Hpgd (15-hydroxyprostaglandin dehydrogenase) - Rat Genome Database

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Gene: Hpgd (15-hydroxyprostaglandin dehydrogenase) Rattus norvegicus
Analyze
Symbol: Hpgd
Name: 15-hydroxyprostaglandin dehydrogenase
RGD ID: 620087
Description: Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity and identical protein binding activity. Involved in several processes, including positive regulation of vascular associated smooth muscle cell proliferation; prostaglandin metabolic process; and thrombin-activated receptor signaling pathway. Located in cytoplasm and extracellular space. Used to study carcinoma. Biomarker of peptic ulcer disease. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-hydroxyprostaglandin dehydrogenase [NAD+]; 15-PGDH; eicosanoid/docosanoid dehydrogenase; hydroxyprostaglandin dehydrogenase 15 (NAD); NAD-dependent 15-hydroxyprostaglandin dehydrogenase; PGDH; prostaglandin dehydrogenase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21633,986,265 - 34,024,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1633,986,266 - 34,024,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1637,595,125 - 37,634,909 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01641,006,491 - 41,046,289 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01637,247,961 - 37,285,984 (-)NCBIRnor_WKY
Rnor_6.01637,457,134 - 37,495,758 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1637,457,135 - 37,495,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01637,259,044 - 37,296,863 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41637,419,901 - 37,457,896 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11637,419,976 - 37,457,971 (-)NCBI
Celera1633,917,230 - 33,953,504 (-)NCBICelera
Cytogenetic Map16p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
15-dehydro-prostaglandin E2  (ISO)
16,16-dimethylprostaglandin E2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
betamethasone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
Echimidine  (EXP)
entinostat  (ISO)
fenoprofen  (ISO)
fenvalerate  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
furan  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
ibuprofen  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
ketamine  (EXP)
ketoprofen  (ISO)
L-methionine  (ISO)
Lasiocarpine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lidocaine  (EXP)
mefenamic acid  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
mifepristone  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nevirapine  (EXP)
nickel sulfate  (ISO)
Niflumic acid  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
prostaglandin E2  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rofecoxib  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sulindac sulfone  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
triamcinolone  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas. Bai JW, etal., Oncol Rep. 2012 Aug;28(2):714-20. doi: 10.3892/or.2012.1806. Epub 2012 May 9.
2. Isolation of rat renal NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Chang WC, etal., Prostaglandins Leukot Essent Fatty Acids. 1990 Sep;41(1):19-25.
3. Effects of steroids on renal NAD+-dependent 15-hydroxyprostaglandin dehydrogenase activity in ovariectomized rats. Chang WC, Prostaglandins Leukot Med. 1987 Sep;29(1):25-32.
4. Altered expression of 15-hydroxyprostaglandin dehydrogenase in tumor-infiltrated CD11b myeloid cells: a mechanism for immune evasion in cancer. Eruslanov E, etal., J Immunol. 2009 Jun 15;182(12):7548-57.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Prostaglandin E2 alterations during sepsis are partially mediated by endotoxin-induced inhibition of prostaglandin 15-hydroxydehydrogenase. Hahn EL, etal., J Trauma. 1998 May;44(5):777-81; discussion 781-2.
8. Expression of genes controlling transport and catabolism of prostaglandin E2 in lipopolysaccharide fever. Ivanov AI, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Mar;284(3):R698-706. Epub 2002 Oct 24.
9. Postnatal regulation of 15-hydroxyprostaglandin dehydrogenase in the rat kidney. Liu Y, etal., Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F388-95. doi: 10.1152/ajprenal.00512.2013. Epub 2014 Mar 19.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. 15-PGDH inhibitors: the antiulcer effects of carbenoxolone, pioglitazone and verapamil in indomethacin induced peptic ulcer rats. Moustafa YM, etal., Eur Rev Med Pharmacol Sci. 2013;17(15):2000-9.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha. Otani T, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Feb;290(2):G361-8. Epub 2005 Sep 29.
15. Kinetic changes in rat renal 15-hydroxy-prostaglandin dehydrogenase induced by chronic ethanol exposure. Pennington SN and Taylor WA, Prostaglandins. 1983 Feb;25(2):291-7.
16. 15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice. Pham H, etal., Mol Carcinog. 2008 Jun;47(6):466-77.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis. Thirumangalakudi L, etal., Neurosci Lett. 2009 Mar 13;452(2):172-5. doi: 10.1016/j.neulet.2009.01.045. Epub 2009 Jan 21.
22. Pulmonary and placental 15-hydroxyprostaglandin dehydrogenase in rat during pregnancy. Tsuruta K and Mori N, Eur J Obstet Gynecol Reprod Biol. 1988 Jan;27(1):71-9.
23. 15-PGDH/15-KETE plays a role in hypoxia-induced pulmonary vascular remodeling through ERK1/2-dependent PAR-2 pathway. Wei L, etal., Cell Signal. 2014 Jul;26(7):1476-88. doi: 10.1016/j.cellsig.2014.03.008. Epub 2014 Mar 18.
24. Cloning and expression of the cDNA for rat NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Zhang H, etal., Gene 1997 Mar 25;188(1):41-4.
Additional References at PubMed
PMID:2025296   PMID:8086429   PMID:10198228   PMID:11821873   PMID:15489334   PMID:15531523   PMID:15542609   PMID:15574495   PMID:15581601   PMID:16757471   PMID:16828555   PMID:19056867  
PMID:20448048   PMID:21072165   PMID:23376485   PMID:25779923  


Genomics

Comparative Map Data
Hpgd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21633,986,265 - 34,024,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1633,986,266 - 34,024,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1637,595,125 - 37,634,909 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01641,006,491 - 41,046,289 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01637,247,961 - 37,285,984 (-)NCBIRnor_WKY
Rnor_6.01637,457,134 - 37,495,758 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1637,457,135 - 37,495,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01637,259,044 - 37,296,863 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41637,419,901 - 37,457,896 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11637,419,976 - 37,457,971 (-)NCBI
Celera1633,917,230 - 33,953,504 (-)NCBICelera
Cytogenetic Map16p11NCBI
HPGD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384174,490,175 - 174,522,893 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4174,490,175 - 174,523,154 (-)EnsemblGRCh38hg38GRCh38
GRCh374175,411,326 - 175,444,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364175,647,955 - 175,680,186 (-)NCBINCBI36Build 36hg18NCBI36
Build 344175,786,110 - 175,818,341NCBI
Celera4172,740,096 - 172,772,812 (-)NCBICelera
Cytogenetic Map4q34.1NCBI
HuRef4171,160,430 - 171,193,154 (-)NCBIHuRef
CHM1_14175,387,688 - 175,420,506 (-)NCBICHM1_1
T2T-CHM13v2.04177,829,876 - 177,862,596 (-)NCBIT2T-CHM13v2.0
Hpgd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39856,747,587 - 56,774,081 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl856,747,620 - 56,774,078 (+)EnsemblGRCm39 Ensembl
GRCm38856,294,552 - 56,321,046 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl856,294,585 - 56,321,043 (+)EnsemblGRCm38mm10GRCm38
MGSCv37858,773,349 - 58,799,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36859,186,738 - 59,212,816 (+)NCBIMGSCv36mm8
Celera858,951,090 - 58,977,585 (+)NCBICelera
Cytogenetic Map8B2NCBI
Hpgd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540332,569,841 - 32,613,763 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540332,569,841 - 32,614,860 (+)NCBIChiLan1.0ChiLan1.0
HPGD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14178,950,152 - 178,982,910 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4178,949,137 - 178,982,910 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04166,716,386 - 166,749,225 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HPGD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12524,964,908 - 24,993,276 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2524,964,908 - 24,993,297 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2525,617,669 - 25,646,014 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02525,128,311 - 25,156,688 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2525,126,217 - 25,157,016 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12525,076,268 - 25,104,599 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02524,965,511 - 24,993,846 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02525,117,290 - 25,145,635 (-)NCBIUU_Cfam_GSD_1.0
Hpgd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494325,138,011 - 25,164,513 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365165,550,203 - 5,578,832 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365165,551,192 - 5,578,796 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPGD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1415,718,678 - 15,760,767 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11415,718,261 - 15,773,534 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21416,909,010 - 16,921,261 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HPGD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17120,589,646 - 120,620,864 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7120,588,462 - 120,621,016 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037100,655,992 - 100,687,031 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hpgd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247696,101,474 - 6,139,793 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247696,101,482 - 6,139,465 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hpgd
99 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:106
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000014229
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat

Markers in Region
UniSTS:498472  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21633,988,329 - 33,988,410 (+)MAPPERmRatBN7.2
Rnor_6.01637,459,601 - 37,459,681NCBIRnor6.0
Rnor_5.01637,261,511 - 37,261,591UniSTSRnor5.0
RGSC_v3.41637,421,677 - 37,421,757UniSTSRGSC3.4
Celera1633,919,287 - 33,919,367UniSTS
Cytogenetic Map16p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 1 11 22 11 11
Low 31 54 40 8 40 8 10 64 13 29 8
Below cutoff 12 2 1 1 1 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014229   ⟹   ENSRNOP00000014229
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1633,986,266 - 34,024,228 (-)Ensembl
Rnor_6.0 Ensembl1637,457,135 - 37,495,758 (-)Ensembl
RefSeq Acc Id: NM_024390   ⟹   NP_077366
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21633,986,265 - 34,024,228 (-)NCBI
Rnor_6.01637,457,134 - 37,495,758 (-)NCBI
Rnor_5.01637,259,044 - 37,296,863 (-)NCBI
RGSC_v3.41637,419,901 - 37,457,896 (-)RGD
Celera1633,917,230 - 33,953,504 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077366 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB53027 (Get FASTA)   NCBI Sequence Viewer  
  AAH62399 (Get FASTA)   NCBI Sequence Viewer  
  EDL87138 (Get FASTA)   NCBI Sequence Viewer  
  O08699 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_077366   ⟸   NM_024390
- UniProtKB: Q6P687 (UniProtKB/Swiss-Prot),   O08699 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014229   ⟸   ENSRNOT00000014229

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08699-F1-model_v2 AlphaFold O08699 1-266 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700078
Promoter ID:EPDNEW_R10602
Type:initiation region
Name:Hpgd_1
Description:15-hydroxyprostaglandin dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01637,495,773 - 37,495,833EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620087 AgrOrtholog
BioCyc Gene G2FUF-11514 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000010610 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000014229 ENTREZGENE
  ENSRNOP00000014229.4 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014229 ENTREZGENE
  ENSRNOT00000014229.5 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599288 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report rno:79242 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72425 IMAGE-MGC_LOAD
NCBI Gene 79242 ENTREZGENE
PANTHER 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)] UniProtKB/Swiss-Prot
  15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)] UniProtKB/Swiss-Prot
Pfam adh_short UniProtKB/Swiss-Prot
PhenoGen Hpgd PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot
  SDRFAMILY UniProtKB/Swiss-Prot
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt O08699 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6P687 ENTREZGENE
UniProt Secondary Q6P687 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Hpgd  15-hydroxyprostaglandin dehydrogenase  Hpgd  hydroxyprostaglandin dehydrogenase 15 (NAD)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hpgd  hydroxyprostaglandin dehydrogenase 15 (NAD)    15-hydroxyprostaglandin dehydrogenase  Name updated 1299863 APPROVED
2004-12-14 Hpgd  15-hydroxyprostaglandin dehydrogenase    NAD-dependent 15-hydroxyprostaglandin dehydrogenase  Name updated 1299863 APPROVED
2002-08-07 Hpgd  NAD-dependent 15-hydroxyprostaglandin dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in intestine and lung 633016