Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | autism spectrum disorder | | ISO | LRRN3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:20678249 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | autism spectrum disorder | | ISO | LRRN3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:20678249 | |
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# | Reference Title | Reference Citation |
1. | Mapping the microtubule binding regions of calponin. | Fattoum A, etal., Biochemistry 2003 Feb 11;42(5):1274-82. |
2. | Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression. | Fukamachi K, etal., Biochem Biophys Res Commun 2001 Sep 14;287(1):257-63. |
3. | Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs. | Fukamachi K, etal., J Biol Chem 2002 Nov 15;277(46):43549-52. |
4. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
5. | Gene Data Set | MGD Curation, June 12, 2002 |
6. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
7. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
8. | GOA pipeline | RGD automated data pipeline |
9. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
10. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
11. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
Lrrn3 (Rattus norvegicus - Norway rat) |
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LRRN3 (Homo sapiens - human) |
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Lrrn3 (Mus musculus - house mouse) |
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Lrrn3 (Chinchilla lanigera - long-tailed chinchilla) |
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LRRN3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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LRRN3 (Canis lupus familiaris - dog) |
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Lrrn3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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LRRN3 (Sus scrofa - pig) |
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LRRN3 (Chlorocebus sabaeus - green monkey) |
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Lrrn3 (Heterocephalus glaber - naked mole-rat) |
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Variants in Lrrn3
187 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 6 | 6 | 5 | 6 | 72 | 12 | 25 | 11 | |||||
Low | 3 | 25 | 51 | 35 | 14 | 35 | 8 | 8 | 2 | 23 | 11 | 8 | |
Below cutoff | 14 | 2 | 4 |
RefSeq Transcripts | NM_030856 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_063262546 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063262547 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AF291437 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BC081791 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473947 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000006 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000008655 ⟹ ENSRNOP00000008655 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000118309 ⟹ ENSRNOP00000092172 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_030856 ⟹ NP_110483 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_063262546 ⟹ XP_063118616 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063262547 ⟹ XP_063118617 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_110483 | (Get FASTA) | NCBI Sequence Viewer |
XP_063118616 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063118617 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAG00604 | (Get FASTA) | NCBI Sequence Viewer |
AAH81791 | (Get FASTA) | NCBI Sequence Viewer | |
EDM03346 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000008655 | ||
ENSRNOP00000008655.1 | |||
ENSRNOP00000092172.1 | |||
GenBank Protein | Q9ESY6 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_110483 ⟸ NM_030856 |
- Peptide Label: | precursor |
- UniProtKB: | Q9ESY6 (UniProtKB/Swiss-Prot), Q642E4 (UniProtKB/Swiss-Prot), A0A0G2JSI7 (UniProtKB/TrEMBL), A6HBE1 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000008655 ⟸ ENSRNOT00000008655 |
RefSeq Acc Id: | ENSRNOP00000092172 ⟸ ENSRNOT00000118309 |
RefSeq Acc Id: | XP_063118617 ⟸ XM_063262547 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A0G2JSI7 (UniProtKB/TrEMBL), A6HBE1 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_063118616 ⟸ XM_063262546 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A0G2JSI7 (UniProtKB/TrEMBL), A6HBE1 (UniProtKB/TrEMBL) |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q9ESY6-F1-model_v2 | AlphaFold | Q9ESY6 | 1-707 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13694573 | ||||||||
Promoter ID: | EPDNEW_R5098 | ||||||||
Type: | single initiation site | ||||||||
Name: | Lrrn3_1 | ||||||||
Description: | leucine rich repeat neuronal 3 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:71066 | AgrOrtholog |
BioCyc Gene | G2FUF-37721 | BioCyc |
Ensembl Genes | ENSRNOG00000006368 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000008655 | ENTREZGENE |
ENSRNOT00000008655.3 | UniProtKB/TrEMBL | |
ENSRNOT00000118309.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.60.40.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
3.80.10.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:7124169 | IMAGE-MGC_LOAD |
InterPro | Cys-rich_flank_reg_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
FN3_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
FN3_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig-like_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig-like_fold | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig_sub | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig_sub2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Leu-rich_rpt | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Leu-rich_rpt_typical-subtyp | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LRR_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LRRNT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:81514 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:93401 | IMAGE-MGC_LOAD |
NCBI Gene | 81514 | ENTREZGENE |
PANTHER | LEUCINE-RICH REPEAT NEURONAL PROTEIN 3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | fn3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ig_3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LRR_8 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Lrrn3 | PhenoGen |
PROSITE | FN3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IG_LIKE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LRR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000006368 | RatGTEx |
SMART | IGc2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
LRR_SD22 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LRR_TYP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LRRCT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LRRNT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SM00409 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | L domain-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF48726 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF49265 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A0G2JSI7 | ENTREZGENE, UniProtKB/TrEMBL |
A6HBE1 | ENTREZGENE, UniProtKB/TrEMBL | |
LRRN3_RAT | UniProtKB/Swiss-Prot | |
Q642E4 | ENTREZGENE | |
Q9ESY6 | ENTREZGENE | |
UniProt Secondary | Q642E4 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2008-09-18 | Lrrn3 | leucine rich repeat neuronal 3 | Lrrn3 | leucine rich repeat protein 3, neuronal | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-07-09 | Lrrn3 | leucine rich repeat protein 3, neuronal | Symbol and Name updated to reflect Human and Mouse nomenclature | 70877 | APPROVED |
Note Type | Note | Reference |
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gene_product | member of the leucine rich repeat superfamily | 633284 |
gene_regulation | amplification of EGF phosphorylation requires C-terminal calthrin-mediated endocytosis motifs | 633284 |