Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Adgrl2 | Rat | 1,2-dichloroethane | decreases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of LPHN2 mRNA | CTD | PMID:28960355 | Adgrl2 | Rat | 17beta-estradiol | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of ADGRL2 mRNA | CTD | PMID:20660070 | Adgrl2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ADGRL2 mRNA | CTD | PMID:20106945 and PMID:21632981 | Adgrl2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ADGRL2 mRNA | CTD | PMID:33387578 | Adgrl2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ADGRL2 mRNA | CTD | PMID:34747641 | Adgrl2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Adgrl2 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of ADGRL2 mRNA | CTD | PMID:25975270 | Adgrl2 | Rat | 2,4-diaminotoluene | decreases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | 2 and 4-diaminotoluene results in decreased expression of ADGRL2 mRNA | CTD | PMID:20713471 | Adgrl2 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of ADGRL2 mRNA | CTD | PMID:21346803 | Adgrl2 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ADGRL2 mRNA | CTD | PMID:30071829 | Adgrl2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ADGRL2 mRNA | CTD | PMID:28628672 | Adgrl2 | Rat | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of ADGRL2 mRNA | CTD | PMID:19162173 | Adgrl2 | Rat | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of ADGRL2 mRNA | CTD | PMID:30723492 | Adgrl2 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | Fenretinide results in increased expression of ADGRL2 mRNA | CTD | PMID:28973697 | Adgrl2 | Rat | 5-fluorouracil | affects response to substance | ISO | ADGRL2 (Homo sapiens) | 6480464 | ADGRL2 protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | Adgrl2 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of ADGRL2 mRNA and Propylthiouracil results in increased expression of LPHN2 mRNA | CTD | PMID:24780913 more ... | Adgrl2 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of ADGRL2 mRNA | CTD | PMID:31881176 | Adgrl2 | Rat | acrylamide | increases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of ADGRL2 mRNA | CTD | PMID:32763439 | Adgrl2 | Rat | aflatoxin B1 | decreases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of ADGRL2 mRNA | CTD | PMID:19770486 | Adgrl2 | Rat | aflatoxin B1 | increases methylation | ISO | ADGRL2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of ADGRL2 intron | CTD | PMID:30157460 | Adgrl2 | Rat | aristolochic acid A | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of ADGRL2 mRNA | CTD | PMID:33212167 | Adgrl2 | Rat | arsenite(3-) | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | arsenite results in decreased expression of ADGRL2 mRNA | CTD | PMID:23974009 | Adgrl2 | Rat | benzo[a]pyrene | decreases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of ADGRL2 mRNA | CTD | PMID:19770486 | Adgrl2 | Rat | benzo[a]pyrene | decreases methylation | ISO | ADGRL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of LPHN2 5' UTR | CTD | PMID:27901495 | Adgrl2 | Rat | benzo[a]pyrene | increases methylation | ISO | ADGRL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of LPHN2 promoter | CTD | PMID:27901495 | Adgrl2 | Rat | benzo[a]pyrene | increases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of ADGRL2 mRNA | CTD | PMID:22610609 | Adgrl2 | Rat | benzo[b]fluoranthene | increases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of ADGRL2 mRNA | CTD | PMID:26377693 | Adgrl2 | Rat | beta-naphthoflavone | multiple interactions | ISO | Adgrl2 (Mus musculus) | 6480464 | AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of ADGRL2 mRNA] | CTD | PMID:22234961 | Adgrl2 | Rat | beta-naphthoflavone | decreases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | beta-Naphthoflavone results in decreased expression of ADGRL2 mRNA | CTD | PMID:22234961 | Adgrl2 | Rat | bis(2-chloroethyl) sulfide | affects expression | EXP | | 6480464 | Mustard Gas affects the expression of ADGRL2 mRNA | CTD | PMID:15651846 | Adgrl2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of ADGRL2 mRNA | CTD | PMID:12075121 more ... | Adgrl2 | Rat | bisphenol A | increases methylation | ISO | ADGRL2 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of ADGRL2 gene | CTD | PMID:31601247 | Adgrl2 | Rat | bisphenol A | increases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of ADGRL2 mRNA | CTD | PMID:29275510 | Adgrl2 | Rat | bisphenol A | decreases methylation | ISO | Adgrl2 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of ADGRL2 promoter | CTD | PMID:27312807 | Adgrl2 | Rat | bisphenol A | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of ADGRL2 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ADGRL2 mRNA | CTD | PMID:28628672 and PMID:31601247 | Adgrl2 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of ADGRL2 mRNA | CTD | PMID:25181051 | Adgrl2 | Rat | butanal | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of ADGRL2 mRNA | CTD | PMID:26079696 | Adgrl2 | Rat | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of ADGRL2 mRNA | CTD | PMID:33453195 | Adgrl2 | Rat | cadmium dichloride | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of ADGRL2 mRNA | CTD | PMID:38568856 | Adgrl2 | Rat | caffeine | affects phosphorylation | ISO | ADGRL2 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of ADGRL2 protein | CTD | PMID:35688186 | Adgrl2 | Rat | calcium atom | multiple interactions | EXP | | 6480464 | [alpha-latrotoxin binds to ADGRL2 protein] which results in increased uptake of Calcium and [black widow spider venom binds to ADGRL2 protein] which results in increased uptake of Calcium | CTD | PMID:10026162 | Adgrl2 | Rat | calcium(0) | multiple interactions | EXP | | 6480464 | [alpha-latrotoxin binds to ADGRL2 protein] which results in increased uptake of Calcium and [black widow spider venom binds to ADGRL2 protein] which results in increased uptake of Calcium | CTD | PMID:10026162 | Adgrl2 | Rat | choline | multiple interactions | ISO | Adgrl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ADGRL2 gene and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of ADGRL2 | CTD | PMID:20938992 | Adgrl2 | Rat | chromium atom | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Chromium results in decreased expression of ADGRL2 mRNA | CTD | PMID:21437242 | Adgrl2 | Rat | copper atom | multiple interactions | ISO | Adgrl2 (Mus musculus) | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of ADGRL2 mRNA | CTD | PMID:15467011 | Adgrl2 | Rat | copper(0) | multiple interactions | ISO | Adgrl2 (Mus musculus) | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of ADGRL2 mRNA | CTD | PMID:15467011 | Adgrl2 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of ADGRL2 mRNA | CTD | PMID:26577399 | Adgrl2 | Rat | cyclosporin A | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of ADGRL2 mRNA | CTD | PMID:20106945 and PMID:25562108 | Adgrl2 | Rat | dexamethasone | decreases expression | EXP | | 6480464 | Dexamethasone results in decreased expression of ADGRL2 mRNA | CTD | PMID:14618091 | Adgrl2 | Rat | dexamethasone | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ADGRL2 mRNA | CTD | PMID:28628672 | Adgrl2 | Rat | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ADGRL2 mRNA | CTD | PMID:21266533 | Adgrl2 | Rat | dibutyl phthalate | increases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of ADGRL2 mRNA | CTD | PMID:17361019 and PMID:21266533 | Adgrl2 | Rat | dorsomorphin | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADGRL2 mRNA | CTD | PMID:27188386 | Adgrl2 | Rat | doxorubicin | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ADGRL2 mRNA | CTD | PMID:29803840 | Adgrl2 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of ADGRL2 mRNA | CTD | PMID:29391264 | Adgrl2 | Rat | epoxiconazole | decreases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of ADGRL2 mRNA | CTD | PMID:35436446 | Adgrl2 | Rat | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of ADGRL2 mRNA | CTD | PMID:15353170 | Adgrl2 | Rat | ethanol | increases expression | ISO | Adgrl2 (Mus musculus) | 6480464 | Ethanol results in increased expression of ADGRL2 mRNA | CTD | PMID:30319688 | Adgrl2 | Rat | flusilazole | affects expression | ISO | Adgrl2 (Mus musculus) | 6480464 | flusilazole affects the expression of ADGRL2 mRNA | CTD | PMID:21195148 | Adgrl2 | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of ADGRL2 mRNA | CTD | PMID:24136188 and PMID:24793618 | Adgrl2 | Rat | folic acid | multiple interactions | ISO | Adgrl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ADGRL2 gene and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of ADGRL2 | CTD | PMID:20938992 | Adgrl2 | Rat | fonofos | increases methylation | ISO | ADGRL2 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of ADGRL2 promoter | CTD | PMID:22847954 | Adgrl2 | Rat | FR900359 | affects phosphorylation | ISO | ADGRL2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of ADGRL2 protein | CTD | PMID:37730182 | Adgrl2 | Rat | fulvestrant | decreases methylation | ISO | ADGRL2 (Homo sapiens) | 6480464 | Fulvestrant results in decreased methylation of ADGRL2 gene | CTD | PMID:31601247 | Adgrl2 | Rat | fulvestrant | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of ADGRL2 gene | CTD | PMID:31601247 | Adgrl2 | Rat | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of ADGRL2 gene | CTD | PMID:22079235 | Adgrl2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of ADGRL2 mRNA | CTD | PMID:33387578 | Adgrl2 | Rat | hexaconazole | affects expression | ISO | Adgrl2 (Mus musculus) | 6480464 | hexaconazole affects the expression of ADGRL2 mRNA | CTD | PMID:21195148 | Adgrl2 | Rat | indometacin | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ADGRL2 mRNA | CTD | PMID:28628672 | Adgrl2 | Rat | L-methionine | multiple interactions | ISO | Adgrl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ADGRL2 gene and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of ADGRL2 | CTD | PMID:20938992 | Adgrl2 | Rat | Licochalcone B | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | licochalcone B results in decreased expression of ADGRL2 mRNA | CTD | PMID:33647349 | Adgrl2 | Rat | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of ADGRL2 mRNA | CTD | PMID:30467583 | Adgrl2 | Rat | methotrexate | affects response to substance | ISO | ADGRL2 (Homo sapiens) | 6480464 | ADGRL2 protein affects the susceptibility to Methotrexate | CTD | PMID:16217747 | Adgrl2 | Rat | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of ADGRL2 mRNA | CTD | PMID:24136188 | Adgrl2 | Rat | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of ADGRL2 mRNA | CTD | PMID:24136188 | Adgrl2 | Rat | nitrofen | decreases expression | EXP | | 6480464 | nitrofen results in decreased expression of ADGRL2 mRNA | CTD | PMID:33484710 | Adgrl2 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of ADGRL2 mRNA | CTD | PMID:25729387 | Adgrl2 | Rat | ozone | multiple interactions | ISO | Adgrl2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of ADGRL2 mRNA | CTD | PMID:34911549 | Adgrl2 | Rat | paracetamol | affects expression | ISO | Adgrl2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of ADGRL2 mRNA | CTD | PMID:17562736 | Adgrl2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of ADGRL2 mRNA | CTD | PMID:33387578 | Adgrl2 | Rat | paracetamol | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of ADGRL2 mRNA | CTD | PMID:21420995 | Adgrl2 | Rat | parathion | increases methylation | ISO | ADGRL2 (Homo sapiens) | 6480464 | Parathion results in increased methylation of ADGRL2 promoter | CTD | PMID:22847954 | Adgrl2 | Rat | pirinixic acid | multiple interactions | ISO | Adgrl2 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADGRL2 mRNA | CTD | PMID:19710929 | Adgrl2 | Rat | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of ADGRL2 mRNA | CTD | PMID:19162173 | Adgrl2 | Rat | potassium chromate | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of ADGRL2 mRNA | CTD | PMID:22714537 | Adgrl2 | Rat | progesterone | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of ADGRL2 mRNA | CTD | PMID:20660070 | Adgrl2 | Rat | quercetin | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of ADGRL2 mRNA | CTD | PMID:21632981 | Adgrl2 | Rat | resveratrol | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of ADGRL2 mRNA | CTD | PMID:23557933 | Adgrl2 | Rat | SB 431542 | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADGRL2 mRNA | CTD | PMID:27188386 | Adgrl2 | Rat | sodium arsenite | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of ADGRL2 mRNA | CTD | PMID:38568856 | Adgrl2 | Rat | sunitinib | increases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of ADGRL2 mRNA | CTD | PMID:31533062 | Adgrl2 | Rat | temozolomide | decreases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of ADGRL2 mRNA | CTD | PMID:31758290 | Adgrl2 | Rat | terbufos | increases methylation | ISO | ADGRL2 (Homo sapiens) | 6480464 | terbufos results in increased methylation of ADGRL2 promoter | CTD | PMID:22847954 | Adgrl2 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of ADGRL2 mRNA | CTD | PMID:33387578 | Adgrl2 | Rat | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of ADGRL2 mRNA | CTD | PMID:30012374 | Adgrl2 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of ADGRL2 mRNA | CTD | PMID:25729387 | Adgrl2 | Rat | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of ADGRL2 mRNA | CTD | PMID:25729387 | Adgrl2 | Rat | triadimefon | affects expression | ISO | Adgrl2 (Mus musculus) | 6480464 | triadimefon affects the expression of ADGRL2 mRNA | CTD | PMID:21195148 | Adgrl2 | Rat | triptonide | affects expression | ISO | Adgrl2 (Mus musculus) | 6480464 | triptonide affects the expression of ADGRL2 mRNA | CTD | PMID:33045310 | Adgrl2 | Rat | valproic acid | increases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ADGRL2 mRNA | CTD | PMID:24383497 more ... | Adgrl2 | Rat | valproic acid | multiple interactions | ISO | ADGRL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADGRL2 mRNA | CTD | PMID:27188386 | Adgrl2 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of ADGRL2 gene | CTD | PMID:31682807 | Adgrl2 | Rat | vorinostat | increases expression | ISO | ADGRL2 (Homo sapiens) | 6480464 | vorinostat results in increased expression of ADGRL2 mRNA | CTD | PMID:27188386 | |
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