporting 4)
Sus scrofa (pig) : ATP2B4 (ATPase plasma membrane Ca2+ transporting 4)
Chlorocebus sabaeus (African green monkey) : ATP2B4 (ATPase plasma membrane Ca2+ transporting 4)
Heterocephalus glaber (naked mole-rat) : Atp2b4 (ATPase plasma membrane Ca2+ transporting 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01350,091,644 - 50,153,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,091,430 - 50,153,823 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,157,902 - 55,204,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,631,205 - 46,697,214 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,645,247 - 46,711,257 (-)NCBI
Celera1345,491,969 - 45,537,415 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
butan-1-ol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
formaldehyde  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lycopene  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
methotrexate  (ISO)
methylseleninic acid  (ISO)
nickel sulfate  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
phenylephrine  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
prostaglandin F2alpha  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zalcitabine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion export  (IMP,ISO)
calcium ion transmembrane transport  (IMP,ISO)
calcium ion transport  (IDA)
cellular calcium ion homeostasis  (IBA,ISO,ISS)
cellular response to acetylcholine  (ISO,ISS)
cellular response to epinephrine stimulus  (ISO)
flagellated sperm motility  (ISO,ISS)
hippocampus development  (IEP)
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of arginine catabolic process  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (IMP,ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (ISO)
negative regulation of cellular response to vascular endothelial growth factor stimulus  (ISO)
negative regulation of citrulline biosynthetic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of nitric oxide mediated signal transduction  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of the force of heart contraction  (ISO)
neural retina development  (IEP)
positive regulation of cAMP-dependent protein kinase activity  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
regulation of cell cycle G1/S phase transition  (ISO)
regulation of cytosolic calcium ion concentration  (IBA)
regulation of transcription by RNA polymerase II  (ISO)
response to hydrostatic pressure  (ISO)
spermatogenesis  (IEP)
urinary bladder smooth muscle contraction  (ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7694502   PMID:7945253   PMID:8428948   PMID:8530416   PMID:11591728   PMID:15078889   PMID:15955804   PMID:16956963   PMID:17242280   PMID:18591664   PMID:19278978   PMID:19715754  
PMID:19946888   PMID:21740891   PMID:22871113   PMID:23549614   PMID:24448801   PMID:25147342   PMID:25798335   PMID:29476059  


Genomics

Comparative Map Data
Atp2b4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01350,091,644 - 50,153,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,091,430 - 50,153,823 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,157,902 - 55,204,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,631,205 - 46,697,214 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,645,247 - 46,711,257 (-)NCBI
Celera1345,491,969 - 45,537,415 (-)NCBICelera
Cytogenetic Map13q13NCBI
ATP2B4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1203,626,561 - 203,744,081 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1203,626,787 - 203,744,081 (+)EnsemblGRCh38hg38GRCh38
GRCh381203,626,832 - 203,744,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371203,595,915 - 203,713,209 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,862,551 - 201,979,832 (+)NCBINCBI36hg18NCBI36
Build 341200,327,584 - 200,444,864NCBI
Celera1176,726,268 - 176,843,554 (+)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1174,761,519 - 174,878,762 (+)NCBIHuRef
CHM1_11205,019,430 - 205,136,718 (+)NCBICHM1_1
Atp2b4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,630,411 - 133,728,797 (-)NCBI
GRCm381133,702,674 - 133,801,059 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,699,457 - 133,801,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv371135,600,842 - 135,650,098 (-)NCBIGRCm37mm9NCBIm37
MGSCv361135,523,068 - 135,569,692 (-)NCBImm8
Celera1136,319,758 - 136,369,233 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.95NCBI
Atp2b4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,552,019 - 39,645,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,552,034 - 39,645,694 (+)NCBIChiLan1.0ChiLan1.0
ATP2B4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11183,524,723 - 183,639,882 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,580,773 - 183,639,882 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01179,231,712 - 179,348,759 (+)NCBIMhudiblu_PPA_v0panPan3
ATP2B4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl38366,656 - 416,952 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.138321,246 - 420,262 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Atp2b4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936567944,825 - 1,039,920 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP2B4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,336,499 - 64,445,663 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,336,354 - 64,445,669 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,628,153 - 70,765,686 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP2B4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2525,602,715 - 25,661,553 (-)Ensembl
ChlSab1.12525,602,857 - 25,716,385 (-)NCBI
Atp2b4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248077,201,924 - 7,292,010 (-)NCBI

Position Markers
D13Wox2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01350,147,494 - 50,147,634NCBIRnor6.0
Rnor_5.01355,201,712 - 55,201,852UniSTSRnor5.0
RGSC_v3.41346,633,558 - 46,633,698UniSTSRGSC3.4
RGSC_v3.41346,633,557 - 46,633,698RGDRGSC3.4
RGSC_v3.11346,647,601 - 46,647,741RGD
Celera1345,494,322 - 45,494,462UniSTS
Cytogenetic Map13q13UniSTS
RH 3.4 Map13173.4UniSTS
RH 3.4 Map13173.4RGD
RH 2.0 Map13366.2RGD


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13901674250513953Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131409633059096330Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131409633059096330Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131444158250799665Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131444158251577031Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131981081464810814Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)132005247765052477Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132148248158537177Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132800833873008338Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132858445273584452Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132907693474076934Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132907693474076934Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133614753364868393Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133734634882346348Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134644457050799665Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134877665553264877Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134905850767207219Rat
12879436Bp395Blood pressure QTL 395arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134999470851081193Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:338
Count of miRNA genes:152
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000004078, ENSRNOT00000041084, ENSRNOT00000046273
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 28 22 17 22 1 1 72 34 40 11 1
Low 13 28 18 2 18 7 10 2 1 1 7
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004078   ⟹   ENSRNOP00000004078
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1350,103,189 - 50,149,839 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000046273   ⟹   ENSRNOP00000039880
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1350,091,430 - 50,153,823 (+)Ensembl
RefSeq Acc Id: NM_001005871   ⟹   NP_001005871
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,103,022 - 50,149,987 (+)NCBI
Rnor_5.01355,157,902 - 55,204,205 (+)NCBI
RGSC_v3.41346,631,205 - 46,697,214 (-)RGD
Celera1345,491,969 - 45,537,415 (-)RGD
Sequence:
RefSeq Acc Id: XM_008769446   ⟹   XP_008767668
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,091,645 - 50,153,808 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769447   ⟹   XP_008767669
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,101,656 - 50,153,808 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769448   ⟹   XP_008767670
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,091,645 - 50,153,808 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769449   ⟹   XP_008767671
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,091,644 - 50,153,808 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769450   ⟹   XP_008767672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,091,644 - 50,149,820 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598773   ⟹   XP_017454262
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,091,644 - 50,153,808 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001005871   ⟸   NM_001005871
- UniProtKB: Q64542 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767671   ⟸   XM_008769449
- Peptide Label: isoform X3
- UniProtKB: Q64542 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767672   ⟸   XM_008769450
- Peptide Label: isoform X4
- UniProtKB: Q64542 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767668   ⟸   XM_008769446
- Peptide Label: isoform X1
- UniProtKB: Q64542 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767670   ⟸   XM_008769448
- Peptide Label: isoform X2
- UniProtKB: Q64542 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767669   ⟸   XM_008769447
- Peptide Label: isoform X1
- UniProtKB: Q64542 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454262   ⟸   XM_017598773
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000004078   ⟸   ENSRNOT00000004078
RefSeq Acc Id: ENSRNOP00000039880   ⟸   ENSRNOT00000046273

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
13 50116624 50116625 A C snv MR/N (MCW)
13 50125564 50125565 T C snv Buf/N (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621305 AgrOrtholog
Ensembl Genes ENSRNOG00000003031 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004078 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000039880 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004078 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000046273 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
InterPro ATP2B4 UniProtKB/Swiss-Prot
  ATP_Ca_trans_C UniProtKB/Swiss-Prot
  ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  P-type_ATPase_IIB UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
KEGG Report rno:29600 UniProtKB/Swiss-Prot
NCBI Gene 29600 ENTREZGENE
PANTHER PTHR24093:SF435 UniProtKB/Swiss-Prot
Pfam ATP_Ca_trans_C UniProtKB/Swiss-Prot
  Cation_ATPase_C UniProtKB/Swiss-Prot
  Cation_ATPase_N UniProtKB/Swiss-Prot
PhenoGen Atp2b4 PhenoGen
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
SMART Cation_ATPase_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81660 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
TIGRFAMs ATPase-IIB_Ca UniProtKB/Swiss-Prot
  ATPase_P-type UniProtKB/Swiss-Prot
UniGene Rn.9986 ENTREZGENE
UniProt AT2B4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q63127 UniProtKB/Swiss-Prot
  Q63445 UniProtKB/Swiss-Prot
  Q64543 UniProtKB/Swiss-Prot
  Q64544 UniProtKB/Swiss-Prot
  Q64545 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp2b4  ATPase plasma membrane Ca2+ transporting 4  Atp2b4  ATPase, Ca++ transporting, plasma membrane 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Atp2b4  ATPase, Ca++ transporting, plasma membrane 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Atp2b4  ATPase, Ca++ transporting, plasma membrane 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalizes with voltage-gated Ca2+ channels 628395
gene_function binds to and extrudes Ca++ from neurons 628395
gene_process meidates Ca2+ expulsion from the somata of dorsal root ganglion (DRG) neurons and from the presynaptic terminals of photoreceptors 628395
gene_regulation removal of action potential-induced Ca2+ loads in sensory neurons is greatly enhanced by bradykinin and ATP; the carboxy-terminal domains are phosphorylated by protein kinase A (PKA) and protein kinase C (PKC) 628395