Adamdec1 (ADAM-like, decysin 1) - Rat Genome Database

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Gene: Adamdec1 (ADAM-like, decysin 1) Rattus norvegicus
Analyze
Symbol: Adamdec1
Name: ADAM-like, decysin 1
RGD ID: 1309861
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human ADAMDEC1 (ADAM like decysin 1); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADAM DEC1; LOC290338
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81547,076,011 - 47,097,065 (-)NCBIGRCr8
mRatBN7.21542,900,629 - 42,921,684 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1542,900,636 - 42,921,712 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1544,765,281 - 44,786,328 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01545,915,508 - 45,936,555 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01544,360,879 - 44,381,942 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01549,485,604 - 49,521,638 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1549,485,611 - 49,505,553 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01553,218,715 - 53,238,690 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41548,250,970 - 48,272,395 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11548,267,607 - 48,288,140 (-)NCBI
Celera1542,534,343 - 42,555,121 (-)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Adamdec1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81547,076,011 - 47,097,065 (-)NCBIGRCr8
mRatBN7.21542,900,629 - 42,921,684 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1542,900,636 - 42,921,712 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1544,765,281 - 44,786,328 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01545,915,508 - 45,936,555 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01544,360,879 - 44,381,942 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01549,485,604 - 49,521,638 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1549,485,611 - 49,505,553 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01553,218,715 - 53,238,690 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41548,250,970 - 48,272,395 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11548,267,607 - 48,288,140 (-)NCBI
Celera1542,534,343 - 42,555,121 (-)NCBICelera
Cytogenetic Map15p11NCBI
ADAMDEC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38824,384,285 - 24,406,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl824,384,285 - 24,406,013 (+)EnsemblGRCh38hg38GRCh38
GRCh37824,241,798 - 24,263,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36824,297,916 - 24,319,471 (+)NCBINCBI36Build 36hg18NCBI36
Build 34824,297,915 - 24,319,471NCBI
Celera823,205,384 - 23,227,107 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef822,786,429 - 22,808,152 (+)NCBIHuRef
CHM1_1824,443,956 - 24,465,678 (+)NCBICHM1_1
T2T-CHM13v2.0824,659,416 - 24,681,139 (+)NCBIT2T-CHM13v2.0
Adamdec1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391468,800,829 - 68,819,535 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1468,800,829 - 68,819,544 (-)EnsemblGRCm39 Ensembl
GRCm381468,563,387 - 68,582,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1468,563,380 - 68,582,095 (-)EnsemblGRCm38mm10GRCm38
MGSCv371469,181,444 - 69,200,129 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361467,516,717 - 67,535,402 (-)NCBIMGSCv36mm8
Celera1466,331,214 - 66,349,962 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1435.69NCBI
Adamdec1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540347,421,102 - 47,439,501 (+)NCBIChiLan1.0ChiLan1.0
ADAMDEC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2742,892,991 - 42,914,657 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1818,627,118 - 18,648,797 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0823,653,257 - 23,674,893 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1820,570,606 - 20,590,177 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl820,570,606 - 20,591,383 (+)Ensemblpanpan1.1panPan2
ADAMDEC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12533,046,404 - 33,061,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2533,046,312 - 33,061,731 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2533,630,692 - 33,646,155 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02533,252,217 - 33,267,658 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2533,252,441 - 33,267,811 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12533,200,387 - 33,215,843 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02533,056,965 - 33,072,405 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02533,215,149 - 33,230,607 (-)NCBIUU_Cfam_GSD_1.0
Adamdec1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,873,411 - 10,883,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365557,686,841 - 7,697,078 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365557,686,841 - 7,697,084 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMDEC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl148,456,134 - 8,471,088 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1148,455,964 - 8,483,308 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2149,498,092 - 9,512,852 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMDEC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1822,516,511 - 22,537,706 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl822,516,639 - 22,537,731 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605219,647,053 - 19,668,264 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamdec1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475819,519,526 - 19,534,259 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475819,519,526 - 19,534,409 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamdec1
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:401
Count of miRNA genes:221
Interacting mature miRNAs:272
Transcripts:ENSRNOT00000028974
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system reproductive system respiratory system
High
Medium 3 1 1 1
Low 13 12 1 12 1 3
Below cutoff 22 22 2 22 8 9 7

Sequence


RefSeq Acc Id: ENSRNOT00000028974   ⟹   ENSRNOP00000037152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1542,900,636 - 42,921,712 (-)Ensembl
Rnor_6.0 Ensembl1549,485,611 - 49,505,553 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117651   ⟹   ENSRNOP00000081269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1542,902,963 - 42,921,712 (-)Ensembl
RefSeq Acc Id: NM_001401660   ⟹   NP_001388589
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81547,076,011 - 47,097,065 (-)NCBI
mRatBN7.21542,900,629 - 42,921,684 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388589 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85426 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037152
  ENSRNOP00000037152.4
  ENSRNOP00000081269.1
RefSeq Acc Id: ENSRNOP00000037152   ⟸   ENSRNOT00000028974
RefSeq Acc Id: ENSRNOP00000081269   ⟸   ENSRNOT00000117651
RefSeq Acc Id: NP_001388589   ⟸   NM_001401660
- Peptide Label: precursor
- UniProtKB: D3ZW34 (UniProtKB/TrEMBL)
Protein Domains
Disintegrin   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZW34-F1-model_v2 AlphaFold D3ZW34 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699792
Promoter ID:EPDNEW_R10315
Type:multiple initiation site
Name:Adamdec1_1
Description:ADAM-like, decysin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01549,505,525 - 49,505,585EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309861 AgrOrtholog
BioCyc Gene G2FUF-13283 BioCyc
Ensembl Genes ENSRNOG00000030724 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028974 ENTREZGENE
  ENSRNOT00000028974.4 UniProtKB/TrEMBL
  ENSRNOT00000117651.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene 290338 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  PTHR11905:SF125 UniProtKB/TrEMBL
Pfam Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adamdec1 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030724 RatGTEx
SMART DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0A8I6G5P7_RAT UniProtKB/TrEMBL
  D3ZW34 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Adamdec1  ADAM-like, decysin 1   Adamdec1_predicted  ADAM-like, decysin 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Adamdec1_predicted  ADAM-like, decysin 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED