Kiss1 (KiSS-1 metastasis-suppressor) - Rat Genome Database
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Gene: Kiss1 (KiSS-1 metastasis-suppressor) Rattus norvegicus
Analyze
Symbol: Kiss1
Name: KiSS-1 metastasis-suppressor
RGD ID: 727850
Description: Exhibits kisspeptin receptor binding activity. Involved in several processes, including generation of ovulation cycle rhythm; positive regulation of cell communication; and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Localizes to several cellular components, including apical plasma membrane; extracellular space; and neuronal cell body. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Orthologous to human KISS1 (KiSS-1 metastasis suppressor); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: eseptin; Kiss1 variant E1a-E2b-E3; Kiss1 variant E1b-E2a-E3; Kiss1 variant E1b-E2b-E3; kisspeptin-1; metastasis-suppressor; metastasis-suppressor KiSS-1; metastin; MLL septin-like fusion; MLL septin-like fusion gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kiss1tm1Nips  
Genetic Models: WI-Kiss1tm1Nips
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01350,529,506 - 50,537,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,529,510 - 50,535,389 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,582,365 - 55,590,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,244,786 - 46,247,288 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,258,828 - 46,261,331 (+)NCBI
Celera1345,110,972 - 45,113,474 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Adachi S, etal., J Reprod Dev. 2007 Apr;53(2):367-78. Epub 2007 Jan 10.
2. Arai AC, etal., J Neurophysiol. 2005 Nov;94(5):3648-52.
3. Dhillo WS, etal., Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E878-84. Epub 2006 Jun 6.
4. Dun SL, etal., Neurosci Lett 2003 Jan 2;335(3):197-201.
5. Farina A, etal., Prenat Diagn. 2006 Dec;26(12):1115-20.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Gaytan M, etal., Cell Tissue Res. 2007 Sep;329(3):571-9. Epub 2007 May 15.
8. GOA data from the GO Consortium
9. Gutierrez-Pascual E, etal., J Neuroendocrinol. 2007 Jul;19(7):521-30.
10. Jiang T, etal., Zhonghua Zhong Liu Za Zhi. 2005 Apr;27(4):229-31.
11. Jiang Y, etal., Clin Exp Metastasis. 2005;22(5):369-76.
12. Kinoshita M, etal., Endocrinology. 2005 Oct;146(10):4431-6. Epub 2005 Jun 23.
13. Kotani M, etal., J Biol Chem 2001 Sep 14;276(37):34631-6. Epub 2001 Jul 16.
14. Marot D, etal., Endocr Relat Cancer. 2007 Sep;14(3):691-702.
15. Martin TA, etal., Clin Exp Metastasis. 2005;22(6):503-11.
16. Navarro VM, etal., Endocrinology 2004 Oct;145(10):4565-74. Epub 2004 Jul 8.
17. Navarro VM, etal., J Physiol. 2004 Dec 1;561(Pt 2):379-86. Epub 2004 Oct 14.
18. Nazian SJ J Androl. 2006 May-Jun;27(3):444-9. Epub 2005 Dec 8.
19. NCBI rat LocusLink and RefSeq merged data October 15, 2003
20. Nicolle G, etal., Ann Oncol. 2007 Mar;18(3):605-7. Epub 2006 Dec 12.
21. OMIM Disease Annotation Pipeline
22. Prentice LM, etal., BMC Med. 2007 Nov 15;5:33.
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Sanchez-Carbayo M, etal., Am J Pathol. 2003 Feb;162(2):609-17.
26. Stark AM, etal., J Cancer Res Clin Oncol. 2005 Mar;131(3):191-8. Epub 2004 Dec 8.
27. Uenoyama Y, etal., J Neuroendocrinol. 2015 Mar;27(3):187-97. doi: 10.1111/jne.12257.
Additional References at PubMed
PMID:12359743   PMID:15157736   PMID:15219839   PMID:15593369   PMID:15637288   PMID:15932928   PMID:16825322   PMID:16930819   PMID:16936210   PMID:17204549   PMID:17289848   PMID:17377846  
PMID:17698953   PMID:18069123   PMID:18208554   PMID:18573184   PMID:18628614   PMID:18703622   PMID:18775461   PMID:18787387   PMID:18834866   PMID:18845637   PMID:19094090   PMID:19106226  
PMID:19111911   PMID:19141682   PMID:19228890   PMID:19500221   PMID:19500223   PMID:19734277   PMID:19944729   PMID:20016824   PMID:20083512   PMID:20621140   PMID:20665248   PMID:20673302  
PMID:20680515   PMID:20807723   PMID:21029216   PMID:21045176   PMID:21074602   PMID:21177834   PMID:21363930   PMID:21458520   PMID:21484804   PMID:21815953   PMID:21979277   PMID:22132116  
PMID:22193294   PMID:22240892   PMID:22454148   PMID:22508514   PMID:22530935   PMID:22536815   PMID:22582096   PMID:22733968   PMID:22791648   PMID:22851291   PMID:23034157   PMID:23150555  
PMID:23312234   PMID:23391862   PMID:23457311   PMID:23518222   PMID:23550002   PMID:23550008   PMID:23651990   PMID:23660487   PMID:23668015   PMID:23684378   PMID:23736294   PMID:24424033  
PMID:24424048   PMID:24456164   PMID:24617524   PMID:24830702   PMID:24845101   PMID:25051440   PMID:25421515   PMID:25542298   PMID:25615539   PMID:25758403   PMID:25875299   PMID:26094983  
PMID:26248220   PMID:26365586   PMID:26446276   PMID:26556532   PMID:26653570   PMID:26853724   PMID:26930799   PMID:27233219   PMID:27344056   PMID:27373140   PMID:27388714   PMID:27665725  
PMID:27688161   PMID:27856623   PMID:27900820   PMID:28377404   PMID:28552864   PMID:28765538   PMID:29017168   PMID:29203206   PMID:29244919   PMID:29974847   PMID:30026056   PMID:30218420  
PMID:30224608   PMID:30305620   PMID:30348767   PMID:30562556   PMID:31155522  


Genomics

Comparative Map Data
Kiss1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01350,529,506 - 50,537,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,529,510 - 50,535,389 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,582,365 - 55,590,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,244,786 - 46,247,288 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,258,828 - 46,261,331 (+)NCBI
Celera1345,110,972 - 45,113,474 (+)NCBICelera
Cytogenetic Map13q13NCBI
KISS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1204,190,341 - 204,196,491 (-)EnsemblGRCh38hg38GRCh38
GRCh381204,190,341 - 204,196,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371204,159,469 - 204,165,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,426,092 - 202,432,242 (-)NCBINCBI36hg18NCBI36
Build 341200,891,126 - 200,897,271NCBI
Celera1177,294,719 - 177,301,077 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1175,324,487 - 175,330,608 (-)NCBIHuRef
CHM1_11205,583,149 - 205,589,536 (-)NCBICHM1_1
Kiss1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,249,625 - 133,257,460 (+)NCBIGRCm39mm39
GRCm381133,321,887 - 133,329,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,321,875 - 133,329,901 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,309,827 - 133,329,722 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,223,789 - 135,226,299 (+)NCBIGRCm37mm9NCBIm37
MGSCv361135,154,758 - 135,157,263 (+)NCBImm8
Celera1135,939,680 - 135,942,194 (+)NCBICelera
Cytogenetic Map1E4NCBI
Kiss1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,043,133 - 40,045,386 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,043,139 - 40,045,973 (-)NCBIChiLan1.0ChiLan1.0
KISS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11184,080,570 - 184,087,378 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,080,570 - 184,104,815 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01179,792,116 - 179,800,377 (-)NCBIMhudiblu_PPA_v0panPan3
KISS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl38768,585 - 773,382 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.138768,333 - 774,328 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Kiss1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936567584,443 - 595,045 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KISS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,834,820 - 64,853,610 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,834,822 - 64,841,071 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,168,052 - 71,175,099 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KISS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12525,151,642 - 25,159,723 (+)NCBI
Kiss1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248076,800,144 - 6,805,555 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131409633059096330Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131409633059096330Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131444158250799665Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131444158251577031Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131981081464810814Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)132005247765052477Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132148248158537177Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132800833873008338Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132858445273584452Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132907693474076934Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132907693474076934Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133614753364868393Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133734634882346348Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134644457050799665Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134877665553264877Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134905850767207219Rat
12879436Bp395Blood pressure QTL 395arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134999470851081193Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135026035750897964Rat


Genetic Models
This gene Kiss1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:118
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000035583
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 3 25 25 25 17 6
Below cutoff 20 16 3 16 42 14 25 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000076506   ⟹   ENSRNOP00000068332
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1350,529,510 - 50,535,389 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077054   ⟹   ENSRNOP00000068288
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1350,529,601 - 50,535,110 (-)Ensembl
RefSeq Acc Id: NM_181692   ⟹   NP_859043
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,529,601 - 50,532,103 (-)NCBI
Rnor_5.01355,582,365 - 55,590,432 (-)NCBI
RGSC_v3.41346,244,786 - 46,247,288 (+)RGD
Celera1345,110,972 - 45,113,474 (+)RGD
Sequence:
RefSeq Acc Id: XM_008769443   ⟹   XP_008767665
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,529,506 - 50,535,464 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598697   ⟹   XP_017454186
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,529,506 - 50,537,603 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_859043   ⟸   NM_181692
- Peptide Label: precursor
- UniProtKB: Q7TSB7 (UniProtKB/Swiss-Prot),   J7H5M8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767665   ⟸   XM_008769443
- Peptide Label: isoform X1
- UniProtKB: Q7TSB7 (UniProtKB/Swiss-Prot),   J7H5M8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454186   ⟸   XM_017598697
- Peptide Label: isoform X1
- UniProtKB: Q7TSB7 (UniProtKB/Swiss-Prot),   J7H5M8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068288   ⟸   ENSRNOT00000077054
RefSeq Acc Id: ENSRNOP00000068332   ⟸   ENSRNOT00000076506

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727850 AgrOrtholog
Ensembl Genes ENSRNOG00000047481 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000068288 UniProtKB/Swiss-Prot
  ENSRNOP00000068332 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000076506 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000077054 UniProtKB/Swiss-Prot
InterPro Metastasis-suppressor_KiSS-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:289023 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 289023 ENTREZGENE
PANTHER PTHR16955 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kisspeptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kiss1 PhenoGen
UniGene Rn.66008 ENTREZGENE
UniProt J7H5M8 ENTREZGENE, UniProtKB/TrEMBL
  KISS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Kiss1  KiSS-1 metastasis-suppressor    metastin  Name updated 1299863 APPROVED