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Gene: Dtnb (dystrobrevin, beta) Rattus norvegicus
Analyze
Symbol:
Dtnb
Name:
dystrobrevin, beta
RGD ID:
1309579
Description:
Predicted to have zinc ion binding activity. Predicted to localize to cytoplasm and synapse. Orthologous to human DTNB (dystrobrevin beta); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
beta-dystrobrevin; DTN-B; dystrobrevin beta; LOC362715
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DTNB (dystrobrevin beta) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):
Dtnb (dystrobrevin, beta) HGNC
NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Dtnb (dystrobrevin beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
DTNB (dystrobrevin beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
DTNB (dystrobrevin beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Dtnb (dystrobrevin beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
DTNB (dystrobrevin beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
DTNB (dystrobrevin beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Dtnb (dystrobrevin beta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
DTNA (dystrobrevin alpha) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
DTNB (dystrobrevin beta)
Alliance
DIOPT (HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Mus musculus (house mouse):
Dtnb (dystrobrevin, beta)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
dtnbb (dystrobrevin, beta b)
Alliance
DIOPT (InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Caenorhabditis elegans (roundworm):
dyb-1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
Dyb
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoInspector|PANTHER|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 6 26,566,418 - 26,763,467 (+) NCBI Rnor_6.0 Ensembl 6 27,975,417 - 28,177,214 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_6.0 6 27,975,302 - 28,177,236 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 6 37,787,793 - 37,986,165 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 26,542,148 - 26,742,199 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 26,545,100 - 26,745,151 (+) NCBI Celera 6 26,042,938 - 26,238,448 (+) NCBI Celera Cytogenetic Map 6 q14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1,2-dimethylhydrazine increases expression ISO RGD:1319992 6480464 1, 2-Dimethylhydrazine results in increased expression of DTNB mRNA CTD PMID:22206623 17alpha-ethynylestradiol affects expression ISO RGD:1319992 6480464 Ethinyl Estradiol affects the expression of DTNB mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:1319992 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DTNB mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:1319992 6480464 Ethinyl Estradiol results in increased expression of DTNB mRNA CTD PMID:17942748 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in decreased expression of DTNB mRNA CTD PMID:26496021 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1319992 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:1319992 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1319992 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DTNB mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1319992 6480464 Tetrachlorodibenzodioxin affects the expression of DTNB mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of DTNB mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1319992 6480464 Tetrachlorodibenzodioxin results in increased expression of DTNB mRNA CTD PMID:17942748 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of DTNB mRNA CTD PMID:21346803 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 acrolein multiple interactions ISO RGD:1319991 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of DTNB mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of DTNB mRNA CTD PMID:32699268 aflatoxin B1 affects methylation ISO RGD:1319991 6480464 Aflatoxin B1 affects the methylation of DTNB intron CTD PMID:30157460 alpha-pinene multiple interactions ISO RGD:1319991 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of DTNB mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of DTNB mRNA CTD PMID:32699268 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of DTNB mRNA CTD PMID:30779732 benzo[a]pyrene multiple interactions ISO RGD:1319992 6480464 AHR protein affects the reaction [Benzoapyrene affects the expression of DTNB mRNA] CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:1319991 6480464 Benzoapyrene affects the methylation of DTNB intron CTD PMID:30157460 benzo[a]pyrene decreases methylation ISO RGD:1319991 6480464 Benzoapyrene results in decreased methylation of DTNB 3' UTR CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:1319991 6480464 Benzoapyrene results in decreased expression of DTNB mRNA CTD PMID:26238291 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1319991 6480464 7 more ... CTD PMID:26238291 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DTNB mRNA CTD PMID:18164116 bezafibrate decreases expression ISO RGD:1319992 6480464 Bezafibrate results in decreased expression of DTNB mRNA CTD PMID:18787029 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in decreased expression of DTNB mRNA CTD PMID:26496021 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of DTNB mRNA CTD PMID:25181051 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of DTNB mRNA CTD PMID:19167457 calcitriol increases expression ISO RGD:1319991 6480464 Calcitriol results in increased expression of DTNB mRNA CTD PMID:26485663 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of DTNB mRNA CTD PMID:18668222 clofibrate multiple interactions ISO RGD:1319992 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of DTNB mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DTNB mRNA] CTD PMID:17585979 dexamethasone increases expression ISO RGD:1319992 6480464 Dexamethasone results in increased expression of DTNB mRNA CTD PMID:22733784 dibutyl phthalate decreases expression ISO RGD:1319992 6480464 Dibutyl Phthalate results in decreased expression of DTNB mRNA CTD PMID:21266533 diuron decreases expression EXP 6480464 Diuron results in decreased expression of DTNB mRNA CTD PMID:21551480 enzyme inhibitor multiple interactions ISO RGD:1319991 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DTNB protein CTD PMID:23301498 furan increases methylation EXP 6480464 furan results in increased methylation of DTNB gene CTD PMID:22079235 hypochlorous acid decreases expression ISO RGD:1319992 6480464 Hypochlorous Acid results in decreased expression of DTNB mRNA CTD PMID:19376150 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DTNB mRNA CTD PMID:18164116 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of DTNB mRNA CTD PMID:25729387 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of DTNB mRNA CTD PMID:25729387 ozone multiple interactions ISO RGD:1319991 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of DTNB mRNA more ... CTD PMID:32699268 paracetamol multiple interactions ISO RGD:1319992 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of DTNB mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DTNB mRNA] CTD PMID:17585979 paracetamol increases expression ISO RGD:1319991 6480464 Acetaminophen results in increased expression of DTNB mRNA CTD PMID:22230336 , PMID:29067470 paracetamol affects expression ISO RGD:1319992 6480464 Acetaminophen affects the expression of DTNB mRNA CTD PMID:17562736 PCB138 multiple interactions ISO RGD:1319992 6480464 [2 more ... CTD PMID:25510870 pirinixic acid increases expression ISO RGD:1319992 6480464 pirinixic acid results in increased expression of DTNB mRNA CTD PMID:18301758 , PMID:23811191 Soman decreases expression EXP 6480464 Soman results in decreased expression of DTNB mRNA CTD PMID:19281266 tamoxifen affects expression ISO RGD:1319992 6480464 Tamoxifen affects the expression of DTNB mRNA CTD PMID:17555576 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of DTNB mRNA CTD PMID:23411599 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of DTNB mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of DTNB mRNA CTD PMID:25729387 valproic acid affects expression ISO RGD:1319991 6480464 Valproic Acid affects the expression of DTNB mRNA CTD PMID:25979313 vinclozolin increases methylation EXP 6480464 vinclozolin results in increased methylation of DTNB gene CTD PMID:31079544
1,2-dimethylhydrazine (ISO) 17alpha-ethynylestradiol (ISO) 17beta-estradiol (EXP) 2,2',4,4',5,5'-hexachlorobiphenyl (ISO) 2,2',5,5'-tetrachlorobiphenyl (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2,4-dinitrotoluene (EXP) 3,3',4,4',5-pentachlorobiphenyl (EXP) acrolein (ISO) aflatoxin B1 (ISO) alpha-pinene (ISO) amphetamine (EXP) benzo[a]pyrene (ISO) benzo[a]pyrene diol epoxide I (ISO)
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
738023 Alc17 Alcohol consumption QTL 17 3.1 0.003 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) 6 1 35623029 Rat 1354616 Despr12 Despair related QTL 12 0.0012 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 6 1 35623029 Rat 1549905 Stresp10 Stress response QTL 10 6.83 0.0066 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 6 1 35623029 Rat 2300176 Bmd51 Bone mineral density QTL 51 11.7 0.0001 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) 6 1 35623029 Rat 2300190 Bmd52 Bone mineral density QTL 52 11.2 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 6 1 35623029 Rat 1331743 Uae28 Urinary albumin excretion QTL 28 4.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 6 1 41917988 Rat 9589048 Scfw3 Subcutaneous fat weight QTL 3 4.57 0.001 subcutaneous adipose mass (VT:1000472) abdominal subcutaneous fat pad weight (CMO:0002069) 6 1 42388212 Rat 9589129 Insul24 Insulin level QTL 24 19.06 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 6 1 42388212 Rat 7411603 Foco13 Food consumption QTL 13 5.5 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 6 1 42388212 Rat 7411542 Bw127 Body weight QTL 127 5.5 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 6 1 42388212 Rat 8552962 Pigfal16 Plasma insulin-like growth factor 1 level QTL 16 9.4 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 6 1 42388212 Rat 2293709 Bss23 Bone structure and strength QTL 23 5.18 0.0001 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) 6 1 43665660 Rat 2293650 Bss31 Bone structure and strength QTL 31 5.05 0.0001 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) 6 1 43665660 Rat 2293656 Bss28 Bone structure and strength QTL 28 6.79 0.0001 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 6 1 43665660 Rat 7411584 Foco4 Food consumption QTL 4 4.3 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 6 1 44015370 Rat 738024 Sach5 Saccharine consumption QTL 5 3.9 0.00039 consumption behavior trait (VT:0002069) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) 6 1 44570292 Rat 2301972 Bp325 Blood pressure QTL 325 4.8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 1 75623393 Rat 1359023 Bp272 Blood pressure QTL 272 2.5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 1120393 28706721 Rat 2292589 Emca10 Estrogen-induced mammary cancer QTL 10 0.048 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 6 1120393 46120393 Rat 1354664 Slep2 Serum leptin concentration QTL 2 4.49 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 6 1120393 75023446 Rat 1576309 Emca7 Estrogen-induced mammary cancer QTL 7 4 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 6 2537030 111715717 Rat 1578665 Bss16 Bone structure and strength QTL 16 4.4 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) 6 6161722 76002731 Rat 1578668 Bmd14 Bone mineral density QTL 14 3.8 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 6 6161722 76002731 Rat 4145119 Mcs25 Mammary carcinoma susceptibility QTL 25 0.0001 mammary gland integrity trait (VT:0010552) ratio of deaths to total study population during a period of time (CMO:0001023) 6 7009971 115379601 Rat 634322 Bw12 Body weight QTL 12 0 body mass (VT:0001259) body weight (CMO:0000012) 7 10173862 55173862 Rat 1300128 Rf16 Renal function QTL 16 3.89 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 13122958 34367603 Rat 1300164 Rf15 Renal function QTL 15 3.12 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 13122958 57516539 Rat 10401812 Kidm54 Kidney mass QTL 54 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 6 16810107 61810107 Rat 10401800 Kidm49 Kidney mass QTL 49 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 6 16810107 61810107 Rat 8552910 Pigfal5 Plasma insulin-like growth factor 1 level QTL 5 4.3 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 6 19417887 64417887 Rat 1641898 Colcr4 Colorectal carcinoma resistance QTL4 3.71 0.0007 intestine integrity trait (VT:0010554) well differentiated malignant colorectal tumor surface area measurement (CMO:0002077) 6 21515302 65784818 Rat 2293839 Kiddil2 Kidney dilation QTL 2 4.8 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat 2293841 Kiddil4 Kidney dilation QTL 4 4.4 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat
