Ltbp1 (latent transforming growth factor beta binding protein 1) - Rat Genome Database

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Gene: Ltbp1 (latent transforming growth factor beta binding protein 1) Rattus norvegicus
Analyze
Symbol: Ltbp1
Name: latent transforming growth factor beta binding protein 1
RGD ID: 68379
Description: Predicted to enable microfibril binding activity and transforming growth factor beta binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including dendrite; neuronal cell body; and perinuclear region of cytoplasm. Part of large latent transforming growth factor-beta complex. Biomarker of glomerulonephritis and transient cerebral ischemia. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LanC (bacterial lantibiotic synthetase component C)-like 1; latent-transforming growth factor beta-binding protein 1; LTBP-1; TGF-beta-1-BP-1; transforming growth factor beta-1-binding protein 1; transforming growth factor beta-1-masking protein large subunit; transforming growth factor-beta (TGF-beta) masking protein large subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2620,029,629 - 20,425,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx620,357,932 - 20,753,550 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0620,673,805 - 21,069,397 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0620,154,255 - 20,549,858 (-)NCBIRnor_WKY
Rnor_6.0621,203,502 - 21,600,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl621,203,502 - 21,600,451 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0631,097,090 - 31,491,815 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4619,942,626 - 20,355,084 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1620,157,811 - 20,358,038 (-)NCBI
Celera619,596,894 - 19,988,483 (-)NCBICelera
Cytogenetic Map6q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
graphite  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Anti-latent TGF-beta binding protein-1 antibody or synthetic oligopeptides inhibit extracellular matrix expression induced by stretch in cultured rat mesangial cells. Hori Y, etal., Kidney Int. 1998 Jun;53(6):1616-25.
3. Parathyroid hormone stimulation and PKA signaling of latent transforming growth factor-beta binding protein-1 (LTBP-1) mRNA expression in osteoblastic cells. Kwok S, etal., J Cell Biochem. 2005 Aug 1;95(5):1002-11.
4. Chronic hyperglycaemia increases TGFbeta2 signaling and the expression of extracellular matrix proteins in the rat parotid gland. Lamers ML, etal., Matrix Biol. 2007 Sep;26(7):572-82. Epub 2007 May 16.
5. The first stage of transforming growth factor beta1 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3). Maeda S, etal., Calcif Tissue Int. 2002 Jan;70(1):54-65. Epub 2001 Dec 21.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Vitamin D3 metabolites regulate LTBP1 and latent TGF-beta1 expression and latent TGF-beta1 incorporation in the extracellular matrix of chondrocytes. Pedrozo HA, etal., J Cell Biochem. 1999 Jan 1;72(1):151-65.
9. Growth plate chondrocytes store latent transforming growth factor (TGF)-beta 1 in their matrix through latent TGF-beta 1 binding protein-1. Pedrozo HA, etal., J Cell Physiol. 1998 Nov;177(2):343-54.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Induction and coexpression of latent transforming growth factor beta-binding protein-1 and fibrillin-1 in experimental glomerulonephritis. Porst M, etal., Nephron Exp Nephrol. 2006;102(3-4):e99-104. Epub 2005 Nov 11.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Subcellular localization of (latent) transforming growth factor beta and the latent TGF-beta binding protein in rat hepatocytes and hepatic stellate cells. Roth-Eichhorn S, etal., Hepatology. 1998 Dec;28(6):1588-96.
17. Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Soo C, etal., Am J Pathol. 2000 Aug;157(2):423-33.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues. Tsuji T, etal., Proc Natl Acad Sci U S A 1990 Nov;87(22):8835-9.
20. PDGF-BB induces expression of LTBP-1 but not TGF-beta1 in a rat cirrhotic fat storing cell line. Westhoff JH, etal., Growth Factors. 2003 Sep-Dec;21(3-4):121-30.
21. Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia. Zhu Y, etal., Neuroscience. 2001;107(4):593-602.
Additional References at PubMed
PMID:2022183   PMID:7593177   PMID:8617200   PMID:9008713   PMID:10743502   PMID:10930463   PMID:11104663   PMID:12429738   PMID:12606526   PMID:15677465   PMID:16157329   PMID:18672106  
PMID:20551380   PMID:23979707   PMID:24006456   PMID:25807483   PMID:27068509  


Genomics

Comparative Map Data
Ltbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2620,029,629 - 20,425,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx620,357,932 - 20,753,550 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0620,673,805 - 21,069,397 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0620,154,255 - 20,549,858 (-)NCBIRnor_WKY
Rnor_6.0621,203,502 - 21,600,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl621,203,502 - 21,600,451 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0631,097,090 - 31,491,815 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4619,942,626 - 20,355,084 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1620,157,811 - 20,358,038 (-)NCBI
Celera619,596,894 - 19,988,483 (-)NCBICelera
Cytogenetic Map6q13NCBI
LTBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38232,946,953 - 33,399,509 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl232,946,953 - 33,399,509 (+)EnsemblGRCh38hg38GRCh38
GRCh37233,172,020 - 33,624,576 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36233,025,896 - 33,478,080 (+)NCBINCBI36Build 36hg18NCBI36
Build 34233,084,042 - 33,536,224NCBI
Celera233,011,085 - 33,463,289 (+)NCBICelera
Cytogenetic Map2p22.3NCBI
HuRef232,905,956 - 33,358,305 (+)NCBIHuRef
CHM1_1233,101,861 - 33,553,940 (+)NCBICHM1_1
T2T-CHM13v2.0232,992,680 - 33,445,650 (+)NCBIT2T-CHM13v2.0
Ltbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391775,312,475 - 75,699,507 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1775,312,563 - 75,699,507 (+)EnsemblGRCm39 Ensembl
GRCm381775,005,480 - 75,392,512 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1775,005,568 - 75,392,512 (+)EnsemblGRCm38mm10GRCm38
MGSCv371775,404,869 - 75,791,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361774,910,589 - 75,296,829 (+)NCBIMGSCv36mm8
Celera1779,300,183 - 79,689,321 (+)NCBICelera
Cytogenetic Map17E2NCBI
Ltbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554411,232,041 - 1,627,470 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554411,405,340 - 1,626,668 (+)NCBIChiLan1.0ChiLan1.0
LTBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A33,854,604 - 34,120,593 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A33,667,191 - 34,120,602 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A32,956,937 - 33,409,286 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LTBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11726,129,528 - 26,521,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1726,130,781 - 26,521,779 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1725,920,743 - 26,311,820 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01726,696,150 - 27,088,547 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1726,695,727 - 27,088,544 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11725,992,669 - 26,384,315 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01726,065,391 - 26,457,908 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01726,223,816 - 26,614,580 (+)NCBIUU_Cfam_GSD_1.0
Ltbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629270,199,425 - 70,586,169 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936493253,216 - 640,140 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936493253,390 - 640,140 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3106,300,750 - 106,724,737 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13106,300,748 - 106,724,538 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23113,356,459 - 113,442,576 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LTBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11474,063,258 - 74,441,042 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1474,064,087 - 74,548,825 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604537,507,594 - 37,952,425 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ltbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473814,602,805 - 15,034,805 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473814,602,790 - 15,035,610 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ltbp1
2352 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:442
Count of miRNA genes:233
Interacting mature miRNAs:280
Transcripts:ENSRNOT00000047674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat

Markers in Region
D6Rat39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2620,338,777 - 20,338,915 (+)MAPPERmRatBN7.2
Rnor_6.0621,515,302 - 21,515,439NCBIRnor6.0
Rnor_5.0631,405,370 - 31,405,507UniSTSRnor5.0
Celera619,903,413 - 19,903,550UniSTS
RH 2.0 Map6179.7RGD
SHRSP x BN Map620.6398RGD
FHH x ACI Map620.5099RGD
Cytogenetic Map6q12UniSTS
D6Got317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2620,128,530 - 20,128,637 (+)MAPPERmRatBN7.2
Rnor_6.0621,302,503 - 21,302,609NCBIRnor6.0
Rnor_5.0631,195,928 - 31,196,034UniSTSRnor5.0
RGSC_v3.4620,040,716 - 20,040,822UniSTSRGSC3.4
Celera619,695,651 - 19,695,757UniSTS
Cytogenetic Map6q12UniSTS
D6Got300  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2620,258,115 - 20,258,220 (+)MAPPERmRatBN7.2
Rnor_6.0621,434,002 - 21,434,106NCBIRnor6.0
Rnor_5.0631,324,070 - 31,324,174UniSTSRnor5.0
RGSC_v3.4620,168,131 - 20,168,235UniSTSRGSC3.4
Celera619,823,913 - 19,824,017UniSTS
Cytogenetic Map6q12UniSTS
RH141349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2620,029,854 - 20,030,038 (+)MAPPERmRatBN7.2
Rnor_6.0621,203,728 - 21,203,911NCBIRnor6.0
Rnor_5.0631,097,316 - 31,097,499UniSTSRnor5.0
RGSC_v3.4619,942,852 - 19,943,035UniSTSRGSC3.4
Celera619,597,120 - 19,597,303UniSTS
Cytogenetic Map6q12UniSTS
BE100782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2620,029,782 - 20,029,893 (+)MAPPERmRatBN7.2
Rnor_6.0621,203,656 - 21,203,766NCBIRnor6.0
Rnor_5.0631,097,244 - 31,097,354UniSTSRnor5.0
RGSC_v3.4619,942,780 - 19,942,890UniSTSRGSC3.4
Celera619,597,048 - 19,597,158UniSTS
Cytogenetic Map6q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 41 11 8 13 8 7 7 14 31 33 11 7
Low 1 2 46 33 6 33 1 4 60 4 8 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047674   ⟹   ENSRNOP00000040099
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)Ensembl
Rnor_6.0 Ensembl621,203,502 - 21,600,451 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098888   ⟹   ENSRNOP00000087809
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101612   ⟹   ENSRNOP00000088104
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112287   ⟹   ENSRNOP00000078120
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)Ensembl
RefSeq Acc Id: NM_021587   ⟹   NP_067598
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2620,029,629 - 20,425,339 (-)NCBI
Rnor_6.0621,203,502 - 21,600,441 (-)NCBI
Rnor_5.0631,097,090 - 31,491,815 (-)NCBI
RGSC_v3.4619,942,626 - 20,355,084 (-)RGD
Celera619,596,894 - 19,988,483 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067598 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42235 (Get FASTA)   NCBI Sequence Viewer  
  EDM02827 (Get FASTA)   NCBI Sequence Viewer  
  Q00918 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_067598   ⟸   NM_021587
- Peptide Label: precursor
- UniProtKB: D3ZAA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040099   ⟸   ENSRNOT00000047674
RefSeq Acc Id: ENSRNOP00000087809   ⟸   ENSRNOT00000098888
RefSeq Acc Id: ENSRNOP00000088104   ⟸   ENSRNOT00000101612
RefSeq Acc Id: ENSRNOP00000078120   ⟸   ENSRNOT00000112287
Protein Domains
EGF-like   TB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00918-F1-model_v2 AlphaFold Q00918 1-1712 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694407
Promoter ID:EPDNEW_R4932
Type:single initiation site
Name:Ltbp1_1
Description:latent transforming growth factor beta binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0621,600,451 - 21,600,511EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68379 AgrOrtholog
BioCyc Gene G2FUF-38461 BioCyc
Ensembl Genes ENSRNOG00000033090 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000040099 ENTREZGENE
  ENSRNOP00000040099.3 UniProtKB/TrEMBL
  ENSRNOP00000078120.1 UniProtKB/TrEMBL
  ENSRNOP00000087809.1 UniProtKB/TrEMBL
  ENSRNOP00000088104.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047674 ENTREZGENE
  ENSRNOT00000047674.5 UniProtKB/TrEMBL
  ENSRNOT00000098888.1 UniProtKB/TrEMBL
  ENSRNOT00000101612.1 UniProtKB/TrEMBL
  ENSRNOT00000112287.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.290.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59107 UniProtKB/Swiss-Prot
NCBI Gene 59107 ENTREZGENE
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00683 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ltbp1 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS51364 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57581 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217900
UniProt A0A8I5Y739_RAT UniProtKB/TrEMBL
  A0A8I6A553_RAT UniProtKB/TrEMBL
  A0A8I6AA33_RAT UniProtKB/TrEMBL
  D3ZAA3 ENTREZGENE, UniProtKB/TrEMBL
  LTBP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ltbp1  latent transforming growth factor beta binding protein 1    LanC (bacterial lantibiotic synthetase component C)-like 1  Name updated 1299863 APPROVED
2003-04-09 Ltbp1  LanC (bacterial lantibiotic synthetase component C)-like 1    latent transforming growth factor beta binding protein 1   Name updated 629478 APPROVED
2002-06-10 Ltbp1  latent transforming growth factor beta binding protein 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains precursor contains seven N-linked glycosylation sites, 18 epidermal growth factor-like domains and four cysteine-rich internal repeats 68275