Xpnpep2 (X-prolyl aminopeptidase 2) - Rat Genome Database

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Gene: Xpnpep2 (X-prolyl aminopeptidase 2) Rattus norvegicus
Analyze
Symbol: Xpnpep2
Name: X-prolyl aminopeptidase 2
RGD ID: 621277
Description: Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular exosome. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2); PARTICIPATES IN kallikrein-kinin cascade pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC102551432; mAPP; membrane-bound aminopeptidase P; membrane-bound APP; X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound; xaa-Pro aminopeptidase 2; xaa-Pro aminopeptidase 2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X127,287,765 - 127,317,036 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX127,287,979 - 127,317,223 (+)Ensembl
Rnor_6.0X134,940,656 - 134,969,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX134,940,615 - 134,969,996 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X135,012,378 - 135,043,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,474,960 - 134,501,782 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X134,548,132 - 134,575,444 (+)NCBI
CeleraX126,240,976 - 126,267,444 (+)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (EXP)
chrysene  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dimethylarsinic acid  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
endosulfan  (EXP)
flutamide  (EXP)
glafenine  (EXP)
graphite  (EXP)
GW 4064  (ISO)
L-ascorbic acid  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
orphenadrine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
quercetin  (ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Triptolide  (EXP)
trovafloxacin  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. Prueitt RL, etal., Cytogenet Cell Genet 2000;89(1-2):44-50.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12941294   PMID:17515839   PMID:19056867   PMID:21082674   PMID:23376485   PMID:25568306  


Genomics

Comparative Map Data
Xpnpep2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X127,287,765 - 127,317,036 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX127,287,979 - 127,317,223 (+)Ensembl
Rnor_6.0X134,940,656 - 134,969,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX134,940,615 - 134,969,996 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X135,012,378 - 135,043,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,474,960 - 134,501,782 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X134,548,132 - 134,575,444 (+)NCBI
CeleraX126,240,976 - 126,267,444 (+)NCBICelera
Cytogenetic MapXq36NCBI
XPNPEP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X129,738,979 - 129,769,536 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX129,738,949 - 129,769,536 (+)EnsemblGRCh38hg38GRCh38
GRCh37X128,872,955 - 128,903,512 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X128,700,627 - 128,731,206 (+)NCBINCBI36hg18NCBI36
Build 34X128,598,460 - 128,629,060NCBI
CeleraX129,259,509 - 129,290,027 (+)NCBI
Cytogenetic MapXq26.1NCBI
HuRefX118,278,391 - 118,304,600 (+)NCBIHuRef
CHM1_1X128,784,288 - 128,814,871 (+)NCBICHM1_1
T2T-CHM13v2.0X128,057,775 - 128,088,323 (+)NCBI
Xpnpep2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X47,195,790 - 47,225,859 (+)NCBIGRCm39mm39
GRCm39 EnsemblX47,197,602 - 47,225,858 (+)Ensembl
GRCm38X48,106,913 - 48,136,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX48,108,725 - 48,136,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X45,461,902 - 45,490,158 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X44,353,502 - 44,381,608 (+)NCBImm8
CeleraX35,611,298 - 35,639,452 (+)NCBICelera
Cytogenetic MapXA4NCBI
Xpnpep2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554735,245,746 - 5,274,698 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554735,248,065 - 5,274,469 (-)NCBIChiLan1.0ChiLan1.0
XPNPEP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X129,166,287 - 129,197,347 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX129,165,882 - 129,197,347 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X118,869,083 - 118,900,639 (+)NCBIMhudiblu_PPA_v0panPan3
XPNPEP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X100,951,679 - 100,979,666 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX100,951,888 - 100,978,766 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX87,125,596 - 87,153,589 (+)NCBI
ROS_Cfam_1.0X102,803,123 - 102,831,127 (+)NCBI
ROS_Cfam_1.0 EnsemblX102,802,723 - 102,831,747 (+)Ensembl
UMICH_Zoey_3.1X100,221,644 - 100,249,427 (+)NCBI
UNSW_CanFamBas_1.0X102,067,636 - 102,095,611 (+)NCBI
UU_Cfam_GSD_1.0X101,845,408 - 101,873,412 (+)NCBI
Xpnpep2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X99,183,357 - 99,213,760 (+)NCBI
SpeTri2.0NW_0049364791,773,797 - 1,883,606 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XPNPEP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX106,333,825 - 106,363,641 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X106,333,785 - 106,363,412 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X122,102,765 - 122,131,719 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XPNPEP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X105,014,789 - 105,047,149 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX105,015,221 - 105,046,423 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606542,433,962 - 42,462,483 (+)NCBIVero_WHO_p1.0
Xpnpep2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247978,961,835 - 8,992,767 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247978,962,080 - 8,992,049 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:223
Count of miRNA genes:145
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000005604
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 23 23 23 23 2 11
Low 1 13 30 16 16 16 7 10 3 8 18 7
Below cutoff 28 4 2 3 2 1 1 69 4 19 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005604   ⟹   ENSRNOP00000005604
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX127,287,979 - 127,317,223 (+)Ensembl
Rnor_6.0 EnsemblX134,940,615 - 134,969,996 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098779   ⟹   ENSRNOP00000095320
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX127,290,220 - 127,317,223 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102614   ⟹   ENSRNOP00000079032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX127,292,519 - 127,317,223 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115461   ⟹   ENSRNOP00000078740
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX127,290,220 - 127,313,452 (+)Ensembl
RefSeq Acc Id: NM_057155   ⟹   NP_476496
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X127,290,480 - 127,317,034 (+)NCBI
Rnor_6.0X134,943,331 - 134,969,867 (+)NCBI
Rnor_5.0X135,012,378 - 135,043,522 (+)NCBI
RGSC_v3.4X134,474,960 - 134,501,782 (+)RGD
CeleraX126,240,976 - 126,267,444 (+)RGD
Sequence:
RefSeq Acc Id: XM_008773513   ⟹   XP_008771735
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X127,287,766 - 127,317,036 (+)NCBI
Rnor_6.0X134,940,658 - 134,969,874 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773514   ⟹   XP_008771736
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X127,287,767 - 127,317,036 (+)NCBI
Rnor_6.0X134,940,659 - 134,969,874 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601898   ⟹   XP_017457387
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X127,287,765 - 127,317,036 (+)NCBI
Rnor_6.0X134,940,656 - 134,969,874 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099427   ⟹   XP_038955355
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X127,290,110 - 127,317,036 (+)NCBI
RefSeq Acc Id: XM_039099428   ⟹   XP_038955356
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X127,290,126 - 127,317,036 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_476496   ⟸   NM_057155
- Peptide Label: precursor
- UniProtKB: Q99MA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771735   ⟸   XM_008773513
- Peptide Label: isoform X1
- UniProtKB: Q99MA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771736   ⟸   XM_008773514
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017457387   ⟸   XM_017601898
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000005604   ⟸   ENSRNOT00000005604
RefSeq Acc Id: XP_038955355   ⟸   XM_039099427
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955356   ⟸   XM_039099428
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000095320   ⟸   ENSRNOT00000098779
RefSeq Acc Id: ENSRNOP00000078740   ⟸   ENSRNOT00000115461
RefSeq Acc Id: ENSRNOP00000079032   ⟸   ENSRNOT00000102614

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MA2-F1-model_v2 AlphaFold Q99MA2 1-674 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
X 134969077 134969078 C T snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), GH/OmrMcwi (MCW), WKY/N (MCW), WKY/NCrl (RGD), WKY/NHsd (RGD), WKY/NCrl (2019), WKY/N (2020), FHH/EurMcwi (2019), FHH/EurMcwi (RGD), FHL/EurMcwi (RGD), WKY/Gcrc (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621277 AgrOrtholog
BioCyc Gene G2FUF-1140 BioCyc
Ensembl Genes ENSRNOG00000004009 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005604 ENTREZGENE
  ENSRNOP00000078740.1 UniProtKB/TrEMBL
  ENSRNOP00000079032.1 UniProtKB/TrEMBL
  ENSRNOP00000095320 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005604 ENTREZGENE
  ENSRNOT00000098779 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000102614.1 UniProtKB/TrEMBL
  ENSRNOT00000115461.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.350.10 UniProtKB/Swiss-Prot
  3.90.230.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7098467 IMAGE-MGC_LOAD
InterPro Creatin/AminoP/Spt16_NTD UniProtKB/Swiss-Prot
  Creatinase/aminopeptidase-like UniProtKB/Swiss-Prot
  Creatinase_N UniProtKB/Swiss-Prot
  Pept_M24 UniProtKB/Swiss-Prot
  Pept_M24B UniProtKB/Swiss-Prot
  Peptidase_M24_C UniProtKB/Swiss-Prot
  Peptidase_M24B_aminopep-P_CS UniProtKB/Swiss-Prot
KEGG Report rno:117522 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91533 IMAGE-MGC_LOAD
NCBI Gene 117522 ENTREZGENE
Pfam Creatinase_N UniProtKB/Swiss-Prot
  Peptidase_M24 UniProtKB/Swiss-Prot
  Peptidase_M24_C UniProtKB/Swiss-Prot
PhenoGen Xpnpep2 PhenoGen
PROSITE PROLINE_PEPTIDASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53092 UniProtKB/Swiss-Prot
  SSF55920 UniProtKB/Swiss-Prot
UniProt A0A8I5ZLJ6_RAT UniProtKB/TrEMBL
  A0A8I5ZM13_RAT UniProtKB/TrEMBL
  Q99MA2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 Xpnpep2  X-prolyl aminopeptidase 2  Xpnpep2  X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Xpnpep2  X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound  LOC102551432  xaa-Pro aminopeptidase 2-like  Data Merged 737654 PROVISIONAL
2013-12-17 LOC102551432  xaa-Pro aminopeptidase 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Xpnpep2  X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Xpnpep2  X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound      Symbol and Name status set to provisional 70820 PROVISIONAL