Syde1 (synapse defective Rho GTPase homolog 1)

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Gene: Syde1 (synapse defective Rho GTPase homolog 1) Rattus norvegicus

Analyze

Symbol:

Syde1

Name:

synapse defective Rho GTPase homolog 1

RGD ID:

1305857

Description:

Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including positive regulation of trophoblast cell migration; regulation of Ras protein signal transduction; and regulation of cytoskeleton organization. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; synaptic vesicle docking; and synaptonemal complex assembly. Predicted to be located in cerebellar mossy fiber and cytosol. Predicted to be active in synaptic membrane. Orthologous to human SYDE1 (synapse defective Rho GTPase homolog 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC362842; RGD1305857; rho GTPase-activating protein SYDE1; similar to hypothetical protein FLJ13511; synapse defective 1, Rho GTPase, homolog 1; synapse defective 1, Rho GTPase, homolog 1 (C. elegans); synapse defective protein 1 homolog 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	11,032,931 - 11,038,917 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	11,032,898 - 11,039,869 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	13,851,843 - 13,857,840 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	15,729,230 - 15,735,227 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	13,607,127 - 13,613,134 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	14,037,646 - 14,043,632 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	14,037,620 - 14,043,779 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	14,191,914 - 14,201,067 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	12,586,155 - 12,592,141 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	12,586,131 - 12,592,156 (+)	NCBI
Celera	7	9,156,062 - 9,160,395 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (EXP,ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

coumarin (ISO)

decabromodiphenyl ether (EXP)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

fenamidone (ISO)

fluoranthene (ISO)

fonofos (ISO)

hydrogen peroxide (ISO)

hydroquinone O-beta-D-glucopyranoside (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

orphenadrine (EXP)

ozone (ISO)

paracetamol (ISO)

parathion (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

Soman (EXP)

sulindac sulfide (ISO)

temozolomide (ISO)

terbufos (ISO)

thioacetamide (EXP)

urethane (ISO)

valproic acid (ISO)

vincaleukoblastine (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (ISO)

cell migration (IBA,ISO)

labyrinthine layer blood vessel development (ISO)

labyrinthine layer development (ISO)

positive regulation of synaptic transmission (ISO)

positive regulation of trophoblast cell migration (ISO)

regulation of cytoskeleton organization (ISO)

regulation of Ras protein signal transduction (IBA,ISO)

signal transduction (IEA)

synaptic vesicle docking (ISO)

synaptonemal complex assembly (ISO)

Cellular Component

cerebellar mossy fiber (ISO)

cytosol (ISO)

presynapse (IEA)

synaptic membrane (IBA,ISO)

Molecular Function

GTPase activator activity (IBA,ISO)

GTPase regulator activity (ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:23791195	PMID:27917469

Genomics

Comparative Map Data

Syde1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	11,032,931 - 11,038,917 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	11,032,898 - 11,039,869 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	13,851,843 - 13,857,840 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	15,729,230 - 15,735,227 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	13,607,127 - 13,613,134 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	14,037,646 - 14,043,632 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	14,037,620 - 14,043,779 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	14,191,914 - 14,201,067 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	12,586,155 - 12,592,141 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	12,586,131 - 12,592,156 (+)	NCBI
Celera	7	9,156,062 - 9,160,395 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

SYDE1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	15,107,401 - 15,114,974 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	15,107,401 - 15,114,985 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	15,218,212 - 15,225,785 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	15,079,214 - 15,086,789 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	15,113,949 - 15,121,526 (+)	NCBI		Celera
Cytogenetic Map	19	p13.12	NCBI
HuRef	19	14,786,043 - 14,793,619 (+)	NCBI		HuRef
CHM1_1	19	15,217,698 - 15,225,274 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	15,232,344 - 15,239,918 (+)	NCBI		T2T-CHM13v2.0

Syde1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	78,420,336 - 78,427,798 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	78,420,337 - 78,427,798 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	78,584,502 - 78,591,964 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	78,584,503 - 78,591,964 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	78,047,248 - 78,054,709 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	77,987,621 - 77,995,093 (-)	NCBI		MGSCv36	mm8
Celera	10	79,606,719 - 79,614,175 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Syde1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	8,136,810 - 8,147,289 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	8,140,152 - 8,147,491 (-)	NCBI	ChiLan1.0	ChiLan1.0

SYDE1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	19	19,023,882 - 19,031,469 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	14,640,493 - 14,648,080 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	15,625,095 - 15,632,623 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	15,625,096 - 15,631,600 (+)	Ensembl	panpan1.1		panPan2

SYDE1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	47,021,789 - 47,028,606 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	47,021,775 - 47,028,714 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	46,872,562 - 46,879,385 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	47,514,235 - 47,521,060 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	47,514,240 - 47,521,055 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	46,746,333 - 46,753,156 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	47,165,399 - 47,172,222 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	47,436,664 - 47,443,487 (-)	NCBI		UU_Cfam_GSD_1.0

Syde1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	205,803,674 - 205,810,424 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	5,349,776 - 5,359,538 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936596	5,352,813 - 5,359,561 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SYDE1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	62,447,037 - 62,453,949 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	62,447,030 - 62,453,944 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	62,008,057 - 62,014,927 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SYDE1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	13,709,110 - 13,717,249 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	13,709,148 - 13,716,241 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	5,816,677 - 5,825,219 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Syde1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624901	2,191,241 - 2,197,877 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624901	2,191,219 - 2,197,786 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Syde1
31 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	152
Count of miRNA genes:	109
Interacting mature miRNAs:	120
Transcripts:	ENSRNOT00000009606
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat

Markers in Region

RH129156

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	11,039,651 - 11,039,834 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	14,044,367 - 14,044,549	NCBI	Rnor6.0
Rnor_5.0	7	14,200,850 - 14,201,032	UniSTS	Rnor5.0
RGSC_v3.4	7	12,592,876 - 12,593,058	UniSTS	RGSC3.4
Celera	7	9,161,130 - 9,161,312	UniSTS
RH 3.4 Map	7	66.4	UniSTS
Cytogenetic Map	7	q11	UniSTS

RH138757

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	11,037,421 - 11,037,553 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	14,042,137 - 14,042,268	NCBI	Rnor6.0
Rnor_5.0	7	14,198,620 - 14,198,751	UniSTS	Rnor5.0
RGSC_v3.4	7	12,590,646 - 12,590,777	UniSTS	RGSC3.4
Celera	7	9,158,900 - 9,159,031	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		37	14	4	7	4			6	23	33	11
Low	3	6	43	37	12	37	8	11	68	12	8		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000009606 ⟹ ENSRNOP00000009606

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	11,032,898 - 11,039,869 (+)	Ensembl
Rnor_6.0 Ensembl	7	14,037,620 - 14,043,779 (+)	Ensembl

RefSeq Acc Id:

NM_001191876 ⟹ NP_001178805

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	11,032,931 - 11,038,917 (+)	NCBI
Rnor_6.0	7	14,037,646 - 14,043,632 (+)	NCBI
Rnor_5.0	7	14,191,914 - 14,201,067 (+)	NCBI
Celera	7	9,156,062 - 9,160,395 (+)	NCBI

Sequence:

show sequence

ATGGCCGAGCCGCTGCTCAGGAAGACCTTCTCCCGCTTGCGGGGTCGGGAGAAACTTCCCCGGA
AAAAGTCAGATGCCAAGGACCGCGGCCGCCCAGCCCAGCGCTCAGAGCCCAAACCCCCAGAACC
AGAACCTCGCGTCCTTGAAGGGTCTCAGGCTGGAGCAGAGGTACCACTCAGCCCCGAGACACCT
CGGAGCCCCGCTCGCGGTGCCTACCTGCAAAGCCTGGAGCCCAGTAGCCGCCGATGGGTGCTAG
GAGGGGCTAAACCACCGGAGGAGATATCTTTAGGGCCTAGGACACCTAGCAGTGGGGAGCCTGC
TGGTGAGATTTGGTACAACCCCATCCCTGAAGAAGACCCCAGACCTCCAGCACCTGAGCCCGTG
GGATCGCAGCTAGCTTCCTCTGAGCCAGAAGGCCCGATCCTCCAAGGTGCAGCCCCTACCAGCC
CCCCTACCAAAACCTCCCGTACCAAGTCCCCAGGCCCTGCAAGGCGCCTCTCTATGAAGATGAA
AAAGCTTCCAGAGCTGCGCCGCCGCCTGAGCCTAAGAAGTACTCGCACTAGCAGGGAACGAGAG
AGGACCGCCCCAGCAGGCTCTGTCATCAGCCGCTACCACCTGGACAGCAGTGTGGCGACTCCTG
GGCAGGCATCAGTGGCTGGAGGGACTAGGAGCCCAAGGGGTGGGTACCTCAGCGATGGTGATTC
GCCGGAGCGTCCTGGGGGACCACCATCACCCACTGCCTTCCGGCCCTATGAAGTGGGCCCATCA
GCCCGGGCTCCTCCAGCCGCGCTCTGGGGGCGTCTCAGCCTGCACCTGTATGGGCTAGGGGGTC
TGCGGCCAACTCCGGGGGCTACTCCTCGTGATCTCTGCTGTCTTCTCCAAGTGGATGGAGTAGC
TCGGGCCCGCACAGGGCCACTTCGAAGCGGGCCAGACTTCCTGAGGCTGGATCACACCTTCCAC
TTGGAGCTGGAGGCCGCTCGGCTGCTGCGGGCCTTGGTACTTGCGTGGGACCCTGGTGTGAGGC
GGCACCGGCCCTGTGCCCAGGGCACTGTGCTACTGCCAACCATCTTTCGAGGGTGCCAAGCGCA
ACAACTGGCCGTTCGACTGGAACCCCAGGGACTTCTGTATGCCAAGCTAACGTTGTCGGAACAG
CAAGAAGCCCCTGCCACAGTGGAGCCCCGTGTTTTCGGGCTCCCGCTGCAGCTTCTGGTAGAAC
GTGAGCAGTCTCCAGGCCAGGTGCCTCTCATCATCCGAAAGTGTGTGGGGCAGATCGAGTGCCG
AGGGCTGCGGGTCGTGGGGCTGTACCGTCTCTGTGGCTCAGCCGCGGTGAAGAAAGAGCTTCGA
GATGCCTTTGAGCAGGACAGTGCAGCTGTGTGCCTCTCTGAAGATGTGTACCCCGATATCAATG
TCATCACAGGCATCCTCAAGGATTACCTTCGAGAGCTGCCAACGCCGCTCATCACCCAGCCCCT
CTACCAGGTGGTGCTGGAGGCCATGGCCCAAGGACACCCAAGCAGGGCTTCCCTGGGTCCTGAA
GGCACCAGAGGACTCCTCAGCTGCCTGCCAGATGTGGAGAGGGCCACACTGACGCTTCTTCTGG
ACCATCTGCGCCTTGTCTCCTCCTTCCACACCCACAACCGCATGACCCCGCAGAACTTGGCGGT
GTGCTTCGGACCGGTGCTGCTGCCAGCGAGACAAACACCCTCTCGGACCCGGCTCCGTGGCTCC
GGCCCAGGAGTCAGCAGCGCTGTGGATTTCAAGCGCCACATTGAAGTCCTGCATTACTTGTTAC
AGTCTTGGCCAGATACCCGCCGGCCCTCAGAGACCCCAGACGTCGCACCGTATTTGCGGCCCAA
ACGACAGCCACCGCTGCACTTGCCGCTGGATGGCCCAGAAGTGGTGACTCGGCCTCGGGGCCGT
GGAGGCCCCGAAAGTCCCCCAAGCAACCGCTATGCAGGCGACTGGAGCGTGTGCGGGGGAGATT
TACTGCCGCGTGGGCGGGACTTCCTGTCCGGACCTGACTATGACCACGTGACAGGCAGCGACAG
TGAGGAAGATGAGGATGAGAGTGGAGAGCCGAGGGGCACTACGGACTTCGAAGATGAGTTTGAT
GCACCCTTCAACCCACACCTGAATCTCAAAGACTTTGATGCCCTCATCCTGGATCTGGAGAGAG
AACTTTCCAAGCAGATCAATGTGTGCCTCTGAGCCCTCAAAGCAGGGGATGGATTTTCGTTACT
AGGGAATTGCTTCCTG

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Protein Sequences


Protein RefSeqs	NP_001178805	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZZN9	(Get FASTA)	NCBI Sequence Viewer
	EDL89449	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001178805 ⟸ NM_001191876

- UniProtKB:

D3ZZN9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEPLLRKTFSRLRGREKLPRKKSDAKDRGRPAQRSEPKPPEPEPRVLEGSQAGAEVPLSPETP
RSPARGAYLQSLEPSSRRWVLGGAKPPEEISLGPRTPSSGEPAGEIWYNPIPEEDPRPPAPEPV
GSQLASSEPEGPILQGAAPTSPPTKTSRTKSPGPARRLSMKMKKLPELRRRLSLRSTRTSRERE
RTAPAGSVISRYHLDSSVATPGQASVAGGTRSPRGGYLSDGDSPERPGGPPSPTAFRPYEVGPS
ARAPPAALWGRLSLHLYGLGGLRPTPGATPRDLCCLLQVDGVARARTGPLRSGPDFLRLDHTFH
LELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTIFRGCQAQQLAVRLEPQGLLYAKLTLSEQ
QEAPATVEPRVFGLPLQLLVEREQSPGQVPLIIRKCVGQIECRGLRVVGLYRLCGSAAVKKELR
DAFEQDSAAVCLSEDVYPDINVITGILKDYLRELPTPLITQPLYQVVLEAMAQGHPSRASLGPE
GTRGLLSCLPDVERATLTLLLDHLRLVSSFHTHNRMTPQNLAVCFGPVLLPARQTPSRTRLRGS
GPGVSSAVDFKRHIEVLHYLLQSWPDTRRPSETPDVAPYLRPKRQPPLHLPLDGPEVVTRPRGR
GGPESPPSNRYAGDWSVCGGDLLPRGRDFLSGPDYDHVTGSDSEEDEDESGEPRGTTDFEDEFD
APFNPHLNLKDFDALILDLERELSKQINVCL

hide sequence

RefSeq Acc Id:

ENSRNOP00000009606 ⟸ ENSRNOT00000009606

Protein Domains

C2 Rho-GAP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZZN9-F1-model_v2	AlphaFold	D3ZZN9	1-735	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305857	AgrOrtholog
BioCyc Gene	G2FUF-34838	BioCyc
Ensembl Genes	ENSRNOG00000007307	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000009606	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000009606	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.555.10	UniProtKB/Swiss-Prot
InterPro	C2_dom	UniProtKB/Swiss-Prot
	Rho_GTPase_activation_prot	UniProtKB/Swiss-Prot
	RhoGAP_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:362842	UniProtKB/Swiss-Prot
NCBI Gene	362842	ENTREZGENE
PANTHER	RHO GTPASE-ACTIVATING PROTEIN 100F	UniProtKB/Swiss-Prot
	RHO GTPASE-ACTIVATING PROTEIN SYDE1	UniProtKB/Swiss-Prot
Pfam	RhoGAP	UniProtKB/Swiss-Prot
PhenoGen	Syde1	PhenoGen
PROSITE	PS50004	UniProtKB/Swiss-Prot
	RHOGAP	UniProtKB/Swiss-Prot
SMART	RhoGAP	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48350	UniProtKB/Swiss-Prot
UniProt	D3ZZN9	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-05	Syde1	synapse defective Rho GTPase homolog 1	Syde1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Syde1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	Syde1_predicted	synapse defective 1, Rho GTPase, homolog 1 (C. elegans) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Syde1_predicted	synapse defective 1, Rho GTPase, homolog 1 (C. elegans) (predicted)	RGD1305857_predicted	similar to hypothetical protein FLJ13511 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1305857_predicted	similar to hypothetical protein FLJ13511 (predicted)	LOC362842_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC362842_predicted	similar to hypothetical protein FLJ13511 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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