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Gene: Cdc42bpa (CDC42 binding protein kinase alpha) Rattus norvegicus

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Symbol:

Cdc42bpa

Name:

CDC42 binding protein kinase alpha

RGD ID:

621406

Description:

Enables several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Involved in several processes, including actomyosin structure organization; protein phosphorylation; and regulation of small GTPase mediated signal transduction. Located in actomyosin; cell leading edge; and cell-cell junction. Orthologous to human CDC42BPA (CDC42 binding protein kinase alpha); INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CDC42-binding protein kinase alpha; Mrck; MRCK alpha; myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy protein kinase-like alpha; mytonic dystrophy kinase-related Cdc42-binding kinase; Pk428; Ser-Thr protein kinase related to the myotonic dystrophy protein kinase; serine/threonine-protein kinase MRCK alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CDC42BPA (CDC42 binding protein kinase alpha)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cdc42bpa (CDC42 binding protein kinase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cdc42bpa (CDC42 binding protein kinase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CDC42BPA (CDC42 binding protein kinase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CDC42BPA (CDC42 binding protein kinase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cdc42bpa (CDC42 binding protein kinase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CDC42BPA (CDC42 binding protein kinase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CDC42BPA (CDC42 binding protein kinase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cdc42bpa (CDC42 binding protein kinase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Cdc42bpa (CDC42 binding protein kinase alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CDC42BPA (CDC42 binding protein kinase alpha)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cdc42bpab (CDC42 binding protein kinase alpha (DMPK-like) b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cdc42bpaa (CDC42 binding protein kinase alpha (DMPK-like) a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	gek	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mrck-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cdc42bpa	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	94,215,359 - 94,435,681 (+)	NCBI		GRCr8
mRatBN7.2	13	91,683,775 - 91,903,732 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	91,684,007 - 91,903,732 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	94,189,194 - 94,408,912 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	95,589,354 - 95,809,080 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	92,764,044 - 92,983,789 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	98,231,326 - 98,447,762 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	98,231,326 - 98,447,762 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	103,238,053 - 103,453,991 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	95,640,342 - 95,865,501 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	95,829,277 - 96,054,435 (+)	NCBI
Celera	13	91,234,788 - 91,448,806 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

gastrointestinal stromal tumor (ISO)

parathyroid carcinoma (ISO)

primary coenzyme Q10 deficiency 4 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (EXP)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

5-azacytidine (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bucladesine (ISO)

butanal (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (EXP)

chlorpyrifos (EXP)

cobalt dichloride (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

DDE (ISO)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fonofos (ISO)

fulvestrant (ISO)

glyphosate (EXP)

irinotecan (ISO)

medroxyprogesterone acetate (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

parathion (ISO)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sevoflurane (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

T-2 toxin (ISO)

temozolomide (ISO)

terbufos (ISO)

thiram (ISO)

titanium dioxide (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

vitamin E (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IDA,ISO)

actomyosin structure organization (IBA,IMP,ISO)

cell migration (IMP,ISO)

cytoskeleton organization (IDA,IEA)

microtubule cytoskeleton organization (ISO)

nuclear migration (ISO)

protein phosphorylation (IDA,ISO)

regulation of small GTPase mediated signal transduction (IDA)

Cellular Component

actomyosin (IBA,IDA,ISO)

cell leading edge (IDA)

cell projection (IEA)

cell-cell junction (IDA)

cytoplasm (IBA,IEA)

cytoskeleton (IBA)

lamellipodium (IEA,ISO,ISS)

Molecular Function

ATP binding (IDA,IEA,ISO)

identical protein binding (IPI,ISO)

kinase activity (IEA)

magnesium ion binding (IDA,ISO)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (IPI,ISO)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IDA,IEA,ISO)

transferase activity (IEA)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.	Lee IC, etal., J Biol Chem. 2014 Sep 26;289(39):26989-7003. doi: 10.1074/jbc.M114.588079. Epub 2014 Aug 8.
3.	Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.	Leung T, etal., Mol Cell Biol 1998 Jan;18(1):130-40.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.	Tan I, etal., Cell. 2008 Oct 3;135(1):123-36. doi: 10.1016/j.cell.2008.09.018.
10.	Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha.	Tan I, etal., Mol Cell Biol. 2001 Apr;21(8):2767-78.

Additional References at PubMed

PMID:9092543	PMID:11340065	PMID:11399775	PMID:15882626	PMID:17702745	PMID:19056867	PMID:21457715	PMID:23414517

Genomics

Comparative Map Data

Cdc42bpa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	94,215,359 - 94,435,681 (+)	NCBI		GRCr8
mRatBN7.2	13	91,683,775 - 91,903,732 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	91,684,007 - 91,903,732 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	94,189,194 - 94,408,912 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	95,589,354 - 95,809,080 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	92,764,044 - 92,983,789 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	98,231,326 - 98,447,762 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	98,231,326 - 98,447,762 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	103,238,053 - 103,453,991 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	95,640,342 - 95,865,501 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	95,829,277 - 96,054,435 (+)	NCBI
Celera	13	91,234,788 - 91,448,806 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

CDC42BPA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	226,989,858 - 227,318,492 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	226,989,865 - 227,318,492 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	227,177,559 - 227,506,193 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	225,244,189 - 225,572,449 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	223,486,787 - 223,812,561	NCBI
Celera	1	200,368,385 - 200,714,137 (-)	NCBI		Celera
Cytogenetic Map	1	q42.13	NCBI
HuRef	1	197,694,156 - 198,022,367 (-)	NCBI		HuRef
CHM1_1	1	228,450,048 - 228,778,008 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	226,178,223 - 226,506,850 (-)	NCBI		T2T-CHM13v2.0

Cdc42bpa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	179,787,058 - 179,993,171 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	179,788,037 - 179,993,168 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	179,960,079 - 180,165,606 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	179,960,472 - 180,165,603 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	181,891,220 - 182,095,733 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	181,797,234 - 182,002,443 (+)	NCBI		MGSCv36	mm8
Celera	1	187,025,201 - 187,227,563 (+)	NCBI		Celera
Cytogenetic Map	1	H4	NCBI
cM Map	1	84.01	NCBI

Cdc42bpa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	9,906,195 - 10,174,465 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	9,906,195 - 10,178,281 (+)	NCBI	ChiLan1.0	ChiLan1.0

CDC42BPA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	22,218,301 - 22,550,221 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	22,166,675 - 22,498,600 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	202,448,571 - 202,780,486 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	207,438,330 - 207,767,265 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	207,438,330 - 207,766,907 (-)	Ensembl	panpan1.1		panPan2

CDC42BPA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	37,775,133 - 38,084,136 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	37,775,127 - 38,081,733 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	37,257,758 - 37,566,798 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	37,608,217 - 37,918,760 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	37,608,477 - 37,915,525 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	37,448,901 - 37,757,738 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	37,456,073 - 37,764,872 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	37,725,913 - 38,035,278 (+)	NCBI		UU_Cfam_GSD_1.0

Cdc42bpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	50,751,931 - 51,060,891 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	3,690,422 - 3,995,095 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936526	3,686,403 - 3,996,035 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDC42BPA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	14,652,855 - 14,940,825 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	14,649,278 - 14,940,988 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	16,930,459 - 17,259,392 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDC42BPA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	2,463,764 - 2,777,699 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	2,464,952 - 2,773,353 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	2,418,681 - 2,742,409 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdc42bpa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	12,314,570 - 12,591,015 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624771	12,314,566 - 12,591,071 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cdc42bpa
1092 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	89
Count of miRNA genes:	70
Interacting mature miRNAs:	83
Transcripts:	ENSRNOT00000003837
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	66451204	106807694	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC139413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF021935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003837 ⟹ ENSRNOP00000003837

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	91,684,007 - 91,903,732 (+)	Ensembl
Rnor_6.0 Ensembl	13	98,231,326 - 98,447,762 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082844 ⟹ ENSRNOP00000073612

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	91,768,441 - 91,903,732 (+)	Ensembl
Rnor_6.0 Ensembl	13	98,311,827 - 98,447,312 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102712 ⟹ ENSRNOP00000093143

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	91,684,007 - 91,903,732 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105577 ⟹ ENSRNOP00000081450

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	91,684,007 - 91,903,732 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109203 ⟹ ENSRNOP00000086891

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	91,684,007 - 91,903,732 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116713 ⟹ ENSRNOP00000077481

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	91,684,007 - 91,903,732 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119463 ⟹ ENSRNOP00000078690

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	91,684,007 - 91,903,732 (+)	Ensembl

RefSeq Acc Id:

NM_053657 ⟹ NP_446109

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,215,959 - 94,435,681 (+)	NCBI
mRatBN7.2	13	91,684,007 - 91,903,732 (+)	NCBI
Rnor_6.0	13	98,231,326 - 98,447,762 (+)	NCBI
Rnor_5.0	13	103,238,053 - 103,453,991 (+)	NCBI
RGSC_v3.4	13	95,640,342 - 95,865,501 (+)	RGD
Celera	13	91,234,788 - 91,448,806 (+)	RGD

Sequence:

show sequence

CATTTGCAGCACATTTTTGGCTTTCCCTCCCCCTCCATACATTCCCCCCCTCCTTTTTCAATTT
TTCTTCTTCCCGGGAAGTGAATTGCTGATGCCAAGGGGACTTTAATTCCATTAATGATGCAACT
GGATTCGTTTCAGGATTATGTTGCACGAATTGAATTTTGAATGAAGGAGGTTTTTTTTTTCTTT
TTGAAAGAAGTGTTGATTCTTTAGTTCGTTGTACTTTTAATTATTATTTTATTTAAATATACAA
TTTAATTGTATTATTCTCTTAAAAATATTAAATCTATATTTTATGGAAACTTACCCTCAAAATA
TATATGTTTATGGGTGAAATTGAAGACGCTTCCGTTAAGTGAGGTGACTGGTGTATTGGATGTT
TAATTGAGCACCGGCATTGCATGACAGTTGTTGAATAACAAGTGGTTTATTTTTAAAAACCACA
TCTTTAAAATTTTAGGTTCAGATAGTAACAGTAGACATCGTAAGGGCATTTAAAAGAAAACCAG
CAGAAATCGAAGCAAACATGTCTGGAGAAGTGCGTTTGAGGCAGTTGGAACAGTTTATTTTAGA
TGGGCCAGCTCAGACCAATGGGCAGTGCTTCAGTGTGGAGACGTTACTGGACATACTCATCTGT
CTTTATGATGAATGCAATAATTCTCCATTGAGAAGAGAGAAGAACATTCTTGAATATCTAGAAT
GGGCTAAACCATTCACTTCTAAAGTGAAGCAAATGCGCTTACATAGAGAAGACTTCGAAATATT
AAAGGTGATTGGTCGAGGAGCTTTTGGTGAGGTTGCTGTAGTTAAACTGAAAAATGCAGATAAA
GTATTTGCCATGAAAATTCTGAACAAGTGGGAAATGCTGAAAAGAGCTGAGACAGCGTGCTTTC
GTGAAGAGAGGGATGTGTTGGTAAATGGAGACAGTAAGTGGATAACCACTCTGCACTATGCTTT
TCAGGATGACAATAACTTATACCTGGTTATGGATTATTATGTTGGTGGGGATTTACTTACTCTG
CTCAGCAAATTTGAAGATCGATTGCCAGAAGAGATGGCTCGGTTTTACTTGGCTGAGATGGTGA
TAGCCATTGACTCAGTTCACCAGCTCCACTATGTTCACAGAGACATCAAACCTGACAATATATT
GATGGATATGAATGGACATATTCGTTTAGCAGATTTTGGTTCTTGTCTGAAGCTGATGGAAGAT
GGAACGGTCCAGTCCTCAGTGGCAGTTGGAACTCCAGACTACATTTCCCCGGAAATCCTTCAGG
CTATGGAGGACGGGAAAGGCAGATATGGACCAGAGTGTGACTGGTGGTCCTTGGGAGTCTGCAT
GTATGAGATGCTTTACGGAGAAACACCATTCTATGCGGAATCTCTGGTGGAGACATATGGAAAA
ATTATGAATCATAAAGAGAGGTTTCAGTTTCCAACCCAAGTGACTGATGTGTCTGAAAATGCTA
AAGATCTTATTCGAAGACTCATTTGTAGCAGAGAACATCGACTTGGCCAGAATGGAATAGAAGA
CTTTAAGAAACATCCGTTTTTCAGTGGAATTGATTGGGATAACATCCGAAACTGTGAAGCACCT
TACATTCCAGAAGTTAGTAGTCCAACAGACACGTCAAATTTCGATGTGGATGACGACTGTTTAA
AAAACTCTGAAACAATGCCCCCACCAACACATACTGCATTTTCTGGCCATCATCTACCATTTGT
TGGGTTTACATATACTAGTAGCTGTGTTCTTTCTGATCGGAGCTGTTTAAGAGTCACAGCAGGT
CCCACCTCACTGGATCTTGACGTCAATGTCCAGAGGACTCTAGATAATAACTTAGCAACTGAAG
CTTATGAAAGAAGAATTAAACGGCTAGAACAGGAAAAGCTTGAACTTACTAGAAAACTTCAAGA
GTCAACACAGACTGTTCAAGCCCTGCAGTATTCAACTGTTGATGGTCCACTAACGGCAAGCAAA
GATTTAGAAATTAAAAGTCTGAAAGAAGAGATTGAAAAACTAAGAAAACAAGTAGCAGAAGTGA
ATCATTTGGAACAACAACTTGAAGAAGCTAATTCTGTGAGACGAGAACTAGATGATGCTTTTAG
GCAAATCAAAGCTTTTGAAAAACAAATCAAAACTTTGCAGCAGGAAAGAGAAGAGCTAAATAAG
GAACTAGTCCAGGCTAGTGAGCGATTAAAAAACCAATCCAAAGAGCTGAAAGACGCACACTGTC
AGAGGAAACTGGCCATGCAGGAGTTCATGGAGATCAATGAGCGACTAACAGAATTGCACACCCA
AAAGCAGAAACTTGCTCGCCATGTCCGAGATAAGGAAGAAGAGGTGGACCTGGTGATGCAAAAA
GCTGAGAGCTTAAGGCAGGAGCTTCGCAGAGCAGAAAGAGCCAAGAAAGAGCTGGAGGTTCACA
CTGAAGCTCTAATTGCTGAAGCCTCAAAGGACCGGAAGCTCCGAGAGCAGAGCAGACATTATTC
TAAACAGCTGGAAAATGAATTGGAGGGACTGAAGCAAAAACAAATTAGTTACTCACCAGGAATA
TGCAGCATAGAACACCAGCAAGAGATAACTAAACTGAAAACTGACTTGGAAAAGAAAAGTATCT
TTTATGAAGAAGAAATCTCTAAAAGAGAAGGAATTCATGCAAGTGAGATTAAAAATCTGAAGAA
GGAGCTGCATGACTCAGAAGGCCAGCAACTTGCTCTCAACAAAGAAATTATGGTTTTAAAAGAC
AAATTGGAAAAAACCAGAAGGGAAAGTCAAAGTGAAAGGGAAGAATTTGAAAATGAGTTCAAGC
AACAATATGAACGGGAAAAAGTATTATTAACTGAAGAGAATAAAAAGTTAACGAGTGAACTCGA
TAAGCTAACTTCGTTGTATGAGAGCTTAAGTTTGCGCAACCAGCACTTAGAAGAAGAGGTCAAA
GATCTAGCAGATAAGAAGGAATCAGTTGCCCACTGGGAAGCCCAAATCACAGAGATAATCCAAT
GGGTGAGTGATGAGAAGGACGCACGGGGCTATCTTCAGGCCTTAGCTTCTAAAATGACTGAAGA
ATTAGAAGCGTTAAGGAATTCCAGCCTGGGGACACGAGCGACAGATATGCCCTGGAAAATGCGT
CGTTTTGCAAAACTGGACATGTCAGCTAGACTAGAGTTGCAATCTGCCCTGGATGCAGAAATCA
GAGCTAAGCAGGCCATCCAGGAAGAGCTGAATAAAGTCAAAGCATCCAACATCATAACAGAATG
TAAACTGAAAGATTCAGAGAAGAAGAACTTGGAACTGTTGTCCGAAATCGAGCAGCTGATAAAG
GACACTGAAGAGCTTAGATCTGAAAAGGGTGTAGAGCACCGAGACTCACAGCACTCTTTCTTGG
CATTTTTGAATACGCCTACCGATGCTCTGGATCAATTTGAACGCTCTCCGTCCTGTACTCCAGC
TGGCAAAGGCAGACGTATTGCAGACTCTGCTCCGCTTCCAGTTCACACACCAACTTTAAGGAAA
AAGGGATGCCCAGCTTCAGCTGGTTTTCCACCTAAGCGCAAGACTCATCAGTTTTTCGTGAAGT
CTTTCACTGCCCCTACCAAGTGCCATCAGTGTACCTCCTTGATGGTCGGTTTGATAAGACAGGG
CTGTTCCTGCGAAGTCTGTGGGTTCTCATGTCATATAACTTGTGTGAACAAAGCCCCGACCACT
TGCCCAGTTCCTCCTGAGCAAACTAAAGGCCCACTCGGTATAGACCCCCAGAAGGGAGTAGGGA
CAGCGTATGAGGGCCATGTCCGGATCCCTAAGCCGGCGGGAGTGAAGAAAGGGTGGCAGAGAGC
ACTGGCTGTGGTCTGTGACTTCAAACTGTTTCTTTATGATATCGCGGAGGGAAAAGCATCGCAG
CCCAGCTCCGTCATTAGTCAAGTGATCGACATGAGAGATGAAGAATTTTCCGTGAGTTCAGTCT
TGGCTTCTGATGTTATTCATGCAAGTCGAAAAGATATTCCCTGTATATTTAGAGTCACAGCCTC
CCAGCTCTCAGCACCTAGTGACAAATGTTCCATCCTGATGCTAGCCGACAGCGAGACTGAGAGG
AGTAAGTGGGTGGGAGTGCTGAGTGAACTCCACAAGGTTCTGAAGAAAAACAAGTTCAGAGACC
GCTCAGTGTATGTCCCCAAAGAGGCTTACGACAGCACTCTACCCCTCATTAAAACAACGCAGGC
CGCGGCAATCATAGATCATGAGCGGGTAGCTTTGGGAAATGAAGAAGGATTATTTGTTGTGCAT
GTCACTAAAGATGAGATTATTAGAGTTGGTGATAATAAGAAAATTCATCAGATTGAACTCATTC
CAAGTGACCAGCTTGTTGCTGTGATCTCAGGCCGAAATCGCCACGTCCGACTTTTCCCTATGTC
AGCTTTGGATGGGCGAGAGACGGATTTTTATAAACTGGCAGAGACTAAAGGGTGTCAAACCATA
GCTGCTGGGAAGGTGCGCCATGGAGCTCTGTCCTGCCTGTGTGTGGCCATGAAAAGACAGGTCC
TCTGCTATGAACTGTTCCAAAGCAAGACCAGGCACAGGAAGTTTAAGGAGATTCAAGTCCCATG
TAATGTCCAGTGGATGGCCATCTTCAGTGAACATCTCTGTGTGGGATTCCAGTCAGGATTTCTC
AGATACCCCCTGAATGGGGAAGGAAGTCCATGCAATATGCTCCATTCAAATGACCACACACTGG
CATTCATTACACACCAACCAATGGATGCTATCTGTGCCGTTGAGATCTCCAACAAAGAGTATTT
GCTGTGTTTTAGCAGCATTGGGATATACACGGACTGCCAGGGCCGAAGATCTAGACAGCAGGAA
CTGATGTGGCCAGCAAATCCTTCCTCCTGTTGTTACAATGCACCATATCTCTCCATTTACAGTG
AAAATGCAGTTGATATCTTTGATGTAAACTCCATGGAATGGATACAGACGCTTCCTCTCAAGAA
GGTTCGACCTTTAAACACTGAAGGATCATTAAATCTTTTAGGGTTGGAGACCATTAGATTAATA
TATTTCAAAAATAAGATGGCAGAAGGGGATGAACTTGTAGTTCCTGAAACATCAGATAATAGCC
GAAAACAGATGGTTAGAAACATCAACAACAAACGGCGTTACTCCTTCCGGGTCCCAGAAGAAGA
GAGGATGCAGCAGAGAAGGGAGATGCTACGAGATCCAGAAATGAGAAATAAATTAATTTCTAAC
CCAACTAATTTTAACCACATAGCACACATGGGTCCTGGAGATGGAATACAGATCCTAAAAGACC
TGCCCATGAACCCACGGCCTCAGGAAAGCCGGACAGTATTCAGTGGCTCCGTCAGTATTCCCTC
CATCACCAAGTCCCGCCCTGAGCCAGGCCGCTCCATGAGTGCCAGCAGTGGCCTGTCTGCACGG
TCATCAGCCCAGAATGGCAGTGCGCTAAAGAGGGAATTCTCTGGAGGAAGCTACAACACGAAGC
GACAGCCCATGCCCTCTCCCTCAGAAGGCTCTTTGTCATCAGGAGGCGTGGACCAAGGAAGTGA
CGCCCCCGTGAGGGACTATGATGGAGAGGACTCTGATTCTCCAAGGCATTCCACAGCTTCCAAC
AGCTCTAACCTGAGCAGCCCCCCAAGCCCCGTTTCACCCCGAAAGACCAAGAGCCTCTCCTTGG
AGAGCACAGACCGTGGGAGCTGGGATCCATGAGCAGGACCAGTGACTCCAGGCAGGGACCCTGC
CCTCCCACTCTGACAACGCGCCTGGCAGCAGCATCACCTTCCACACTGCCTGCCACCGAGGATT
CCTTCACAGCCAGGCCCGCTTCACCCTTCCCCCAACCCCCAGGTAGCTTCTGTAGACAGACTGC
GCAGACGCAGCGCTAAGAGTAGACCGGTTGTGTTCTCACCGTAGCCCTCACGTAGCCCTCACGT
AGCGCCCAGCAGCCTCCATGAGCGTCAGCTGACTGTTGCCAGGAAATAAACCCTCATGAATTAA
AACAATGCATATTTTTACTACAATAAAGAGTTTAAATAAATACATAGATGTAGACGTTAAATAC
TGAAGTATAAATAGTCAAAGAAGCATCTCTTGTGTTCGATGAAAGATGGATGCGATATAAGAAA
GATCATTTAATTTAAAAAAAAAAAGTGTTGTTTCTTATCTGTTTCCCAGCTAAGTCATAATACA
GGGTAGAAAGGCCTCAAGTGACATTTATAAAGACACAGAAGTCAGGTCCCGGTGGTGTCTGTCC
TCAAGCCTAGGCAGCTGTGGTCACAGGGAAGTCTAATGTCTGGAGATTACTCGTGCCGAATTC

hide sequence

RefSeq Acc Id:

XM_039090235 ⟹ XP_038946163

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,215,359 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,776 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090237 ⟹ XP_038946165

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,777 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090242 ⟹ XP_038946170

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,777 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090245 ⟹ XP_038946173

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,778 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090246 ⟹ XP_038946174

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,777 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090247 ⟹ XP_038946175

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,778 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090251 ⟹ XP_038946179

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,215,397 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,779 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090256 ⟹ XP_038946184

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,778 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090257 ⟹ XP_038946185

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,780 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090259 ⟹ XP_038946187

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,781 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090261 ⟹ XP_038946189

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,782 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090262 ⟹ XP_038946190

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,215,397 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,778 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090264 ⟹ XP_038946192

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,781 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_039090266 ⟹ XP_038946194

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI
mRatBN7.2	13	91,683,781 - 91,903,732 (+)	NCBI

RefSeq Acc Id:

XM_063271956 ⟹ XP_063128026

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI

RefSeq Acc Id:

XM_063271957 ⟹ XP_063128027

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI

RefSeq Acc Id:

XM_063271958 ⟹ XP_063128028

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,639 - 94,435,674 (+)	NCBI

RefSeq Acc Id:

XM_063271959 ⟹ XP_063128029

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,215,397 - 94,435,674 (+)	NCBI

RefSeq Acc Id:

XM_063271960 ⟹ XP_063128030

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,435,674 (+)	NCBI

RefSeq Acc Id:

XM_063271961 ⟹ XP_063128031

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,216,141 - 94,431,736 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_446109	(Get FASTA)	NCBI Sequence Viewer
	XP_038946163	(Get FASTA)	NCBI Sequence Viewer
	XP_038946165	(Get FASTA)	NCBI Sequence Viewer
	XP_038946170	(Get FASTA)	NCBI Sequence Viewer
	XP_038946173	(Get FASTA)	NCBI Sequence Viewer
	XP_038946174	(Get FASTA)	NCBI Sequence Viewer
	XP_038946175	(Get FASTA)	NCBI Sequence Viewer
	XP_038946179	(Get FASTA)	NCBI Sequence Viewer
	XP_038946184	(Get FASTA)	NCBI Sequence Viewer
	XP_038946185	(Get FASTA)	NCBI Sequence Viewer
	XP_038946187	(Get FASTA)	NCBI Sequence Viewer
	XP_038946189	(Get FASTA)	NCBI Sequence Viewer
	XP_038946190	(Get FASTA)	NCBI Sequence Viewer
	XP_038946192	(Get FASTA)	NCBI Sequence Viewer
	XP_038946194	(Get FASTA)	NCBI Sequence Viewer
	XP_063128026	(Get FASTA)	NCBI Sequence Viewer
	XP_063128027	(Get FASTA)	NCBI Sequence Viewer
	XP_063128028	(Get FASTA)	NCBI Sequence Viewer
	XP_063128029	(Get FASTA)	NCBI Sequence Viewer
	XP_063128030	(Get FASTA)	NCBI Sequence Viewer
	XP_063128031	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC02941	(Get FASTA)	NCBI Sequence Viewer
	EDL94816	(Get FASTA)	NCBI Sequence Viewer
	EDL94817	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003837
	ENSRNOP00000077481
	ENSRNOP00000081450
	ENSRNOP00000086891
	ENSRNOP00000093143
	ENSRNOP00000099199
	ENSRNOP00000103002
GenBank Protein	O54874	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446109 ⟸ NM_053657

- UniProtKB:

O54874 (UniProtKB/Swiss-Prot), G3V6C9 (UniProtKB/TrEMBL), A6JGG0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFT
SKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDV
LVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSV
HQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGK
GRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTDVSENAKDLIRR
LICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETM
PPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRI
KRLEQEKLELTRKLQESTQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQ
LEEANSVRRELDDAFRQIKAFEKQIKTLQQEREELNKELVQASERLKNQSKELKDAHCQRKLAM
QEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKAESLRQELRRAERAKKELEVHTEALIA
EASKDRKLREQSRHYSKQLENELEGLKQKQISYSPGICSIEHQQEITKLKTDLEKKSIFYEEEI
SKREGIHASEIKNLKKELHDSEGQQLALNKEIMVLKDKLEKTRRESQSEREEFENEFKQQYERE
KVLLTEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEK
DARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAI
QEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGVEHRDSQHSFLAFLNTP
TDALDQFERSPSCTPAGKGRRIADSAPLPVHTPTLRKKGCPASAGFPPKRKTHQFFVKSFTAPT
KCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGVGTAYEGH
VRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPSSVISQVIDMRDEEFSVSSVLASDVI
HASRKDIPCIFRVTASQLSAPSDKCSILMLADSETERSKWVGVLSELHKVLKKNKFRDRSVYVP
KEAYDSTLPLIKTTQAAAIIDHERVALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPSDQLV
AVISGRNRHVRLFPMSALDGRETDFYKLAETKGCQTIAAGKVRHGALSCLCVAMKRQVLCYELF
QSKTRHRKFKEIQVPCNVQWMAIFSEHLCVGFQSGFLRYPLNGEGSPCNMLHSNDHTLAFITHQ
PMDAICAVEISNKEYLLCFSSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSIYSENAVDI
FDVNSMEWIQTLPLKKVRPLNTEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVR
NINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPR
PQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYNTKRQPMPS
PSEGSLSSGGVDQGSDAPVRDYDGEDSDSPRHSTASNSSNLSSPPSPVSPRKTKSLSLESTDRG
SWDP

hide sequence

Ensembl Acc Id:

ENSRNOP00000073612 ⟸ ENSRNOT00000082844

Ensembl Acc Id:

ENSRNOP00000003837 ⟸ ENSRNOT00000003837

RefSeq Acc Id:	XP_038946163 ⟸ XM_039090235
- Peptide Label:	isoform X1
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038946170 ⟸ XM_039090242
- Peptide Label:	isoform X3
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038946165 ⟸ XM_039090237
- Peptide Label:	isoform X2
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038946174 ⟸ XM_039090246
- Peptide Label:	isoform X5
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038946173 ⟸ XM_039090245
- Peptide Label:	isoform X4
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038946175 ⟸ XM_039090247
- Peptide Label:	isoform X6
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038946184 ⟸ XM_039090256
- Peptide Label:	isoform X10
- UniProtKB:	A0A8I6A4M2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946190 ⟸ XM_039090262
- Peptide Label:	isoform X16
- UniProtKB:	A0A8I6G3L7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946179 ⟸ XM_039090251
- Peptide Label:	isoform X8
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038946185 ⟸ XM_039090257
- Peptide Label:	isoform X11
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot), A0A8I6AWL9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946187 ⟸ XM_039090259
- Peptide Label:	isoform X13
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038946192 ⟸ XM_039090264
- Peptide Label:	isoform X17
- UniProtKB:	A0A8I6A4M2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946194 ⟸ XM_039090266
- Peptide Label:	isoform X20
- UniProtKB:	A0A8I5ZRP1 (UniProtKB/TrEMBL), A0A8I6G3L7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946189 ⟸ XM_039090261
- Peptide Label:	isoform X15
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot), A0A8I5Y183 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000093143 ⟸ ENSRNOT00000102712

Ensembl Acc Id:

ENSRNOP00000086891 ⟸ ENSRNOT00000109203

Ensembl Acc Id:

ENSRNOP00000078690 ⟸ ENSRNOT00000119463

Ensembl Acc Id:

ENSRNOP00000081450 ⟸ ENSRNOT00000105577

Ensembl Acc Id:

ENSRNOP00000077481 ⟸ ENSRNOT00000116713

RefSeq Acc Id:	XP_063128029 ⟸ XM_063271959
- Peptide Label:	isoform X14
- UniProtKB:	A0A8I6G3L7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128026 ⟸ XM_063271956
- Peptide Label:	isoform X7
- UniProtKB:	O54874 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063128027 ⟸ XM_063271957
- Peptide Label:	isoform X9
- UniProtKB:	A0A8I6G3L7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128030 ⟸ XM_063271960
- Peptide Label:	isoform X18
- UniProtKB:	A0A8I6G3L7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128031 ⟸ XM_063271961
- Peptide Label:	isoform X19
- UniProtKB:	A6JGG1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128028 ⟸ XM_063271958
- Peptide Label:	isoform X12
- UniProtKB:	A0A0G2K5Z1 (UniProtKB/TrEMBL)

Protein Domains

AGC-kinase C-terminal CNH CRIB PH Phorbol-ester/DAG-type Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O54874-F1-model_v2	AlphaFold	O54874	1-1732	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699055

Promoter ID:

EPDNEW_R9580

Type:

single initiation site

Name:

Cdc42bpa_1

Description:

CDC42 binding protein kinase alpha

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	98,231,519 - 98,231,579	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621406	AgrOrtholog
BioCyc Gene	G2FUF-17134	BioCyc
Ensembl Genes	ENSRNOG00000002841	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000003837	ENTREZGENE
	ENSRNOT00000102712	ENTREZGENE
	ENSRNOT00000105577	ENTREZGENE
	ENSRNOT00000109203	ENTREZGENE
	ENSRNOT00000116713	ENTREZGENE
	ENSRNOT00000151394	ENTREZGENE
	ENSRNOT00000151561	ENTREZGENE
Gene3D-CATH	1.10.287.1490	UniProtKB/Swiss-Prot
	1.20.5.340	UniProtKB/Swiss-Prot
	2.30.29.30	UniProtKB/Swiss-Prot
	3.30.60.20	UniProtKB/Swiss-Prot
	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	AGC-kinase_C	UniProtKB/Swiss-Prot
	C1-like_sf	UniProtKB/Swiss-Prot
	CNH_dom	UniProtKB/Swiss-Prot
	CRIB_dom	UniProtKB/Swiss-Prot
	KELK	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Myotonic_dystrophy_kinase_coil	UniProtKB/Swiss-Prot
	PE/DAG-bd	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	PH_domain	UniProtKB/Swiss-Prot
	Pkinase_C	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Rho-assoc_Ser/Thr_Kinase	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_MRCK_alpha	UniProtKB/Swiss-Prot
KEGG Report	rno:114116	UniProtKB/Swiss-Prot
NCBI Gene	114116	ENTREZGENE
PANTHER	MYOTONIC DYSTROPHY S/T KINASE-RELATED	UniProtKB/Swiss-Prot
	PTHR22988:SF31	UniProtKB/Swiss-Prot
Pfam	C1_1	UniProtKB/Swiss-Prot
	CNH	UniProtKB/Swiss-Prot
	DMPK_coil	UniProtKB/Swiss-Prot
	KELK	UniProtKB/Swiss-Prot
	Pkinase	UniProtKB/Swiss-Prot
	Pkinase_C	UniProtKB/Swiss-Prot
PhenoGen	Cdc42bpa	PhenoGen
PROSITE	AGC_KINASE_CTER	UniProtKB/Swiss-Prot
	CNH	UniProtKB/Swiss-Prot
	CRIB	UniProtKB/Swiss-Prot
	PH_DOMAIN	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
	ZF_DAG_PE_1	UniProtKB/Swiss-Prot
	ZF_DAG_PE_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000002841	RatGTEx
SMART	CNH	UniProtKB/Swiss-Prot
	PBD	UniProtKB/Swiss-Prot
	S_TK_X	UniProtKB/Swiss-Prot
	S_TKc	UniProtKB/Swiss-Prot
	SM00109	UniProtKB/Swiss-Prot
	SM00233	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
	SSF57889	UniProtKB/Swiss-Prot
	Tricorn protease domain 2	UniProtKB/Swiss-Prot
UniProt	A0A0G2K5Z1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5Y183	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZRP1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A4M2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AWL9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G3L7	ENTREZGENE, UniProtKB/TrEMBL
	A6JGG0	ENTREZGENE, UniProtKB/TrEMBL
	A6JGG1	ENTREZGENE, UniProtKB/TrEMBL
	G3V6C9	ENTREZGENE, UniProtKB/TrEMBL
	MRCKA_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Cdc42bpa	CDC42 binding protein kinase alpha	Pk428	Ser-Thr protein kinase related to the myotonic dystrophy protein kinase	Symbol and Name updated	1299863	APPROVED
2002-08-07	Pk428	Ser-Thr protein kinase related to the myotonic dystrophy protein kinase			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar