Kiss1 (KiSS-1 metastasis-suppressor) - Rat Genome Database

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Gene: Kiss1 (KiSS-1 metastasis-suppressor) Rattus norvegicus
Analyze
Symbol: Kiss1
Name: KiSS-1 metastasis-suppressor
RGD ID: 727850
Description: Enables kisspeptin receptor binding activity. Involved in several processes, including generation of ovulation cycle rhythm; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cell communication. Located in apical plasma membrane; extracellular space; and neuronal cell body. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Orthologous to human KISS1 (KiSS-1 metastasis suppressor); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eseptin; Kiss1 variant E1a-E2b-E3; Kiss1 variant E1b-E2a-E3; Kiss1 variant E1b-E2b-E3; kisspeptin-1; metastasis-suppressor; metastasis-suppressor KiSS-1; metastin; MLL septin-like fusion; MLL septin-like fusion gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kiss1tm1Nips   Kiss1tm8Nips  
Genetic Models: WI;WDB-Kiss1tm1Nips WIC;WI;WDB-Kiss1tm8Nips
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21344,775,106 - 44,780,707 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,774,823 - 44,780,612 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,388,122 - 47,390,621 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01348,676,226 - 48,678,725 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,934,083 - 45,936,581 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,529,506 - 50,537,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,529,510 - 50,535,389 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,582,365 - 55,590,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,244,786 - 46,247,288 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11346,258,828 - 46,261,331 (+)NCBI
Celera1345,110,972 - 45,113,474 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
DDE  (EXP)
dextran sulfate  (ISO)
diazinon  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
enzacamene  (EXP)
fenvalerate  (EXP)
flufenamic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP,ISO)
hydrogen peroxide  (ISO)
iodoacetic acid  (ISO)
L-methionine  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
mancozeb  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
pyrethrins  (EXP)
raloxifene  (EXP)
resveratrol  (ISO)
sevoflurane  (ISO)
sodium arsenite  (ISO)
tamoxifen  (EXP,ISO)
testosterone  (EXP,ISO)
tetrodotoxin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. Adachi S, etal., J Reprod Dev. 2007 Apr;53(2):367-78. Epub 2007 Jan 10.
2. Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells. Arai AC, etal., J Neurophysiol. 2005 Nov;94(5):3648-52.
3. Plasma kisspeptin is raised in patients with gestational trophoblastic neoplasia and falls during treatment. Dhillo WS, etal., Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E878-84. Epub 2006 Jun 6.
4. Metastin-like immunoreactivity in the rat medulla oblongata and spinal cord. Dun SL, etal., Neurosci Lett 2003 Jan 2;335(3):197-201.
5. Quantitative distribution of a panel of circulating mRNA in preeclampsia versus controls. Farina A, etal., Prenat Diagn. 2006 Dec;26(12):1115-20.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Expression of KiSS-1 in rat oviduct: possible involvement in prevention of ectopic implantation? Gaytan M, etal., Cell Tissue Res. 2007 Sep;329(3):571-9. Epub 2007 May 15.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion. Gutierrez-Pascual E, etal., J Neuroendocrinol. 2007 Jul;19(7):521-30.
10. [Expression and clinical significance of KISS-1 and GPR54 mRNA in endometrial carcinoma] Jiang T, etal., Zhonghua Zhong Liu Za Zhi. 2005 Apr;27(4):229-31.
11. KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha. Jiang Y, etal., Clin Exp Metastasis. 2005;22(5):369-76.
12. Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats. Kinoshita M, etal., Endocrinology. 2005 Oct;146(10):4431-6. Epub 2005 Jun 23.
13. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. Kotani M, etal., J Biol Chem 2001 Sep 14;276(37):34631-6. Epub 2001 Jul 16.
14. High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors. Marot D, etal., Endocr Relat Cancer. 2007 Sep;14(3):691-702.
15. KiSS-1 expression in human breast cancer. Martin TA, etal., Clin Exp Metastasis. 2005;22(6):503-11.
16. Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Navarro VM, etal., Endocrinology 2004 Oct;145(10):4565-74. Epub 2004 Jul 8.
17. Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. Navarro VM, etal., J Physiol. 2004 Dec 1;561(Pt 2):379-86. Epub 2004 Oct 14.
18. Role of metastin in the release of gonadotropin-releasing hormone from the hypothalamus of the male rat. Nazian SJ J Androl. 2006 May-Jun;27(3):444-9. Epub 2005 Dec 8.
19. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
20. Metastin (KISS-1) and metastin-coupled receptor (GPR54) expression in transitional cell carcinoma of the bladder. Nicolle G, etal., Ann Oncol. 2007 Mar;18(3):605-7. Epub 2006 Dec 12.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma. Prentice LM, etal., BMC Med. 2007 Nov 15;5:33.
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. Sanchez-Carbayo M, etal., Am J Pathol. 2003 Feb;162(2):609-17.
26. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. Stark AM, etal., J Cancer Res Clin Oncol. 2005 Mar;131(3):191-8. Epub 2004 Dec 8.
27. Lack of pulse and surge modes and glutamatergic stimulation of luteinising hormone release in Kiss1 knockout rats. Uenoyama Y, etal., J Neuroendocrinol. 2015 Mar;27(3):187-97. doi: 10.1111/jne.12257.
Additional References at PubMed
PMID:12359743   PMID:15157736   PMID:15219839   PMID:15593369   PMID:15637288   PMID:15932928   PMID:16825322   PMID:16930819   PMID:16936210   PMID:17204549   PMID:17289848   PMID:17377846  
PMID:17698953   PMID:18069123   PMID:18208554   PMID:18573184   PMID:18628614   PMID:18703622   PMID:18775461   PMID:18787387   PMID:18834866   PMID:18845637   PMID:19094090   PMID:19106226  
PMID:19111911   PMID:19141682   PMID:19228890   PMID:19500221   PMID:19500223   PMID:19734277   PMID:19944729   PMID:20016824   PMID:20083512   PMID:20621140   PMID:20665248   PMID:20673302  
PMID:20680515   PMID:20807723   PMID:21029216   PMID:21045176   PMID:21074602   PMID:21177834   PMID:21363930   PMID:21458520   PMID:21484804   PMID:21815953   PMID:21979277   PMID:22132116  
PMID:22193294   PMID:22240892   PMID:22454148   PMID:22508514   PMID:22530935   PMID:22536815   PMID:22582096   PMID:22733968   PMID:22791648   PMID:22851291   PMID:23034157   PMID:23150555  
PMID:23312234   PMID:23391862   PMID:23457311   PMID:23518222   PMID:23550002   PMID:23550008   PMID:23651990   PMID:23660487   PMID:23668015   PMID:23684378   PMID:23736294   PMID:24424033  
PMID:24424048   PMID:24456164   PMID:24617524   PMID:24830702   PMID:24845101   PMID:25051440   PMID:25421515   PMID:25542298   PMID:25615539   PMID:25758403   PMID:25875299   PMID:26094983  
PMID:26248220   PMID:26365586   PMID:26446276   PMID:26556532   PMID:26653570   PMID:26853724   PMID:26930799   PMID:27233219   PMID:27344056   PMID:27373140   PMID:27388714   PMID:27665725  
PMID:27688161   PMID:27856623   PMID:27900820   PMID:28377404   PMID:28552864   PMID:28765538   PMID:29017168   PMID:29203206   PMID:29244919   PMID:29974847   PMID:30026056   PMID:30218420  
PMID:30224608   PMID:30305620   PMID:30348767   PMID:30562556   PMID:31155522   PMID:31724927   PMID:32337911   PMID:32407292   PMID:32818586   PMID:32988245   PMID:33479437   PMID:33592287  
PMID:34268716   PMID:34389474   PMID:34655735   PMID:35180577   PMID:35718292   PMID:35729637   PMID:36099331   PMID:36114434   PMID:36273897   PMID:37230188  


Genomics

Comparative Map Data
Kiss1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21344,775,106 - 44,780,707 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,774,823 - 44,780,612 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,388,122 - 47,390,621 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01348,676,226 - 48,678,725 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,934,083 - 45,936,581 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,529,506 - 50,537,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,529,510 - 50,535,389 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,582,365 - 55,590,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,244,786 - 46,247,288 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11346,258,828 - 46,261,331 (+)NCBI
Celera1345,110,972 - 45,113,474 (+)NCBICelera
Cytogenetic Map13q13NCBI
KISS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381204,190,341 - 204,196,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1204,190,341 - 204,196,491 (-)EnsemblGRCh38hg38GRCh38
GRCh371204,159,469 - 204,165,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,426,092 - 202,432,242 (-)NCBINCBI36Build 36hg18NCBI36
Build 341200,891,126 - 200,897,271NCBI
Celera1177,294,719 - 177,301,077 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1175,324,487 - 175,330,608 (-)NCBIHuRef
CHM1_11205,583,149 - 205,589,536 (-)NCBICHM1_1
T2T-CHM13v2.01203,454,485 - 203,461,086 (-)NCBIT2T-CHM13v2.0
Kiss1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,249,625 - 133,257,460 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,254,950 - 133,257,460 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl1133,237,565 - 133,257,460 (+)EnsemblGRCm39 Ensembl
GRCm381133,321,887 - 133,329,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,321,875 - 133,329,901 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,309,827 - 133,329,722 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,223,789 - 135,226,299 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,154,758 - 135,157,263 (+)NCBIMGSCv36mm8
Celera1135,939,680 - 135,942,194 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.91NCBI
Kiss1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,043,133 - 40,045,386 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,043,139 - 40,045,973 (-)NCBIChiLan1.0ChiLan1.0
KISS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1145,144,115 - 45,152,454 (+)NCBINHGRI_mPanPan1
KISS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.138768,333 - 774,328 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38768,585 - 773,382 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38863,956 - 869,800 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.038763,801 - 769,645 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.138760,344 - 766,184 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,151,734 - 1,157,575 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0381,351,942 - 1,357,788 (-)NCBIUU_Cfam_GSD_1.0
Kiss1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934471,346,799 - 71,352,256 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936567584,443 - 586,837 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936567584,443 - 595,045 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KISS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12525,151,642 - 25,159,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605525,913,552 - 25,920,197 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kiss1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248076,803,265 - 6,805,433 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248076,800,144 - 6,805,555 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kiss1
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:118
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000035583
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879436Bp395Blood pressure QTL 395arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134463918245700190Rat


Genetic Models
This gene Kiss1 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 3 25 25 25 17 6
Below cutoff 20 16 3 16 42 14 25 1

Sequence


RefSeq Acc Id: ENSRNOT00000076506   ⟹   ENSRNOP00000068332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1344,774,823 - 44,780,612 (+)Ensembl
Rnor_6.0 Ensembl1350,529,510 - 50,535,389 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077054   ⟹   ENSRNOP00000068288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1350,529,601 - 50,535,110 (-)Ensembl
RefSeq Acc Id: NM_001412625   ⟹   NP_001399554
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21344,775,106 - 44,780,707 (+)NCBI
RefSeq Acc Id: NM_181692   ⟹   NP_859043
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21344,775,106 - 44,780,707 (+)NCBI
Rnor_6.01350,529,601 - 50,532,103 (-)NCBI
Rnor_5.01355,582,365 - 55,590,432 (-)NCBI
RGSC_v3.41346,244,786 - 46,247,288 (+)RGD
Celera1345,110,972 - 45,113,474 (+)RGD
Sequence:
RefSeq Acc Id: NP_859043   ⟸   NM_181692
- Peptide Label: precursor
- UniProtKB: Q7TSB7 (UniProtKB/Swiss-Prot),   J7H5M8 (UniProtKB/TrEMBL),   J7HBH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068288   ⟸   ENSRNOT00000077054
RefSeq Acc Id: ENSRNOP00000068332   ⟸   ENSRNOT00000076506
RefSeq Acc Id: NP_001399554   ⟸   NM_001412625
- Peptide Label: precursor
- UniProtKB: Q7TSB7 (UniProtKB/Swiss-Prot),   J7H5M8 (UniProtKB/TrEMBL),   J7HBH5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TSB7-F1-model_v2 AlphaFold Q7TSB7 1-130 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727850 AgrOrtholog
BioCyc Gene G2FUF-18290 BioCyc
Ensembl Genes ENSRNOG00000047481 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055021322 UniProtKB/Swiss-Prot
  ENSRNOG00060016607 UniProtKB/Swiss-Prot
  ENSRNOG00065020414 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000076506 ENTREZGENE
  ENSRNOT00000076506.2 UniProtKB/Swiss-Prot
  ENSRNOT00055036445 UniProtKB/Swiss-Prot
  ENSRNOT00060028442 UniProtKB/Swiss-Prot
  ENSRNOT00065034512 UniProtKB/Swiss-Prot
InterPro Metastasis-suppressor_KiSS-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:289023 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 289023 ENTREZGENE
PANTHER METASTASIS-SUPPRESSOR KISS-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16955 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kisspeptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kiss1 PhenoGen
RatGTEx ENSRNOG00000047481 RatGTEx
  ENSRNOG00055021322 RatGTEx
  ENSRNOG00060016607 RatGTEx
  ENSRNOG00065020414 RatGTEx
UniProt J7H5M8 ENTREZGENE, UniProtKB/TrEMBL
  J7HBH5 ENTREZGENE, UniProtKB/TrEMBL
  KISS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Kiss1  KiSS-1 metastasis-suppressor    metastin  Name updated 1299863 APPROVED